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Article ; Online: The impact of diabetic glucose concentration on viability and cardiac differentiation of mesenchymal stem cells.

Nosrati, Shadi / Gheisari, Maryam / Zare, Shahrokh / Dara, Mahintaj / Zolghadri, Samaneh / Razeghian-Jahromi, Iman

2024 Volume 88, Page(s) 102361

Language	English
Publishing date	2024-03-16
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2024.102361
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Article: The impact of high nicotine concentrations on the viability and cardiac differentiation of mesenchymal stromal cells: a barrier to regenerative therapy for smokers.

Gheisari, Maryam / Nosrati, Shadi / Zare, Shahrokh / Dara, Mahintaj / Zolghadri, Samaneh / Razeghian-Jahromi, Iman

Frontiers in cell and developmental biology

2024 Volume 12, Page(s) 1323691

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2024.1323691
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: CRISPR/Cas as a Potential Diagnosis Technique for COVID-19.

Dara, Mahintaj / Talebzadeh, Mahdieh

Avicenna journal of medical biotechnology

2020 Volume 12, Issue 3, Page(s) 201–202

Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2520683-7
ISSN	2008-4625 ; 2008-2835
ISSN (online)	2008-4625
ISSN	2008-2835
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Article ; Online: Premature Death, Underlying Reasons, and Preventive Experiences in Iran: A Narrative Review.

Razeghian-Jahromi, Iman / Ghasemi Mianrood, Yasin / Dara, Mahintaj / Azami, Pouria

Archives of Iranian medicine

2023 Volume 26, Issue 7, Page(s) 403–410

Abstract: Premature mortality (PM) has emerged as a global health challenge. This is of eminent importance in low- and middle-income countries, where nearly three fourths of the deaths occur. The concerning issue is the early occurrence of fatal events in ... ...

Abstract	Premature mortality (PM) has emerged as a global health challenge. This is of eminent importance in low- and middle-income countries, where nearly three fourths of the deaths occur. The concerning issue is the early occurrence of fatal events in productive age. Fatal events before the age of 70 are called PM, which mainly result from cardiovascular diseases (CVDs). Iran as a middle- income country greatly suffers from the cardiovascular burden, which accounts for almost 50% of all PM. Despite substantial success in reducing mortality due to communicable diseases across different age ranges, urbanization and pervasiveness of cardiovascular risk factors have increased the death rate in adults in recent years. Undoubtedly, such lifestyles have imposed heavy costs on the healthcare system; it is possible that PM reduction, as one of the fundamental elements of sustainable development goals defined by the World Health Organization (WHO), would not be reached by the due date. Recently, researchers have introduced a cost-effective fixed-dose drug combination, the so-called polypill, in order to attenuate the detrimental effects of hypertension and hyperlipidemia, as two strong cardiovascular risk factors. PolyIran and PolyIran-Liver studies are two pivotal clinical trials that revealed the feasibility of primary and secondary prevention of premature cardiovascular mortality, both in an urban and a rural population. In the present narrative review, we tried to present a comprehensive appraisal on PM status, its underlying reasons, and the impact of polypill strategy on PM prevention in Iran.
MeSH term(s)	Adult ; Humans ; Mortality, Premature ; Iran/epidemiology ; Hypertension/epidemiology ; Hypertension/complications ; Cardiovascular Diseases/epidemiology ; Drug Combinations
Chemical Substances	Drug Combinations
Language	English
Publishing date	2023-07-01
Publishing country	Iran
Document type	Review ; Journal Article
ZDB-ID	2204979-4
ISSN	1735-3947 ; 1029-2977
ISSN (online)	1735-3947
ISSN	1029-2977
DOI	10.34172/aim.2023.61
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Article ; Online: NRXN3 mutations cause developmental delay, movement disorder, and behavioral problems: CRISPR edited cells based WES results.

Kamal, Neda / Jafari Khamirani, Hossein / Dara, Mahintaj / Dianatpour, Mehdi

Gene

2023 Volume 867, Page(s) 147347

Abstract: NRXN3geneencodesneurexin-III which is a Neural Cell Adhesion Molecule (NCAM) with important synaptic functions in the brain. Neurexin-III deficiency could affect synapse development, synaptic signaling and neurotransmitter release. Hitherto, there is no ... ...

Abstract	NRXN3geneencodesneurexin-III which is a Neural Cell Adhesion Molecule (NCAM) with important synaptic functions in the brain. Neurexin-III deficiency could affect synapse development, synaptic signaling and neurotransmitter release. Hitherto, there is no related disorder in the OMIM due to NRXN3 mutation. In this study, two unrelated Iranian families with homozygous (NM_001330195.2:c.3995G>A, p.Arg1332His) and compound heterozygous (NM_001330195.2:c.4442G>A, p.Arg1481Gln; c.3142+3A>G) variants in theNRXN3gene were detected for the first time. The proband of the first family manifested learning disability, developmental delay, inability to walk, and behavioral problems such as difficulty in social communication. Also, global development delay, intellectual disability, abnormal gait, severe speech problems, muscle weakness, and behavioral problems were observed in the affected individual in the second family. In addition, deciphering the pathogenicity of NRXN3 variants was done by functional studies such as CRISPR edited cells, in-silico analysis, and NGS results. All of these data together with phenotype similarity between observed phenotypes in our patients and manifested symptoms in the homozygousNrxn3α/β knockout mice, demonstrate the homozygous and compound heterozygous mutations of NRXN3 could cause a novel syndromic mendelian genetic disorder with autosomal recessive inheritance. The main phenotype of patients with neurexin-III deficiency includes developmental delay, learning disability, movement disorder, and behavioral problems.
MeSH term(s)	Animals ; Mice ; Clustered Regularly Interspaced Short Palindromic Repeats ; Intellectual Disability/genetics ; Iran ; Movement Disorders/genetics ; Mutation
Chemical Substances	neurexin 3, mouse
Language	English
Publishing date	2023-03-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147347
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Zs.A 1357: Show issues

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Article ; Online: Novel RNA extraction method from human tears.

Dara, Mahintaj / Habibi, Azam / Azarpira, Negar / Dianatpour, Mehdi / Nejabat, Mahmood / Khosravi, Amir / Tanideh, Nader

Molecular biology research communications

2023 Volume 11, Issue 4, Page(s) 167–172

Abstract: Human tears can be used as a noninvasive source of genetic materials and biomarkers in the prognosis and diagnosis of ocular and non-ocular diseases. The present protocol is a novel direct RNA extraction method from tears. This study aims to provide a ... ...

Abstract	Human tears can be used as a noninvasive source of genetic materials and biomarkers in the prognosis and diagnosis of ocular and non-ocular diseases. The present protocol is a novel direct RNA extraction method from tears. This study aims to provide a suitable method for direct extraction of RNA from tears with high quality and quantity. In this study, we develop a TRIzol base protocol for direct RNA extraction from human tears. quality and quantity of extracted RNA measured by calculation of 260/280 UV absorption ratio using Nanodrop and real-time PCR. RNA was extracted with this modified method and a purified (260/280 UV absorption ratio between 1.8 to 2 and a high yield of total RNA, on average 95 μg, from tears was extracted. In conclusion, we developed an easy and suitable method for direct extraction of total RNA from tears with high quality and quantity.
Language	English
Publishing date	2023-02-07
Publishing country	Iran
Document type	Journal Article
ISSN	2345-2005
ISSN (online)	2345-2005
DOI	10.22099/mbrc.2022.45266.1801
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Article ; Online: Post-Weaning Exposure to Sunset Yellow FCF Induces Changes in Testicular Tight and Gap Junctions in Rats: Protective Effects of Coenzyme Q10.

Karimi, Fatemeh / Khodabandeh, Zahra / Nazari, Fatemeh / Dara, Mahintaj / Masjedi, Fatemeh / Momeni-Moghaddam, Madjid

Reproductive sciences (Thousand Oaks, Calif.)

2023 Volume 30, Issue 10, Page(s) 2962–2972

Abstract: Studies on adverse health consequences of azo dyes are limited and conflicting. Coenzyme Q10 (CoQ10) supplementation has been shown to have benefits associated with antioxidant and anti-inflammatory characteristics on several body systems. This work ... ...

Abstract	Studies on adverse health consequences of azo dyes are limited and conflicting. Coenzyme Q10 (CoQ10) supplementation has been shown to have benefits associated with antioxidant and anti-inflammatory characteristics on several body systems. This work investigates the possible toxic effects of the widely used food additive sunset yellow and the probable protective effects of CoQ10 on testicular tight and gap junctions in rats by assessing molecular, immunohistochemical, and histopathological changes. Sixty Sprague-Dawley male weanling rats were randomly divided into six groups (n = 10). The rats received their treatments via daily oral gavages for 6 weeks. The treatments included as follows: low dose of sunset yellow (SY-LD) (2.5 mg/kg/day), high dose of sunset yellow (SY-HD) (70 mg/kg/day), CoQ10 (10 mg/kg/day), CoQ10 with low dose of sunset yellow (CoQ10 + LD), CoQ10 with high dose of sunset yellow (CoQ10 + HD), and distilled water as the control treatment. At the end of the experiment, the rats were anesthetized, and the testes were removed for molecular (real-time quantitative PCR), immunohistochemical, and histopathological (H & E staining) assessments. Claudin 11 and occludin gene expression significantly decreased in HD and CoQ10 + HD groups compared with the controls. Connexin 43 (Cx43) expression in the control and CoQ10 groups was significantly higher than in the HD group. The immunohistochemical and histopathological data were largely in line with these findings. The results showed that exposure to a high dose of sunset yellow led to disturbances in cell-to-cell interactions and testicular function. Simultaneous treatment with CoQ10 had some beneficial effects but did not completely improve these undesirable effects.
MeSH term(s)	Rats ; Male ; Animals ; Testis ; Rats, Sprague-Dawley ; Azo Compounds/pharmacology ; Gap Junctions
Chemical Substances	coenzyme Q10 (EJ27X76M46) ; 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt (H77VEI93A8) ; Azo Compounds
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-023-01240-w
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Zs.A 4113: Show issues

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Article ; Online: NRXN3 mutations cause developmental delay, movement disorder, and behavioral problems: CRISPR edited cells based WES results

Kamal, Neda / Jafari Khamirani, Hossein / Dara, Mahintaj / Dianatpour, Mehdi

Gene. 2023 May, v. 867 p.147347-

2023

Abstract	NRXN3geneencodesneurexin-III which is a Neural Cell Adhesion Molecule (NCAM) with important synaptic functions in the brain. Neurexin-III deficiency could affect synapse development, synaptic signaling and neurotransmitter release. Hitherto, there is no related disorder in the OMIM due to NRXN3 mutation. In this study, two unrelated Iranian families with homozygous (NM_001330195.2:c.3995G>A, p.Arg1332His) and compound heterozygous (NM_001330195.2:c.4442G>A, p.Arg1481Gln; c.3142+3A>G) variants in theNRXN3gene were detected for the first time. The proband of the first family manifested learning disability, developmental delay, inability to walk, and behavioral problems such as difficulty in social communication. Also, global development delay, intellectual disability, abnormal gait, severe speech problems, muscle weakness, and behavioral problems were observed in the affected individual in the second family. In addition, deciphering the pathogenicity of NRXN3 variants was done by functional studies such as CRISPR edited cells, in-silico analysis, and NGS results. All of these data together with phenotype similarity between observed phenotypes in our patients and manifested symptoms in the homozygousNrxn3α/β knockout mice, demonstrate the homozygous and compound heterozygous mutations of NRXN3 could cause a novel syndromic mendelian genetic disorder with autosomal recessive inheritance. The main phenotype of patients with neurexin-III deficiency includes developmental delay, learning disability, movement disorder, and behavioral problems.
Keywords	brain ; cell adhesion molecules ; computer simulation ; gait ; genes ; genetic disorders ; heterozygosity ; homozygosity ; muscles ; mutation ; neurotransmitters ; pathogenicity ; phenotype ; speech ; synapse ; ADHD ; Autism spectrum disorder ; CRISPR/Cas9 ; Intellectual disability ; Neuron ; Neurexin 3 ; WES ; CRISPR ; FACS ; GFP ; HEK ; NGS ; NRXN ; N3D ; PCR ; U-87 MG
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147347
Database	NAL-Catalogue (AGRICOLA)

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Article: Using CRISPR/Cas9 System to Knock out Exon 48 in

Dara, Mahintaj / Razban, Vahid / Talebzadeh, Mahdieh / Moradi, Sepideh / Dianatpour, Mehdi

Avicenna journal of medical biotechnology

2020 Volume 13, Issue 2, Page(s) 54–57

Abstract: Background: Out of frame mutations in : Methods: A pair of guide RNAs (gRNAs) was designed to cleave : Results: Exon 48 was successfully deleted and therefore exon 47 was joined to exon 49.: Conclusion: This result indicated that CRISPR/Cas9 ... ...

Abstract	Background: Out of frame mutations in Methods: A pair of guide RNAs (gRNAs) was designed to cleave Results: Exon 48 was successfully deleted and therefore exon 47 was joined to exon 49. Conclusion: This result indicated that CRISPR/Cas9 system could be used to edit
Language	English
Publishing date	2020-09-09
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2520683-7
ISSN	2008-4625 ; 2008-2835
ISSN (online)	2008-4625
ISSN	2008-2835
DOI	10.18502/ajmb.v13i2.5517
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Article ; Online: Protective Effects of Xanthine Derivatives Against Arsenic Trioxide-Induced Oxidative Stress in Mouse Hepatic and Renal Tissues.

Omidifar, Navid / Gholami, Ahmad / Shokripour, Mansoureh / Nourani, Mohammad Ali / Mohkam, Milad / Mousavi, Seyyed Mojtaba / Hashemi, Seyyed Alireza / Khorram, Bagher / Ahmadabadi, Amir Nili / Dara, Mahintaj

Drug research

2024 Volume 74, Issue 3, Page(s) 133–144

Abstract: In this study, the protective efficacy of pentoxifylline (PTX) as a xanthine derivative against arsenic trioxide (ATO)-induced kidney and liver damage in mice was investigated. Thirty-six mice were divided into six groups, receiving intraperitoneal ... ...

Abstract	In this study, the protective efficacy of pentoxifylline (PTX) as a xanthine derivative against arsenic trioxide (ATO)-induced kidney and liver damage in mice was investigated. Thirty-six mice were divided into six groups, receiving intraperitoneal injections of saline, ATO, PTX, or a combination for four weeks. Blood samples were analyzed for serum biochemistry, while hepatic tissue underwent examination for histopathological changes and assessment of oxidative stress markers and antioxidant gene expression through Real-Time PCR. ATO exposure significantly increased serum markers (creatinine, ALT, BUN, ALP, AST) and induced histopathological changes in the liver. Moreover, it elevated renal and hepatic nitric oxide (NO) and lipid peroxidation (LPO) levels, and reduced antioxidant enzyme expression (CAT, GSR, GPx, MPO, SOD), total thiol groups (TTGs), and total antioxidant capacity (TAC). Conversely, PTX treatment effectively lowered serum hepatic and renal markers, improved antioxidant markers, and induced histopathological alterations. Notably, PTX did not significantly affect renal and hepatic NO levels. These findings suggest that PTX offers therapeutic potential in mitigating liver and acute kidney injuries induced by various insults, including exposure to ATO.
MeSH term(s)	Mice ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Arsenic Trioxide/metabolism ; Arsenic Trioxide/pharmacology ; Liver/metabolism ; Oxidative Stress ; Alkaloids/pharmacology ; Xanthines/metabolism ; Xanthines/pharmacology
Chemical Substances	Antioxidants ; Arsenic Trioxide (S7V92P67HO) ; Alkaloids ; Xanthines
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703847-6
ISSN	2194-9387 ; 2194-9379
ISSN (online)	2194-9387
ISSN	2194-9379
DOI	10.1055/a-2247-5232
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