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  1. Book ; Online: Roy Bhaskar

    Scott, David / Bhaskar, Roy

    A Theory of Education

    (SpringerBriefs in Education)

    2023  

    Series title SpringerBriefs in Education
    Language English
    Size Online-Ressource (87 p)
    Publisher Springer International Publishing
    Publishing place Cham
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9783319198354 ; 3319198351
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article: Roy Bhaskar

    Hartwig, Mervyn / Bhaskar, Roy

    The economic and labour relations review : ELRR Vol. 26, No. 1 , p. 162-163

    (1944 - 2014) ; obituary

    2015  Volume 26, Issue 1, Page(s) 162–163

    Author's details Mervyn Hartwig
    Language English
    Publisher Sage
    Publishing place London [u.a.]
    Document type Article
    ZDB-ID 1304744-9 ; 2500628-9
    ISSN 1838-2673 ; 1035-3046
    ISSN (online) 1838-2673
    ISSN 1035-3046
    Database ECONomics Information System

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  3. Book: Interdisciplinary and wellbeing

    Bhaskar, Roy / Danermark, Berth / Price, Leigh

    a critical realist general theory of interdisciplinarity

    (Routledge studies in critical realism)

    2018  

    Author's details Roy Bhaskar, Berth Danermark, and Leigh Price
    Series title Routledge studies in critical realism
    Language English
    Size ix, 173 Seiten, Illustrationen
    Publisher Routledge
    Publishing place London, New York
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016671354
    ISBN 978-0-415-49666-7 ; 0-415-49666-7 ; 978-0-415-40371-9 ; 9781315177298 ; 0-415-40371-5 ; 1315177293
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2017 A 1264 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: New Insight in Causal Pathways Following Subcortical Stroke: From Correlation to Causation.

    Roy, Bhaskar / Marshall, Randolph S

    Neurology

    2022  Volume 100, Issue 6, Page(s) 271–272

    MeSH term(s) Humans ; Motor Disorders ; Causality ; Stroke
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An insight into the sprawling microverse of microRNAs in depression pathophysiology and treatment response.

    Roy, Bhaskar / Dwivedi, Yogesh

    Neuroscience and biobehavioral reviews

    2023  Volume 146, Page(s) 105040

    Abstract: Stress-related neuropathologies are pivotal in developing major depressive disorder (MDD) and are often governed by gene-regulatory changes. Being a stress-responsive gene-regulatory factor, microRNAs (miRNAs) have tremendous biomolecular potential to ... ...

    Abstract Stress-related neuropathologies are pivotal in developing major depressive disorder (MDD) and are often governed by gene-regulatory changes. Being a stress-responsive gene-regulatory factor, microRNAs (miRNAs) have tremendous biomolecular potential to define an altered gene-regulatory landscape in the MDD brain. MiRNAs' regulatory roles in the MDD brain are closely aligned with changes in plasticity, neurogenesis, and stress-axis functions. MiRNAs act at the epigenetic interface between stress-induced environmental stimuli and cellular pathologies by triggering large-scale gene expression changes in a highly coordinated fashion. The parallel changes in peripheral circulation may provide an excellent opportunity for miRNA to devise more effective treatment strategies and help explore their potential as biomarkers in treatment response. This review discusses the role of miRNAs as epigenetic modifiers in the etiopathogenesis of MDD. Concurrently, key research is highlighted to show the progress in using miRNAs as predictive biomarkers for treatment response.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Depressive Disorder, Major/genetics ; Depression ; Brain/metabolism ; Biomarkers
    Chemical Substances MicroRNAs ; Biomarkers
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Phenotypic spectrum of inclusion body myositis.

    Roy, Bhaskar / Dimachkie, Mazen M / Naddaf, Elie

    Clinical and experimental rheumatology

    2024  Volume 42, Issue 2, Page(s) 445–453

    Abstract: Inclusion body myositis (IBM) is a progressive, debilitating muscle disease commonly encountered in patients over the age of 50. IBM typically presents with asymmetric, painless, progressive weakness and atrophy of deep finger flexors and/or quadriceps ... ...

    Abstract Inclusion body myositis (IBM) is a progressive, debilitating muscle disease commonly encountered in patients over the age of 50. IBM typically presents with asymmetric, painless, progressive weakness and atrophy of deep finger flexors and/or quadriceps muscle. Many patients with IBM develop dysphagia. However, atypical presentations of IBM with isolated dysphagia, asymptomatic hyper-CKemia, foot drop, proximal weakness, axial weakness, and facial diplegia have been reported. Other acquired and some inherited disorders may present similar to IBM, and this list gets more expansive when considering atypical presentations. In general, disease progression of IBM leads to loss of hand function and impaired ambulation, and most IBM patients become wheelchair dependent within 13-15 years of disease onset. Hence, IBM impacts negatively patients' quality of life and reduces longevity compared to the general population. Acknowledging the complete clinical spectrum of IBM presentation and excluding mimics would shorten the time to diagnosis, lead to prompt initiation of supportive management and avoid unproven therapy. Ongoing advanced phase studies in IBM provide hope that a therapy may soon be available. Therefore, an added potential benefit of early diagnosis would be prompt initiation of disease-modifying therapy once available.
    MeSH term(s) Humans ; Myositis, Inclusion Body/diagnosis ; Myositis, Inclusion Body/genetics ; Myositis, Inclusion Body/therapy ; Deglutition Disorders ; Quality of Life ; Muscle Weakness/etiology ; Myositis
    Language English
    Publishing date 2024-02-28
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/fhrx3q
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clinical advances in analytical profiling of signature lipids: implications for severe non-communicable and neurodegenerative diseases.

    Sarkar, Sutanu / Roy, Deotima / Chatterjee, Bhaskar / Ghosh, Rajgourab

    Metabolomics : Official journal of the Metabolomic Society

    2024  Volume 20, Issue 2, Page(s) 37

    Abstract: Background: Lipids play key roles in numerous biological processes, including energy storage, cell membrane structure, signaling, immune responses, and homeostasis, making lipidomics a vital branch of metabolomics that analyzes and characterizes a wide ... ...

    Abstract Background: Lipids play key roles in numerous biological processes, including energy storage, cell membrane structure, signaling, immune responses, and homeostasis, making lipidomics a vital branch of metabolomics that analyzes and characterizes a wide range of lipid classes. Addressing the complex etiology, age-related risk, progression, inflammation, and research overlap in conditions like Alzheimer's Disease, Parkinson's Disease, Cardiovascular Diseases, and Cancer poses significant challenges in the quest for effective therapeutic targets, improved diagnostic markers, and advanced treatments. Mass spectrometry is an indispensable tool in clinical lipidomics, delivering quantitative and structural lipid data, and its integration with technologies like Liquid Chromatography (LC), Magnetic Resonance Imaging (MRI), and few emerging Matrix-Assisted Laser Desorption Ionization- Imaging Mass Spectrometry (MALDI-IMS) along with its incorporation into Tissue Microarray (TMA) represents current advances. These innovations enhance lipidomics assessment, bolster accuracy, and offer insights into lipid subcellular localization, dynamics, and functional roles in disease contexts.
    Aim of the review: The review article summarizes recent advancements in lipidomic methodologies from 2019 to 2023 for diagnosing major neurodegenerative diseases, Alzheimer's and Parkinson's, serious non-communicable cardiovascular diseases and cancer, emphasizing the role of lipid level variations, and highlighting the potential of lipidomics data integration with genomics and proteomics to improve disease understanding and innovative prognostic, diagnostic and therapeutic strategies.
    Key scientific concepts of review: Clinical lipidomic studies are a promising approach to track and analyze lipid profiles, revealing their crucial roles in various diseases. This lipid-focused research provides insights into disease mechanisms, biomarker identification, and potential therapeutic targets, advancing our understanding and management of conditions such as Alzheimer's Disease, Parkinson's Disease, Cardiovascular Diseases, and specific cancers.
    MeSH term(s) Humans ; Lipids/analysis ; Metabolomics/methods ; Alzheimer Disease/diagnosis ; Neurodegenerative Diseases/diagnosis ; Cardiovascular Diseases/diagnosis ; Parkinson Disease/diagnosis ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Neoplasms/diagnosis
    Chemical Substances Lipids
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2250617-2
    ISSN 1573-3890 ; 1573-3882
    ISSN (online) 1573-3890
    ISSN 1573-3882
    DOI 10.1007/s11306-024-02100-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Mycobacterium indicus pranii therapy suppresses systemic dissemination of tumor cells in B16F10 murine model of melanoma.

    Chakraborty, Anush / Roy, Gargi / Fatima, Farheen / Swami, Bharati / Bhaskar, Sangeeta

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 160, Page(s) 114307

    Abstract: Cancer associated morbidity is mostly attributed to the dissemination of tumor cells from their primary niche into the circulation known as "metastasis". Mycobacterium indicus pranii (MIP) an approved immunotherapeutic agent against lung cancer (NSCLC) ... ...

    Abstract Cancer associated morbidity is mostly attributed to the dissemination of tumor cells from their primary niche into the circulation known as "metastasis". Mycobacterium indicus pranii (MIP) an approved immunotherapeutic agent against lung cancer (NSCLC) has shown potent anti-tumor activity in prior studies. While evaluating anti-tumor activity of MIP in mouse model, MIP treated animals typically exhibited less metastatic lesions in their pulmonary compartment. To study the role of MIP in metastasis closely, B16F10 melanoma cells were implanted subcutaneously in the mice, and the dissemination of tumor cells from the solid tumor was evaluated over a period of time. When B16F10 melanoma cells were treated with MIP in vitro, downregulation of epithelial mesenchymal transition markers was observed in these cells, which in turn suppressed the invasion, migration and adhesion of tumor cells. Notably, MIP therapy was found to be effectively reducing the metastatic burden in murine model of melanoma. Molecular characterization of MIP treated tumor cells substantiated that MIP upregulates the PPARγ expression within the tumor cells, which attenuates the NFκB/p65 levels within the nucleus, resulting in the suppression of Mmp9 expression in tumor cells. Besides that, MIP also downregulated the surface expression of chemokine receptor CXCR4 in murine melanoma cells, where chromatin immunoprecipitation confirmed the impeded recruitment of p50 and c-Rel factors to the Cxcr4 promoter, resulting in its downregulation transcriptionally. Taken together, MIP suppressed the dissemination of tumor cells in vivo, by regulating the expression of MMP9 and CXCR4 on these cells.
    MeSH term(s) Animals ; Mice ; Matrix Metalloproteinase 9 ; Disease Models, Animal ; Mycobacterium ; Melanoma/therapy
    Chemical Substances Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2023-02-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Challenges for Treatment Trials of Inclusion Body Myositis.

    Roy, Bhaskar / Griggs, Robert C

    Neurology

    2021  Volume 96, Issue 12, Page(s) 555–556

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Humans ; Muscle, Skeletal ; Myositis, Inclusion Body
    Chemical Substances Antibodies, Monoclonal, Humanized ; bimagrumab (N15SW1DIV8)
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Tumor targeted delivery of mycobacterial adjuvant encapsulated chitosan nanoparticles showed potential anti-cancer activity and immune cell activation in tumor microenvironment.

    Chakraborty, Anush / Roy, Gargi / Swami, Bharati / Bhaskar, Sangeeta

    International immunopharmacology

    2022  Volume 114, Page(s) 109463

    Abstract: Targeting immunotherapeutics inside the tumor microenvironment (TME) with intact biological activity remains a pressing issue. Mycobacterium indicus pranii (MIP), an approved adjuvant therapy for leprosy has exhibited promising results in clinical trials ...

    Abstract Targeting immunotherapeutics inside the tumor microenvironment (TME) with intact biological activity remains a pressing issue. Mycobacterium indicus pranii (MIP), an approved adjuvant therapy for leprosy has exhibited promising results in clinical trials of lung (NSCLC) and bladder cancer. Whole MIP as well as its cell wall fraction have shown tumor growth suppression and enhanced survival in mice model of melanoma, when administered peritumorally. Clinically, peritumoral delivery remains a procedural limitation. In this study, a tumor targeted delivery system was designed, where chitosan nanoparticles loaded with MIP adjuvants, when administered intravenously showed preferential accumulation within the TME, exploiting the principle of enhanced permeability and retention effect. Bio-distribution studies revealed their highest concentration inside the tumor after 6 h of administration. Interestingly, MIP adjuvant nano-formulations significantly reduced the tumor volume in the treated groups and increased the frequency of activated immune cells inside the TME. For chemoimmunotherapeutics studies, MIP nano-formulation was combined with standard dosage regimen of Paclitaxel. Combined therapy exhibited a further reduction in tumor volume relative to either of the MIP nano formulations. From this study a three-pronged strategy emerged as the underlying mechanism; chitosan and Paclitaxel have shown direct role in tumor cell death and the MIP nano-formulation activates the tumor residing immune cells which ultimately leads to the reduced tumor growth.
    Language English
    Publishing date 2022-11-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2022.109463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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