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Article ; Online: Does intravenous ibuprofen have an effect on pain control and drug use after upper limb orthopedic surgery? A double-blind randomized clinical trial Study

Mehrdad Malekshoar / Majid Vatankhah

فصلنامه دانشگاه علوم پزشکی جهرم, Vol 19, Iss 2, Pp 14-

2021 Volume 18

Abstract: Introduction: Pain after surgery is an unpleasant experience. This process causes physiological disorders in all systems of the body. Methods: In this randomized double-blind clinical trial study, 60 patients with anesthesia class I and II underwent ... ...

Abstract	Introduction: Pain after surgery is an unpleasant experience. This process causes physiological disorders in all systems of the body. Methods: In this randomized double-blind clinical trial study, 60 patients with anesthesia class I and II underwent upper limb orthopedic surgery. Patients were randomly divided into intravenous and control ibuprofen. Systolic and diastolic blood pressure, mean arterial pressure and heart rate before surgery, 1, 10 and 20 minutes after surgery were recorded. Pain was measured before, 6, 12 and 24 hours after surgery. Results: Ibuprofen and control groups were similar in terms of gender, age, BMI and ASA. The results of Chi-square test showed that in recovery and 6 and 12 hours after surgery, pain in patients in the ibuprofen group was significantly less than the control group (P <0.05). Also, the intragroup pain trend was significant in ibuprofen and control groups (P <0.05). Mean pain in ibuprofen group decreased more than control (P <0.001). Conclusion: The results of the present study showed that intravenous ibuprofen is better in controlling pain intensity and drug use than the control group. Ibuprofen seems to be very effective in controlling pain and postoperative drug use in orthopedic surgeries.
Keywords	intravenous ibuprofen ; pain ; orthopedics ; upper limb ; drug use ; Medicine ; R
Subject code	616
Language	Persian
Publishing date	2021-05-01T00:00:00Z
Publisher	Jahrom University of Medical Sciences
Document type	Article ; Online
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Article ; Online: CRISPR-Cas9 Targeted Enrichment and Next-Generation Sequencing for Mutation Detection.

Malekshoar, Mehrdad / Azimi, Sajad Ataei / Kaki, Arastoo / Mousazadeh, Leila / Motaei, Jamshid / Vatankhah, Majid

The Journal of molecular diagnostics : JMD

2023 Volume 25, Issue 5, Page(s) 249–262

Abstract: Despite the rapid application of next-generation sequencing (NGS) technologies, target sequencing in regions of the genome is often required to diagnose many genetic diseases. Target enrichment can be an effective factor in reducing the cost of ... ...

Abstract	Despite the rapid application of next-generation sequencing (NGS) technologies, target sequencing in regions of the genome is often required to diagnose many genetic diseases. Target enrichment can be an effective factor in reducing the cost of sequencing and the duration of sequencing. Recently, several clustered system regularly interspaced short palindromic repeats (CRISPR)-based methods (amplification-free sequencing) have been developed to target enrichment in combination with one of the NGS platforms. CRISPR-based target enrichment strategies act as an auxiliary tool to improve NGS analytical performance, thereby indirectly facilitating nucleic acid detection. The direct DNA cleavage approach by CRISPR-CRISPR-associated (Cas) at genome-specific sites enhances the possibility of separating native large fragments from disease-related genomic regions. The CRISPR-Cas can isolate the target region without any amplification; subsequently, long-read sequencing technologies were also implemented. These methods, as promising tools, have the ability to assess genetic and epigenetic composition for clinical application and treatment responses in cancer precision medicine. By modifying CRISPR-based enrichment protocols, it is possible to identify different types of mutations, including structural variants, short tandem repeats, fusion genes, and mobile elements. The Cas9 can specifically eliminate wild-type sequences, and it also enables the enrichment and detection of small amounts of tumor DNA fragments among the highly heterogeneous fragments of wild-type DNA.
MeSH term(s)	Humans ; CRISPR-Cas Systems/genetics ; Mutation/genetics ; DNA/genetics ; Genomics ; High-Throughput Nucleotide Sequencing
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2000060-1
ISSN	1943-7811 ; 1525-1578
ISSN (online)	1943-7811
ISSN	1525-1578
DOI	10.1016/j.jmoldx.2023.01.010
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Article ; Online: Does oral clonidine have an effect on pain control after laparoscopic cholecystectomy? A double-blind randomized clinical trial study

Mehrdad Malekshoar / masomeh Gholami / Majid Vatankhah

فصلنامه دانشگاه علوم پزشکی جهرم, Vol 19, Iss 3, Pp 0-

2021

Abstract: Introduction: Postoperative pain is an unpleasant experience. This process causes physiological disorders in all systems of the body. Clonidine as an alpha dual agonist is one of the drugs used to control pain after laparoscopic cholecystectomy. ... ...

Abstract	Introduction: Postoperative pain is an unpleasant experience. This process causes physiological disorders in all systems of the body. Clonidine as an alpha dual agonist is one of the drugs used to control pain after laparoscopic cholecystectomy. Therefore, this study was performed to evaluate the effect of oral clonidine on pain control and opioid use after laparoscopic cholecystectomy. Methods: In this randomized double-blind clinical trial study, 50 patients with class I and II anesthesia underwent laparoscopic cholecystectomy. Patients were randomly divided into oral and control clonidine groups. Systolic and diastolic blood pressure, mean arterial pressure and intraoperative heart rate were recorded. Pain was measured in recovery, 6, 12 and 24 hours after surgery. Postoperative drug use was recorded in both groups. Data analysis was performed using SPSS software version 21 and using descriptive and inferential statistical tests. Results: The studied groups are similar in terms of demographic variables of age, weight, height, body mass index and gender. The results of chi-square test showed that there was a significant difference between clonidine and control groups in terms of pain at zero, 6 hours, 12 hours and 24 hours. (P<0.001). The results of chi-square test showed that there was a significant difference between the control and clonidine groups in receiving pethidine. Conclusion: The results of the present study showed that oral clonidine is more effective in controlling pain intensity and drug use than the control group. Oral clonidine laparoscopic cholecystectomy surgery seems to be effective in controlling pain and postoperative drug use.
Keywords	clonidine ; pain ; cholecystectomy ; laparoscopy ; opioid analgesics ; Medicine ; R
Subject code	796
Language	Persian
Publishing date	2021-09-01T00:00:00Z
Publisher	Jahrom University of Medical Sciences
Document type	Article ; Online
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Article: Three-dimensional (3D) Visualization Educational Modeling for Ophthalmology Residents' Training: Viewpoints.

Vatankhah, Roya / Etezad Razavi, Mohammad / Nekooei, Sirous / Khadem Rezaiyan, Majid / Tafaghodi Yousefi, Bahar / Karimi Moonaghi, Hossein / Emadzadeh, Ali

Medical journal of the Islamic Republic of Iran

2022 Volume 36, Page(s) 115

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-10-05
Publishing country	Iran
Document type	Journal Article
ZDB-ID	1095990-7
ISSN	1016-1430
ISSN	1016-1430
DOI	10.47176/mjiri.36.115
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Article ; Online: Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial.

Ameri, Ali / Frouz Asadi, Masoomeh / Ziaei, Ava / Vatankhah, Majid / Safa, Omid / Kamali, Manoochehr / Fathalipour, Mohammad / Mahmoodi, Masoumeh / Hassanipour, Soheil

Inflammopharmacology

2022 Volume 31, Issue 1, Page(s) 265–274

Abstract: Patients with COVID-19 have shown melatonin deficiency. We evaluated the efficacy and safety of administration oral melatonin in patients with COVID-19-induced pneumonia. Patients were randomly assigned in a 1:1 ratio to receive melatonin plus standard ... ...

Abstract	Patients with COVID-19 have shown melatonin deficiency. We evaluated the efficacy and safety of administration oral melatonin in patients with COVID-19-induced pneumonia. Patients were randomly assigned in a 1:1 ratio to receive melatonin plus standard treatment or standard treatment alone. The primary outcomes were mortality rate and requirement of IMV. The clinical status of patients was recorded at baseline and every day over hospitalization based on seven-category ordinal scale from 1 (discharged) to 7 (death). A total of 226 patients (109 in the melatonin group and 117 in the control group) were enrolled (median age; in melatonin group: 54.60 ± 11.51, in control group: 54.69 ± 13.40). The mortality rate was 67% in the melatonin group and 94% in the control group (OR; 7.75, 95% CI, 3.27-18.35, P < 0.001). The rate of IMV requirement was 51.4% in the melatonin group and 70.9% in the control group, for an OR of 2.31 (95% CI, 1.34-4.00, P < 0.001). The median number of days to hospital discharge was 15 days (13-17) in the melatonin group and 21 days (14-24) in the control group (OR; 5.00, 95% CI, 0.15-9.84, P = 0.026). Time to clinical status improvement by ≥ 2 on the ordinal scale in was 12 days (9-13) in the melatonin group and 16 days (10-19) in the control group (OR; 3.92, 95% CI, 1.69-6.14, P = 0.038). Melatonin significantly improved clinical status with a safe profile in patients with severe COVID-19 pneumonia.
MeSH term(s)	Humans ; COVID-19 ; Melatonin ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Melatonin (JL5DK93RCL)
Language	English
Publishing date	2022-11-19
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-022-01096-7
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Article: 3D Printed Models for Teaching Orbital Anatomy, Anomalies and Fractures.

Vatankhah, Roya / Emadzadeh, Ali / Nekooei, Sirous / Yousefi, Bahar Tafaghodi / Rezaiyan, Majid Khadem / Moonaghi, Hossein Karimi / Razavi, Mohammad Etezad

Journal of ophthalmic & vision research

2021 Volume 16, Issue 4, Page(s) 611–619

Abstract: Purpose: The aim of this study was to determine the efficacy of using 3D printing models in the learning process of orbital anatomy and pathology by ophthalmology residents.: Methods: A quasi-experimental study was performed with 24 residents of ... ...

Abstract	Purpose: The aim of this study was to determine the efficacy of using 3D printing models in the learning process of orbital anatomy and pathology by ophthalmology residents. Methods: A quasi-experimental study was performed with 24 residents of ophthalmology at Mashhad University of Medical Sciences. Each stratum was randomized into two groups. The educational booklets were distributed, and various forms of orbital 3D models were printed from orbital computed tomography (CT) scans. Knowledge enhancement on the topics was measured by comparing pretest and posttest scores. Results: Thirteen residents who were trained using traditional methods were deemed the control group; while 11 residents who were trained using the 3D printed models were classed as the intervention group. The control group was younger than the intervention group ( Conclusion: This study is the first one in Iran quantifying the effects of learning using 3D printed models in medical education. In fact, 3D modeling training is seemingly effective in teaching ophthalmic residents. As residents have never encountered such technology before, their experience using 3D models proved to be satisfactory and had a surprising positive effect on the learning process through visual training.
Language	English
Publishing date	2021-10-25
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2008-2010
ISSN	2008-2010
DOI	10.18502/jovr.v16i4.9751
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Article ; Online: Evaluation of the effect of melatonin in patients with COVID-19-induced pneumonia admitted to the Intensive Care Unit: A structured summary of a study protocol for a randomized controlled trial.

Ameri, Ali / Asadi, Masoomeh Frouz / Kamali, Manoochehr / Vatankhah, Majid / Ziaei, Ava / Safa, Omid / Mahmudi, Masoomeh / Fathalipour, Mohammad

Trials

2021 Volume 22, Issue 1, Page(s) 194

Abstract: Objectives: We investigate the effects of melatonin, compared to the usual therapeutic regimen on clinical symptoms and laboratory signs in severely ill patients with confirmed COVID-19 who are admitted to the Intensive Care Unit (ICU).: Trial design!# ...

Abstract	Objectives: We investigate the effects of melatonin, compared to the usual therapeutic regimen on clinical symptoms and laboratory signs in severely ill patients with confirmed COVID-19 who are admitted to the Intensive Care Unit (ICU). Trial design: This is a single-center, open-label, randomized, clinical trial with a parallel-group design. This study is being conducted at Shahid Mohammadi Hospital, Bandar Abbas, Iran. Participants: All patients admitted to the ICU of Shahid Mohammadi Hospital, Bandar Abbas, Iran, will be screened for the following criteria. Inclusion criteria 1. Age >20 years 2. Definitive diagnosis of COVID-19 based on RT-PCR or/and serological testing 3. Severe pneumonia and lung involvement in imaging 4. Signing informed consent Exclusion criteria 1. Underlying diseases, including convulsive disorders, chronic hepatic and renal diseases 2. Use of mechanical ventilation 3. History of known allergy to Melatonin 4. Pregnancy and breastfeeding INTERVENTION AND COMPARATOR: Intervention group: The standard treatment regimen for COVID-19, according to the Iranian Ministry of Health and Medical Education's protocol, along with Melatonin soft gelatin capsule (Danna Pharmaceutical Company) at a dose of 5 mg twice a day for a period of seven days. Control group: The standard treatment for COVID-19 based on the Iranian Ministry of Health and Medical Education's protocol for a period of seven days. Main outcomes: The primary outcomes are the recovery rate of clinical symptoms and checking arterial blood gas (ABG), C-reactive protein (C-RP), Ferritin, Lactate dehydrogenase (LDH) within seven days of randomization. The secondary outcomes are time to improvement of clinical and paraclinical features and length of stay in the ICU, need for mechanical ventilation, and mortality rate within seven days of randomization. Randomization: Included patients will be allocated to one of the study arms using block randomization in a 1:1 ratio (each block consists of 6 patients). This randomization method ensures a balanced allocation between the arms during the study. A web-based system will generate random numbers for the allocation sequence and concealment of participants. Each number relates to one of the study arms. Blinding (masking): This is an open-label trial without blinding and placebo control. Numbers to be randomized (sample size): A total of 60 participants randomizes (30 patients allocated to the intervention group and 30 patients allocated to the control group). Trial status: The protocol is Version 1.0, February 16, 2021. Recruitment began February 28, 2021, and is anticipated to be completed by July 31, 2021. Trial registration: The trial protocol has been registered in the Iranian Registry of Clinical Trials (IRCT). The registration number is " IRCT20200506047323N7 ". The registration date was February 16, 2021. Full protocol: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest of expediting the dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.
MeSH term(s)	Antioxidants/therapeutic use ; Blood Gas Analysis ; C-Reactive Protein/metabolism ; COVID-19/drug therapy ; COVID-19/metabolism ; COVID-19/physiopathology ; Ferritins/metabolism ; Humans ; Intensive Care Units ; Iran ; L-Lactate Dehydrogenase/metabolism ; Melatonin/therapeutic use ; Randomized Controlled Trials as Topic ; SARS-CoV-2
Chemical Substances	Antioxidants ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Clinical Trial Protocol ; Letter
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-021-05162-3
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Article ; Online: Alternative Medical Interventions Versus Conventional Treatment of Renal Colic: An Updated Systematic Review and Network Meta-Analysis.

Seghatoleslami, Ghazal / Sanie Jahromi, Mohammad Sadegh / Farzaneh, Roohie / Rahsepar, Sara / Malekshoar, Mehrdad / Vatankhah, Majid / Akhavan, Reza / Abbasi, Bita / Akhavan, Hossein / Abiri, Samaneh / Taheri, Lohrasb / Kalani, Navid / Foroughian, Mahdi / Hakemi, Arman

Urology journal

2022 Volume 19, Issue 6, Page(s) 412–419

Abstract: Purpose: To systematically review the recent alternative medical interventions on renal colic pain and compare their efficiency with conventional treatments.: Materials and methods: This was a systematic review and network meta-analysis (NMA) study, ... ...

Abstract	Purpose: To systematically review the recent alternative medical interventions on renal colic pain and compare their efficiency with conventional treatments. Materials and methods: This was a systematic review and network meta-analysis (NMA) study, based on the PRISMA guidelines on online databases of PubMed, Scopus, and web of science. We quarried these databases with relevant keywords for clinical trial studies that aimed at reducing renal colic pain in patients refereeing to the ED from after January 2011 to February 2022. Randomized clinical trials that used the Visual Analogue Scale (VAS) for assessment of renal colic pain before and after medical interventions in adult patients were included in this study. NMA was conducted based on the continuous values of the mean difference of the pain after 30 and 60 minutes of the medication administration. Results: Twenty-four studies that were meeting the inclusion criteria were included in our review with 2724 adult participants who were mostly male. Study arms included conventional medications (NSAID, Opioid, paracetamol), ketamine, MgSo4, desmopressin, and lidocaine. Based on the qualitative synthesis, ten studies (41.7%) did not find significant differences between conventional and alternative treatments. Also, there is no agreement on some more recent medications like using ketamine or desmopressin while MgSO4 and lidocaine use are supported by most studies. NMA revealed that desmopressin is significantly having worse pain reduction properties. NMA did not show any difference between ketamine, lidocaine, and MgSo4, versus the conventional treatment. Conclusion: To conclude, lidocaine and MgSo4 might be good alternative treatments for renal colic when conventional treatments are contraindicated or pain is not responding to those. Ketamine might be indicated in patient-based circumstances. Desmopressin may be agreeably avoided in further research or clinics.
MeSH term(s)	Humans ; Male ; Female ; Renal Colic/drug therapy ; Renal Colic/etiology ; Network Meta-Analysis ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-12-06
Publishing country	Iran
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2251940-3
ISSN	1735-546X ; 1735-1308
ISSN (online)	1735-546X
ISSN	1735-1308
DOI	10.22037/uj.v19i.7204
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Article ; Online: Reporting a Case

Majid Vatankhah / Seyed Hamed Hojati / Navid Kalani / Mohammad Hasan Damshens

Journal of Research in Medical and Dental Science, Vol 6, Iss 6, Pp 218-

Cardio-respiratory Arrest after Spinal Anesthesia

2018 Volume 220

Abstract: Introduction: Hypotension, bradycardia and even cardiac arrest are considered as risk factors for spinal anesthesia. Cardiac arrest due to neuraxial anesthesia requires rapid intervention to prevent neurological damages and death. Introducing the patient: ...

Abstract	Introduction: Hypotension, bradycardia and even cardiac arrest are considered as risk factors for spinal anesthesia. Cardiac arrest due to neuraxial anesthesia requires rapid intervention to prevent neurological damages and death. Introducing the patient: A 91year-old patient referred to the operating room of Jahrom Peymanieh Hospital, because of previous operation of femoral neck fracture and bed ridden with bed sore in the sacrum area. The patient did not show any significant problems during the spinal anesthesia during the operation, but at the end of the operation and after changing his lateral position to supine position suffered a cardio-respiratory arrest, which immediately we began the CPR and after recovery of the patient, he transferred to the ICU. Conclusion: When patients position changed from lateral to supine, a possibility of cardiopulmonary arrest, especially in the elderly.
Keywords	Spinal anesthesia ; Bradycardia ; Hypotension ; Cardiac arrest ; Dentistry ; RK1-715 ; Medicine (General) ; R5-920
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Amber Publication
Document type	Article ; Online
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Article ; Online: Evaluation of the effect of melatonin in patients with COVID-19-induced pneumonia admitted to the Intensive Care Unit

Ali Ameri / Masoomeh Frouz Asadi / Manoochehr Kamali / Majid Vatankhah / Ava Ziaei / Omid Safa / Masoomeh Mahmudi / Mohammad Fathalipour

Trials, Vol 22, Iss 1, Pp 1-

A structured summary of a study protocol for a randomized controlled trial

2021 Volume 2

Abstract: Abstract Objectives We investigate the effects of melatonin, compared to the usual therapeutic regimen on clinical symptoms and laboratory signs in severely ill patients with confirmed COVID-19 who are admitted to the Intensive Care Unit (ICU). Trial ... ...

Abstract	Abstract Objectives We investigate the effects of melatonin, compared to the usual therapeutic regimen on clinical symptoms and laboratory signs in severely ill patients with confirmed COVID-19 who are admitted to the Intensive Care Unit (ICU). Trial design This is a single-center, open-label, randomized, clinical trial with a parallel-group design. This study is being conducted at Shahid Mohammadi Hospital, Bandar Abbas, Iran. Participants All patients admitted to the ICU of Shahid Mohammadi Hospital, Bandar Abbas, Iran, will be screened for the following criteria. Inclusion criteria 1. Age >20 years 2. Definitive diagnosis of COVID-19 based on RT-PCR or/and serological testing 3. Severe pneumonia and lung involvement in imaging 4. Signing informed consent Exclusion criteria 1. Underlying diseases, including convulsive disorders, chronic hepatic and renal diseases 2. Use of mechanical ventilation 3. History of known allergy to Melatonin 4. Pregnancy and breastfeeding Intervention and Comparator Intervention group: The standard treatment regimen for COVID-19, according to the Iranian Ministry of Health and Medical Education’s protocol, along with Melatonin soft gelatin capsule (Danna Pharmaceutical Company) at a dose of 5 mg twice a day for a period of seven days. Control group: The standard treatment for COVID-19 based on the Iranian Ministry of Health and Medical Education’s protocol for a period of seven days. Main outcomes The primary outcomes are the recovery rate of clinical symptoms and checking arterial blood gas (ABG), C-reactive protein (C-RP), Ferritin, Lactate dehydrogenase (LDH) within seven days of randomization. The secondary outcomes are time to improvement of clinical and paraclinical features and length of stay in the ICU, need for mechanical ventilation, and mortality rate within seven days of randomization. Randomization Included patients will be allocated to one of the study arms using block randomization in a 1:1 ratio (each block consists of 6 patients). This randomization method ...
Keywords	COVID-19 ; Randomized controlled trial ; Protocol ; Melatonin ; Inflammation ; Intensive Care Unit ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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