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Article ; Online: Crosstalk between inflammasome sensors and DNA damage response pathways.

Burlet, Delphine / Huber, Anne-Laure / Tissier, Agnès / Petrilli, Virginie

2024

Abstract: Eukaryotic cells encounter diverse threats jeopardizing their integrity, prompting the development of defense mechanisms against these stressors. Among these mechanisms, inflammasomes are well-known for their roles in coordinating the inflammatory ... ...

Abstract	Eukaryotic cells encounter diverse threats jeopardizing their integrity, prompting the development of defense mechanisms against these stressors. Among these mechanisms, inflammasomes are well-known for their roles in coordinating the inflammatory response against infections. Extensive research has unveiled their multifaceted involvement in cellular processes beyond inflammation. Recent studies emphasize the intricate relationship between the inflammasome and the DNA damage response (DDR). They highlight how the DDR participates in inflammasome activation and the reciprocal impact of inflammasome on DDR and genome integrity preservation. Moreover, novel functions of inflammasome sensors in DDR pathways have emerged, broadening our understanding of their roles. Finally, this review delves into identifying common signals that drive the activation of inflammasome sensors alongside activation cues for the DNA damage response, offering potential insights into shared regulatory pathways between these critical cellular processes.
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.17060
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cryptochromes modulate E2F family transcription factors.

Chan, Alanna B / Huber, Anne-Laure / Lamia, Katja A

Scientific reports

2020 Volume 10, Issue 1, Page(s) 4077

Abstract: Early 2 factor (E2F) family transcription factors participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and metabolism. Circadian rhythms influence many of these phenomena. Here we ...

Abstract	Early 2 factor (E2F) family transcription factors participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and metabolism. Circadian rhythms influence many of these phenomena. Here we find that a mammalian circadian rhythm component, Cryptochrome 2 (CRY2), regulates E2F family members. Furthermore, CRY1 and CRY2 cooperate with the E3 ligase complex SKP-CULLIN-FBXL3 (SCF
MeSH term(s)	Animals ; Circadian Rhythm ; Cryptochromes/physiology ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism ; Gene Expression Regulation ; Mice, Knockout ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligase Complexes/genetics ; Ubiquitin-Protein Ligase Complexes/metabolism
Chemical Substances	Cry1 protein, mouse ; Cry2 protein, mouse ; Cryptochromes ; E2F Transcription Factors ; Transcription Factors ; Ubiquitin-Protein Ligase Complexes (EC 2.3.2.23)
Language	English
Publishing date	2020-03-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-61087-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Optogenetically controlled inflammasome activation demonstrates two phases of cell swelling during pyroptosis.

Nadjar, Julien / Monnier, Sylvain / Bastien, Estelle / Huber, Anne-Laure / Oddou, Christiane / Bardoulet, Léa / Leloup, Hubert B / Ichim, Gabriel / Vanbelle, Christophe / Py, Bénédicte F / Destaing, Olivier / Petrilli, Virginie

Science signaling

2024 Volume 17, Issue 833, Page(s) eabn8003

Abstract: Inflammasomes are multiprotein platforms that control caspase-1 activation, which process the inactive precursor forms of the inflammatory cytokines IL-1β and IL-18, leading to an inflammatory type of programmed cell death called pyroptosis. Studying ... ...

Abstract	Inflammasomes are multiprotein platforms that control caspase-1 activation, which process the inactive precursor forms of the inflammatory cytokines IL-1β and IL-18, leading to an inflammatory type of programmed cell death called pyroptosis. Studying inflammasome-driven processes, such as pyroptosis-induced cell swelling, under controlled conditions remains challenging because the signals that activate pyroptosis also stimulate other signaling pathways. We designed an optogenetic approach using a photo-oligomerizable inflammasome core adapter protein, apoptosis-associated speck-like containing a caspase recruitment domain (ASC), to temporally and quantitatively manipulate inflammasome activation. We demonstrated that inducing the light-sensitive oligomerization of ASC was sufficient to recapitulate the classical features of inflammasomes within minutes. This system showed that there were two phases of cell swelling during pyroptosis. This approach offers avenues for biophysical investigations into the intricate nature of cellular volume control and plasma membrane rupture during cell death.
MeSH term(s)	Pyroptosis ; Inflammasomes/metabolism ; Optogenetics/methods ; Animals ; Humans ; CARD Signaling Adaptor Proteins/metabolism ; CARD Signaling Adaptor Proteins/genetics ; Mice ; Caspase 1/metabolism ; Caspase 1/genetics ; Interleukin-1beta/metabolism ; Interleukin-1beta/genetics
Chemical Substances	Inflammasomes ; CARD Signaling Adaptor Proteins ; Caspase 1 (EC 3.4.22.36) ; Interleukin-1beta
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.abn8003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cryptochromes modulate E2F family transcription factors

Alanna B. Chan / Anne-Laure Huber / Katja A. Lamia

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 9

Abstract: Abstract Early 2 factor (E2F) family transcription factors participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and metabolism. Circadian rhythms influence many of these phenomena. ...

Abstract	Abstract Early 2 factor (E2F) family transcription factors participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and metabolism. Circadian rhythms influence many of these phenomena. Here we find that a mammalian circadian rhythm component, Cryptochrome 2 (CRY2), regulates E2F family members. Furthermore, CRY1 and CRY2 cooperate with the E3 ligase complex SKP-CULLIN-FBXL3 (SCFFBXL3) to reduce E2F steady state protein levels. These findings reveal an unrecognized molecular connection between circadian clocks and cell cycle regulation and highlight another mechanism to maintain appropriate E2F protein levels for proper cell growth.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neural correlates of memory recovery: Preliminary findings in children and adolescents with acquired brain injury.

Mouthon, Anne-Laure / Meyer-Heim, Andreas / Huber, Reto / Van Hedel, Hubertus J A

Restorative neurology and neuroscience

2021 Volume 39, Issue 1, Page(s) 61–71

Abstract: Background: After acquired brain injury (ABI), patients show various neurological impairments and outcome is difficult to predict. Identifying biomarkers of recovery could provide prognostic information about a patient's neural potential for recovery ... ...

Abstract	Background: After acquired brain injury (ABI), patients show various neurological impairments and outcome is difficult to predict. Identifying biomarkers of recovery could provide prognostic information about a patient's neural potential for recovery and improve our understanding of neural reorganization. In healthy subjects, sleep slow wave activity (SWA, EEG spectral power 1-4.5 Hz) has been linked to neuroplastic processes such as learning and brain maturation. Therefore, we suggest that SWA might be a suitable measure to investigate neural reorganization underlying memory recovery. Objectives: In the present study, we used SWA to investigate neural correlates of recovery of function in ten paediatric patients with ABI (age range 7-15 years). Methods: We recorded high-density EEG (128 electrodes) during sleep at the beginning and end of rehabilitation. We used sleep EEG data of 52 typically developing children to calculate age-normalized values for individual patients. In patients, we also assessed every-day life memory impairment at the beginning and end of rehabilitation. Results: In the course of rehabilitation, memory recovery was paralleled by longitudinal changes in SWA over posterior parietal brain areas. SWA over left prefrontal and occipital brain areas at the beginning of rehabilitation predicted memory recovery. Conclusions: We show that longitudinal sleep-EEG measurements are feasible in the clinical setting. While posterior parietal and prefrontal brain areas are known to belong to the memory "core network", occipital brain areas have never been related to memory. While we have to remain cautious in interpreting preliminary findings, we suggest that SWA is a promising measure to investigate neural reorganization.
MeSH term(s)	Adolescent ; Brain/diagnostic imaging ; Brain Injuries ; Brain Mapping ; Child ; Electroencephalography ; Humans ; Sleep
Language	English
Publishing date	2021-02-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1017098-4
ISSN	1878-3627 ; 0922-6028
ISSN (online)	1878-3627
ISSN	0922-6028
DOI	10.3233/RNN-201140
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Methods in pediatric sleep research and sleep medicine.

Mouthon, Anne-Laure / Huber, Reto

Neuropediatrics

2015 Volume 46, Issue 3, Page(s) 159–170

Abstract: Several methods are used to evaluate sleep in infants, children, and adolescents including: Questionnaires and diaries, actigraphy, polysomnography, and electroencephalography which are well established. Novel approaches such as high-density ... ...

Abstract	Several methods are used to evaluate sleep in infants, children, and adolescents including: Questionnaires and diaries, actigraphy, polysomnography, and electroencephalography which are well established. Novel approaches such as high-density electroencephalography, simultaneous electroencephalography-functional magnetic resonance imaging and nonpharmacological methods aiming for a modulation of sleep are currently only used for research. These approaches might become valuable methods for clinical application in the future. The purpose of this review is to present an overview of current methods and their respective fields of application and to report available rules and recommendations for their use.
MeSH term(s)	Actigraphy ; Adolescent ; Biomedical Research ; Brain Mapping ; Child ; Electroencephalography ; Humans ; Infant ; Magnetic Resonance Imaging ; Pediatrics ; Polysomnography ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/therapy ; Surveys and Questionnaires
Language	English
Publishing date	2015-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0035-1550232
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Neural correlates of memory recovery

Mouthon, Anne-Laure / Meyer-Heim, Andreas / Huber, Reto / Van Hedel, Hubertus J. A.

Restorative Neurology and Neuroscience

Preliminary findings in children and adolescents with acquired brain injury

2021 Volume 39, Issue 1, Page(s) 61–71

Title translation	Neuronale Korrelate der Gedächtniserholung: Vorläufige Ergebnisse bei Kindern und Jugendlichen mit erworbenen Hirnverletzungen. (DeepL)
Abstract	Background: After acquired brain injury (ABI), patients show various neurological impairments and outcome is difficult to predict. Identifying biomarkers of recovery could provide prognostic information about a patient's neural potential for recovery and improve our understanding of neural reorganization. In healthy subjects, sleep slow wave activity (SWA, EEG spectral power 1-4.5 Hz) has been linked to neuroplastic processes such as learning and brain maturation. Therefore, we suggest that SWA might be a suitable measure to investigate neural reorganization underlying memory recovery. Objectives: In the present study, we used SWA to investigate neural correlates of recovery of function in ten paediatric patients with ABI (age range 7-15 years). Methods: We recorded high-density EEG (128 electrodes) during sleep at the beginning and end of rehabilitation. We used sleep EEG data of 52 typically developing children to calculate age-normalized values for individual patients. In patients, we also assessed every-day life memory impairment at the beginning and end of rehabilitation. Results: In the course of rehabilitation, memory recovery was paralleled by longitudinal changes in SWA over posterior parietal brain areas. SWA over left prefrontal and occipital brain areas at the beginning of rehabilitation predicted memory recovery. Conclusions: We show that longitudinal sleep-EEG measurements are feasible in the clinical setting. While posterior parietal and prefrontal brain areas are known to belong to the memory "core network", occipital brain areas have never been related to memory. While we have to remain cautious in interpreting preliminary findings, we suggest that SWA is a promising measure to investigate neural reorganization.
Keywords	Biological Markers ; Biologische Marker ; Brain Injuries ; Cognitive Impairment ; Electroencephalography ; Elektroenzephalographie ; Genesung ; Hirnverletzungen ; Kognitive Beeinträchtigung ; NREM Sleep ; NREM-Schlaf ; Neurorehabilitation ; Pediatrics ; Pädiatrie ; Recovery (Disorders) ; Schlaf ; Sleep
Language	English
Document type	Article
ZDB-ID	1017098-4
ISSN	1878-3627 ; 0922-6028
ISSN (online)	1878-3627
ISSN	0922-6028
DOI	10.3233/RNN-201140
Database	PSYNDEX

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Article: Methods in Pediatric Sleep Research and Sleep Medicine

Mouthon, Anne-Laure / Huber, Reto

Neuropediatrics

(Sleep and Neurodevelopmental Disorders)

2015 Volume 46, Issue 03, Page(s) 159–170

Series title	Sleep and Neurodevelopmental Disorders
Abstract	Several methods are used to evaluate sleep in infants, children, and adolescents including: Questionnaires and diaries, actigraphy, polysomnography, and electroencephalography which are well established. Novel approaches such as high-density electroencephalography, simultaneous electroencephalography–functional magnetic resonance imaging and nonpharmacological methods aiming for a modulation of sleep are currently only used for research. These approaches might become valuable methods for clinical application in the future. The purpose of this review is to present an overview of current methods and their respective fields of application and to report available rules and recommendations for their use.
Keywords	sleep ; development ; questionnaires ; actigraphy ; polysomnography ; electroencephalography
Language	English
Publishing date	2015-05-11
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0035-1550232
Database	Thieme publisher's database

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Article ; Online: Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress.

Life science alliance

2023 Volume 6, Issue 4

Abstract: NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis, Alzheimer disease, and ... ...

Abstract	NLRP3 is a pattern recognition receptor with a well-documented role in inducing inflammasome assembly in response to cellular stress. Deregulation of its activity leads to many inflammatory disorders including gouty arthritis, Alzheimer disease, and cancer. Whereas its role in the context of cancer has been mostly explored in the immune compartment, whether NLRP3 exerts functions unrelated to immunity in cancer development remains unexplored. Here, we demonstrate that NLRP3 interacts with the ATM kinase to control the activation of the DNA damage response, independently of its inflammasome activity. NLRP3 down-regulation in both broncho- and mammary human epithelial cells significantly impairs ATM pathway activation, leading to lower p53 activation, and provides cells with the ability to resist apoptosis induced by acute genotoxic stress. Interestingly, NLRP3 expression is down-regulated in non-small cell lung cancers and breast cancers, and its expression positively correlates with patient overall survival. Our findings identify a novel non-immune function for NLRP3 in maintaining genome integrity and strengthen the concept of a functional link between innate immunity and DNA damage sensing pathways to maintain cell integrity.
MeSH term(s)	Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Immunity, Innate ; DNA Damage ; Apoptosis/genetics ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; ATM protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202201494
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: Personalized cancer vaccine strategy elicits polyfunctional T cells and demonstrates clinical benefits in ovarian cancer.

NPJ vaccines

2021 Volume 6, Issue 1, Page(s) 68

Language	English
Publishing date	2021-05-04
Publishing country	England
Document type	Published Erratum
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-021-00332-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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