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  1. Article ; Online: Rebuttal from Samuel Chung, Charles D. Bengtson, Michael D. Kim and Matthias Salathe.

    Chung, Samuel / Bengtson, Charles D / Kim, Michael D / Salathe, Matthias

    The Journal of physiology

    2020  Volume 598, Issue 15, Page(s) 3059–3060

    MeSH term(s) Electronic Nicotine Delivery Systems ; Lung ; Nicotine
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP280093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir).

    Metsänen, Toni T / Lexa, Katrina W / Santiago, Celine B / Chung, Cheol K / Xu, Yingju / Liu, Zhijian / Humphrey, Guy R / Ruck, Rebecca T / Sherer, Edward C / Sigman, Matthew S

    Chemical science

    2018  Volume 9, Issue 34, Page(s) 6922–6927

    Abstract: ... an aza-Michael conjugate addition for the asymmetric synthesis of letermovir. A hybrid approach combining ...

    Abstract Quantitative structure-activity relationships have an extensive history for optimizing drug candidates, yet they have only recently been applied in reaction development. In this report, the predictive power of multivariate parameterization has been explored toward the optimization of a catalyst promoting an aza-Michael conjugate addition for the asymmetric synthesis of letermovir. A hybrid approach combining 2D QSAR and modern 3D physical organic parameters performed better than either approach in isolation. Using these predictive models, a series of new catalysts were identified, which catalyzed the reaction to provide the desired product in improved enantioselectivity relative to the parent catalyst.
    Language English
    Publishing date 2018-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c8sc02089b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Efficient one pot multi-component domino Aldol condensation–Michael addition–Suzuki coupling reaction for the highly functionalized quinolines

    Ubba, Eethamukkala / C. Dasaradhan / Euh Duck Jeong / Eun Hyuk Chung / Fazlur-Rahman Nawaz Khan / Y. Suneel Kumar

    Tetrahedron letters. 2015 Aug. 12, v. 56, no. 33

    2015  

    Abstract: ... Aldol condensation–Michael addition–Suzuki coupling approach for a variety of 2,3-disubstituted highly ...

    Abstract A parallel and advantageous multi-component one pot reaction has been developed utilizing domino Aldol condensation–Michael addition–Suzuki coupling approach for a variety of 2,3-disubstituted highly functionalized quinolines. The domino reactions of 2-chloro-3-formylquinolines, 1 acetophenones, 2 and distinctive boronic acids, 3 were carried out utilizing PdCl2(PPh3)2/tripotassium phosphate/ethanol–water system. At 80°C they gave diversified functionalized quinolines in good yields.
    Keywords acetophenones ; boronic acids ; chemical reactions ; chemical structure ; quinolines
    Language English
    Dates of publication 2015-0812
    Size p. 4744-4748.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2015.06.040
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
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  4. Article ; Online: A serendipitous C-C bond formation reaction between Michael donors and diiminoquinoid ring assisted by quaternary ammonium fluoride.

    Paike, Vijaykumar V / Balakumar, R / Chen, Hsin-Yu / Shih, Hong-Pin / Han, Chien-Chung

    Organic letters

    2009  Volume 11, Issue 24, Page(s) 5586–5589

    Abstract: ... the typical Michael addition fashion and proceeds to completion within 1 h at 70 degrees C in acetonitrile ...

    Abstract An efficient C-C bond formation reaction assisted by a fluoride ion has been identified for N,N'-diphenyl-1,4-phenylenediimine with the compounds having an active methylene group. The reaction follows the typical Michael addition fashion and proceeds to completion within 1 h at 70 degrees C in acetonitrile in the presence of tetrabutylammonium fluoride (TBAF), while the same reaction failed to proceed in the absence of a fluoride anion. The new finding reported herein also offers an unprecedented method for a direct functionalization of polyaniline backbone with versatile functional alkyl groups.
    Language English
    Publishing date 2009-12-17
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/ol9025843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Ionic liquid supported synthesis of tricyclic pyrimido[1,2-a]benzimidazoles by a telescoped Michael/hetero annulation strategy

    Selvaraju, Manikandan / Kulkarni, Manohar V / Shiu, Wei-Shuen / Sun, Chung-Ming

    RSC advances. 2013 Oct. 21, v. 3, no. 44

    2013  

    Abstract: ... 2-a]benzimidazoles. The perceived regioselectivity was presumed in terms of preferential Michael ...

    Abstract A telescoped sequence involves the reaction of cationic imidazolium attached 2-aminobenzimidazoles with in situ generated 1,1-dicyano-2-aryl ethylenes was explored for the regioselective synthesis of pyrimido[1,2-a]benzimidazoles. The perceived regioselectivity was presumed in terms of preferential Michael addition of 2-aminobenzimidazole followed by intramolecular annulation to the exclusive formation of 4-iminopyrimidines on an ionic liquid support. A plausible mechanistic pathway for their selective formation is discussed and fully supported by X-ray analysis. The present strategy reveals both the amine function and the ring nitrogen in substituted 2-aminobenzimidazoles are active sites for nucleophilic attack on α,β-unsaturated nitriles.
    Keywords active sites ; benzimidazoles ; chemical reactions ; imidazoles ; ionic liquids ; Lewis bases ; nitriles ; nitrogen ; regioselectivity
    Language English
    Dates of publication 2013-1021
    Size p. 22314-22318.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c3ra42658k
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  6. Article: TiO2 nano crystallites catalyzed water mediated microwave assisted regioselective three component domino hydrolysis/aldol condensation/Michael addition reaction of 3-(1,5-dioxo-1,5-diphenylpentan-3-yl)quinolin-2(1H)-one

    Ubba, Eethamukkala / Chung, Eun Hyuk / Jeong, Euh Duck / Nawaz Khan, Fazlur-Rahman

    RSC advances. 2014 Nov. 03, v. 4, no. 100

    2014  

    Abstract: ... hydrolysis/aldol condensation/Michael addition. The current methodology provides the coveted synthetic ...

    Abstract A facile microwave supported, water intervened and nano crystalline TiO2 catalyzed synthesis of 1,5-dicarbonyl derivatives, 3-(1,5-dioxo-1,5-diphenylpentan-3-yl)quinolin-2(1H)-ones, is described. This strategy utilizes the reversible water adsorption/de-sorption property of TiO2 nano crystallites for the domino hydrolysis/aldol condensation/Michael addition. The current methodology provides the coveted synthetic building blocks in an ecologically benevolent procedure, including a reusable catalyst, safe, universal water medium, microwave support, a multistep reaction in one pot and a selective process.
    Keywords adsorption ; catalysts ; catalytic activity ; condensation reactions ; crystallites ; hydrolysis ; microwave treatment ; regioselectivity ; titanium dioxide
    Language English
    Dates of publication 2014-1103
    Size p. 57016-57025.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c4ra10051d
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  7. Article: Novel poly(amino ester)s obtained from Michael addition polymerizations of trifunctional amine monomers with diacrylates: safe and efficient DNA carriers.

    Liu, Ye / Wu, Decheng / Ma, Yuexia / Tang, Guping / Wang, Shu / He, Chaobin / Chung, Taishung / Goh, Suathong

    Chemical communications (Cambridge, England)

    2003  , Issue 20, Page(s) 2630–2631

    Abstract: ... were obtained from the Michael addition polymerizations of trifunctional amine monomers ...

    Abstract Novel biodegradable poly(amino ester)s containing secondary and tertiary amines in the backbones were obtained from the Michael addition polymerizations of trifunctional amine monomers with diacrylates, and showed high transfection efficiency for the delivery of DNA comparable to those of polyethylenimine (PEI) and low cytotoxicity.
    MeSH term(s) Acrylates/chemistry ; Amines/chemistry ; Biodegradation, Environmental ; Cell Line ; DNA/administration & dosage ; Genetic Vectors/chemical synthesis ; Genetic Vectors/chemistry ; Genetic Vectors/toxicity ; Humans ; Molecular Structure ; Plasmids ; Polyamines/chemical synthesis ; Polyamines/chemistry ; Polyamines/toxicity ; Polyesters/chemical synthesis ; Polyesters/toxicity ; Polyethyleneimine/toxicity ; Transfection/methods
    Chemical Substances Acrylates ; Amines ; Polyamines ; Polyesters ; Polyethyleneimine (9002-98-6) ; DNA (9007-49-2)
    Language English
    Publishing date 2003-09-01
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/b309487a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Differential effects of thiols on DNA modifications via alkylation and Michael addition by alpha-acetoxy-N-nitrosopyrrolidine.

    Wang, M / Nishikawa, A / Chung, F L

    Chemical research in toxicology

    1992  Volume 5, Issue 4, Page(s) 528–531

    Abstract: ... intermediates capable of modifying DNA with guanine either by simple alkylation or by Michael type addition ... adducts 1 and 2) and Michael addition (adducts 3-5). The results showed that the addition of mesna ...

    Abstract The hepatocarcinogen NPYR is metabolically activated by alpha-hydroxylation mediated by cytochrome P-450 enzymes to yield a 4-oxobutylating agent and 2-butenal (crotonaldehyde). Both are reactive intermediates capable of modifying DNA with guanine either by simple alkylation or by Michael type addition, respectively. In order to assess the roles of these pathways in NPYR tumorigenesis, we are interested in identifying agents which can selectively modify one of these two pathways. In this study, we examined the effects of three thiols--(mesna), glutathione (Glu), and N-acetylcysteine (Nac)--on DNA adduct formation by alpha-acetoxyNPYR, a stable precursor of alpha-hydroxyNPYR. Calf thymus DNA isolated from incubation of alpha-acetoxyNPYR with or without thiol was hydrolyzed and analyzed for the adducts formed by alkylation (adducts 1 and 2) and Michael addition (adducts 3-5). The results showed that the addition of mesna completely blocked the formation of the crotonaldehyde-derived adducts 3-5, whereas it exerted little effect on the formation of the alkylated adducts 1 and 2. These results indicate the preferential conjugation of mesna with crotonaldehyde. In contrast, Nac had little selectivity on adduct formation; levels of adducts 1 to 5 were were reduced by 36-75%. These results suggest that Nac conjugated with both alkylating agent and crotonaldehyde. Similar to mesna, Glu blocked the formation of the crotonaldehyde-derived adducts (adducts 3-5) efficiently. However, unlike mesna, Glu inhibited the formation of adduct 1, while it did not inhibit the formation of adduct 2, although both adducts are presumably derived from the 4-oxobutylating agent.(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Acetylcysteine/chemistry ; Aldehydes/chemistry ; Alkylation ; DNA/chemistry ; Glutathione/chemistry ; Guanine/analysis ; Mesna/chemistry ; N-Nitrosopyrrolidine/analogs & derivatives ; N-Nitrosopyrrolidine/chemistry ; Sulfhydryl Compounds/chemistry
    Chemical Substances Aldehydes ; Sulfhydryl Compounds ; alpha-acetoxy-N-nitrosopyrrolidine (59435-85-7) ; Guanine (5Z93L87A1R) ; DNA (9007-49-2) ; 2-butenal (9G72074TUW) ; Glutathione (GAN16C9B8O) ; Mesna (NR7O1405Q9) ; N-Nitrosopyrrolidine (SZ4J5WK201) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 1992-07
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/tx00028a011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2320: Show issues Location:
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  9. Article: Novel poly(amino ester)s obtained from Michael addition polymerizations of trifunctional amine monomers with diacrylates: safe and efficient DNA carriers

    Liu, Ye / Wu, Decheng / Ma, Yuexia / Tang, Guping / Wang, Shu / He, Chaobin / Chung, Taishung / Goh, Suathong

    Chemical communications. 2003 Oct. 3, , no. 20

    2003  

    Abstract: ... were obtained from the Michael addition polymerizations of trifunctional amine monomers ...

    Abstract Novel biodegradable poly(amino ester)s containing secondary and tertiary amines in the backbones were obtained from the Michael addition polymerizations of trifunctional amine monomers with diacrylates, and showed high transfection efficiency for the delivery of DNA comparable to those of polyethylenimine (PEI) and low cytotoxicity.
    Keywords DNA ; biodegradability ; cytotoxicity ; polyethyleneimine ; polymerization ; tertiary amines ; transfection
    Language English
    Dates of publication 2003-1003
    Size p. 2630-2631.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/b309487a
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  10. Book ; Online ; Conference proceedings: Proceedings of the Meaning in Life International Conference 2022 - Cultivating, Promoting, and Enhancing Meaning in Life Across Cultures and Life Span (MIL 2022)

    Chan, Alex Chi-Keung / Steger, Michael F. / Chui, Raymond Chi-Fai / Siu, Nicolson Yat-Fan / Wong Ip, Susanna Chung Ping / Lam, Bess Yin-Hung

    (Atlantis Highlights in Social Sciences, Education and Humanities ; 704)

    2022  

    Author's details edited by Alex Chi-Keung Chan, Michael F. Steger, Raymond Chi-Fai Chui, Nicolson Yat-Fan Siu, Susanna Chung Ping Wong Ip, Bess Yin-Hung Lam
    Series title Atlantis Highlights in Social Sciences, Education and Humanities ; 704
    Keywords Social psychology ; Educational psychology ; Counseling
    Subject code 302
    Language English
    Size 1 Online-Ressource (XII, 242 p. 23 illus., 11 illus. in color)
    Edition 1st ed. 2022
    Publisher Atlantis Press International BV ; Imprint: Atlantis Press
    Publishing place Dordrecht
    Document type Book ; Online ; Conference proceedings
    HBZ-ID HT021682040
    ISBN 978-94-6463-096-1 ; 9789464630954 ; 94-6463-096-5 ; 9464630957
    DOI 10.2991/978-94-6463-096-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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