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Article: Hyperosmolar hyperglycemic state in children: case report and review of the literature.

Shahramian, Iraj / Ostad Rahimi, Pouya / Radvar, Sepideh

Journal fur klinische Endokrinologie und Stoffwechsel

2022 Volume 15, Issue 2, Page(s) 60–62

Abstract: Hyperosmolar hyperglycemic state (HHS) is a rare complication in children and a life-threatening emergency that presents with a significant increase in blood sugar and hyperosmolarity with or without low ketosis. This study reports the case of a 9-year- ... ...

Abstract	Hyperosmolar hyperglycemic state (HHS) is a rare complication in children and a life-threatening emergency that presents with a significant increase in blood sugar and hyperosmolarity with or without low ketosis. This study reports the case of a 9-year-old boy with severe HHS due to type 1 diabetes. The patient's initial serum glucose level was 1600; however, he was discharged in a stable condition. The patient presented many of the known complications of HHS, including decreased level of consciousness, hypovolemic shock, acute kidney injury, and very high serum glucose levels. The patient responded well to invasive fluid resuscitation and insulin administration, was discharged in good general condition without HHS-related complications, and was followed up with insulin therapy. As the prevalence of HHS in children is increasing, it is necessary for physicians to be aware of the unusual manifestations in children, especially children with type 1 diabetes, and to have the ability to diagnose and manage HHS and differentiate it from diabetic ketoacidosis.
Language	English
Publishing date	2022-05-31
Publishing country	Austria
Document type	Journal Article
ZDB-ID	2592092-3
ISSN	1998-7781 ; 1998-7773
ISSN (online)	1998-7781
ISSN	1998-7773
DOI	10.1007/s41969-022-00164-1
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Article ; Online: CT Manifestation of COVID-19 Pneumonia; Role of Multiplanar Imaging.

Ostad, S P / Haseli, S / Iranpour, P

Academic radiology

2020 Volume 27, Issue 5, Page(s) 753–754

MeSH term(s)	Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-04-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2020.03.028
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Zs.A 4594: Show issues

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Article: Grant funding among underrepresented minority and women urologists at academic institutions.

White, Simon / Tella, David / Ostad, Bahrom / Barquin, David / Smith, Caleigh / King, Rebecca / Greene, Kirsten L / Downs, Tracy / Kern, Nora G

The Canadian journal of urology

2024 Volume 31, Issue 1, Page(s) 11777–11783

Abstract: ... associated with non-URiM status (p < 0.001) and men (p < 0.0001). On multivariable analysis, Doximity rank (p ... < 0.001) and academic rank (p < 0.001) were significant predictors of receiving a grant; male gender ... of grants received (p = 0.04) and total funding (p = 0.04); years of practice, Doximity rank, URiM status ...

Abstract	Introduction: Grant funding to Urology has decreased over the last decade. Documented lack of gender and race diversity at the faculty level raises concerns for funding disparities. This study sought to characterize disparities based upon race and gender in National Institutes of Health (NIH) funding data to Urologic faculty. Methods and materials: Data from 145 ACGME accredited Urology residency programs incorporating faculty gender and underrepresented in medicine (URiM) status was utilized. The NIH Research Portfolio Online Report Tool was queried between 1985 and 2023 for grants related to current Urology faculty. URiM status, gender, years of practice, academic rank, and Doximity residency program rank were factors in multivariable analysis. Results: A total of 2,131 faculty were included. Three hundred one Urologists received 793 urologic grants for a total of $993,919,052 in funding. By race, grants were awarded to: White 72.9%, Asian 21.8%, Hispanic 3.0%, Black 2.1%. Men received 708 grants (89.3%) worth $917,083,475 total. Women received 85 grants (10.7%) worth $76,835,577 total. Likelihood of being awarded a grant was significantly associated with non-URiM status (p < 0.001) and men (p < 0.0001). On multivariable analysis, Doximity rank (p < 0.001) and academic rank (p < 0.001) were significant predictors of receiving a grant; male gender, URiM status, and years of practice were not. Academic rank was also a significant predictor of number of grants received (p = 0.04) and total funding (p = 0.04); years of practice, Doximity rank, URiM status, and gender were not. Conclusions: NIH grants were more likely awarded to higher ranked faculty from higher Doximity ranked institutions with no differences based on URiM status or gender.
MeSH term(s)	United States ; Humans ; Male ; Female ; Urologists ; National Institutes of Health (U.S.) ; Urology ; Biomedical Research
Language	English
Publishing date	2024-02-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2064475-9
ISSN	1195-9479
ISSN	1195-9479
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Article: CT Manifestation of COVID-19 Pneumonia; Role of Multiplanar Imaging

Ostad, S P / Haseli, S / Iranpour, P

Acad Radiol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32276754
Database	COVID19

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Article ; Online: CT Manifestation of COVID-19 Pneumonia; Role of Multiplanar Imaging

Ostad, S.P. / Haseli, S. / Iranpour, P.

Academic Radiology

2020 Volume 27, Issue 5, Page(s) 753–754

Keywords	Radiology Nuclear Medicine and imaging ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1355509-1
ISSN	1076-6332
ISSN	1076-6332
DOI	10.1016/j.acra.2020.03.028
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Thermal stress and TiO

Habibi, Peymaneh / Ostad, Seyed Nasser / Monazzam, Mohammad Reza / Foroushani, Abbas Rahimi / Ghazi-Khansari, Mahmoud / Aliebrahimi, Shima / Montazeri, Vahideh / Golbabaei, Farideh

Environmental science and pollution research international

2022 Volume 29, Issue 60, Page(s) 90128–90139

Abstract: Titanium dioxide (nano- ... ...

Abstract	Titanium dioxide (nano-TiO
MeSH term(s)	Humans ; Animals ; Mice ; Policy ; Oxidative Stress ; Apoptosis
Language	English
Publishing date	2022-07-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-21796-5
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Article ; Online: Design, Synthesis and Anticancer Evaluation of Novel Series of Indibulin Analogues.

Moghadam, Ebrahim S / Saravani, Farhad / Ostad, Seyednasser / Tavajohi, Shohreh / Hamedani, Morteza P / Amini, Mohsen

Medicinal chemistry (Shariqah (United Arab Emirates))

2018 Volume 15, Issue 3, Page(s) 231–239

Abstract: Background: Cancer is an important cause of human death worldwide. During the last decades, many anticancer agents with anti-tubulin mechanism have been synthesized or extracted from nature and some of them also entered clinical use. Indibulin is one of ...

Abstract	Background: Cancer is an important cause of human death worldwide. During the last decades, many anticancer agents with anti-tubulin mechanism have been synthesized or extracted from nature and some of them also entered clinical use. Indibulin is one of the most potent tubulin polymerization inhibitors with minimal peripheral neuropathy, which is a big problem by some of the antimitotic agents such as taxanes and vinka alkaloids. With respect to this giant benefit, herein we decided to design and synthesize novel indibulin related compounds and investigate their anticancer activity against HT-29, Caco-2 and T47-D cancerous cell lines as well as NIH-T3T as normal cell line. Objective: The aim of this study was to synthesize new anti-cancer agents and evaluates their cytotoxic activity on diverse cancerous and normal cell lines. Method: Target compounds were synthesized in multistep reaction and cytotoxic activity was investigated by MTT cell viability assay. Results: Herein, nine novel target compounds were synthesized in moderate to good yield. Some of the compounds exerted good cytotoxic activity against cancerous cell lines. Annexin V/PI staining showed that compound 4g could induce apoptosis and necrosis in HT-29 cell line. Conclusion: It is valuable to do further investigation on compound 4g which showed the highest activity against HT-29 and Caco-2 (IC50 values are 6.9 and 7 µM respectively). Also, synthesis of new derivatives of current synthesized compounds is suggested.
MeSH term(s)	Acetamides/chemical synthesis ; Acetamides/chemistry ; Acetamides/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Indoles/pharmacology ; Inhibitory Concentration 50 ; Proton Magnetic Resonance Spectroscopy ; Spectrum Analysis/methods
Chemical Substances	Acetamides ; Antineoplastic Agents ; Indoles ; indibulin (80K4H2RB8P)
Language	English
Publishing date	2018-10-15
Publishing country	Netherlands
Document type	Journal Article
ISSN	1875-6638
ISSN (online)	1875-6638
DOI	10.2174/1573406414666181015145945
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Article ; Online: Effect of heat stress on DNA damage: a systematic literature review.

Habibi, Peymaneh / Ostad, Seyed Naser / Heydari, Ahad / Aliebrahimi, Shima / Montazeri, Vahideh / Foroushani, Abbas Rahimi / Monazzam, Mohammad Reza / Ghazi-Khansari, Mahmoud / Golbabaei, Farideh

International journal of biometeorology

2022 Volume 66, Issue 11, Page(s) 2147–2158

Abstract: Thermal stress has a direct effect on various types of DNA damage, which depends on the stage of the cell cycle when the cell is exposed to different climate conditions. A literature review was conducted to systematically investigate and assess the ... ...

Abstract	Thermal stress has a direct effect on various types of DNA damage, which depends on the stage of the cell cycle when the cell is exposed to different climate conditions. A literature review was conducted to systematically investigate and assess the overall effect of heat stress and DNA damage following heat exposure. In this study, electronic databases including PubMed, Scopus, and Web of Science were searched to find relevant literature on DNA damage in different ambient temperatures. Outcomes included (1) measurement of DNA damage in heat exposure, (2) three different quantification methods (comet assay, 8-hydroxy-2-deoxyguanosine (8-OHdG), and γ-H2AX), and (3) protocols used for moderate (31) and high temperatures (42). The evidence shows that long exposure and very high temperature can induce an increase in DNA damage through aggregate in natural proteins, ROS generation, cell death, and reproductive damage in hot-humid and hot-dry climate conditions. A substantial increase in DNA damage occurs following acute heat stress exposure, especially in tropical and subtropical climate conditions. The results of this systematic literature review showed a positive association between thermal stress exposure and inhibition of repair of DNA damage.
MeSH term(s)	Humans ; DNA Damage ; 8-Hydroxy-2'-Deoxyguanosine ; Heat Stress Disorders ; Heat-Shock Response ; Hot Temperature
Chemical Substances	8-Hydroxy-2'-Deoxyguanosine (88847-89-6)
Language	English
Publishing date	2022-09-30
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	280324-0
ISSN	1432-1254 ; 0020-7128
ISSN (online)	1432-1254
ISSN	0020-7128
DOI	10.1007/s00484-022-02351-w
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Zs.A 998: Show issues

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Article ; Online: Temporal trends and predictors of inhospital death in patients hospitalised for heart failure in Germany.

Keller, Karsten / Hobohm, Lukas / Ostad, Mir A / Göbel, Sebastian / Lankeit, Mareike / Konstantinides, Stavros / Münzel, Thomas / Wenzel, Philip

European journal of preventive cardiology

2020 Volume 28, Issue 9, Page(s) 990–997

Abstract: ... estimate 0.06, 95% confidence interval (CI) 0.06 to 0.07, P < 0.001) in parallel with median age and ... 95% CI -0.37 to -0.35, P < 0.001) and the rate of major adverse cardiovascular and cerebrovascular ... events (β estimate -0.24, 95% CI -0.25 to -0.23, P < 0.001) decreased from 12.7% to 10.3%. Age 70 years ...

Abstract	Aims: We investigated trends in incidence, case fatality rate, patient characteristics and adverse inhospital events of patients hospitalised for heart failure in Germany. Methods and results: The German nationwide inpatient sample (2005-2016) was used for this analysis. Patients hospitalised due to heart failure were selected for analysis. Temporal trends in the incidence of hospitalisations, case fatality rate and treatments were analysed and predictors of inhospital death were identified. The analysis comprised a total number of 4,539,140 hospitalisations (52.0% women, 81.0% aged ≥70 years) due to heart failure. Although hospitalisations increased from 381 (2005) to 539 per 100,000 population (2016) (β estimate 0.06, 95% confidence interval (CI) 0.06 to 0.07, P < 0.001) in parallel with median age and prevalence of comorbidities, the inhospital case fatality rate decreased from 11.1% to 8.1% (β estimate -0.36, 95% CI -0.37 to -0.35, P < 0.001) and the rate of major adverse cardiovascular and cerebrovascular events (β estimate -0.24, 95% CI -0.25 to -0.23, P < 0.001) decreased from 12.7% to 10.3%. Age 70 years and older (odds ratio (OR) 2.60, 95% CI 2.57 to 2.63, P < 0.001) and cancer (OR 1.93, 95% CI 1.91 to 1.96, P < 0.001) were independent predictors of inhospital death. Conclusion: Hospitalisations for heart failure increased in Germany from 2005 to 2016, whereas the major adverse cardiovascular and cerebrovascular event rate and inhospital case fatality rate decreased during this period despite higher patient age and increasing prevalence of comorbidities.
MeSH term(s)	Aged ; Comorbidity ; Female ; Germany/epidemiology ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/therapy ; Hospital Mortality ; Hospitalization ; Humans ; Male
Language	English
Publishing date	2020-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487320936020
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Zs.A 4686: Show issues

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Article ; Online: 5-Year Experience of In-Hospital Outcomes After Percutaneous Left Atrial Appendage Closure in Germany.

Hobohm, Lukas / von Bardeleben, Ralph S / Ostad, Mir A / Wenzel, Philip / Münzel, Thomas / Gori, Tommaso / Keller, Karsten

JACC. Cardiovascular interventions

2019 Volume 12, Issue 11, Page(s) 1044–1052

Abstract: ... 0.95 to 1.01; p < 0.001), with a nonsignificant uptrend of in-hospital mortality (from 0.5% in 2011 ... to 0.9% in 2015; β = 0.01; 95% CI: -0.09 to 0.32; p = 0.271). Patient characteristics shifted ... of in-hospital mortality were cancer (odds ratio [OR]: 2.49; 95% CI: 1.00 to 6.12; p = 0.050), heart failure (OR: 2.42; 95 ...

Abstract	Objectives: The aim of this study was to evaluate 5-year in-hospital trends and safety outcomes of left atrial appendage (LAA) closure in the German nationwide inpatient sample. Background: The safety and efficacy of percutaneous LAA closure have been demonstrated in randomized trials and prospective cohort studies, but results from large samples are missing. Methods: Data on patient characteristics and in-hospital safety outcomes for all percutaneous LAA closures performed in Germany between 2011 and 2015 were analyzed. Overall, 15,895 inpatients were included. Results: The annual number of LAA occlusions increased from 1,347 in 2011 to 4,932 in 2015 (β = 1.00; 95% confidence interval [CI]: 0.95 to 1.01; p < 0.001), with a nonsignificant uptrend of in-hospital mortality (from 0.5% in 2011 to 0.9% in 2015; β = 0.01; 95% CI: -0.09 to 0.32; p = 0.271). Patient characteristics shifted toward older age and higher prevalence of comorbidities such as heart failure, chronic obstructive pulmonary disease, and chronic renal insufficiency over time. Important independent predictors of in-hospital mortality were cancer (odds ratio [OR]: 2.49; 95% CI: 1.00 to 6.12; p = 0.050), heart failure (OR: 2.42; 95% CI: 1.72 to 3.41; p < 0.001), stroke (OR: 5.39; 95% CI: 2.76 to 10.53; p < 0.001), acute renal failure (OR: 13.28; 95% CI: 9.08 to 19.42; p < 0.001), pericardial effusion (OR: 5.65; 95% CI: 3.76 to 8.48; p < 0.001), and shock (OR: 45.11; 95% CI: 31.01 to 65.58; p < 0.001). Conclusions: The use of percutaneous LAA closure increased 3.6-fold from 2011 to 2015, with a nonsignificant uptrend of in-hospital mortality rate in this real-world setting. Important predictors of in-hospital death were acute renal failure, pericardial effusion, and ischemic stroke during hospitalization.
MeSH term(s)	Aged ; Aged, 80 and over ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/physiopathology ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/mortality ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/therapy ; Atrial Function, Left ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/mortality ; Cardiac Catheterization/trends ; Cause of Death/trends ; Comorbidity ; Female ; Germany/epidemiology ; Health Status ; Hospital Mortality/trends ; Humans ; Male ; Risk Factors ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2019-05-31
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2019.04.002
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