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Article: [Shang Zhijun, a famous contemporary philogist in herbal literature research].

Peng, H S / Xie, B W / Wan, F

Zhonghua yi shi za zhi (Beijing, China : 1980)

2019 Volume 49, Issue 1, Page(s) 34–37

Abstract: Mr. Shang is a famous herbalist in contemporary China and he devoted his life to the research ...

Abstract	Mr. Shang is a famous herbalist in contemporary China and he devoted his life to the research of herbal literatures. During his lifetime, he has compiled and published a total 19 herbal literatures, 33 works of herbal literature, 268 academic papers, and more than 20 million words of handwritten herbal transcripts. In the field of herbal literature research, he has achieved fruitful results that are highly recognized by the academic communities. The research results can be roughly summarized as four aspects: the establishment of a two-line research network of herbal formulae, the research and collection of lost herbal works, the collation of the survived ancient herbal works and the textual research of famous herbal works. Many of his research results on herbal literature have been included in the modern higher education professional textbooks, and his outstanding academic achievements have opened the door for later scholars, influencing many scholars both home and abroad.
Language	Chinese
Publishing date	2019-04-10
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.issn.0255-7053.2019.01.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [On historical stages of studies on the science of Shang Han Lun].

Wan, X

Zhonghua yi shi za zhi (Beijing, China : 1980)

1995 Volume 25, Issue 2, Page(s) 89–91

Abstract: Based on the inherent rule and historical characteristics, the history of studies on Shang Han Lun ...

Abstract	Based on the inherent rule and historical characteristics, the history of studies on Shang Han Lun can be divided into 5 stages, viz. (1) Formation (Pre-Qin period - 219 AD); (2) Copying (219 - 1065); (3) Stressing clinical application (1065 - 1144); (4) Stressing both theory and practice (1140 - 1894); (5) Comprehensive study (1894 -). Brief descriptions are given to each stage.
MeSH term(s)	China ; Common Cold/history ; Historiography ; History, Ancient ; History, Early Modern 1451-1600 ; History, Medieval ; History, Modern 1601- ; Humans
Language	Chinese
Publishing date	1995
Publishing country	China
Document type	English Abstract ; Historical Article ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
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Article ; Online: Co-targeting ASK1 and THRβ synergistically improves steatohepatitis and fibrosis in a MASH animal model.

Shang, Shu / Wan, Qin / Chen, Faxiu / Hu, Jian

Biochemical and biophysical research communications

2024 Volume 705, Page(s) 149739

Abstract: Purpose: Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that has gained widespread attention globally. Unfortunately, there is no approved treatment for this condition yet. However, recent research has identified Apoptosis ... ...

Abstract	Purpose: Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that has gained widespread attention globally. Unfortunately, there is no approved treatment for this condition yet. However, recent research has identified Apoptosis signal-regulating kinase 1 (ASK1) and thyroid hormone receptor-β (THR-β) as potential targets for treating MASH. Although the individual effects of these two targets have been studied, their combinatory effect has not been well defined. Therefore, further research is needed to investigate the potential benefits of targeting both ASK1 and THR-β for treating MASH. Methods: We established a MASH model using the HFHFrC diet (high fat, high fructose, and cholesterol) and carbon tetrachloride (CCL4). Forty mice were evenly assigned to four groups: vehicle, GS4997 (an ASK1 inhibitor), MGL3196 (a THRβ agonist), GS4997+ MGL3196 combination (combo). The drugs were administered for 8 weeks, after which the mice were sacrificed for serum biochemical tests, liver TG and TC evaluation, liver histopathological study, and gene expression validation. Results: GS4997 and MGL3196, when used in combination, have been shown to have synergistic effects on various parameters. Firstly, they synergistically reduced body weight and liver body weight ratio. Secondly, this combination also synergistically lowered AST and TC. Thirdly, synergistic effects were also observed in liver TG and TC reduction. Fourthly, we further confirmed that GS4997 mildly improved liver inflammation, ballooning, and fibrosis, but exhibited incredible histopathological efficacy when combined with MGL3196. Finally, this combinatory effect can be interpreted by synergistically regulating lipid-related genes such as Dio1, Ctp1-α, and Cat, inflammation-related genes such as Il-6, Il-8, and Mcp-1, and fibrosis-related genes such as Tgf-β, Col1α1, and Col6α3. Conclusion: GS4997 and MGL3196, when used in combination, have been shown to have a comprehensive effect on MASH by synergistically regulating lipid, inflammation, and fibrosis-related gene expression through co-targeting ASK1 and THRβ.
MeSH term(s)	Mice ; Animals ; MAP Kinase Kinase Kinase 5/genetics ; MAP Kinase Kinase Kinase 5/metabolism ; Fatty Liver/metabolism ; Liver/metabolism ; Fibrosis ; Inflammation/pathology ; Models, Animal ; Liver Cirrhosis/pathology ; Body Weight ; Lipids ; Non-alcoholic Fatty Liver Disease/metabolism
Chemical Substances	MAP Kinase Kinase Kinase 5 (EC 2.7.11.25) ; Lipids
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149739
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Article ; Online: Association between dietary flavonoid intake and hypertension among U.S. adults.

Wan, Yingying / Ma, Dan / Shang, Qinghua / Xu, Hao

Frontiers in immunology

2024 Volume 15, Page(s) 1380493

Abstract: Background: Hypertension is one of the major risk factors for cardiovascular disease. Dietary flavonoids have been reported to reduce inflammation, protect against oxidative stress, protect the vascular endothelium, and improve vascular health. However, ...

Abstract	Background: Hypertension is one of the major risk factors for cardiovascular disease. Dietary flavonoids have been reported to reduce inflammation, protect against oxidative stress, protect the vascular endothelium, and improve vascular health. However, the relationship between dietary flavonoid intake and the prevalence of hypertension remains controversial. Methods: This study included 8010 adults from the 2007-2010 and 2017-2018 National Health and Nutrition Examination Surveys (NHANES). The relationship between dietary flavonoid intake and the prevalence of hypertension was explored by weighted logistic regression and weighted restricted cubic spline. Results: We found an inverse relationship between total anthocyanin intake and the prevalence of hypertension in the fourth quartile compared with the first quartile [0.81(0.66,0.99), p = 0.04]. Moreover, the prevalence of hypertension tended to decrease with increasing total anthocyanin intake in participants over 60 years of age. In addition, we found a U-shaped relationship between the prevalence of hypertension and total flavan-3-ol intake. Total flavan-3-ol intake was inversely associated with hypertension prevalence in the third quartile compared with the first quartile [0.79 (0.63,0.99), p = 0.04]. Moreover, there was a significant negative association between the prevalence of hypertension and total flavan-3-ol intake when total flavan-3-ol intake was below 48.26 mg/day. Conclusion: Our study found a negative association between the prevalence of hypertension and moderate total anthocyanins intake and total flavan-3-ols intake. Our study provides evidence from a population-based study for a negative association between dietary flavonoid intake and the prevalence of hypertension.
MeSH term(s)	Humans ; Hypertension/epidemiology ; Male ; Female ; Flavonoids/administration & dosage ; Middle Aged ; Adult ; United States/epidemiology ; Prevalence ; Nutrition Surveys ; Diet ; Aged ; Anthocyanins/administration & dosage ; Risk Factors ; Cross-Sectional Studies
Chemical Substances	Flavonoids ; Anthocyanins
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1380493
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Construction of a direct Z-scheme CeO

Zhang, Heling / Wan, Yuqi / Shang, Simin / Cheng, Qingrong / Pan, Zhiquan

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 14, Page(s) 4562–4573

Abstract: In this study, hollow ... ...

Abstract	In this study, hollow CeO
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d2dt03797a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Molecular modeling of interfacial properties of the hydrogen + water + decane mixture in three-phase equilibrium.

Yang, Yafan / Wan, Jingyu / Li, Jingfa / Zhao, Guangsi / Shang, Xiangyu

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 43, Page(s) 29641–29655

Abstract: The understanding of interfacial phenomena between ... ...

Abstract	The understanding of interfacial phenomena between H
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp04406h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Molecular insights into fluid-solid interfacial tensions in water + gas + solid systems at various temperatures and pressures.

Yang, Yafan / Wan, Jingyu / Shang, Xiangyu / Sun, Shuyu

The Journal of chemical physics

2023 Volume 159, Issue 9

Abstract: The fluid-solid interfacial tension is of great importance to many applications including the geological storage of greenhouse gases and enhancing the recovery of geo-resources, but it is rarely studied. Extensive molecular dynamics simulations are ... ...

Abstract	The fluid-solid interfacial tension is of great importance to many applications including the geological storage of greenhouse gases and enhancing the recovery of geo-resources, but it is rarely studied. Extensive molecular dynamics simulations are conducted to calculate fluid-solid interfacial properties in H2O + gas (H2, N2, CH4, and CO2) + rigid solid three-phase systems at various temperatures (298-403 K), pressures (0-100 MPa), and wettabilities (hydrophilic, neutral, and hydrophobic). Our results on the H2O + solid system show that vapor-solid interfacial tension should not be ignored in cases where the fluid-solid interaction energy is strong or the contact angle is close to 90°. As the temperature rises, the magnitude of H2O's liquid-solid interfacial tension declines because the oscillation of the interfacial density/pressure profile weakens at high temperatures. However, the magnitude of H2O vapor-solid interfacial tension is enhanced with temperature due to the stronger adsorption of H2O. Moreover, the H2O-solid interfacial tension in H2O + gas (H2 or N2) + solid systems is weakly dependent on pressure, while the pressure effects on H2O-solid interfacial tensions in systems with CH4 or CO2 are significant. We show that the assumption of pressure independent H2O-solid interfacial tensions should be cautiously applied to Neumann's method for systems containing non-hydrophilic surfaces with strong gas-solid interaction. Meanwhile, the magnitude of gas-solid interfacial tension increases with pressure and gas-solid interaction. High temperatures generally decrease the magnitude of gas-solid interfacial tensions. Further, we found that the increment of contact angle due to the presence of gases follows this order: H2 < N2 < CH4 < CO2.
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0157957
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integration of transcriptomic and metabolomic analysis unveils the response mechanism of sugar metabolism in Cyclocarya paliurus seedlings subjected to PEG-induced drought stress.

Li, Chenhui / Wan, Yifeng / Shang, Xulan / Fang, Shengzuo

Plant physiology and biochemistry : PPB

2023 Volume 201, Page(s) 107856

Abstract: Cyclocarya paliurus (Batal.) Iljinskaja is a multiple function tree species used for functional food and valued timber production. Carbohydrates, especially water-soluble carbohydrates, play an important role in osmotic protection, signal transduction ... ...

Abstract	Cyclocarya paliurus (Batal.) Iljinskaja is a multiple function tree species used for functional food and valued timber production. Carbohydrates, especially water-soluble carbohydrates, play an important role in osmotic protection, signal transduction and carbon storage. Under the circumstance of global climate change the abiotic stress would restrict the development of C. paliurus plantation, whereas there is few knowledge on the regulatory mechanisms of sugar metabolism under drought stress in C. paliurus. To investigate the drought response of C. paliurus at molecular level, we conducted an integrated analysis of transcriptomic and metabolomic of C. paliurus at three PEG-induced drought stress levels (0%: control; 15%: moderate drought; 25%: severe drought) in short term. Both moderate and severe drought treatments activated the chemical defense with lowering relative water content, and enhancing the contents of soluble protein, proline and malondialdehyde in the leaves. Meanwhile, alterations in the expression of differentially expressed genes and carbohydrate metabolism profiles were observed among the treatments. Weighted gene co-expression network analysis (WGCNA) showed 3 key modules, 8 structural genes (such as genes encoding beta-fructofuranosidase (INV), sucrose synthase (SUS), raffinose synthase (RS)) and 14 regulatory transcription factors were closely linked to sugar metabolism. Our results provided the foundation to understand the response mechanism of sugar metabolism in C. paliurus under drought stress, and would drive progress in breeding of drought-tolerant varieties and plantation development of the species.
MeSH term(s)	Transcriptome/genetics ; Seedlings/metabolism ; Droughts ; Plant Breeding ; Carbohydrate Metabolism/genetics ; Carbohydrates ; Juglandaceae/genetics ; Water/metabolism ; Sugars/metabolism
Chemical Substances	Carbohydrates ; Water (059QF0KO0R) ; Sugars
Language	English
Publishing date	2023-06-20
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2023.107856
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Article ; Online: Comparison of

Shang, Fumei / Cao, Yinghao / Wan, Lixin / Ren, Zhonghai / Wang, Xinghao / Huang, Mudan / Guo, Yingyun

mBio

2023 , Page(s) e0153123

Abstract: Helicobacter ... ...

Abstract	Helicobacter pylori
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.01531-23
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Article: [Schistosomiasis control in Sichuan Province since the 12th Five - Year Plan period: progress and prospects].

Shang, J / Zhang, Y / Pu, C / Wan, J / Chen, L / Wu, Z / Liu, Y

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

2024 Volume 35, Issue 6, Page(s) 539–544

Abstract: An ambitious goal has been set for elimination of schistosomiasis in all endemic counties (districts) in Sichuan Province by 2023. To achieve this goal, and to continue to consolidate the control achievements, it is necessary to understand the current ... ...

Abstract	An ambitious goal has been set for elimination of schistosomiasis in all endemic counties (districts) in Sichuan Province by 2023. To achieve this goal, and to continue to consolidate the control achievements, it is necessary to understand the current endemic status of schistosomiasis, identify the challenges and analyze the experiences and lessons from the schistosomiasis control program, and develop targeted control strategies and interventions in the province. This paper reviews the progress of schistosomiasis control in Sichuan Province since the 12th Five-Year Plan period, analyzes the challenges in the schistosomiasis elimination program, and proposes recommendations for future directions and priorities.
MeSH term(s)	Humans ; Animals ; Schistosomiasis/epidemiology ; Schistosomiasis/prevention & control ; China/epidemiology ; Snails
Language	Chinese
Publishing date	2024-02-27
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ISSN	1005-6661
ISSN	1005-6661
DOI	10.16250/j.32.1374.2023156
Database	MEDical Literature Analysis and Retrieval System OnLINE

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