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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages.

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of ethnopharmacology

2023 Volume 312, Page(s) 116444

Abstract: ... of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule ...

Abstract	Ethnopharmacological relevance: Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. Aim of the study: This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. Materials and methods: The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE Results: The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. Conclusion: SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
MeSH term(s)	Mice ; Animals ; Plaque, Atherosclerotic/metabolism ; Cholesterol, HDL ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Atherosclerosis/etiology ; Macrophages ; Cholesterol/metabolism ; Lysosomes/metabolism ; Apolipoproteins E
Chemical Substances	Cholesterol, HDL ; Cholesterol (97C5T2UQ7J) ; Apolipoproteins E
Language	English
Publishing date	2023-04-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Optimized Extraction, Identification and Anti-Biofilm Action of Wu Wei Zi (

Zhang, Zongyi / Zhao, Yanan / Cai, Jing / Wang, Tong / Song, Yujie / Lu, Jingyi / Du, Hairuo / Wang, Wenfang / Zhao, Yan / Guo, Lei

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: The pathogenicity of ... ...

Abstract	The pathogenicity of foodborne
MeSH term(s)	Vibrio parahaemolyticus/genetics ; Schisandra ; Biofilms
Chemical Substances	schizandrol B (58546-54-6) ; schizandrer A (82042-38-4) ; schizandrin C (C8754W6B3G)
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052268
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Article ; Online: San-wei-tan-xiang capsule attenuates atherosclerosis by increasing lysosomal activity in adipose tissue macrophages

Ye, Heng / Wang, Gang / Wang, Xuchao / Wang, Lin / Ni, Wei / Chen, Linjian / Zhu, Yifan / Zhao, Longshan / Xiong, Zhili / Wang, Yan / Dai, Cuilian / Liu, Binbin

Journal of Ethnopharmacology. 2023 Aug., v. 312 p.116444-

2023

Abstract: ... of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts ...

Abstract	Dyslipidemia is the leading risk factor of atherosclerosis (AS). Adipose tissue macrophages (ATMs) can regulate postprandial cholesterol levels via uptake and hydrolyzation of lipids and regulation of macrophage cholesterol efflux (MCE). San-wei-tan-xiang (SWTX) capsule, a Traditional Chinese medicine, exerts clinical benefits in patients with atherosclerotic cardiovascular diseases. This work is aimed to evaluate the chemical ingredients and mechanisms of SWTX in anti-AS. The chemical ingredients of SWTX identified by liquid chromatography coupled with tandem mass spectrometry were used for network pharmacological analysis. The atheroprotective function of SWTX was evaluated in ApoE⁻/⁻ mice fed a cholesterol-enriched diet. The chemical ingredients identified in SWTX were predicated to be important for lipid metabolism and AS. Animals studies suggested that SWTX effectively attenuated the atherosclerotic plaque growth, elevated postprandial HDL cholesterol levels, elevated the proportion of Tim4 and CD36-expressed ATMs, and upregulated the uptake of lipid and lysosomal activity in ATMs. SWTX-induced elevation of postprandial HDL cholesterol levels was dependent on increased lysosomal activity, since chloroquine, an inhibitor of lysosomal function, blocked the effect of SWTX. Lastly, some predicated bioactive compounds in SWTX can elevate lysosomal activity in vitro. SWTX could attenuate atherosclerotic plaque formation by elevating lysosomal activity and enhancing MCE in ATMs.
Keywords	Oriental traditional medicine ; adipose tissue ; atherosclerosis ; chloroquine ; diet ; high density lipoprotein cholesterol ; hyperlipidemia ; lipid metabolism ; liquid chromatography ; macrophages ; risk factors ; tandem mass spectrometry ; Adipose tissue macrophage ; Lysosomal activity ; Postprandial cholesterol level ; San-wei-tan-xiang capsule
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116444
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tibetan medicine Si-Wei-Qiang-Wei Powder ameliorates cholecystitis via inhibiting the production of pro-inflammatory cytokines and regulating the MAPK signaling pathway.

Zheng, Zhe / Xiong, Hui / Zhao, Zhongqiu / Zhou, Keli / Fu, Miao / Liu, Xinqiao / Mei, Zhinan

Journal of ethnopharmacology

2022 Volume 303, Page(s) 116026

Abstract: Ethnopharmacological relevance: Si-Wei-Qiang-Wei Powder (SWQ) is a formulated ...

Abstract	Ethnopharmacological relevance: Si-Wei-Qiang-Wei Powder (SWQ) is a formulated traditional Tibetan medicine preparation that has been used clinically to treat liver and gallbladder diseases for centuries. Previous work has confirmed its clinical effectiveness, however, the specific mechanism of SWQ is still unknown. Aim of the study: This study aims to explore the anti-inflammatory effect of SWQ on cholecystitis and its possible mechanism. Materials and methods: The main chemical components of SWQ were analyzed by HPLC. The network pharmacology database was used to screen and construct the network of the main components and molecular targets of SWQ, and to predict the molecular pathways of its core targets. Cholecystitis guinea pig model and LPS stimulated cultured human gallbladder epithelial cells (HGBEC) were used, as in vivo and in vitro methods respectively, to study the anti-cholecystitis activity of SWQ. Specifically, gallbladder wall thickness, hematoxylin-eosin (H&E) staining, and liver function indexes were used to evaluate the anti-inflammatory activities of SWQ in cholecystitis; qRT-PCR and ELISA were used to detect the changes of the production of inflammatory cytokines; Western blot analysis was used to analyze the effects of SWQ on phosphorylation of P38, ERK1/2, JNK and AKT. Results: SWQ decreased the indexes of ALT, AST, TBA, CHOL, DBIL in serum and TBIL, TC and Ca Conclusion: In summary, our research showed that SWQ relieves gallbladder inflammation by inhibiting the MAPK pathway.
Language	English
Publishing date	2022-12-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.116026
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Article: Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.

Zhao, Ning / Wang, Ying / Ma, Yan / Liang, Xiaoxue / Zhang, Xi / Gao, Yuan / Dong, Yingying / Bai, Dong / Hu, Jingqing

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1038273

Abstract: Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao ...

Abstract	Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites. Methods: An acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera Conclusion: This work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1038273
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Article ; Online: Zuotai (β-HgS)-containing 70 Wei Zhen-Zhu-Wan differs from mercury chloride and methylmercury on hepatic cytochrome P450 in mice.

Nie, Yu / Xu, Shang-Fu / Lu, Yan-Liu / Zhao, Xiu-Rong / Li, Cen / Wei, Li-Xin / Liu, Jie

F1000Research

2021 Volume 10, Page(s) 203

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Chlorides ; Cytochrome P-450 Enzyme System ; Liver ; Mercuric Chloride ; Mercury ; Mercury Compounds ; Methylmercury Compounds ; Mice
Chemical Substances	Chlorides ; Mercury Compounds ; Methylmercury Compounds ; zuotai ; Mercuric Chloride (53GH7MZT1R) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.40667.2
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Article ; Online: Psychological distance and physical distance induced residents' heterogeneous willingness to pay for transboundary watershed ecosystem services in the Wei River Basin, China.

Shi, Yuxing / Li, Chaoqiong / Zhao, Minjuan / Ni, Qi

Environmental management

2023 Volume 72, Issue 6, Page(s) 1259–1276

Abstract: ... on residents' preference and WTP for the Wei River Basin ESs. The results showed that midstream and downstream ...

Abstract	Under the framework of payment for transboundary watershed ecosystem services (ESs), identifying midstream and downstream residents' preference and willingness to pay (WTP) for ESs provided by the upstream is crucial for sustainable watershed management. The residents' preferences and WTP are not evenly distributed within the watershed. This study uses a choice experiment assessing the spatial impact of physical distance (including residents' watershed location and distance to waterbody) and psychological distance on residents' preference and WTP for the Wei River Basin ESs. The results showed that midstream and downstream residents' preference and WTP for the ecological attributes have a significant distance-decay effect, either the physical distance to the upstream exit or physical and psychological distance to the waterbody. However, compared with the residents in the midstream, the residents downstream have a stronger preference and WTP for upstream ecological governance. Besides, the distance-decay effect differs between urban and rural residents. There is a psychological distance-decay effect in rural residents' preference for water quality and a physical distance-decay effect in their preference for water quantity, entertainment area, and cost; there is a physical distance decay effect in urban residents' preference for entertainment areas. The above differences lead to heterogeneity in WTP and total economic value (TEV) for ESs. When calculating the TEV of the transboundary watershed ES and charging the public, policymakers should consider the location of the residents, the physical and psychological distance to the water body, and the difference between urban and rural areas.
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1478932-2
ISSN	1432-1009 ; 0364-152X
ISSN (online)	1432-1009
ISSN	0364-152X
DOI	10.1007/s00267-023-01850-9
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Article ; Online: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress.

Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

RSC advances

2022 Volume 12, Issue 8, Page(s) 4455–4468

Abstract: Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia ...

Abstract	Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra08778a
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Article ; Online: Spatial variability of microplastic pollution on surface of rivers in a mountain-plain transitional area: A case study in the Chin Ling-Wei River Plain, China.

Bian, Pengyang / Liu, Yixuan / Zhao, Kaihui / Hu, Yue / Zhang, Jie / Kang, Le / Shen, Weibo

Ecotoxicology and environmental safety

2022 Volume 232, Page(s) 113298

Abstract: ... human settlements) in the Chin Ling-Wei River Plain Rivers, and assessed the pollution risk. Rivers in the Chin Ling ... Wei River Plain contained various levels of microplastics (2.30-21.05 items/L), and the main stream ...

Abstract	Inland lakes and rivers are large reservoirs of microplastics. But currently, not too much research was done on microplastics of mountain rivers. The protection of water sources from microplastics is extremely significant for the safety of human drinking water. We quantified the distribution and variation of microplastics in the surface water from tributary (upstream water-source regions) to main stream (human settlements) in the Chin Ling-Wei River Plain Rivers, and assessed the pollution risk. Rivers in the Chin Ling-Wei River Plain contained various levels of microplastics (2.30-21.05 items/L), and the main stream of the river contained higher concentrations most commonly of microplastics than tributaries. The microplastics were fragments and films; they constituted 82.3% of the total abundance of microplastics. Microplastics with a particle size < 500 µm accounted for 64.3% of all the samples. As rivers flow from the mountains to the plains, the land-use types along the rivers become more multifunctional. Thus, the risk of river microplastic pollution increases sharply with distance downstream. Our research explored the microplastics pollution in the Chin Ling mountains based on topography and land-use types and thus provides a reference for further studies exploring the spatial distribution characteristics of microplastics in small-scale rivers and for pollution risk assessments.
MeSH term(s)	Chin ; China ; Environmental Monitoring ; Humans ; Microplastics ; Plastics ; Water Pollutants, Chemical/analysis
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical
Language	English
Publishing date	2022-02-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113298
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Article ; Online: UPLC-Q-TOF-MS/MS Combined with Network Pharmacology, Molecular Docking, and Animal Verification Reveals the Mechanism of Insomnia Treatment by Shen Qi Wu Wei Zi capsules.

Bai, Fengyun / Wang, Jie / Xia, Ning / Sun, Ying / Xie, Yundong / Zhao, Chongbo / Sun, Jing / Zhang, Xiaofei

Combinatorial chemistry & high throughput screening

2023

Abstract: Background: Shen Qi Wu Wei Zi capsules (SQWWZ) are often used to treat insomnia ... the mechanism underlying the therapeutic effects of the Shen Qi Wu Wei Zi capsules on insomnia.: Methods ...

Abstract	Background: Shen Qi Wu Wei Zi capsules (SQWWZ) are often used to treat insomnia; however, the potential therapeutic mechanism is still unclear. Objective: This study aimed to investigate the mechanism underlying the therapeutic effects of the Shen Qi Wu Wei Zi capsules on insomnia. Methods: The components of SQWWZ were identified using the UPLC-Q-TOF-MS/MS technique in conjunction with relevant literature. Insomnia-related targets were searched in the GeneCards and DisGeNET databases, and the intersection targets were obtained using a Venn diagram. A component-target-insomnia network diagram was constructed using Cytoscape 3.7.2 software. Core targets underwent GO and KEGG enrichment analyses. Molecular docking techniques were employed to verify the key proteins involved in the pathway and their corresponding compounds. Insomnia was induced in SD rats through the intraperitoneal injection of pchlorophenylalanine (DL-4-chlorophenylalanine, PCPA). The rats were treated orally with SQWWZ, and the serum levels of 5-HT and GABA in each group were determined using ELISA. Histological analysis of hippocampal tissue sections from the rats was performed using HE staining. Results: Using UPLC-Q-TOF-MS/MS and reviewing relevant literature, we identified 49 components of SQWWZ. Additionally, we obtained 1,043 drug targets and 367 insomnia-related targets. Among these, 82 targets were found to be common to both drug and insomnia targets. Following drug administration, rats in the treatment group exhibited a significant increase in the serum levels of 5-HT and GABA. Moreover, histological analysis using HE staining revealed neatly arranged hippocampal neuronal cells in the treated rats. Conclusion: The active components of SQWWZ had good inhibition of insomnia. This study provides a reference and guidance for the in-depth study of SQWWZ for the treatment of insomnia.
Language	English
Publishing date	2023-12-27
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073275553231202153259
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