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Article ; Online: Imaging the External Ear: Practical Approach to Normal and Pathologic Conditions.

Tsuno, Niedja S G / Tsuno, Marco Y / Coelho Neto, Carlos A F / Noujaim, Samir E / Decnop, Marcos / Pacheco, Felipe T / Souza, Soraia A / Fonseca, Ana P A / Garcia, Marcio R T

Radiographics : a review publication of the Radiological Society of North America, Inc

2022 Volume 42, Issue 2, Page(s) 522–540

Abstract: The external ear (EE) is an osseous-cartilaginous structure that extends from the auricle to the tympanic membrane. It is divided into two parts: the auricle (or pinna) and the external auditory canal (EAC). Given the ease of access to the EE, imaging ... ...

Abstract	The external ear (EE) is an osseous-cartilaginous structure that extends from the auricle to the tympanic membrane. It is divided into two parts: the auricle (or pinna) and the external auditory canal (EAC). Given the ease of access to the EE, imaging studies are not always needed to make a diagnosis. However, when lesions block visual access to areas deep to the EE abnormality, complications are suspected, or there is lack of response to treatment, imaging becomes essential. A basic understanding of the embryologic development and knowledge of the anatomy of the auricle and EAC are useful for accurate diagnosis of EE lesions. Congenital, traumatic, inflammatory, neoplastic, and vascular conditions can affect the EE. An overview of the anatomy and embryologic development of the EE is presented, with discussion and illustrations of common and uncommon conditions that affect EE structures and a focus on the CT and MRI features that are of interest to radiologists. CT is usually the first diagnostic modality used to evaluate the EAC and is the superior method for demonstrating bone changes. MRI provides excellent tissue characterization and enables one to better define lesion extension and perineural tumor spread. In addition, a flowchart to facilitate the differential diagnosis of EE abnormalities is provided.
MeSH term(s)	Diagnosis, Differential ; Ear Canal/abnormalities ; Ear Canal/diagnostic imaging ; Ear Canal/pathology ; Humans ; Magnetic Resonance Imaging
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.210148
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Article: Acute Lesion Imaging in Predicting Chronic Tissue Injury in the Ventricles.

El Hajjar, Abdel Hadi / Huang, Chao / Zhang, Yichi / Mekhael, Mario / Noujaim, Charbel / Dagher, Lilas / Nedunchezhian, Saihariharan / Pottle, Christopher / Kholmovski, Eugene / Ayoub, Tarek / Dhorepatil, Aneesh / Barakat, Michel / Yamaguchi, Takano / Chelu, Mihail / Marrouche, Nassir

Frontiers in cardiovascular medicine

2022 Volume 8, Page(s) 791217

Abstract: Background: Chronic lesion formation after cardiac tissue ablation is an important indicator for procedural outcome. Moreover, there is a lack of knowledge regarding the features that predict chronic lesion formation.: Objective: The aim of this ... ...

Abstract	Background: Chronic lesion formation after cardiac tissue ablation is an important indicator for procedural outcome. Moreover, there is a lack of knowledge regarding the features that predict chronic lesion formation. Objective: The aim of this study is to determine whether acute lesion visualization using late gadolinium enhanced magnetic resonance imaging (LGE-MRI) can reliably predict chronic lesion size. Methods: Focal lesions were created in left and right ventricles of canine models using either radiofrequency (RF) ablation or cryofocal ablation. Multiple ablation parameters were used. The first LGE-MRI was acquired within 1-5 h post-ablation and the second LGE-MRI was obtained 47-82 days later. Corview software was used to perform lesion segmentations and size calculations. Results: Fifty-Five lesions were created in different locations in the ventricles. Chronic volume size decreased by a mean of 62.5 % (95% CI 58.83-67.97, Conclusion: Chronic tissue injury related to catheter ablation can be reliably modeled as a linear function of the acute lesion volume as assessed by LGE-MRI, regardless of the ablation parameters.
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.791217
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Article ; Online: Bioengineered peptibodies as blockers of ion channels.

Chidipi, Bojjibabu / Chang, Mengmeng / Cui, Meng / Abou-Assali, Obada / Reiser, Michelle / Pshenychnyi, Sergii / Logothetis, Diomedes E / Teng, Michael N / Noujaim, Sami F

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 50, Page(s) e2212564119

Abstract: We engineered and produced an ion channel blocking peptibody, that targets the acetylcholine-activated inwardly rectifying potassium current ( ... ...

Abstract	We engineered and produced an ion channel blocking peptibody, that targets the acetylcholine-activated inwardly rectifying potassium current (I
MeSH term(s)	Humans ; Animals ; Bees ; Mice ; Potassium
Chemical Substances	Potassium (RWP5GA015D)
Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2212564119
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Article ; Online: The association of disparities in neighborhood median household income and mortality in patients admitted to the hospital with atrial fibrillation.

Dhore-Patil, Aneesh / Crawford, Michael / Nedunchezhian, Saihaiharan / El Hajjar, Abdel Hadi / Mekhael, Mario / O'Keefe, Evan / Daghar, Lilas / Noujaim, Charbel / Bhatnagar, Arezu / Pottle, Christopher / Sidhu, Gursukhmandeep / Marrouche, Nassir

Progress in cardiovascular diseases

2022 Volume 76, Page(s) 84–90

Abstract: ... Methods: Data from the regional United States (U.S.) electronic medical records database, Research Action ...

Abstract	Background: Lower neighborhood median household income (nMHI) is associated with increased adverse outcomes in patients with atrial fibrillation (AF). However, its effect on mortality is yet unknown. Methods: Data from the regional United States (U.S.) electronic medical records database, Research Action for Health Network (REACHnet), was extracted for adult patients with AF at Tulane Medical Center over 10 years. Annual nMHI & neighborhood high school graduation (HSG) data was collected from the US Census bureau. Only African Americans (AA) and Caucasians (CC) who had socioeconomic data were included. Low nMHI and low HSG were defined as ≤$25,000 & <90% respectively. High nMHI and HSG were defined as >$50,000 & ≥90% respectively. Primary endpoints were all cause and cardiovascular (CV) mortality. Cox-proportional hazard ratios were used to evaluate the endpoints. Results: We included 4616 patients diagnosed with AF. During a median follow up of 4.6 years, 434 patients died of which 32.7% patients had CV mortality. There was a stepwise decrease in incidence of both all-cause and CV mortality as nMHI increased. Patients with low nMHI had the greatest risk of all-cause mortality (HR 1.9, C.I. 1.2-3.2, P 0.004). The association between low nMHI and all-cause mortality persisted after adjusting for age, sex, race, HSG and stroke risk factors using CHA Conclusion: Low nMHI is an independent risk factor for all cause and CV mortality in AF. Higher burden of co-morbidities is the driving force behind this disparity. Future studies should evaluate the role of educational and therapeutic intervention in these populations to reduce mortality.
MeSH term(s)	Adult ; Humans ; United States/epidemiology ; Atrial Fibrillation/drug therapy ; Stroke/etiology ; Risk Factors ; Hospitalization ; Anticoagulants/therapeutic use ; Hospitals
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-11-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209312-1
ISSN	1873-1740 ; 1532-8643 ; 0033-0620
ISSN (online)	1873-1740 ; 1532-8643
ISSN	0033-0620
DOI	10.1016/j.pcad.2022.11.016
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Zs.A 229: Show issues

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Article ; Online: Eribulin in advanced liposarcoma and leiomyosarcoma.

Setola, Elisabetta / Noujaim, Jonathan / Benson, Charlotte / Chawla, Sant / Palmerini, Emanuela / Jones, Robin L

Expert review of anticancer therapy

2017 Volume 17, Issue 8, Page(s) 717–723

Abstract: Introduction: The heterogeneity of soft tissue sarcomas (STS) presents a formidable management challenge. Consequently, one of the main research goals is to define specific tailored therapy for each histological subtype and to develop a more ... ...

Abstract	Introduction: The heterogeneity of soft tissue sarcomas (STS) presents a formidable management challenge. Consequently, one of the main research goals is to define specific tailored therapy for each histological subtype and to develop a more personalised approach to treatment. The standard first line chemotherapy for advanced STS is doxorubicin, with or without ifosfamide, however, a number of different drugs are emerging as active therapies beyond first-line. Areas covered: Eribulin has recently been approved for advanced liposarcoma, after an anthracycline-containing regimen, demonstrating an overall survival (OS) advantage in liposarcoma and leiomyosarcoma in a randomised Phase III clinical trial. In this manuscript, an overview of the efficacy and safety of eribulin in STS is presented, highlighting different clinical outcomes between histological subtypes and comparing data with other effective drugs used in the treatment of sarcomas. The potential mechanisms of action of eribulin are also described, including its activity as potent microtubule-destabilizing anticancer agent, which has other antitumor biological effects. Expert commentary: Eribulin is highly effective in some STS populations and also has an acceptable toxicity profile. Further studies are required to better understand the precise mechanism of action of this agent and potential role in combination schedules.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacology ; Doxorubicin/administration & dosage ; Furans/administration & dosage ; Furans/adverse effects ; Furans/pharmacology ; Humans ; Ifosfamide/administration & dosage ; Ketones/administration & dosage ; Ketones/adverse effects ; Ketones/pharmacology ; Leiomyosarcoma/drug therapy ; Leiomyosarcoma/pathology ; Liposarcoma/drug therapy ; Liposarcoma/pathology ; Randomized Controlled Trials as Topic ; Survival Rate
Chemical Substances	Antineoplastic Agents ; Furans ; Ketones ; Doxorubicin (80168379AG) ; eribulin (LR24G6354G) ; Ifosfamide (UM20QQM95Y)
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1080/14737140.2017.1344098
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Zs.A 5907: Show issues

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Article ; Online: Canadian consensus on TRK-inhibitor therapy for NTRK fusion-positive sarcoma.

Simmons, Christine / Deyell, Rebecca J / MacNeill, Andrea J / Vera-Badillo, Francisco E / Smrke, Alannah / Abdul Razak, Albiruni R / Banerji, Shantanu / McLeod, Deanna / Noujaim, Jonathan

International journal of cancer

2021 Volume 149, Issue 9, Page(s) 1691–1704

Abstract: Malignant sarcomas are rare accounting for <1% of all adult solid malignancies and approximately 11% to 13% of all pediatric malignancies. TRK-inhibitors have demonstrated robust and long-lasting responses in patients with NTRK fusion-positive solid ... ...

Abstract	Malignant sarcomas are rare accounting for <1% of all adult solid malignancies and approximately 11% to 13% of all pediatric malignancies. TRK-inhibitors have demonstrated robust and long-lasting responses in patients with NTRK fusion-positive solid tumors, including sarcoma. Access to these agents in many jurisdictions such as Canada remains limited. We undertook a modified Delphi consensus to articulate and convey the clinical importance of these agents for the Canadian sarcoma community. A systematic search of published and presented literature was conducted to identify clinical trials reporting outcomes on the use of TRK-inhibitors in relapsed/refractory NTRK fusion-positive sarcoma. Three main consensus questions were identified: (a) is there currently an unmet clinical need for systemic therapy options in relapsed/refractory sarcoma? (b) do TRK-inhibitors confer a clinical benefit to patients with NTRK fusion-positive sarcoma? (c) do phase I/II basket trials provide sufficient evidence to justify funding of TRK-inhibitors in NTRK fusion-positive sarcoma? Response rates to the first and second surveys were 57% (n = 30) and 42% (n = 22), respectively. There was strong agreement among the Canadian sarcoma community that there was unmet clinical need for effective systemic therapy options in relapsed/refractory sarcoma, that TRK-inhibitors are a safe and effective treatment option for patients with NTRK fusion-positive sarcoma, and that available phase I/II basket trials provide sufficient evidence to support funding of these agents in relapsed/refractory NTRK fusion-positive sarcoma. TRK-inhibitors are a safe and effective systemic therapy option for patients with relapsed/refractory NTRK fusion-positive sarcoma.
MeSH term(s)	Adolescent ; Adult ; Aged ; Canada ; Consensus ; Disease Progression ; Humans ; Middle Aged ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Protein Kinase Inhibitors/therapeutic use ; Receptor, trkA/genetics ; Receptor, trkA/metabolism ; Receptor, trkC/antagonists & inhibitors ; Receptor, trkC/genetics ; Receptor, trkC/metabolism ; Sarcoma/drug therapy ; Sarcoma/genetics ; Sarcoma/metabolism ; Surveys and Questionnaires/statistics & numerical data ; Survival Analysis ; Young Adult
Chemical Substances	Oncogene Proteins, Fusion ; Protein Kinase Inhibitors ; Receptor, trkA (EC 2.7.10.1) ; Receptor, trkC (EC 2.7.10.1)
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.33723
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article ; Online: The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.

Xu, Yu / Cantwell, Lucas / Molosh, Andrei I / Plant, Leigh D / Gazgalis, Dimitris / Fitz, Stephanie D / Dustrude, Erik T / Yang, Yuchen / Kawano, Takeharu / Garai, Sumanta / Noujaim, Sami F / Shekhar, Anantha / Logothetis, Diomedes E / Thakur, Ganesh A

The Journal of biological chemistry

2020 Volume 295, Issue 11, Page(s) 3614–3634

Abstract: G-protein-gated inwardly-rectifying ... ...

Abstract	G-protein-gated inwardly-rectifying K
MeSH term(s)	Allosteric Regulation/drug effects ; Amygdala/metabolism ; Animals ; Behavior, Animal/drug effects ; Binding Sites ; Brain/metabolism ; Cognition/drug effects ; Extinction, Psychological/drug effects ; Fear/drug effects ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/agonists ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/chemistry ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/metabolism ; HEK293 Cells ; Heart Atria/diagnostic imaging ; Humans ; Ion Channel Gating/drug effects ; Ligands ; Mice, Inbred C57BL ; Motor Activity/drug effects ; Mutation/genetics ; Myocardium/metabolism ; Organ Specificity ; Phenylurea Compounds/pharmacology ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphorylation/drug effects ; Protein Structure, Secondary ; Protein Subunits/metabolism ; Pyrazoles/pharmacology ; Small Molecule Libraries/pharmacology ; Xenopus
Chemical Substances	CID 56642816 ; G Protein-Coupled Inwardly-Rectifying Potassium Channels ; Ligands ; Phenylurea Compounds ; Phosphatidylinositol 4,5-Diphosphate ; Protein Subunits ; Pyrazoles ; Small Molecule Libraries
Language	English
Publishing date	2020-01-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA119.011527
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Article ; Online: Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Adults.

Bebb, D Gwyn / Banerji, Shantanu / Blais, Normand / Desmeules, Patrice / Gill, Sharlene / Grin, Andrea / Feilotter, Harriet / Hansen, Aaron R / Hyrcza, Martin / Krzyzanowska, Monika / Melosky, Barbara / Noujaim, Jonathan / Purgina, Bibiana / Ruether, Dean / Simmons, Christine E / Soulieres, Denis / Torlakovic, Emina Emilia / Tsao, Ming-Sound

Current oncology (Toronto, Ont.)

2021 Volume 28, Issue 1, Page(s) 523–548

Abstract: The tyrosine receptor kinase (TRK) inhibitors larotrectinib and entrectinib were recently approved in Canada for the treatment of solid tumours harbouring neurotrophic tyrosine receptor kinase ( ...

Abstract	The tyrosine receptor kinase (TRK) inhibitors larotrectinib and entrectinib were recently approved in Canada for the treatment of solid tumours harbouring neurotrophic tyrosine receptor kinase (
MeSH term(s)	Adult ; Biomarkers ; Canada ; Carcinoma, Non-Small-Cell Lung ; Consensus ; Humans ; Lung Neoplasms ; Receptor, trkA/genetics
Chemical Substances	Biomarkers ; Receptor, trkA (EC 2.7.10.1)
Language	English
Publishing date	2021-01-15
Publishing country	Switzerland
Document type	Guideline ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol28010053
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Article ; Online: A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels.

Cui, Meng / Alhamshari, Yaser / Cantwell, Lucas / Ei-Haou, Said / Eptaminitaki, Giasemi C / Chang, Mengmeng / Abou-Assali, Obada / Tan, Haozhou / Xu, Keman / Masotti, Meghan / Plant, Leigh D / Thakur, Ganesh A / Noujaim, Sami F / Milnes, James / Logothetis, Diomedes E

The Journal of biological chemistry

2021 Volume 296, Page(s) 100535

Abstract: Atrial fibrillation (AF) is the most commonly diagnosed cardiac arrhythmia and is associated with increased morbidity and mortality. Currently approved AF antiarrhythmic drugs have limited efficacy and/or carry the risk of ventricular proarrhythmia. The ... ...

Abstract	Atrial fibrillation (AF) is the most commonly diagnosed cardiac arrhythmia and is associated with increased morbidity and mortality. Currently approved AF antiarrhythmic drugs have limited efficacy and/or carry the risk of ventricular proarrhythmia. The cardiac acetylcholine activated inwardly rectifying K
MeSH term(s)	Action Potentials ; Animals ; Anti-Arrhythmia Agents/chemistry ; Anti-Arrhythmia Agents/pharmacology ; Atrial Fibrillation/drug therapy ; Benzopyrans/chemistry ; Benzopyrans/pharmacology ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/antagonists & inhibitors ; Humans ; Ion Channel Gating ; Mice ; Molecular Docking Simulation
Chemical Substances	Anti-Arrhythmia Agents ; Benzopyrans ; G Protein-Coupled Inwardly-Rectifying Potassium Channels
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100535
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Article ; Online: Understanding the Elevated Lethality of COVID-19 in Liver Transplant Recipients: Does Immunosuppression Management Matter? Results from a Brazilian Multicentric Historical Cohort.

Boin, Ilka Fsf / Riccetto, Eduardo / Genzini, Tercio / Santos, Regina Gomes / Moreira, Lucio Figueira Pacheco / Pinto, Laura Cristina Machado / Garcia, Jose Huygens Parente / Stucchi, Raquel Sb / Perales, Simone Reges / Zanaga, Leticia / Da Silva, Renato Fereira / Da Silva, Rita Cm Fereira / Haddad, Luciana / Ac D Albuquerque, Luiz / Dealmeida, Marcio Dias / Watanabe, Andre / Peixoto, Gustavo S / De Melo, Claudio Moura Lacerda / Bezerra, Renata Ferreira /

Tefilli, Nertan Luiz / Halpern, Marcia / Godoy, Maira Silva / Nogara, Marcelo / Mancero, Jorge Marcelo Padilla / Noujaim, Huda Maria / Rangel, Erika Bevilaqua / Ataide, Elaine Cristina

Transplantation proceedings

2023 Volume 55, Issue 8, Page(s) 1815–1821

Abstract: Background: Infections by SARS-CoV-2 in liver transplant recipients (LT) patients are of particular concern, notably due to perceived added risks related to immunosuppression and comorbidity burden. Current literature on this topic often relies on small, ...

Abstract	Background: Infections by SARS-CoV-2 in liver transplant recipients (LT) patients are of particular concern, notably due to perceived added risks related to immunosuppression and comorbidity burden. Current literature on this topic often relies on small, non-standardized, and geographically limited studies. This manuscript describes COVID-19 presentations and causes for elevated mortality in a large cohort of LT recipients. Methods: This study was designed as a multicentric historical cohort, including LT recipient patients with COVID-19 in 25 study centers, with the primary endpoint being COVID-related death. We also collected demographic, clinical, and laboratory data regarding presentation and disease progression. Results: Two hundred and thirty-four cases were included. The study population was predominantly male and White and had a median age of 60 years. The median time from transplantation was 2.6 years (IQR 1-6). Most patients had at least one comorbidity (189, 80.8%). Patient age (P = .04), dyspnea (P < .001), intensive care unit admission (P < .001), and mechanical ventilation (P < .001) were associated with increased mortality. Modifications of immunosuppressive therapy (P < .001), specifically the suspension of tacrolimus, maintained significance in multivariable analysis. Conclusions: Attention to risk factors and the individualization of patient care, especially regarding immunosuppression management, is crucial for delivering more precise interventions to these individuals.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; COVID-19/epidemiology ; SARS-CoV-2 ; Liver Transplantation/adverse effects ; Brazil/epidemiology ; Immunosuppression Therapy/adverse effects ; Transplant Recipients
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2023.05.007
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