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Article: Advances in Brain Metastasis Models.

Lee, Jung Eun / Yang, Seung Ho

2023 Volume 11, Issue 1, Page(s) 16–21

Abstract: To obtain achievements in addressing the clinical challenges of brain metastasis, we need a clear understanding of its biological mechanisms. Brain metastasis research is challenged by many practical scientific barriers. Depending on the purpose of the ... ...

Abstract	To obtain achievements in addressing the clinical challenges of brain metastasis, we need a clear understanding of its biological mechanisms. Brain metastasis research is challenged by many practical scientific barriers. Depending on the purpose of the study, experimental brain metastasis models
Language	English
Publishing date	2023-02-10
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	3018737-0
ISSN	2288-2413 ; 2288-2405
ISSN (online)	2288-2413
ISSN	2288-2405
DOI	10.14791/btrt.2022.0037
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Exploring Cardiac Exosomal RNAs of Acute Myocardial Infarction.

Jung, Seung Eun / Kim, Sang Woo / Choi, Jung-Won

Biomedicines

2024 Volume 12, Issue 2

Abstract: Background: Myocardial infarction (MI), often a frequent symptom of coronary artery disease (CAD), is a leading cause of death and disability worldwide. Acute myocardial infarction (AMI), a major form of cardiovascular disease, necessitates a deep ... ...

Abstract	Background: Myocardial infarction (MI), often a frequent symptom of coronary artery disease (CAD), is a leading cause of death and disability worldwide. Acute myocardial infarction (AMI), a major form of cardiovascular disease, necessitates a deep understanding of its complex pathophysiology to develop innovative therapeutic strategies. Exosomal RNAs (exoRNA), particularly microRNAs (miRNAs) within cardiac tissues, play a critical role in intercellular communication and pathophysiological processes of AMI. Methods: This study aimed to delineate the exoRNA landscape, focusing especially on miRNAs in animal models using high-throughput sequencing. The approach included sequencing analysis to identify significant miRNAs in AMI, followed by validation of the functions of selected miRNAs through in vitro studies involving primary cardiomyocytes and fibroblasts. Results: Numerous differentially expressed miRNAs in AMI were identified using five mice per group. The functions of 20 selected miRNAs were validated through in vitro studies with primary cardiomyocytes and fibroblasts. Conclusions: This research enhances understanding of post-AMI molecular changes in cardiac tissues and investigates the potential of exoRNAs as biomarkers or therapeutic targets. These findings offer new insights into the molecular mechanisms of AMIs, paving the way for RNA-based diagnostics and therapeutics and therapies and contributing to the advancement of cardiovascular medicine.
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020430
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Article: The Expression and Amplification of HER2 Has a Significant Impact on the Prognosis of Endometrial Carcinoma in Korean Patients.

Kim, Wook Youn / Yang, Eun Jung / Jang, Eun Bi / Lee, A Jin / So, Kyeong A / Shim, Seung-Hyuk / Kim, Tae Jin / Lee, Sun Joo

Journal of clinical medicine

2024 Volume 13, Issue 8

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2024-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13082158
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Article ; Online: [CORRIGENDUM: Development of a Diabetic Foot Ulceration Prediction Model and Nomogram].

Lee, Eun Joo / Jeong, Ihn Sook / Woo, Seung Hun / Jung, Hyuk Jae / Han, Eun Jin / Kang, Chang Wan / Hyun, Sookyung

Journal of Korean Academy of Nursing

2024 Volume 53, Issue 6, Page(s) 678

Abstract: This corrects the article on p. 280 in vol. 51, PMID: 34215707. ...

Abstract	This corrects the article on p. 280 in vol. 51, PMID: 34215707.
Language	Korean
Publishing date	2024-01-11
Publishing country	Korea (South)
Document type	English Abstract ; Published Erratum
ZDB-ID	2619665-7
ISSN	2093-758X ; 2093-758X
ISSN (online)	2093-758X
ISSN	2093-758X
DOI	10.4040/jkan.23144
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Article ; Online: GULP1 deficiency reduces adipogenesis and glucose uptake via downregulation of PPAR signaling and disturbing of insulin/ERK signaling in 3T3-L1 cells.

Kim, Soon-Young / Park, Seung-Yoon / Kim, Jung-Eun

Journal of cellular physiology

2024 Volume 239, Issue 2, Page(s) e31173

Abstract: Obesity and metabolic disorders caused by alterations in lipid metabolism are major health issues in developed, affluent societies. Adipose tissue is the only organ that stores lipids and prevents lipotoxicity in other organs. Mature adipocytes can ... ...

Abstract	Obesity and metabolic disorders caused by alterations in lipid metabolism are major health issues in developed, affluent societies. Adipose tissue is the only organ that stores lipids and prevents lipotoxicity in other organs. Mature adipocytes can affect themselves and distant metabolism-related tissues by producing various adipokines, including adiponectin and leptin. The engulfment adaptor phosphotyrosine-binding domain-containing 1 (GULP1) regulates intracellular trafficking of glycosphingolipids and cholesterol, suggesting its close association with lipid metabolism. However, the role of GULP1 in adipocytes remains unknown. Therefore, this study aimed to investigate the function of GULP1 in adipogenesis, glucose uptake, and the insulin signaling pathway in adipocytes. A 3T3-L1 cell line with Gulp1 knockdown (shGulp1) and a 3T3-L1 control group (U6) were established. Changes in shGulp1 cells due to GULP1 deficiency were examined and compared to those in U6 cells using microarray analysis. Glucose uptake was monitored via insulin stimulation in shGulp1 and U6 cells using a 2-NBDG glucose uptake assay, and the insulin signaling pathway was investigated by western blot analysis. Adipogenesis was significantly delayed, lipid metabolism was altered, and several adipogenesis-related genes were downregulated in shGulp1 cells compared to those in U6 cells. Microarray analysis revealed significant inhibition of peroxisome proliferator-activated receptor signaling in shGulp1 cells compared with U6 cells. The production and secretion of adiponectin as well as the expression of adiponectin receptor were decreased in shGulp1 cells. In particular, compared with U6 cells, glucose uptake via insulin stimulation was significantly decreased in shGulp1 cells through the disturbance of ERK1/2 phosphorylation. This is the first study to identify the role of GULP1 in adipogenesis and insulin-stimulated glucose uptake by adipocytes, thereby providing new insights into the differentiation and functions of adipocytes and the metabolism of lipids and glucose, which can help better understand metabolic diseases.
MeSH term(s)	Animals ; Mice ; 3T3-L1 Cells ; Adipogenesis/genetics ; Adiponectin/genetics ; Adiponectin/metabolism ; Cell Differentiation ; Down-Regulation ; Glucose/metabolism ; Insulin/metabolism ; Lipids ; Peroxisome Proliferator-Activated Receptors/genetics ; Peroxisome Proliferator-Activated Receptors/metabolism ; PPAR gamma/metabolism ; Signal Transduction ; Extracellular Signal-Regulated MAP Kinases/metabolism
Chemical Substances	Adiponectin ; Glucose (IY9XDZ35W2) ; Insulin ; Lipids ; Peroxisome Proliferator-Activated Receptors ; PPAR gamma ; GULP protein, mouse ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.31173
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Article ; Online: A Comparative Study on Clinico-Histopathological Features of Granulomatous Rosacea and Lupus Miliaris Disseminatus Faciei.

Park, So Hee / Ahn, Sang Woo / Jang, Seung Hee / Hong, Seong Min / Jin, Woo Jung / Seol, Jung Eun / Jung, So Young / Kim, Hyojin

Annals of dermatology

2024 Volume 36, Issue 1, Page(s) 58–61

Language	English
Publishing date	2024-02-05
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	1012662-4
ISSN	2005-3894 ; 1013-9087
ISSN (online)	2005-3894
ISSN	1013-9087
DOI	10.5021/ad.22.229
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Zs.A 2800: Show issues

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Article ; Online: Real-World Safety and Effectiveness of Fluticasone Furoate/Vilanterol in Patients with Asthma and/or Chronic Obstructive Pulmonary Disease: A Post-Marketing Study in Korea.

Cho, Eun-Yeong / Cho, Jung-Eun / Jang, Seung Hun / Hwang, Ki-Eun

Drug safety

2023 Volume 46, Issue 10, Page(s) 951–960

Abstract: Background and objective: Fluticasone furoate/vilanterol (FF/VI; RELVAR ELLIPTA) is approved in Korea for patients with asthma or chronic obstructive pulmonary disease (COPD). This study evaluated the effectiveness and safety of FF/VI in Korean patients ...

Abstract	Background and objective: Fluticasone furoate/vilanterol (FF/VI; RELVAR ELLIPTA) is approved in Korea for patients with asthma or chronic obstructive pulmonary disease (COPD). This study evaluated the effectiveness and safety of FF/VI in Korean patients with asthma and/or COPD over a 6-year period. Methods: This was an open-label, multicentre, observational, post-marketing surveillance study in patients newly treated with FF/VI (100 or 200 μg/25 μg once daily). Safety endpoints were the incidence of adverse events (AEs), including unexpected AEs/adverse drug reactions (ADRs) and serious AEs/ADRs. Effectiveness was assessed after 24 weeks by Global Physician Assessment (logistic regression) and forced expiratory volume in 1 s (FEV Results: Of the 3426 patients enrolled across 45 hospitals between July 2014 and June 2020, 3216 were included in the safety analysis (50.5% female; mean age ± standard deviation [SD]: 58.6 ± 16.3 years). Overall incidence of AEs was 30.9% (n = 992); 4.1% (n = 132) were ADRs. Serious AEs were reported in 4.1% (n = 132) of patients; 0.1% (n = 4) were ADRs. Of 1543 patients analysed for symptomatic improvement, 89.2% (n = 1377) improved, 9.4% (n = 145) were unchanged, and 1.4% (n = 21) worsened. Mean FEV Conclusion: In this real-world study, FF/VI administered to Korean patients was well tolerated and effective for the treatment of asthma and COPD. These results were consistent with other studies in Asian and global populations.
MeSH term(s)	Humans ; Female ; Male ; Drug Combinations ; Administration, Inhalation ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Asthma/drug therapy ; Republic of Korea/epidemiology ; Treatment Outcome
Chemical Substances	fluticasone furoate (JS86977WNV) ; vilanterol (028LZY775B) ; Drug Combinations
Language	English
Publishing date	2023-08-31
Publishing country	New Zealand
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018059-x
ISSN	1179-1942 ; 0114-5916
ISSN (online)	1179-1942
ISSN	0114-5916
DOI	10.1007/s40264-023-01337-w
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Zs.A 2127: Show issues

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Article ; Online: Immunohistochemical differentiation of keratins and involucrin between palmar psoriasis, chronic hand eczema and hyperkeratotic hand eczema.

Baek, Eun Joo / Jung, Da Yeon / Seung, Na Reu / Jang, Ye Ji / Park, Eun Joo / Kim, Kwang Ho

Contact dermatitis

2024 Volume 90, Issue 4, Page(s) 385–393

Abstract: Background: Common hyperkeratotic palmar skin lesions include chronic hand eczema (CHE), hyperkeratotic hand eczema (HHE), palmar psoriasis (PP). However, clinically differentiating these disorders is often challenging.: Objectives: To compare the ... ...

Abstract	Background: Common hyperkeratotic palmar skin lesions include chronic hand eczema (CHE), hyperkeratotic hand eczema (HHE), palmar psoriasis (PP). However, clinically differentiating these disorders is often challenging. Objectives: To compare the expressions of keratin (K) 5, K9, K14 and involucrin in palmar hyperkeratotic lesions (HHE, CHE and PP). Materials and methods: Immunohistochemical staining was performed on skin biopsy specimens obtained from the palms of patients clinically diagnosed with CHE, HHE and PP (n = 21, 24 and 18, respectively). Results: K5 and K14 expression levels were higher in the spinous and granular layers of PP and HHE compared to CHE. Involucrin was expressed in the basal layer of PP and HHE but not in CHE. K9 expression was decreased in PP and HHE compared to CHE. Conclusion: Keratin and involucrin expression in the epidermis are markers of keratinocyte differentiation. Expression levels of keratin and involucrin were similar between the HHE and PP groups, suggesting that HHE shares pathogenesis with PP rather than CHE.
MeSH term(s)	Humans ; Keratins/metabolism ; Dermatitis, Allergic Contact ; Psoriasis ; Skin Diseases ; Eczema ; Protein Precursors
Chemical Substances	Keratins (68238-35-7) ; involucrin (60108-77-2) ; Protein Precursors
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.14499
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Zs.A 1116: Show issues

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Article ; Online: Skin rejuvenation through topical application of indocyanine green with diffractive optical element mode of 785 nm picosecond laser in Asian females.

Jung, Dayeon / Seung, Na Reu / Seo, Suk Bae / Park, Eun Joo / Kim, Kwang Ho

Journal of cosmetic dermatology

2024

Abstract: Background: Indocyanine green (ICG) exhibits robust absorption near 800 nm.: Aims: To examine the clinical effects of combining ICG with a 785 nm picosecond laser for treating photo-aged skin.: Patient/methods: A 785 nm 600 picosecond laser was ... ...

Abstract	Background: Indocyanine green (ICG) exhibits robust absorption near 800 nm. Aims: To examine the clinical effects of combining ICG with a 785 nm picosecond laser for treating photo-aged skin. Patient/methods: A 785 nm 600 picosecond laser was used on the facial area of 16 female patients with Fitzpatrick skin type III and IV (mean age: 58.44 ± 5.24 years) after applying 0.0125% ICG cream. A total of 3000 shots were administered in diffractive optical element mode at a pulse energy of 200 mJ and frequency of 10 Hz. Hyperpigmented lesions were treated using the Zoom handpiece set at a spot size of 3-4 mm, pulse energy of 60-120 mJ, and frequency of 3-7 Hz. Patients underwent five sessions of treatment at intervals of 1-2 weeks. Wrinkles, pores and pigmented lesions were assessed at the initial assessment and 4 weeks after the final treatment using the Modified Fitzpatrick Wrinkle Scale and 10-point visual analog scale, respectively. Skin biopsy of the postauricular area was performed on two consenting patients. Results: Significant improvements in wrinkles (p = 0.02), pores (p = 0.034), and hyperpigmentation (p = 0.036) were observed, along with increased patient subjective improvement. Adverse effects were transient and well-tolerated. Hematoxylin and eosin and Masson's trichrome staining revealed increased and thickened dermal collagen fibers. Immunohistochemical staining revealed increased expression of collagen I and III throughout the papillary and upper reticular dermis, along with diffuse increase of STRO-1 in the dermis. Conclusions: The combined application of a 785 nm picosecond laser and ICG yielded promising clinical outcomes for treating photo-aged skin in Asian patients with Fitzpatrick skin type III and IV.
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.16275
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Article: Difficult airway management in a patient with unexpected laryngeal deformities.

Song, Seung Eun / Kim, Hyun Jung

Saudi journal of anaesthesia

2022 Volume 16, Issue 4, Page(s) 469–471

Abstract: We report an experience with difficult airway management due to unexpected laryngeal deformities. A 69-year-old man who had been diagnosed with left vocal cord paralysis was scheduled for eye surgery. After the induction of anesthesia, mask ventilation ... ...

Abstract	We report an experience with difficult airway management due to unexpected laryngeal deformities. A 69-year-old man who had been diagnosed with left vocal cord paralysis was scheduled for eye surgery. After the induction of anesthesia, mask ventilation was inadequate and intubation was impossible, so an emergency tracheostomy had to be performed. In the larynx examination, the left vocal cord was paralyzed close to the midline and the left corniculate tubercle was enlarged and partially blocked the rima glottidis. Laryngeal deformities may cause unexpected difficult airway management. Clinicians always have to pay close attention to the potential risk and prepare for emergency situations including an invasive approach to the airway.
Language	English
Publishing date	2022-09-03
Publishing country	India
Document type	Case Reports
ZDB-ID	2562174-9
ISSN	0975-3125 ; 1658-354X
ISSN (online)	0975-3125
ISSN	1658-354X
DOI	10.4103/sja.sja_75_22
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