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  1. Article ; Online: Response to Aspirin Therapy in COVID-19: Prevention of NETosis.

    Lal, Amos / Gajic, Ognjen

    Archivos de bronconeumologia

    2022  Volume 59, Issue 2, Page(s) 130

    MeSH term(s) Humans ; COVID-19/prevention & control ; Analgesics ; Aspirin/therapeutic use
    Chemical Substances Analgesics ; Aspirin (R16CO5Y76E)
    Language Spanish
    Publishing date 2022-10-20
    Publishing country Spain
    Document type Letter
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inhaled NO in COVID-19 Acute Respiratory Distress Syndrome: Yes or No?

    Lal, Amos / Gladwin, Mark T / Gajic, Ognjen

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 12, Page(s) 1259–1261

    MeSH term(s) Humans ; Nitric Oxide ; COVID-19 ; Respiratory Distress Syndrome/drug therapy ; Respiratory Insufficiency
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1823ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cerebral Venous Thrombosis: A Critical Appraisal.

    Lal, Amos / Hui, Andrew C F

    Annals of Indian Academy of Neurology

    2020  Volume 23, Issue 5, Page(s) 582–583

    Language English
    Publishing date 2020-12-08
    Publishing country India
    Document type Editorial
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_814_20
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  4. Article ; Online: Physiologic approach to diuresis in de-resuscitation phase in intensive care.

    Lal, Amos / Garces, Juan Pablo Domecq

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 270

    MeSH term(s) Critical Care ; Diuresis ; Humans ; Intensive Care Units ; Resuscitation
    Language English
    Publishing date 2020-05-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-02900-y
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  5. Article: Regulatory oversight and ethical concerns surrounding software as medical device (SaMD) and digital twin technology in healthcare.

    Lal, Amos / Dang, Johnny / Nabzdyk, Christoph / Gajic, Ognjen / Herasevich, Vitaly

    Annals of translational medicine

    2022  Volume 10, Issue 18, Page(s) 950

    Language English
    Publishing date 2022-10-04
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-4203
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  6. Article ; Online: Pneumomediastinum and pneumothorax in acute respiratory distress syndrome (ARDS) patients: a narrative review.

    Teo, Yi Xiang / Geetha, Harinivaas Shanmugavel / Mishra, Ajay Kumar / Lal, Amos

    Mediastinum (Hong Kong, China)

    2023  Volume 8, Page(s) 3

    Abstract: Background and objective: Acute respiratory distress syndrome (ARDS) is a severe, life-threatening medical condition characterized by poor oxygenation due to non-compliant lungs secondary diffuse alveolar damage. Encouragingly, the incidence of ARDS has ...

    Abstract Background and objective: Acute respiratory distress syndrome (ARDS) is a severe, life-threatening medical condition characterized by poor oxygenation due to non-compliant lungs secondary diffuse alveolar damage. Encouragingly, the incidence of ARDS has declined steadily recently, attributed mainly to implementation of keystone guidelines and continuous research efforts. Mechanical ventilation is the cornerstone of supportive care for ARDS patients. This review aims to consolidate the current knowledge on pneumothorax (PNX) and pneumomediastinum (PMD) and to enhance the understanding of the readers. The objectives are to (I) explore the etiology and risk factors of PNX and PMD, (II) discuss the various diagnostic modalities available, (III) evaluate management options, and (IV) recent advancements.
    Methods: A search of the literature was conducted using PubMed, MEDLINE, and Google Scholar for relevant articles pertaining to PNX and PMD in ARDS population. The clinical presentation, diagnostic and management strategies of PNX, PMD, and ARDS were summarized, and all authors reviewed the selection and decide which studies to include.
    Key content and findings: The adoption of lung-protective ventilation strategies, based on the review of literature from the recent years, shows that it has played a significant role in reducing the occurrence of barotrauma, such as PNX and PMD. However, PNX and PMD remains to be a challenging complication to manage. With a specific focus on PNX and PMD, this review provides valuable insights into effectively managing and understanding these critical complications among ARDS patients.
    Conclusions: ARDS, with its evolving definition, continues to pose a life-threatening threat. Despite the widespread adoption of lung-protective ventilation strategies, PNX and PMD present persistent challenges in management. Further research is imperative to enhance the risk assessment of ARDS patients prone to developing PNX and PMD and to institute more effective prevention and treatment measures.
    Language English
    Publishing date 2023-12-12
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2522-6711
    ISSN (online) 2522-6711
    DOI 10.21037/med-23-39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Clinical and Echocardiographic Predictors of Recovery of Moderate-to-severe Sepsis-associated Acute Kidney Injury in Critically Ill Patients.

    Mukhtar, Osama / Lal, Amos / Tabi, Meir / Jentzer, Jacob / Kashani, Kianoush

    Journal of community hospital internal medicine perspectives

    2023  Volume 13, Issue 2, Page(s) 7–17

    Abstract: Background: Acute kidney injury (AKI) is associated with significant short- and long-term morbidity and mortality. In critically ill patients with sepsis, AKI tends to be more severe, more likely to require kidney replacement therapy (KRT), with less ... ...

    Abstract Background: Acute kidney injury (AKI) is associated with significant short- and long-term morbidity and mortality. In critically ill patients with sepsis, AKI tends to be more severe, more likely to require kidney replacement therapy (KRT), with less chance of recovery. Consequently, critically ill patients with sepsis-associated AKI (SA-AKI) have extended intensive care unit (ICU) stays and higher mortality rates. This study evaluated the predictive value of clinical and transthoracic echocardiographic (TTE) parameters for recovery from moderate-to-severe SA-AKI in critically ill patients.
    Methods: This single-center historical cohort study was conducted at a tertiary academic medical center. We analyzed the data of all adults (age ≥18 years) admitted to the ICU at Mayo Clinic, Rochester, MN, from June 1, 2018, to December 31, 2020. We included all patients who developed sepsis within the initial 24 h of their ICU stay.
    Results: We identified 2919 eligible septic patients with available TTE, among which 1431 patients (49%) had moderate-to-severe SA-AKI. The mean age of the patients was 68 ± 15 years, and the male-to-female ratio was 1.3:1. The most common comorbidities were diabetes mellitus and chronic lung and kidney diseases. Clinical predictors associated with SA-AKI non-recovery were the presence of stage III AKI (
    Conclusion: Our data from a single-center provide new information on the clinical (AKI stage, utilization of KRT, BMI, and peak serum creatinine) and echocardiographic features (TAPSE) associated with improved recovery in SA-AKI. There is a definite knowledge gap in the current literature regarding optimizing recovery in moderate-to-severe SA-AKI. Larger, multi-center studies are required to confirm these findings.
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.55729/2000-9666.1159
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  8. Article ; Online: Burden of firearm-related injuries as associated secondary diagnosis in the United States from National Inpatient Sample Dataset.

    Lal, Amos / John, Kevin John / Mishra, Ajay Kumar / Sherif, Akil Adrian

    Internal and emergency medicine

    2023  Volume 18, Issue 2, Page(s) 457–465

    Abstract: There is little known about the differences, from the point of view of healthcare resource utilization, between non-fatal versus fatal firearm-related injuries. We undertook this research project utilizing the National Inpatient Sample (NIS) database to ... ...

    Abstract There is little known about the differences, from the point of view of healthcare resource utilization, between non-fatal versus fatal firearm-related injuries. We undertook this research project utilizing the National Inpatient Sample (NIS) database to address this critical knowledge gap. Our aims for this study were to describe the patterns of FRI in the United States during the period of 2016-2019 and to evaluate the patient-centered outcomes in the survivor (non-fatal injuries) versus the non-survivor (fatal injuries) groups. We used the National Inpatient Sample (NIS) Database, 2016-2019 (5) (~ 20% of United States hospitalizations) to identify patients with an associated diagnosis of firearm-related injuries (FRI) [Gibson T et al (2016) in Agency for Healthcare Research and Quality 2016-02]. We found that the individuals from the lowest quartile of annual household income, males, young Americans, and racial minorities were disproportionally affected The non-survivor (fatal injuries) group had a shorter length of stay in the hospital by 5.1 days (95% CI - 5.64 to - 4.58, p value =  < 0.01), the higher median cost of hospitalization by $8903 (95% confidence interval $311.9 to $17,494.2, p value = 0.04), and a higher median cost of hospitalization per day by $41,576.74 (95% confidence interval $ 40,333.1 to $42,820.3, p value =  < 0.01). In conclusion, the individuals from the lowest quartile of annual household income, males, young Americans and racial minorities were disproportionally affected. Firearm-related injuries pose a persistent healthcare cost burden with the cumulative and per day cost of hospitalization for fatal injuries being significantly higher than the non-fatal injuries despite a shorter hospital LOS.
    MeSH term(s) Male ; Humans ; United States/epidemiology ; Length of Stay ; Wounds, Gunshot/epidemiology ; Inpatients ; Hospitalization ; Hospitals ; Retrospective Studies
    Language English
    Publishing date 2023-01-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-022-03190-8
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  9. Article ; Online: Clinical utility of hybrid (SPECT/CT) imaging in calciphylaxis.

    Sahu, Kamal Kant / Lal, Amos / Mishra, Ajay Kumar

    Nefrologia

    2021  Volume 41, Issue 5, Page(s) 603–604

    MeSH term(s) Calciphylaxis/diagnostic imaging ; Humans ; Single Photon Emission Computed Tomography Computed Tomography ; Tomography, Emission-Computed, Single-Photon/methods
    Language English
    Publishing date 2021-10-05
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2020.11.014
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  10. Article ; Online: Utility of AI models in critical care: union of man and the machine.

    Lal, Amos / Herasevich, Vitaly / Gajic, Ognjen

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 46

    MeSH term(s) Artificial Intelligence ; Critical Care ; Humans ; Intelligence ; Machine Learning
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03478-9
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