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Article: Synergistic Differential DNA Demethylation Activity of

Hassan, Amr / Rijo, Patrícia / Abuamara, Tamer M M / Ali Lashin, Lashin Saad / Kamar, Sherif A / Bangay, Gabrielle / Al-Sawahli, Majid Mohammed / Fouad, Marina K / Zoair, Mohammad A / Abdalrhman, Tamer I / Elebeedy, Dalia / Ibrahim, Ibrahim A / Mohamed, Aly F / Abd El Maksoud, Ahmed I

Biomedicines

2024 Volume 12, Issue 2

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a major hepatic disorder occurring in non-alcohol-drinking individuals. Salvianic acid A ... ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) is a major hepatic disorder occurring in non-alcohol-drinking individuals. Salvianic acid A or
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020279
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ovarian reserve in adolescent girls with autoimmune thyroiditis.

Metwalley, Kotb A / Farghaly, Hekma S / Tamer, Deiaaeldin M / Ali, Ahmed M / Embaby, Mostafa / Elnakeeb, Islam F / Kamaleldeen, Eman B

Archives of endocrinology and metabolism

2023 Volume 67, Issue 3, Page(s) 395–400

Abstract: Objective: To assess serum anti-Müllerian hormone (AMH) levels as an ovarian reserve marker in adolescent girls with autoimmune thyroiditis (AIT) and explore the relationship of this marker with autoimmunity and thyroid function biomarkers.: Subjects ... ...

Abstract	Objective: To assess serum anti-Müllerian hormone (AMH) levels as an ovarian reserve marker in adolescent girls with autoimmune thyroiditis (AIT) and explore the relationship of this marker with autoimmunity and thyroid function biomarkers. Subjects and methods: This study included 96 adolescent girls with newly diagnosed AIT and 96 healthy, age- and sex-matched controls. All participants were evaluated with detailed history taking and physical examination, thyroid ultrasound, and measurement of levels of thyroid-stimulating hormone (TSH), free thyroxin (FT4), free triiodothyronine (FT3), antithyroid peroxidase antibodies (TPOAb), antithyroglobulin antibody (TGAb), estradiol, total testosterone, and anti-Müllerian hormone (AMH) levels. The LH/FSH ratio was also calculated. Among 96 patients evaluated, 78 were overtly hypothyroid and 18 were euthyroid. AMH levels were significantly lower in participants with overt hypothyroidism and euthyroidism compared with controls. Results: Serum levels of AMH correlated negatively with age, body mass index (BMI) standard deviation score (SDS), and TPOAb, TGAb, and TSH levels but positively with FT4 levels. In multivariate analysis, AMH levels correlated significantly with age (odds ratio [OR] = 1.65, 95% confidence interval [CI] 1.18-2.32, p = 0.05), BMI SDS (OR = 2.3, 95% CI, 2.23-3.50, p = 0.01), TSH (OR = 2.43, 95% CI 1.5-2.8, p = 0.01), and TPOAb (OR = 4.1, 95% CI 3.26-8.75, p = 0.001). Conclusion: Ovarian reserve of adolescent girls with AIT, as measured by serum AMH levels, is affected by thyroid autoimmunity and hypothyroidism, indicating a possible need for ovarian reserve monitoring in these patients.
MeSH term(s)	Female ; Humans ; Adolescent ; Thyroiditis, Autoimmune ; Ovarian Reserve ; Anti-Mullerian Hormone ; Hashimoto Disease ; Thyrotropin ; Hypothyroidism
Chemical Substances	Anti-Mullerian Hormone (80497-65-0) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2023-02-07
Publishing country	Brazil
Document type	Journal Article
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.20945/2359-3997000000597
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Article ; Online: RETRACTION: Effect of preoperative ureteral stenting on the surgical outcomes of patients with 1-2 cm renal stones managed by retrograde intrarenal surgery using a ureteral access sheath.

Abouelgreed, Tamer A / Elhelaly, Mohamed A / El-Agamy, El-Sayed I / Ahmed, Rasha / Haggag, Yasser M / Abdelwadood, M / Abdelkader, Salma F / Ali, Sameh S / Aboelsoud, Naglaa M / Alassal, Mosab F / Bashir, Gehad A / Gharib, Tarek

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2024 Volume 96, Issue 1, Page(s) 12437

Abstract: This retracts the article "Effect of preoperative ureteral stenting on the surgical outcomes of patients with 1-2 cm renal stones managed by retrograde intrarenal surgery using a ureteral access sheath" (https://doi.org/10.4081/aiua.2023.12102) ... ...

Abstract	This retracts the article "Effect of preoperative ureteral stenting on the surgical outcomes of patients with 1-2 cm renal stones managed by retrograde intrarenal surgery using a ureteral access sheath" (https://doi.org/10.4081/aiua.2023.12102) published on December 28, 2023.
Language	English
Publishing date	2024-03-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2024.12437
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Article: Automated wound care by employing a reliable U-Net architecture combined with ResNet feature encoders for monitoring chronic wounds.

Alabdulhafith, Maali / Ba Mahel, Abduljabbar S / Samee, Nagwan Abdel / Mahmoud, Noha F / Talaat, Rawan / Muthanna, Mohammed Saleh Ali / Nassef, Tamer M

Frontiers in medicine

2024 Volume 11, Page(s) 1310137

Abstract: Quality of life is greatly affected by chronic wounds. It requires more intensive care than acute wounds. Schedule follow-up appointments with their doctor to track healing. Good wound treatment promotes healing and fewer problems. Wound care requires ... ...

Abstract	Quality of life is greatly affected by chronic wounds. It requires more intensive care than acute wounds. Schedule follow-up appointments with their doctor to track healing. Good wound treatment promotes healing and fewer problems. Wound care requires precise and reliable wound measurement to optimize patient treatment and outcomes according to evidence-based best practices. Images are used to objectively assess wound state by quantifying key healing parameters. Nevertheless, the robust segmentation of wound images is complex because of the high diversity of wound types and imaging conditions. This study proposes and evaluates a novel hybrid model developed for wound segmentation in medical images. The model combines advanced deep learning techniques with traditional image processing methods to improve the accuracy and reliability of wound segmentation. The main objective is to overcome the limitations of existing segmentation methods (UNet) by leveraging the combined advantages of both paradigms. In our investigation, we introduced a hybrid model architecture, wherein a ResNet34 is utilized as the encoder, and a UNet is employed as the decoder. The combination of ResNet34's deep representation learning and UNet's efficient feature extraction yields notable benefits. The architectural design successfully integrated high-level and low-level features, enabling the generation of segmentation maps with high precision and accuracy. Following the implementation of our model to the actual data, we were able to determine the following values for the Intersection over Union (IOU), Dice score, and accuracy: 0.973, 0.986, and 0.9736, respectively. According to the achieved results, the proposed method is more precise and accurate than the current state-of-the-art.
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1310137
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Article ; Online: A Proposed Association between Improving Energy Metabolism of HepG2 Cells by Plant Extracts and Increasing Their Sensitivity to Doxorubicin.

Al-Shafie, Tamer A / Mahrous, Engy A / Shukry, Mustafa / Alshahrani, Mohammad Y / Ibrahim, Samah F / Fericean, Liana / Abdelkader, Afaf / Ali, Mennatallah A

Toxics

2023 Volume 11, Issue 2

Abstract: Increasing cancer cell sensitivity to chemotherapy by amending aberrant metabolism using plant extracts represents a promising strategy to lower chemotherapy doses while retaining the same therapeutic outcome. Here, we incubated HepG2 cells with four ... ...

Abstract	Increasing cancer cell sensitivity to chemotherapy by amending aberrant metabolism using plant extracts represents a promising strategy to lower chemotherapy doses while retaining the same therapeutic outcome. Here, we incubated HepG2 cells with four plant extracts that were selected based on an earlier assessment of their cytotoxicity, viz asparagus, green tea, rue, and avocado, separately, before treatment with doxorubicin. MTT assays elucidated a significant decrease in doxorubicin-IC
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11020182
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Article: Proactive visual prediction auditing the green eco-safety through backcasting approach booster by grey recruitment priority conceptual framework.

Abed, Ahmed M / AlArjani, Ali / Seddek, Laila F / Gaafar, Tamer S

Heliyon

2022 Volume 8, Issue 11, Page(s) e11729

Abstract: Climate change is a challenge that endangers societal TBL elements' stability. The countries' economies focus on planning for reducing carbon emissions 'CE' and replacing them with low CE energy. This objective needs accurate prediction for CE till 2030 ... ...

Abstract	Climate change is a challenge that endangers societal TBL elements' stability. The countries' economies focus on planning for reducing carbon emissions 'CE' and replacing them with low CE energy. This objective needs accurate prediction for CE till 2030 via recording the most significant variables related to CE causes. The variables (
Language	English
Publishing date	2022-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e11729
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Article: Neurosurgery training in war-torn countries: A perspective from Iraq and Syria.

Hoz, Samer S / Tamer, Wardan A / Al-Awadi, Osama M / Al-Sharshahi, Zahraa F / Dolachee, Ali A

Surgical neurology international

2020 Volume 11, Page(s) 430

Language	English
Publishing date	2020-12-11
Publishing country	United States
Document type	Journal Article
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_513_2020
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Article ; Online: Ovarian reserve in adolescent girls with autoimmune thyroiditis

Kotb A. Metwalley / Hekma S. Farghaly / Deiaaeldin M. Tamer / Ahmed M. Ali / Mostafa Embaby / Islam F. Elnakeeb / Eman B. Kamaleldeen

Archives of Endocrinology and Metabolism (2023)

2023

Abstract: ABSTRACT Objectives: To assess serum anti-Müllerian hormone (AMH) levels as an ovarian reserve marker in adolescent girls with autoimmune thyroiditis (AIT) and explore the relationship of this marker with autoimmunity and thyroid function biomarkers. ... ...

Abstract	ABSTRACT Objectives: To assess serum anti-Müllerian hormone (AMH) levels as an ovarian reserve marker in adolescent girls with autoimmune thyroiditis (AIT) and explore the relationship of this marker with autoimmunity and thyroid function biomarkers. Subjects and methods: This study included 96 adolescent girls with newly diagnosed AIT and 96 healthy, age- and sex-matched controls. All participants were evaluated with detailed history taking and physical examination, thyroid ultrasound, and measurement of levels of thyroid-stimulating hormone (TSH), free thyroxin (FT4), free triiodothyronine (FT3), antithyroid peroxidase antibodies (TPOAb), antithyroglobulin antibody (TGAb), estradiol, total testosterone, and anti-Müllerian hormone (AMH) levels. The LH/FSH ratio was also calculated. Among 96 patients evaluated, 78 were overtly hypothyroid and 18 were euthyroid. AMH levels were significantly lower in participants with overt hypothyroidism and euthyroidism compared with controls. Results: Serum levels of AMH correlated negatively with age, body mass index (BMI) standard deviation score (SDS), and TPOAb, TGAb, and TSH levels but positively with FT4 levels. In multivariate analysis, AMH levels correlated significantly with age (odds ratio [OR] = 1.65, 95% confidence interval [CI] 1.18-2.32, p = 0.05), BMI SDS (OR = 2.3, 95% CI, 2.23-3.50, p = 0.01), TSH (OR = 2.43, 95% CI 1.5-2.8, p = 0.01), and TPOAb (OR = 4.1, 95% CI 3.26-8.75, p = 0.001). Conclusions: Ovarian reserve of adolescent girls with AIT, as measured by serum AMH levels, is affected by thyroid autoimmunity and hypothyroidism, indicating a possible need for ovarian reserve monitoring in these patients.
Keywords	Autoimmune thyroiditis ; ovarian reserve ; anti-Müllerian hormone ; adolescent ; Medicine ; R ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Brazilian Society of Endocrinology and Metabolism
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is quadratus lumborum block combined with low dose-spinal anesthesia an effective alternative to general anesthesia in patients undergoing percutaneous nephrolithotomy?

Abouelgreed, Tamer A / Elgarhy, Ahmed M / Elatreisy, Adel / Ewieda, Tamer M / Ibrahim, Wael M / Yahia, Othman Saadeldien / Elnaggar, Ahmed M / Elbadawy, Mohamed A / Alkumity, Ali A / Badran, Yasser / Ali, Mahmoud / Gomaa, Aly / Elebiary, Mohame F / Aboelnasr, Mahmoud

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2023 Volume 95, Issue 3, Page(s) 11584

Abstract: Background: General anesthesia in high-risk patients has many complications and needs long preoperative preparations and postoperative intensive care unit (ICU). Therefore the present study aimed to evaluate the efficacy of combined low-dose spinal ... ...

Abstract	Background: General anesthesia in high-risk patients has many complications and needs long preoperative preparations and postoperative intensive care unit (ICU). Therefore the present study aimed to evaluate the efficacy of combined low-dose spinal anesthesia with quadratus lumborum block (QLB) as an alternative to general anesthesia for patients undergoing percutaneous nephrolithotomy. Patients and methods: A prospective study was conducted at the urology department of Al-Azhar University Hospitals in Cairo, Egypt, from January 2021 to January 2022. The study included 60 patients of ASA ll-lll scheduled for percutaneous nephrolithotomy. All patients received low-dose spinal anesthesia (5 mg bupivacaine) and QLB (QL1-QL2-QL3) approaches. The primary observation parameter was the efficacy of this technique as an alternative to general anesthesia. The secondary parameters measured were evaluation of need for intraoperative narcotics, postoperative pain score (VAS), and patients satisfaction as assessed using a 5-point Likert Scale. Results: None of the patients was given general anesthesia, and intraoperative sedation was given to nineteen patients (32.2%). No hemodynamic changes were observed in all patients. There was a significant correlation between the use of intraoperative sedation and stone site, intraoperative blood loss, and hospital stay. Pain intensity on VAS at rest and movement was low until the 24th postoperative hour. Patient satisfaction score was 3, 4, and 5 in 1 (1.7%), 4 (6.7%), and 55 (91.6%) patients, respectively. Conclusions: Combined low-dose spinal anesthesia with quadratus lumborum block is an effective alternative to general anesthesia in patients undergoing PCNL procedures with good postoperative analgesia. Patients with lower calyceal punctures have a lower incidence of intraoperative sedation requirements.
MeSH term(s)	Humans ; Anesthesia, Spinal ; Anesthetics, Local ; Nephrolithotomy, Percutaneous ; Prospective Studies ; Analgesics, Opioid ; Spinal Puncture ; Anesthesia, General ; Ultrasonography, Interventional/methods
Chemical Substances	Anesthetics, Local ; Analgesics, Opioid
Language	English
Publishing date	2023-09-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2023.11584
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Article ; Online: Safety and efficacy of percutaneous nephrolithotripsy in comorbid patients: A 3 years prospective observational study.

Abouelgreed, Tamer A / Ismail, Hassan / Ali, Sameh S / Koritenah, Ayman K / Badran, Yasser / Ali, Mahmoud / Ahmed, Rasha / Algammal, Mohamed / Alrefaey, Ahmed / Gomaa, Aly / Elebiary, Mohame F / Eldamanhory, Hany A / Khattab, Abdelhamid A / Abdelmonem, Nermeen M / Alnajem, Mohamed Thabet / Abdelhamid, Tamer G / Abdelwahed, Ahmed A / Abdelkader, Salma F

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2023 Volume 95, Issue 3, Page(s) 11581

Abstract: Purpose: To report the result of percutaneous nephrolithotripsy (PCNL) via standard nephrostomy tract in a single training institution. The perioperative complications in relation to the comorbid state are particularly assessed.: Patients and methods!# ...

Abstract	Purpose: To report the result of percutaneous nephrolithotripsy (PCNL) via standard nephrostomy tract in a single training institution. The perioperative complications in relation to the comorbid state are particularly assessed. Patients and methods: A prospective interventional study between January 2019 to November 2022, included 210 patients scheduled for PCNL. The average age was 40.3 ± 11.8 years (range 18- 67 years). Patients were categorized into two groups. The first group comprised 146 cases (69 .5%) with no associated co-morbidities while the second group 64 (30.5%) had co-morbidities such as obesity in 4 cases (1.9%), hypertension (HTN) in 24 cases (11.4%) cases, diabetes mellitus (DM) in 17 (8.1%) cases, history of recurrent stone surgery in 11 (5.2%) cases and more than one in 8 cases (3.8%). Co-morbidities, stone burden, location of stone, time of surgery, stay in the hospital, further operations, and negative events were among the reported data. Complications and the stone-free rate were the main outcome indicators. Results: Intraoperative complications were reported in 40 (18.8%) patients (18 group 1 and 22 group 2) during PCNL. Bleeding occurred in 22 (10.5%) patients (9 group 1 and 13 group 2), blood transfusions were needed in 4 (1.9%) (2 group 1 and 2 group 2), extravasation was observed in 11 patients (5.2%) (6 group 1 and 5 group 2) and cardiac arrhythmia in 3 (1.4%) (1 group 1 and 2 group 2) patients. Postoperative complications occurred in 61 patients (29%) (24 group 1 and 37 group 2) in the form of fever in 10 patients (4.8 %) (3 group 1 and 7 group 2) and prolonged leakage in 50 patients (23.8%) (21 group 1 and 29 group 2). One patient of group 2 died from postoperative sepsis. Extravasation and postoperative leakage were higher in diabetic patients than in non-diabetics. Stonefree rate was 60.5% (127 of 210). Clinically significant residual fragments (CSRFs) found in 70 cases (33.3%) (33 group 1 and 37 group 2). In 13 cases (6.2%) (5 group 1 and 8 group 2), clinically insignificant residual fragments (CIRFs) were found. In 8 (3 group 1 and 5 group 2) of the 13 cases, spontaneous stone passage was observed within 4-6 weeks of surgery. Residual stones in three cases (1 group 1 and 2 group 2) were asymptomatic and 4 mm or less, whereas stones increased in two cases of group 2. Among all factors studied, stone burden was significantly correlated to both intraoperative and postoperative complications. The occurrence of postoperative fever increased with large stone burden. Conclusions: PCNL is a therapeutic modality that is effective, feasible, and safe for a wide range of patients with concurrent medical issues. A steep curve is required to reduce intraoperative and postoperative complications.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Kidney Calculi/surgery ; Kidney Calculi/etiology ; Prospective Studies ; Nephrostomy, Percutaneous ; Lithotripsy/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Treatment Outcome
Language	English
Publishing date	2023-09-12
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2023.11581
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