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  1. Article: Transcriptomic Profile of Lin

    Mahajan, Neha / Luo, Qianyi / Abhyankar, Surabhi / Bhatwadekar, Ashay D

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The Lin : Highlights: Bone marrow mobilopathy with long-standing diabetesSwitch in LSK ...

    Abstract The Lin
    Highlights: Bone marrow mobilopathy with long-standing diabetesSwitch in LSK transcriptomic profile towards inflammation and angiogenesisDiscovered 35 miRNAs, including two novel miRNAs, miR-3968 and miR-1971LSK dysfunction reflected in inflammation and neurovascular deficits of the retina.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.22.576754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Screen of the Conserved Kinome for Negative Regulators of LIN-12 Negative Regulatory Region ("NRR")-Missense Activity in

    Deng, Yuting / Luo, Katherine Leisan / Shaye, Daniel D / Greenwald, Iva

    G3 (Bethesda, Md.)

    2019  Volume 9, Issue 11, Page(s) 3567–3574

    Abstract: Genetic analysis of LIN-12/Notch signaling in ...

    Abstract Genetic analysis of LIN-12/Notch signaling in
    MeSH term(s) Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/antagonists & inhibitors ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Female ; Mutation, Missense ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA Interference ; RNA, Double-Stranded/metabolism ; Receptors, Notch/antagonists & inhibitors ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Regulatory Sequences, Nucleic Acid/genetics ; Signal Transduction/genetics ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Vulva/cytology ; Vulva/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; Cell Cycle Proteins ; Lin-12 protein, C elegans ; RNA, Double-Stranded ; Receptors, Notch ; SEL-10 protein, C elegans ; Transcription Factors ; lin-15B protein, C elegans ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2019-11-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1534/g3.119.400471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28.

    Kiontke, Karin C / Herrera, R Antonio / Vuong, Edward / Luo, Jintao / Schwarz, Erich M / Fitch, David H A / Portman, Douglas S

    Developmental cell

    2019  Volume 49, Issue 4, Page(s) 542–555.e9

    Abstract: ... facilitates the degradation of LIN-28, a conserved miRNA regulator specifying the juvenile state. Both LIN-28 ... and LEP-2 associate with lep-5 in vivo, suggesting that lep-5 directly regulates LIN-28 stability and ...

    Abstract Biological roles for most long non-coding RNAs (lncRNAs) remain mysterious. Here, using forward genetics, we identify lep-5, a lncRNA acting in the C. elegans heterochronic (developmental timing) pathway. Loss of lep-5 delays hypodermal maturation and male tail tip morphogenesis (TTM), hallmarks of the juvenile-to-adult transition. We find that lep-5 is a ∼600 nt cytoplasmic RNA that is conserved across Caenorhabditis and possesses three essential secondary structure motifs but no essential open reading frames. lep-5 expression is temporally controlled, peaking prior to TTM onset. Like the Makorin LEP-2, lep-5 facilitates the degradation of LIN-28, a conserved miRNA regulator specifying the juvenile state. Both LIN-28 and LEP-2 associate with lep-5 in vivo, suggesting that lep-5 directly regulates LIN-28 stability and may function as an RNA scaffold. These studies identify a key biological role for a lncRNA: by regulating protein stability, it provides a temporal cue to facilitate the juvenile-to-adult transition.
    MeSH term(s) Amino Acid Sequence ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Morphogenesis/genetics ; Morphogenesis/physiology ; Mutation ; Phenotype ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Transcription Factors/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; LIN-28 protein, C elegans ; RNA, Long Noncoding ; Repressor Proteins ; Ribonucleoproteins ; Transcription Factors
    Language English
    Publishing date 2019-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2019.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 76: Show issues

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  4. Article ; Online: Inhibition of Notch 1 receptor influenced the differentiation of Lin-CD45RA-dendritic cell precursors within ovarian carcinoma microenvironment.

    Qian, Xue-Qian / Chen, Li-Li / Cheng, Qi / Tian, Yang / Luo, Xiao-Feng / Wan, Xiao-Yun

    BMC immunology

    2016  Volume 17, Issue 1, Page(s) 14

    Abstract: Background: Previous evidence suggested that the differentiation of Lin-CD45RA-DC precursors were ... signal pathway in the differentiation of Lin-CD45RA-DC precursors.: Methods: The CD34+ ... hematopoietic stem cells were extracted from umbilical cord blood in term parturition, and Lin-CD45RA-DC precusors were ...

    Abstract Background: Previous evidence suggested that the differentiation of Lin-CD45RA-DC precursors were prior to plasmcytoid dendritic cells (pDCs) than myeloid dendritic cells (mDCs) within ovarian cancer microenvironment. However, the mechanism is still unclear. Therefore, we investigated the function of Notch 1 signal pathway in the differentiation of Lin-CD45RA-DC precursors.
    Methods: The CD34+ hematopoietic stem cells were extracted from umbilical cord blood in term parturition, and Lin-CD45RA-DC precusors were separated and induced mature. Expression of Notch1 receptor and ligands in Lin-CD45RA-DC precusors was detected by Real-time PCR and was down-regulated by shRNA or γ-secretase inhibitor (GSI). Flow cytometry was used to analyze the subset of DCs with or without SKOV3 culture supernatants. IL-12 level was detected by ELISA.
    Results: Expression of Notch1 receptors and ligands were detected in Lin-CD45RA-DC precursor cells. The Notch1 mRNA in Lin-CD45RA-DC precursors can be down-regulated by shRNA-Notch1 lentivirus transfection and GSI. ShRNA mediated Notch 1 knock-down significantly differentiated less plasmcytoid dendritic cells (pDCs), but generated more myeloid dendritic cells (mDCs), and this would not be influenced by the supernatant of the ovarian carcinoma cell line. GSI had the same effect in the differentiation of pDC. The secretion of IL-12 significantly increased after Notch1 knock-down with or without SKOV3 culture supernatants.
    Conclusions: Notch1 is an important signaling pathway in the differentiation of Lin-CD45RA-DC precursor cells to plasmcytoid dendritic cells (pDCs). And this would not be affected by the supernatant of the ovarian carcinoma cell line.
    MeSH term(s) Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Cell Differentiation ; Cell Line, Tumor ; Cell Lineage ; Dendritic Cells/immunology ; Female ; Fetal Blood/cytology ; Gene Expression Regulation ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/immunology ; Humans ; Interleukin-12/metabolism ; Leukocyte Common Antigens/metabolism ; Oligopeptides/pharmacology ; Ovarian Neoplasms/immunology ; RNA, Small Interfering/genetics ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Tumor Microenvironment
    Chemical Substances NOTCH1 protein, human ; Oligopeptides ; RNA, Small Interfering ; Receptor, Notch1 ; benzyloxycarbonyl-leucyl-leucyl-norleucinal ; Interleukin-12 (187348-17-0) ; Leukocyte Common Antigens (EC 3.1.3.48) ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language English
    Publishing date 2016-06-04
    Publishing country England
    Document type Journal Article
    ISSN 1471-2172
    ISSN (online) 1471-2172
    DOI 10.1186/s12865-016-0150-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Intrinsic Estimator, Alternative Estimates, and Predictions of Mortality Trends: A Comment on Masters, Hummer, Powers, Beck, Lin, and Finch.

    Te Grotenhuis, Manfred / Pelzer, Ben / Luo, Liying / Schmidt-Catran, Alexander W

    Demography

    2016  Volume 53, Issue 4, Page(s) 1245–1252

    Abstract: In this article, we discuss a study by Masters et al. (2014), published in Demography. Masters and associates estimated age, period, and cohort (APC) effects on U.S. mortality rates between 1959 and 2009 using the intrinsic estimator (IE). We first argue ...

    Abstract In this article, we discuss a study by Masters et al. (2014), published in Demography. Masters and associates estimated age, period, and cohort (APC) effects on U.S. mortality rates between 1959 and 2009 using the intrinsic estimator (IE). We first argue that before applying the IE, a grounded theoretical justification is needed for its fundamental constraint on minimum variance of the estimates. We next demonstrate IE's high sensitivity to the type of dummy parameterization used to obtain the estimates. Finally, we discuss challenges in the interpretation of APC models. Our comments are not restricted to the article in question but pertain generally to any research that uses the IE.
    MeSH term(s) Age Factors ; Continental Population Groups ; Data Interpretation, Statistical ; Demography/methods ; Humans ; Models, Theoretical ; Mortality/ethnology ; Mortality/trends ; United States
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280612-5
    ISSN 1533-7790 ; 0070-3370
    ISSN (online) 1533-7790
    ISSN 0070-3370
    DOI 10.1007/s13524-016-0476-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1487: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: N,N-Di-phenyl-4-(1H-pyrrolo[1,2-f][1,10]phenanthro-lin-2-yl)-aniline ethanol monosolvate.

    Luo, Jun-Shan / Zhang, Yan-Yan / Liu, Zhao-Di / Tian, Yu-Peng

    Acta crystallographica. Section E, Structure reports online

    2013  Volume 69, Issue Pt 5, Page(s) o675–6

    Abstract: The title compound, C32H21N4·C2H5OH, crystallized as an ethanol monosolvate. In the mol-ecule of this phenanthroline derivative, the pyridine rings are almost coplanar, making a dihedral angle of 1.54 (13)°. The tri-phenyl-amine group, introduced as an ... ...

    Abstract The title compound, C32H21N4·C2H5OH, crystallized as an ethanol monosolvate. In the mol-ecule of this phenanthroline derivative, the pyridine rings are almost coplanar, making a dihedral angle of 1.54 (13)°. The tri-phenyl-amine group, introduced as an electron donor, shows a propeller-type structure, and the dihedral angles between the benzene rings are 68.71 11), 63.92 (16) and 70.81 (15)°. In the crystal, the phenanthroline mol-ecules are linked via the solvent mol-ecule by N-H⋯O, O-H⋯N and C-H⋯O hydrogen bonds, leading to the formation of zigzag chains propagating along [010]. These chains are linked via C-H⋯N hydrogen bonds, forming undulating two-dimensional networks extending in the a- and b-axis directions.
    Language English
    Publishing date 2013-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 1600-5368
    ISSN 1600-5368
    DOI 10.1107/S1600536813008477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Wu lin wai shi

    Gu, Long / Luo, Liqun

    xia

    (Gu long zuo pin ji : 古龙作品集 ; : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 12)

    1998  

    Series title Gu long zuo pin ji : 古龙作品集
    : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 12
    Language Chinese
    Dates of publication 1998-1995
    Size p. 541-1115
    Edition Di 1 ban, di 4 ci yin shua
    Publisher Zhu hai chu ban she
    Publishing place Zhuhai
    Document type Book
    ISBN 9787806070574 ; 7806070575
    Database Former special subject collection: coastal and deep sea fishing

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  8. Book: Wu lin wai shi

    Gu, Long / Luo, Liqun

    shang

    (Gu long zuo pin ji : 古龙作品集 ; : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 11)

    1998  

    Series title Gu long zuo pin ji : 古龙作品集
    : zhen cang ben / Gu long zhu; luo li qun ce hua zhu bian ; 11
    Language Chinese
    Dates of publication 1998-1995
    Size 8, 2, 540 p
    Edition Di 1 ban, di 4 ci yin shua
    Publisher Zhu hai chu ban she
    Publishing place Zhuhai
    Document type Book
    ISBN 9787806070574 ; 7806070575
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article: [Study on a downstream signal molecule of human CASK/LIN-2].

    Qi, J / Luo, X / Luo, Q

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

    2000  Volume 17, Issue 6, Page(s) 404–408

    Abstract: Objective: To elucidate the function of human CASK/LIN-2, a novel member ...

    Abstract Objective: To elucidate the function of human CASK/LIN-2, a novel member of membrane-associated guanylate kinase homologs family (MAGUK), by using the yeast two-hybrid system(LexA) to screen the protein interacting with the guanylate kinase-like domain(GK) of hCASK and identify possible protein that might involve downstream signal transduction of hCASK.
    Methods: PCR strategy was used to amplify GK domain cDNA fragment of hCASK. The DNA was subcloned into pLexA to construct bait vector pLexA-GK. The pLexA-GK was transformed into yeast host strain EGY48; through testing the bait protein and a repression assay, it was demonstrated that the bait protein did not have transcription activation for leu and lacZ reporter genes, however it could enter nucleus, bind LexA operator. Human fetus brain cDNA library plasmids were transformed into EGY48 containing pLexA-GK and p8op-lacZ, and screened on plates of Gal/Raf his- trp- ura- leu- and Gal/Raf his- trp- ura-X-gal. The clones with galactose dependent leu+ and lacZ+ were isolated; their library plasmids were rescued by means of transforming E.coli KC8. These library plasmids were transformed into the yeast again to re-screen. The remaining positive clones were analyzed by PCR and restriction endonuclease. Finally two kinds of target DNA fragments were obtained.
    Results: The specificity testing indicated that the two target proteins could specially bind GK domain of hCASK. After DNA sequencing and BLASTn analysis on NCBI, it was shown that the two target DNA fragments, 732 and 683 bp, had high sequence similarity with human inhibitors of differentiation 1(Id1) mRNA, with identities of 97%(630/645) and 98%(656/666), respectively.
    Conclusion: GK domain of hCASK could specially interact with Id1 in yeast. Id1 might be a downstream signal molecule of hCASK, which might involve in regulation of cell differentiation.
    MeSH term(s) Base Sequence ; Calcium-Calmodulin-Dependent Protein Kinases ; Guanylate Kinases ; Helminth Proteins/genetics ; Helminth Proteins/physiology ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/physiology ; Molecular Sequence Data ; Nucleoside-Phosphate Kinase/physiology ; Signal Transduction
    Chemical Substances Helminth Proteins ; Lin-2 protein, C elegans ; Membrane Proteins ; CASK kinases (EC 2.7.11.1) ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17) ; Nucleoside-Phosphate Kinase (EC 2.7.4.4) ; Guanylate Kinases (EC 2.7.4.8)
    Language Chinese
    Publishing date 2000-12
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1003-9406
    ISSN 1003-9406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Zhong yi lin chuang zhi liao te se yu you shi zhi nan

    Luo, Yunjian

    2007  

    Title variant Zhi liao te se yu you shi zhi nan
    Author's details zhu bian Luo Yunjian, Sun Sulun ; fu zhu bian Xu Zhiren ... [deng]
    MeSH term(s) Medicine, Chinese Traditional.
    Language Chinese
    Size 2, 2, 5, 986 p.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787117092456 ; 7117092459
    Database Catalogue of the US National Library of Medicine (NLM)

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