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Article: Metaplastic breast cancer with chondroid differentiation-case report and literature review.

Leite, Cláudia / Dias, Nuno / Oliveira, Domingos / Mesquita Pinto, Rita / Cortez Vaz, Francisco

Journal of surgical case reports

2021 Volume 2021, Issue 4, Page(s) rjab113

Abstract: Metaplastic breast cancer (MBC) comprises less than 1% of all breast cancers, and it is defined by a mixture of adenocarcinoma plus mesenchymal and epithelial components. It is more common in older and black female patients. It has a larger size and ... ...

Abstract	Metaplastic breast cancer (MBC) comprises less than 1% of all breast cancers, and it is defined by a mixture of adenocarcinoma plus mesenchymal and epithelial components. It is more common in older and black female patients. It has a larger size and faster growth, and it is frequently node-negative and triple-negative when compared with invasive ductal carcinoma. The authors report the case of a 72-year-old female patient, presenting with a breast lump, whose biopsy revealed a probable MBC with chondroid differentiation. She underwent a breast conservative surgery (BCS) and axillary sentinel lymph node dissection (SLND). The pathological report was concordant with the biopsy, and the patient was proposed to chemoradiotherapy. Despite its rarity and more severe features at diagnosis, BCS plus SLND plus radiotherapy should be offered to these patients, associated with chemotherapy. Chondroid differentiation is the rarest of all histological subtypes.
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjab113
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Article: Human-umbilical cord matrix mesenchymal cells improved left ventricular contractility independently of infarct size in swine myocardial infarction with reperfusion.

Raposo, Luís / Cerqueira, Rui J / Leite, Sara / Moreira-Costa, Liliana / Laundos, Tiago L / Miranda, Joana O / Mendes-Ferreira, Pedro / Coelho, João Almeida / Gomes, Rita N / Pinto-do-Ó, Perpétua / Nascimento, Diana S / Lourenço, André P / Cardim, Nuno / Leite-Moreira, Adelino

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1186574

Abstract: Background: Human umbilical cord matrix-mesenchymal stromal cells (hUCM-MSC) have demonstrated beneficial effects in experimental acute myocardial infarction (AMI). Reperfusion injury hampers myocardial recovery in a clinical setting and its management ... ...

Abstract	Background: Human umbilical cord matrix-mesenchymal stromal cells (hUCM-MSC) have demonstrated beneficial effects in experimental acute myocardial infarction (AMI). Reperfusion injury hampers myocardial recovery in a clinical setting and its management is an unmet need. We investigated the efficacy of intracoronary (IC) delivery of xenogeneic hUCM-MSC as reperfusion-adjuvant therapy in a translational model of AMI in swine. Methods: In a placebo-controlled trial, pot-belied pigs were randomly assigned to a sham-control group (vehicle-injection; Results: As compared to vehicle, hUCM-MSC enhanced systolic function as shown by higher ejection fraction (65 ± 6% vs. 43 ± 4%; Conclusion: Intracoronary transfer of xenogeneic hUCM-MSC shortly after reperfusion improved left-ventricular systolic function, which could not be explained by the observed extent of infarct size reduction alone. Combined contributions of favourable modification of myocardial interstitial fibrosis, matrix remodelling and enhanced cardiomyocyte contractility in the remote myocardium may provide mechanistic insight for the biological effect.
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1186574
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Article ; Online: Investigação Clínica da Iniciativa do Investigador em Portugal: Identificação de Problemas e Propostas para Melhoria.

Ferreira, João Pedro / Leite-Moreira, Adelino / Da Costa-Pereira, Altamiro / Soares, António José / Robalo-Cordeiro, Carlos / Jerónimo, Cármen / Gavina, Cristina / J Pinto, Fausto / Schmitt, Fernando / Saraiva, Francisca / Vasques-Nóvoa, Francisco / Canhão, Helena / Cyrne-Carvalho, Henrique / Palmeirim, Isabel / Pimenta, Joana / Cabral da Fonseca, João Eurico / Firmino-Machado, João / Correia Pinto, Jorge / Lino /

Castelo Branco, Miguel / Sousa, Nuno / Fontes de Carvalho, Ricardo / Machado Luciano, Teresa / Gil Oliveira, Tiago / Resende Oliveira, Catarina

Acta medica portuguesa

2023 Volume 36, Issue 5, Page(s) 305–308

Title translation	Investigator-Led Clinical Research in Portugal: Problem Identification and Proposals for Improvement.
Language	Portuguese
Publishing date	2023-02-28
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	603078-6
ISSN	1646-0758 ; 0870-399X
ISSN (online)	1646-0758
ISSN	0870-399X
DOI	10.20344/amp.19333
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Article ; Online: Investigação Clínica da Iniciativa do Investigador em Portugal

João Pedro Ferreira / Adelino Leite-Moreira / Altamiro da Costa-Pereira / António José Soares / Carlos Robalo-Cordeiro / Cármen Jerónimo / Cristina Gavina / Fausto J. Pinto / Fernando Schmitt / Francisca Saraiva / Francisco Vasques-Nóvoa / Helena Canhão / Henrique Cyrne-Carvalho / Isabel Palmeirim / Joana Pimenta / João Eurico Cabral da Fonseca / João Firmino-Machado / Jorge Correia Pinto / Lino /

Miguel Castelo Branco / Nuno Sousa / Ricardo Fontes de Carvalho / Teresa Machado Luciano / Tiago Gil Oliveira / Catarina Resende Oliveira

Acta Médica Portuguesa (2023)

Identificação de Problemas e Propostas para Melhoria

2023

Abstract: N/a. ...

Abstract	N/a.
Keywords	Ensaios Clínicos ; Investigadores ; Portugal ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Ordem dos Médicos
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: An NLP Solution to Foster the Use of Information in Electronic Health Records for Efficiency in Decision-Making in Hospital Care

Leite-Moreira, Adelino / Mendes, Afonso / Pedrosa, Afonso / Rocha-Sousa, Amândio / Azevedo, Ana / Amaral-Gomes, André / Pinto, Cláudia / Figueira, Helena / Pereira, Nuno Rocha / Mendes, Pedro / Pimenta, Tiago

2022

Abstract: The project aimed to define the rules and develop a technological solution to automatically identify a set of attributes within free-text clinical records written in Portuguese. The first application developed and implemented on this basis was a ... ...

Abstract	The project aimed to define the rules and develop a technological solution to automatically identify a set of attributes within free-text clinical records written in Portuguese. The first application developed and implemented on this basis was a structured summary of a patient's clinical history, including previous diagnoses and procedures, usual medication, and relevant characteristics or conditions for clinical decisions, such as allergies, being under anticoagulant therapy, etc. The project's goal was achieved by a multidisciplinary team that included clinicians, epidemiologists, computational linguists, machine learning researchers and software engineers, bringing together the expertise and perspectives of a public hospital, the university and the private sector. Relevant benefits to users and patients are related with facilitated access to the patient's history, which translates into exhaustiveness in apprehending the patient's clinical past and efficiency due to time saving. Comment: 11 pages, 2 figures
Keywords	Computer Science - Computation and Language ; Computer Science - Computers and Society
Subject code	020
Publishing date	2022-02-24
Publishing country	us
Document type	Book ; Online
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Article ; Online: mTOR inhibitors in urinary bladder cancer.

Pinto-Leite, R / Arantes-Rodrigues, R / Sousa, Nuno / Oliveira, P A / Santos, L

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

2016 Volume 37, Issue 9, Page(s) 11541–11551

Abstract: Despite the great scientific advances that have been made in cancer treatment, there is still much to do, particularly with regard to urinary bladder cancer. Some of the drugs used in urinary bladder cancer treatment have been in use for more than 30 ... ...

Abstract	Despite the great scientific advances that have been made in cancer treatment, there is still much to do, particularly with regard to urinary bladder cancer. Some of the drugs used in urinary bladder cancer treatment have been in use for more than 30 years and show reduced effectiveness and high recurrence rates. There have been several attempts to find new and more effective drugs, to be used alone or in combination with the drugs already in use, in order to overcome this situation.The biologically important mammalian target of rapamycin (mTOR) pathway is altered in cancer and mTOR inhibitors have raised many expectations as potentially important anticancer drugs. In this article, the authors will review the mTOR pathway and present their experiences of the use of some mTOR inhibitors, sirolimus, everolimus and temsirolimus, in isolation and in conjunction with non-mTOR inhibitors cisplatin and gemcitabine, on urinary bladder tumour cell lines. The non-muscle-invasive cell line, 5637, is the only one that exhibits a small alteration in the mTOR and AKT phosphorylation after rapalogs exposure. Also, there was a small inhibition of cell proliferation. With gemcitabine plus everolimus or temsirolimus, the results were encouraging as a more effective response was noticed with both combinations, especially in the 5637 and T24 cell lines. Cisplatin associated with everolimus or temsirolimus also gave promising results, as an antiproliferative effect was observed when the drugs were associated, in particular on the 5637 and HT1376 cell lines. Everolimus or temsirolimus in conjunction with gemcitabine or cisplatin could have an important role to play in urinary bladder cancer treatment, depending on the tumour grading.
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Signal Transduction/physiology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/physiology ; Urinary Bladder Neoplasms/drug therapy
Chemical Substances	TOR Serine-Threonine Kinases (EC 2.7.1.1)
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605825-5
ISSN	1423-0380 ; 0289-5447 ; 1010-4283
ISSN (online)	1423-0380
ISSN	0289-5447 ; 1010-4283
DOI	10.1007/s13277-016-5083-1
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Article ; Online: Myocardial Edema: an Overlooked Mechanism of Septic Cardiomyopathy?

Vasques-Nóvoa, Francisco / Laundos, Tiago L / Madureira, António / Bettencourt, Nuno / Nunes, José P L / Carneiro, Fátima / Paiva, José A / Pinto-do-Ó, Perpétua / Nascimento, Diana S / Leite-Moreira, Adelino F / Roncon-Albuquerque, Roberto

Shock (Augusta, Ga.)

2019 Volume 53, Issue 5, Page(s) 616–619

Abstract: Septic cardiomyopathy is an increasingly relevant topic in clinical management of septic shock. However, pathophysiological mechanisms and long-term consequences of sepsis-induced myocardial injury are still poorly understood. Herein, new clinical and ... ...

Abstract	Septic cardiomyopathy is an increasingly relevant topic in clinical management of septic shock. However, pathophysiological mechanisms and long-term consequences of sepsis-induced myocardial injury are still poorly understood. Herein, new clinical and histological evidence is provided suggesting an association of myocardial edema formation with tissue injury and subsequent remodeling in septic shock patients. This preliminary data supports myocardial edema as a potentially relevant and largely unexplored mechanism of human septic cardiomyopathy.
MeSH term(s)	Adult ; Cardiomyopathies/etiology ; Cardiomyopathies/pathology ; Edema/etiology ; Edema/pathology ; Female ; Humans ; Male ; Middle Aged ; Shock, Septic/complications ; Shock, Septic/pathology ; Shock, Septic/physiopathology
Language	English
Publishing date	2019-07-24
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000001395
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Article ; Online: Assessing beliefs and attitudes towards antipsychotic medication from a recovery-based perspective: Psychometric properties of a new scale.

Martins, Maria João R V / Pinto, Ana Margarida / Castilho, Paula / Macedo, António F / Pereira, Ana Telma / Bajouco, Miguel / Leite, Rita / Matos, Ondina / Morais, Sofia / Madeira, Nuno / Nogueira, Vasco / Roque, Carolina / Santos, Prazeres / Santos, Telma / Santos, Tiago / Santos, Vítor / Troia, Ana Filipa / Barreto-Carvalho, Célia

Psychiatry research

2019 Volume 273, Page(s) 325–330

Abstract: Antipsychotic medication non-adherence is a complex and multifaceted problem that may hinder recovery in psychosis-spectrum disorders. Therefore, it warrants an early and comprehensive assessment. Current self-report measures focus entirely on behavioral ...

Abstract	Antipsychotic medication non-adherence is a complex and multifaceted problem that may hinder recovery in psychosis-spectrum disorders. Therefore, it warrants an early and comprehensive assessment. Current self-report measures focus entirely on behavioral and attitudinal barriers to adherence, failing to provide insight about key psychosocial drivers such as shame and stigma that may also account for non-adherence. This study's main goals were to develop a brief scale for measuring antipsychotic (non)-adherence and associated intra and interpersonal barriers (Antipsychotic Medication Beliefs and Attitudes Scale - AMBAS), and explore its psychometric properties. One hundred and seventy participants with a psychosis-spectrum disorder were recruited and filled in a battery of self-report measures. Exploratory factor analysis supported a two-factor solution, with one factor tapping the influence of different barriers to medication adherence and other factor encompassing perceived positive effects of medication. The scale presented good reliability and convergent validity as evidenced by significant moderate associations with the Medication Adherence Rating Scale. Although in need for further study, AMBAS seems a valid and reliable measure to assess antipsychotic (non)-adherence and underlying behavioral and psychosocial drivers. With replication, AMBAS might be a useful measure that could be used in different clinical and research settings.
MeSH term(s)	Adult ; Antipsychotic Agents/therapeutic use ; Culture ; Factor Analysis, Statistical ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Medication Adherence/psychology ; Middle Aged ; Psychiatric Status Rating Scales/standards ; Psychometrics ; Reproducibility of Results ; Self Report/standards ; Social Stigma
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2019-01-12
Publishing country	Ireland
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2019.01.043
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Article ; Online: The association of milk and dairy consumption with iodine status in pregnant women in Oporto region.

Ferreira, Pedro / Pinheiro, Cátia / Matta Coelho, Cláudia / Guimarães, Juliana / Pereira, Gonçalo / Xavier Moreira, Nara / Cortez, Alice / Bracchi, Isabella / Pestana, Diogo / Barreiros Mota, Inês / Prucha, Carmo / Martins, Cristina / Alves Ribeiro, Célia / Pinto, Edgar / Almeida, Agostinho / Delerue-Matos, Cristina / Montenegro, Nuno / Dias, Cláudia Camila / Moreira-Rosário, André /

Azevedo, Luís Filipe / Brantsæter, Anne-Lise / Ramalho, Carla / Cruz Fernandes, Virgínia / Calhau, Conceição / Costa Leite, João / Keating, Elisa

The British journal of nutrition

2021 Volume 126, Issue 9, Page(s) 1314–1322

Abstract: The role of milk and dairy products in supplying iodine to pregnant women is unknown in Portugal ... The aim of this study was to evaluate the association between milk and dairy product consumption and ... were considered eligible for analysis. Milk (but not yogurt or cheese) intake was positively associated ...

Abstract	The role of milk and dairy products in supplying iodine to pregnant women is unknown in Portugal. The aim of this study was to evaluate the association between milk and dairy product consumption and the iodine status of pregnant women in the IoMum cohort of the Oporto region. Pregnant women were recruited between 10 and 13 weeks of gestation, when they provided a spot urine sample and information on lifestyle and intake of iodine-rich foods. Urinary iodine concentration (UIC) was determined by inductively coupled plasma MS. A total of 468 pregnant women (269 iodine supplement users and 199 non-supplement users) were considered eligible for analysis. Milk (but not yogurt or cheese) intake was positively associated with UIC, in the whole population (P = 0·02) and in the non-supplement users (P = 0·002), but not in the supplement users (P = 0·29). In non-supplement users, adjusted multinomial logistic regression analysis showed that milk consumption <3 times/month was associated with a five times increased risk of having UIC < 50 µg/l when compared with milk consumption ≥2 times/d (OR 5·4; 95 % CI 1·55, 18·78; P = 0·008). The highest UIC was observed in supplement users who reported consuming milk once per d (160 µg/l). Milk, but not yogurt or cheese, was positively associated with iodine status of pregnant women. Despite the observed positive association, daily milk consumption may not be sufficient to ensure adequate iodine intake in this population.
MeSH term(s)	Animals ; Dairy Products ; Dietary Supplements ; Female ; Humans ; Iodine/analysis ; Milk/chemistry ; Nutritional Status ; Pregnancy ; Pregnant Women
Chemical Substances	Iodine (9679TC07X4)
Language	English
Publishing date	2021-01-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S000711452100009X
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Article ; Online: Iodine knowledge is associated with iodine status in Portuguese pregnant women: results from the IoMum cohort study.

Pinheiro, Cátia / Xavier Moreira, Nara / Ferreira, Pedro / Matta Coelho, Cláudia / Guimarães, Juliana / Pereira, Gonçalo / Cortez, Alice / Bracchi, Isabella / Pestana, Diogo / Barreiros Mota, Inês / Prucha, Carmo / Martins, Cristina / Alves Ribeiro, Célia / Pinto, Edgar / Almeida, Agostinho / Delerue-Matos, Cristina / Montenegro, Nuno / Dias, Cláudia Camila / Moreira-Rosário, André /

Azevedo, Luís Filipe / Brantsæter, Anne-Lise / Ramalho, Carla / Cruz Fernandes, Virgínia / Costa Leite, João / Calhau, Conceição / Keating, Elisa

The British journal of nutrition

2021 Volume 126, Issue 9, Page(s) 1331–1339

Abstract: Lack of knowledge about iodine has been suggested as a risk factor for iodine deficiency in pregnant women, but no studies have addressed this issue in Portugal. So, the aim of this study was to investigate iodine knowledge among Portuguese pregnant ... ...

Abstract	Lack of knowledge about iodine has been suggested as a risk factor for iodine deficiency in pregnant women, but no studies have addressed this issue in Portugal. So, the aim of this study was to investigate iodine knowledge among Portuguese pregnant women and its association with iodine status. IoMum, a prospective observational study, included 485 pregnant women recruited at Centro Hospitalar e Universitário de S. João, Porto, between the 10th and 13th gestational weeks. Partial scores for knowledge on iodine importance, on iodine food sources or on iodised salt were obtained through the application of a structured questionnaire. Then, a total iodine knowledge score was calculated and grouped into low, medium and high knowledge categories. Urinary iodine concentration (UIC) was measured in spot urine samples by inductively coupled plasma MS. Of the pregnant women, 54 % correctly recognised iodine as important to neurocognitive development, 32 % were unable to identify any iodine-rich food and 71 % presented lack of knowledge regarding iodised salt. Of the women, 61 % had a medium total score of iodine knowledge. Knowledge on iodine importance during pregnancy was positively associated with iodine supplementation and also with UIC. Nevertheless, median UIC in women who correctly recognised the importance of iodine was below the cut-off for adequacy in pregnancy (150 µg/l). In conclusion, knowledge on iodine importance is positively associated with iodine status. Despite this, recognising iodine importance during pregnancy may not be sufficient to ensure iodine adequacy. Literacy-promoting actions are urgently needed to improve iodine status in pregnancy.
MeSH term(s)	Cohort Studies ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Iodine/analysis ; Nutritional Status ; Portugal ; Pregnancy ; Pregnant Women ; Sodium Chloride, Dietary
Chemical Substances	Sodium Chloride, Dietary ; Iodine (9679TC07X4)
Language	English
Publishing date	2021-01-19
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114521000155
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