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Article ; Online: Afterglow-Suppressed Lu

Wang, Mingwei / Meng, Yangqi / Zhu, Yaqi / Song, Jia / Yang, Jian / Liu, Chunguang / Zhu, Hancheng / Yan, Duanting / Xu, Changshan / Liu, Yuxue

Inorganic chemistry

2022 Volume 61, Issue 29, Page(s) 11293–11305

Abstract: Lu ...

Abstract	Lu
MeSH term(s)	Energy Transfer ; Europium ; Luminescence ; Polymethyl Methacrylate ; X-Rays
Chemical Substances	Europium (444W947O8O) ; Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.2c01417
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: UV-excited single-component white phosphor of Lu

Zheng, Huibin / Zheng, Chunyu / Lian, Xin / Shi, Yarui / Li, Jianxin / Song, Haixiang / Ding, Bangfu

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 23, Page(s) 8058–8064

Abstract: ... the hydrothermal synthesis, the orthorhombic Lu ...

Abstract	Obtaining white light from a single-component phosphor is still a significant challenge due to the complex energy transfer between multiple luminescent centers. Herein, white light emission is obtained in a single-component lutetium tungstate without any doping elements. By tuning the pH values during the hydrothermal synthesis, the orthorhombic Lu
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt00692a
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Article: The Zhu-Lu formula: a machine learning-based intraocular lens power calculation formula for highly myopic eyes.

Guo, Dongling / He, Wenwen / Wei, Ling / Song, Yunxiao / Qi, Jiao / Yao, Yunqian / Chen, Xu / Huang, Jinhai / Lu, Yi / Zhu, Xiangjia

Eye and vision (London, England)

2023 Volume 10, Issue 1, Page(s) 26

Abstract: ... myopic patients from two other hospitals were used as external test dataset. The Zhu-Lu formula was ... Results: In the internal test dataset, the Zhu-Lu, RBF 3.0 and BUII ranked top three from low to high ... taking into account standard deviations (SDs) of prediction errors (PEs). The Zhu-Lu and RBF 3.0 showed ...

Abstract	Background: To develop a novel machine learning-based intraocular lens (IOL) power calculation formula for highly myopic eyes. Methods: A total of 1828 eyes (from 1828 highly myopic patients) undergoing cataract surgery in our hospital were used as the internal dataset, and 151 eyes from 151 highly myopic patients from two other hospitals were used as external test dataset. The Zhu-Lu formula was developed based on the eXtreme Gradient Boosting and the support vector regression algorithms. Its accuracy was compared in the internal and external test datasets with the Barrett Universal II (BUII), Emmetropia Verifying Optical (EVO) 2.0, Kane, Pearl-DGS and Radial Basis Function (RBF) 3.0 formulas. Results: In the internal test dataset, the Zhu-Lu, RBF 3.0 and BUII ranked top three from low to high taking into account standard deviations (SDs) of prediction errors (PEs). The Zhu-Lu and RBF 3.0 showed significantly lower median absolute errors (MedAEs) than the other formulas (all P < 0.05). In the external test dataset, the Zhu-Lu, Kane and EVO 2.0 ranked top three from low to high considering SDs of PEs. The Zhu-Lu formula showed a comparable MedAE with BUII and EVO 2.0 but significantly lower than Kane, Pearl-DGS and RBF 3.0 (all P < 0.05). The Zhu-Lu formula ranked first regarding the percentages of eyes within ± 0.50 D of the PE in both test datasets (internal: 80.61%; external: 72.85%). In the axial length subgroup analysis, the PE of the Zhu-Lu stayed stably close to zero in all subgroups. Conclusions: The novel IOL power calculation formula for highly myopic eyes demonstrated improved and stable predictive accuracy compared with other artificial intelligence-based formulas.
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2806610-8
ISSN	2326-0254
ISSN	2326-0254
DOI	10.1186/s40662-023-00342-5
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Article ; Online: Analysing the tumor transcriptome of prostate cancer to predict efficacy of Lu-PSMA therapy.

Handke, Analena / Kesch, Claudia / Fendler, Wolfgang Peter / Telli, Tugce / Liu, Yang / Hakansson, Alexander / Davicioni, Elai / Hughes, Jason / Song, Hong / Lueckerath, Katharina / Herrmann, Ken / Hadaschik, Boris / Seifert, Robert

Journal for immunotherapy of cancer

2023 Volume 11, Issue 10

Abstract: Rationale: 177: Methods: Between March 2018 and December 2021, a total of 168 patients were referred to : Results: In the subset of patients who received : Conclusion: Higher PD-L2 signature might be associated with a better response ... ...

Abstract	Rationale: 177 Methods: Between March 2018 and December 2021, a total of 168 patients were referred to Results: In the subset of patients who received Conclusion: Higher PD-L2 signature might be associated with a better response to
MeSH term(s)	Male ; Humans ; Radioisotopes/therapeutic use ; Transcriptome ; Prostate-Specific Antigen ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; RNA/therapeutic use
Chemical Substances	Radioisotopes ; Prostate-Specific Antigen (EC 3.4.21.77) ; RNA (63231-63-0)
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2023-007354
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Article: [Hydrochemical Characteristics, Controlling Factors and Water Quality Evaluation of Shallow Groundwater in Tan-Lu Fault Zone （Anhui Section）].

Liu, Hai / Wei, Wei / Song, Yang / Xu, Jie / Guan, Zheng-Ting / Huang, Jian-Min / Zhao, Guo-Hong

Huan jing ke xue= Huanjing kexue

2024 Volume 45, Issue 5, Page(s) 2665–2677

Abstract: ... Lu fault zone (Anhui section), 86 groundwater samples were taken from the areas surrounding the Tan ... Lu fault zone (Anhui section), which included the Jianghuai Wavy Plain, the Yanjiang Hill Plain, and ... and to evaluate its quality. The results showed that the shallow groundwater in the Tan-Lu fault zone ...

Abstract	To study the hydrochemical characteristics, controlling factors, and groundwater quality of the Tan-Lu fault zone (Anhui section), 86 groundwater samples were taken from the areas surrounding the Tan-Lu fault zone (Anhui section), which included the Jianghuai Wavy Plain, the Yanjiang Hill Plain, and the Dabie Mountains in western Anhui. Descriptive statistics, Piper diagram, Gibbs diagram, ion ratio analysis, saturation index, chloride-alkalinity index, and entropy weight water quality index (EWQI) were used to comprehensively study the hydrochemical characteristics and controlling factors of groundwater and to evaluate its quality. The results showed that the shallow groundwater in the Tan-Lu fault zone (Anhui section) was weakly alkaline, with dominant anions and cations of HCO
Language	Chinese
Publishing date	2024-04-17
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202305144
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Article: Effects of extreme precipitation on hospitalization risk and disease burden of schizophrenia in urban and rural Lu’an, China, from 2010 to 2019

Wu, Yudong / Yao, Zhenghai / Ma, Gongyan / Cheng, Jian / Xu, Huabin / Qin, Wei / Yi, Weizhuo / Pan, Rubing / Wei, Qiannan / Tang, Chao / Liu, Xiangguo / He, Yangyang / Yan, Shuangshuang / Li, Yuxuan / Jin, Xiaoyu / Liang, Yunfeng / Sun, Xiaoni / Mei, Lu / Song, Jian /

Song, Shasha / Su, Hong

Environmental science and pollution research. 2022 Mar., v. 29, no. 13

2022

Abstract: ... from 2010 to 2019 in the city of Lu’an, China. EP could significantly increase the risk of hospitalization ...

Abstract	With the increasing frequency of extreme events caused by global climate change, the association between extreme precipitation (EP) and disease has aroused concern currently. However, no study has examined the relationship between EP and schizophrenia. Our study aimed to explore the relationship between EP and schizophrenia, and to further examine the difference between urban and rural areas. This study used quasi-Poisson generalized linear regression model combined with distributed lag non-linear model (DLNM) to estimate the association between EP (≥ 95th percentile) and hospitalization for schizophrenia from 2010 to 2019 in the city of Lu’an, China. EP could significantly increase the risk of hospitalization for schizophrenia. The effect firstly appeared at lag1 [relative risk (RR): 1.056, 95% confidence interval (95%CI): 1.003–1.110] and continued until lag17 (RR: 1.039, 95%CI: 1.004–1.075). Our research showed that EP had a significant effect on the hospitalization for schizophrenia in both urban and rural areas, and no significant difference was found (p>0.05). EP exerted more acute effects on schizophrenia living in rural areas than those in urban areas in the cold season. Further studies on the burden of schizophrenia found that patients who are male, aged ≤ 39 years or less, and living in urban areas are a priority for future warnings. We should pay more attention to the impact of EP on burden of schizophrenia, especially during the cold season, targeting those vulnerable groups, thereby implementing more accurate and timely preventive measures.
Keywords	burden of disease ; climate change ; cold season ; confidence interval ; males ; nonlinear models ; pollution ; regression analysis ; relative risk ; research ; schizophrenia
Language	English
Dates of publication	2022-03
Size	p. 19176-19184.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-16913-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Room-Temperature Superconductivity in Yb/Lu Substituted Clathrate Hexahydrides under Moderate Pressure.

Du, Mingyang / Song, Hao / Zhang, Zihan / Duan, Defang / Cui, Tian

Research (Washington, D.C.)

2022 Volume 2022, Page(s) 9784309

Abstract: Room temperature superconductivity is a dream that mankind has been chasing for a century. In recent years, the synthesis of ... ...

Abstract	Room temperature superconductivity is a dream that mankind has been chasing for a century. In recent years, the synthesis of H
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article
ISSN	2639-5274
ISSN (online)	2639-5274
DOI	10.34133/2022/9784309
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Article ; Online: Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.

Hopper, Allen T / Juhl, Martin / Hornberg, Jorrit / Badolo, Lassina / Kilburn, John Paul / Thougaard, Annemette / Smagin, Gennady / Song, Dekun / Calice, Londye / Menon, Veena / Dale, Elena / Zhang, Hong / Cajina, Manuel / Nattini, Megan E / Gandhi, Adarsh / Grenon, Michel / Jones, Ken / Khayrullina, Tanzilya / Chandrasena, Gamini /

Thomsen, Christian / Zorn, Stevin H / Brodbeck, Robb / Poda, Suresh Babu / Staal, Roland / Möller, Thomas

Journal of medicinal chemistry

2021 Volume 64, Issue 8, Page(s) 4891–4902

Abstract: ... engagement of Lu AF27139, a novel rodent-active and CNS-penetrant P2X7 receptor antagonist. Lu AF27139 is ...

Abstract	There remains an insufficient number of P2X7 receptor antagonists with adequate rodent potency, CNS permeability, and pharmacokinetic properties from which to evaluate CNS disease hypotheses preclinically. Herein, we describe the molecular pharmacology, safety, pharmacokinetics, and functional CNS target engagement of Lu AF27139, a novel rodent-active and CNS-penetrant P2X7 receptor antagonist. Lu AF27139 is highly selective and potent against rat, mouse, and human forms of the receptors. The rat pharmacokinetic profile is favorable with high oral bioavailability, modest clearance (0.79 L/(h kg)), and good CNS permeability.
MeSH term(s)	Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/pharmacology ; Animals ; Cell Line ; Central Nervous System/drug effects ; Central Nervous System/metabolism ; Dogs ; Female ; Half-Life ; Humans ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/cytology ; Microglia/drug effects ; Microglia/metabolism ; Microsomes, Liver/metabolism ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/metabolism ; Purinergic P2X Receptor Antagonists/chemical synthesis ; Purinergic P2X Receptor Antagonists/metabolism ; Purinergic P2X Receptor Antagonists/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Purinergic P2X7/chemistry ; Receptors, Purinergic P2X7/metabolism
Chemical Substances	Interleukin-1beta ; Lipopolysaccharides ; Purinergic P2X Receptor Antagonists ; Receptors, Purinergic P2X7 ; 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate (4P5DXU1F8Q) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.0c02249
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Article ; Online: Application of machine learning to pretherapeutically estimate dosimetry in men with advanced prostate cancer treated with <sup>177</sup>Lu-PSMA I&T therapy.

Xue, Song / Gafita, Andrei / Dong, Chao / Zhao, Yu / Tetteh, Giles / Menze, Bjoern H / Ziegler, Sibylle / Weber, Wolfgang / Afshar-Oromieh, Ali / Rominger, Axel / Eiber, Matthias / Shi, Kuangyu

European journal of nuclear medicine and molecular imaging

2022 Volume 49, Issue 12, Page(s) 4064–4072

Abstract: ... with ¹⁷⁷Lu-PSMA I&T RLT were included retrospectively. They had available pre-therapy ^{68 ... cycles of ¹⁷⁷Lu-PSMA I&T RLT were applied. Organ-based standard uptake values (SUVs) were ...}

Abstract	Purpose: Although treatment planning and individualized dose application for emerging prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) are generally recommended, it is still difficult to implement in practice at the moment. In this study, we aimed to prove the concept of pretherapeutic prediction of dosimetry based on imaging and laboratory measurements before the RLT treatment. Methods: Twenty-three patients with metastatic castration-resistant prostate cancer (mCRPC) treated with <sup>177</sup>Lu-PSMA I&T RLT were included retrospectively. They had available pre-therapy <sup>68</sup> Ga-PSMA-HEBD-CC PET/CT and at least 3 planar and 1 SPECT/CT imaging for dosimetry. Overall, 43 cycles of <sup>177</sup>Lu-PSMA I&T RLT were applied. Organ-based standard uptake values (SUVs) were obtained from pre-therapy PET/CT scans. Patient dosimetry was calculated for the kidney, liver, spleen, and salivary glands using Hermes Hybrid Dosimetry 4.0 from the planar and SPECT/CT images. Machine learning methods were explored for dose prediction from organ SUVs and laboratory measurements. The uncertainty of these dose predictions was compared with the population-based dosimetry estimates. Mean absolute percentage error (MAPE) was used to assess the prediction uncertainty of estimated dosimetry. Results: An optimal machine learning method achieved a dosimetry prediction MAPE of 15.8 ± 13.2% for the kidney, 29.6% ± 13.7% for the liver, 23.8% ± 13.1% for the salivary glands, and 32.1 ± 31.4% for the spleen. In contrast, the prediction based on literature population mean has significantly larger MAPE (p < 0.01), 25.5 ± 17.3% for the kidney, 139.1% ± 111.5% for the liver, 67.0 ± 58.3% for the salivary glands, and 54.1 ± 215.3% for the spleen. Conclusion: The preliminary results confirmed the feasibility of pretherapeutic estimation of treatment dosimetry and its added value to empirical population-based estimation. The exploration of dose prediction may support the implementation of treatment planning for RLT.
MeSH term(s)	Dipeptides/therapeutic use ; Heterocyclic Compounds, 1-Ring/therapeutic use ; Humans ; Lutetium/therapeutic use ; Machine Learning ; Male ; Positron Emission Tomography Computed Tomography/methods ; Prostate-Specific Antigen ; Prostatic Neoplasms, Castration-Resistant/diagnostic imaging ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Retrospective Studies ; Urea/analogs & derivatives
Chemical Substances	Dipeptides ; Heterocyclic Compounds, 1-Ring ; PSMA I&T ; Lutetium (5H0DOZ21UJ) ; Urea (8W8T17847W) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2022-06-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-022-05883-w
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Article ; Conference proceedings: An Estimation of Radiobiological parameters for 177 Lu-PSMA-617 Radioligand Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer and the Clinical Implications

Hu, J. / Song, X. / Mercolli, L. / Sari, H. / Afshar-Oromieh, A. / Rominger, A. / Shi, K.

Nuklearmedizin - NuclearMedicine

2023 Volume 62, Issue 02

Event/congress	61. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin, Leipzig, 2023-04-19
Language	German
Publishing date	2023-03-30
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2030804-8
ISSN	2567-6407 ; 0029-5566
ISSN (online)	2567-6407
ISSN	0029-5566
DOI	10.1055/s-0043-1766329
Database	Thieme publisher's database

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