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Article ; Online: Diffusion-weighted-MRI versus PET-CT in assessment of chest wall lesions

Youssriah Yahia Sabri / Ikram Hamed Mahmoud / Aya Hussein Muhammed Mabrouk / Mostafa Ahmed Kahiry / Mohamed Raafat Abd El-Mageed / Yasmine Hamdy El Hinnawy / Hossam Zawam / Amira Aly Hegazy / Sally Fouad Tadros

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 55, Iss 1, Pp 1-

2024 Volume 15

Abstract: Abstract Background Chest wall lesions comprise benign and malignant etiologies. Numerous classification systems have been proposed based on etiology, origin site, tissue composition and whether the lesion is benign or malignant. Despite that ... ...

Abstract	Abstract Background Chest wall lesions comprise benign and malignant etiologies. Numerous classification systems have been proposed based on etiology, origin site, tissue composition and whether the lesion is benign or malignant. Despite that conventional radiological studies are able to provide detailed information about the tumor morphology such as size, location, and extent tissue characteristics, yet, they cannot reliably differentiate benign from malignant neoplasms. This study aimed to detect the diagnostic value of diffusion weighted MRI and PET/CT in evaluating chest wall lesions, and in differentiating benign from malignant lesions. Results The chest wall lesions were divided into either benign or malignant; 34 cases (47.9%) were diagnosed as benign, while 37 cases (52.1%) were diagnosed as malignant. The mean ADC value of malignant lesions (0.8 ± 0.3 × 10–3 mm2/s) was significantly lower than that of benign lesions (1.3 ± 0.6 × 10–3 mm2/s). This yielded statistically significant results with cut off value of 1.25 × 10–3 mm2/s for confident diagnosis and differentiation of benign from malignant lesions, with sensitivity of 91.9%, specificity of 70.6%, positive predictive value of 77.27%, negative predictive value of 88.89% and accuracy of 81.7%. The mean SUV of malignant lesions (14.2 ± 6.1) was significantly higher than that of benign lesions (1.5 ± 1.3). This yielded statistically significant results with cut off value of 2.45 for confident diagnosis and differentiation of benign from malignant lesions, with sensitivity of 100%, specificity of 82.4%, positive predictive value of 86.05%, negative predictive value of 100%, and accuracy of 91.5%. Conclusions Both DWI-MRI and PET/CT can reliably differentiate benign from malignant lesions, yet, PET/CT showed higher sensitivity, specificity and accuracy.
Keywords	DWI-MRI ; Chest wall ; PET-CT ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of diffusion MRI in diagnosis of mediastinal lymphoma

Youssriah Yahia Sabri / Nourhan Mohamed Ewis / Hussam Eldin Hamdy Zawam / Mostafa Ahmed Khairy

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

initial assessment and response to therapy

2021 Volume 11

Abstract: Abstract Background Malignant lymphoma accounts for nearly 20% of all mediastinal neoplasms in adults and 50% in children. Hodgkin’s disease is the most common primary mediastinal lymphoma. In non-Hodgkin’s lymphoma, the two most common forms of primary ... ...

Abstract	Abstract Background Malignant lymphoma accounts for nearly 20% of all mediastinal neoplasms in adults and 50% in children. Hodgkin’s disease is the most common primary mediastinal lymphoma. In non-Hodgkin’s lymphoma, the two most common forms of primary mediastinal lymphoma are lymphoblastic lymphoma and diffuse large B-cell lymphoma. The aim of this study is to implement diffusion MRI in the algorithm of diagnosis of mediastinal lymphoma, differentiating Hodgkin's from non-Hodgkin's lymphoma and assessment of post therapeutic response. Results Using Diffusion weighted magnetic resonance imaging DWI-MRI, there were statistic significant difference between ADC values in lymph nodes and mediastinal masses in Hodgkin and non-Hodgkin lymphomas. ADC range in non-treated Hodgkin lymphoma cases was 0.774 to 1.4, while ADC range in in non-treated non-Hodgkin lymphoma was 0.476 to 0.668. In this study, there was statistically significant difference of ADC values in lymphoma cases presented by mediastinal masses with and without chemotherapy. Conclusions Diffusion weighted magnetic resonance imaging DWI-MRI is a promising functional technique in diagnosis of Hodgkin's and non-Hodgkin's lymphoma and assessment of response to treatment with no need for special preparation, contrast injection or radiation exposure.
Keywords	Mediastinum ; Malignant ; Lymphoma ; Hodgkin ; Non-Hodgkin ; Diffusion ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mediastinal lymphadenopathy in sarcoidosis

Youssriah Yahia Sabri / Naglaa Mahmoud Mohamed Mahmoud / Mohammed Raafat Abd El–Mageed / Marwa Mohammed Mohammed Onsy / Sabah Ahmed Mohamed / Mahmoud Mohamed Mohamed Onsy / Mostafa Ahmed Khairy

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 54, Iss 1, Pp 1-

Can diffusion MRI play a role in its evaluation?

2023 Volume 9

Abstract: Abstract Background Sarcoidosis is a multisystem disease defined by non-caseous epithelioid cell granulomas that can affect virtually all organs. Lung, mediastinal and hilar lymph node involvement is prevalent, occurring in around 90% of the patients, ... ...

Abstract	Abstract Background Sarcoidosis is a multisystem disease defined by non-caseous epithelioid cell granulomas that can affect virtually all organs. Lung, mediastinal and hilar lymph node involvement is prevalent, occurring in around 90% of the patients, and is responsible for the majority of the morbidity and mortality related to the disorder. Sarcoidosis is one of the differential diagnoses of the benign mediastinal lymphadenopathy. This research aimed to detect the diagnostic value of magnetic resonance imaging (MRI) diffusion in evaluation of mediastinal lymphadenopathy in sarcoid patients. Results This cross study involved a total of 30 patients known to have sarcoidosis: 6 males and 24 females aged between 18 and 50 years (with a mean age 38.97 ± 8.67); all of them presented with mediastinal lymphadenopathy. For all patients, each lymph node group was evaluated for the average size and average ADC value. The mean ADC measured was (1.76 ± 0.28) × 10−3 mm2/s. Eight patients showed concurrent activity with poor response to the treatment, and they showed different ADC values with one of them showing low ADC with pattern of diffusion restriction displaying mean ADC value of 1.28 × 10−3 mm2/s. Conclusions Diffusion-weighted MRI is an established imaging technique that could be utilized to evaluate mediastinal lymphadenopathy in sarcoidosis as the benign counterpart of mediastinal lymphadenopathy.
Keywords	Sarcoidosis ; Mediastinal lymphadenopathy ; MRI diffusion ; ADC value ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extra-pleural space on CT

Youssriah Yahia Sabri / Mohamed Salah Eldin Mohamed Elroos / Yasmine Hamdy El Hinnawy / Mostafa Ahmed Kahiry / Mohamed Raafat Abd El-Mageed / Sally Fouad Tadros

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 54, Iss 1, Pp 1-

common lesions and diagnostic approach

2023 Volume 9

Abstract: Abstract Background The extra-pleural space is challenging to view radiologically and is commonly overlooked. Therefore, it is important to have a comprehensive understanding of its anatomy in order to correctly classify lesions as either pleural or ... ...

Abstract	Abstract Background The extra-pleural space is challenging to view radiologically and is commonly overlooked. Therefore, it is important to have a comprehensive understanding of its anatomy in order to correctly classify lesions as either pleural or extra-pleural so as to choose the most appropriate treatment. CT with multi-planar reformatting allows the assessment of pathological conditions involving the extra-pleural space. The aim of this cross-sectional study was to assess the role of CT in the detection and evaluation of the extra-pleural space lesions and to classify them according to their CT appearance in order to reach a proper diagnosis and successful management plan. Results This study was conducted on 131 patients who underwent CT scan of the chest for different chest complaints, and the detected extra-pleural space abnormalities were classified according to their CT appearance into three major groups which are fatty expansion and soft tissue stranding group that included 59 cases (45%), abnormal attenuation group that included 13 cases (10%), and soft tissue expansion group that included 59 cases (45%). Out of the 59 cases with increased fatty expansion and soft tissue stranding, 73% were of inflammatory cause (either pulmonary or pleural), 17% were of neoplastic cause, and 3 cases were caused by systemic conditions. The abnormal extra-pleural space attenuation group was classified into air-containing and blood-containing groups, and both were mainly caused by trauma. Soft tissue infiltration of extra-pleural space was classified into neoplastic (85%) and non-neoplastic (15%) lesions, while most of the non-neoplastic pathologies were caused by severe inflammatory processes. The axial images were mostly sufficient to detect extra-pleural space lesions. Conclusions CT has a crucial role in the assessment of extra-pleural space and the different lesions involving it. Those lesions can be classified according to their CT appearance in order to reach a proper diagnosis and as a result aid in better ...
Keywords	Extra-pleural space ; CT ; MPR ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions

Youssriah Yahia Sabri / Eman Zaki Bassyouni Nossair / HebatAllah Hany Assal / Hisham Samir Wahba

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

2020 Volume 16

Abstract: Abstract Background Conducted studies showed that the ADC (apparent diffusion coefficient) values of malignant mediastinal lesions are significantly lower than those of benign lesions. Investigators determined cut-off ADC values to differentiate the two; ...

Abstract	Abstract Background Conducted studies showed that the ADC (apparent diffusion coefficient) values of malignant mediastinal lesions are significantly lower than those of benign lesions. Investigators determined cut-off ADC values to differentiate the two; concluding that ADC value is a promising noninvasive, imaging parameter that helps assess and characterize mediastinal tumors. Taking this a step forward, the primary objective of our prospective study was to investigate the potential of DW-MRI (diffusion-weighted magnetic resonance imaging) to characterize malignant mediastinal lesions using their ADC values. Thirty-three patients that underwent MRI of the chest with DWI and latter pathologically diagnosed with a malignant mediastinal lesion were included in this study. Lesions’ ADC values were measured and correlated with the histopathological results. The statistical significance of differences between measurements was tested using the one-way ANOVA (analysis of variance) test; p values equal to or less than 0.05 were considered significant. Results There was no statistically significant difference between the ADCmean values of the histopathological groups of lesions assessed with the overlap of their ADCmean values. The average ADCmean value of NHL (non-Hodgkin lymphoma) was evidently lower than that of HD (Hodgkin disease) with no overlap between their ADCmean values. DWI failed at characterizing one lesion in this study as a malignant tumor, namely an immature teratoma (germ-cell tumor). Again DWI could not be used to evaluate a mass, latter pathologically diagnosed as an angiosarcoma, because of its overall hemorrhagic nature showing no definite non-hemorrhagic soft tissue components. The aforementioned results did not differ considerably when minimum ADC was used instead of mean ADC. Conclusion There was no statistically significant difference between the ADC values of the malignant mediastinal lesions evaluated. However, regarding lymphoma subtypes, our limited sample study of lymphoma suggested a ...
Keywords	Malignant mediastinal lesions ; DWI (diffusion-weighted imaging) ; ADC (apparent diffusion coefficient) ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnostic accuracy of the trans-abdominal ultrasound in the assessment of dysfunctional hemidiaphragm due to non-pulmonic etiology

Ahmed A. Baz / Amal Abdel Hakam Mohammed Aglan / Sabah Ahmed Mohammed / Youssriah Yahia Sabri

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

2020 Volume 11

Abstract: Abstract Background To evaluate the role of the trans-abdominal ultrasound (TAUS) in the assessment of hemidiaphragmatic dysfunction—due to non-pulmonic causes—as compared to the conventional CT; 36 patients (22 males and 14 females; age range 5 to 84 ... ...

Abstract	Abstract Background To evaluate the role of the trans-abdominal ultrasound (TAUS) in the assessment of hemidiaphragmatic dysfunction—due to non-pulmonic causes—as compared to the conventional CT; 36 patients (22 males and 14 females; age range 5 to 84 years) were included in this study. Results In CT examination, the dysfunctional hemidiaphragm was considered when either a hernia/post-traumatic defects (present in 19.4% of patients, of which 5.5% were depicted on the right side and 13.8% were existing on the left side), or elevated copulae (present in 80.6% of patients, of which 58.8% were found on the right side (21 patients) and 22.2% were seen on the left side (8 patients). The TAUS showed a high sensitivity, specificity, PPV, NPV, and over all accuracy {100% (95% CI = 59.04 to 100.00%), 100% (95% CI = 88.06 to 100.00%), 100%, 100%, 100% (95% CI = 90.26 to 100.00%), respectively} in detection of defects and hernias as compared to CT. A high sensitivity, specificity, PPV, NPV, and over all accuracy {96.55% (95% CI = 82.24 to 99.9%), 100% (95% CI=59.04 to 100.00%), 100%, 87.5% (95% CI = 50.50 to 97.96%), 97.22% (95% CI = 85.47 to 99.93%), respectively} were found in detection of thickness and motion abnormalities, and in the detection of subphrenic collections in cases with relevant elevated copula in CT. Conclusion Trans-abdominal ultrasound (TAUS) could accurately assess the diaphragmatic thickness and provides a real-time image of a dysfunctional hemidiaphragm due to a diaphragmatic and infradiaphragmatic causes as well as the diaphragmatic defects with high sensitivity and specificity in comparison to CT.
Keywords	Trans-abdominal ; Ultrasound ; CT ; Diaphragm ; Dysfunction ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Added value of diffusion-weighted MRI in assessment of pleural lesions

Youssriah Yahia Sabri / Ikram Hamed Mahmoud / Lamis Tarek El-Gendy / Mohamed Raafat Abd El-Mageed / Sally Fouad Tadros

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract Background There are many causes of pleural disease including variable benign and malignant etiologies. DWI is a non-enhanced functional MRI technique that allows qualitative and quantitative characterization of tissues based on their water ... ...

Abstract	Abstract Background There are many causes of pleural disease including variable benign and malignant etiologies. DWI is a non-enhanced functional MRI technique that allows qualitative and quantitative characterization of tissues based on their water molecules diffusivity. The aim of this study was to evaluate the diagnostic value of DWI-MRI in detection and characterization of pleural diseases and its capability in differentiating benign from malignant pleural lesions. Results Conventional MRI was able to discriminate benign from malignant lesions by using morphological features (contour and thickness) with sensitivity 89.29%, specificity 76%, positive predictive value 89%, negative predictive value 76.92%, and accuracy 85.37%. ADC value as a quantitative parameter of DWI found that ADC values of malignant pleural diseases were significantly lower than that of benign lesions (P < 0.001). Hence, we discovered that using ADC mean value of 1.68 × 10-3 mm2/s as a cutoff value can differentiate malignant from benign pleural diseases with sensitivity 89.3%, specificity 100%, positive predictive value 100%, negative predictive value 81.2%, and accuracy 92.68% (P < 0.001). Conclusion Although DWI-MRI is unable to differentiate between malignant and benign pleural effusion, its combined morphological and functional information provide valid non-invasive method to accurately characterize pleural soft tissue diseases differentiating benign from malignant lesions with higher specificity and accuracy than conventional MRI.
Keywords	DWI ; Pleural lesions ; MRI ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MR diffusion imaging in mediastinal masses the differentiation between benign and malignant lesions

Youssriah Yahia Sabri / Marian Fayek Farid Kolta / Mostafa Ahmed Khairy

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 48, Iss 3, Pp 569-

2017 Volume 580

Abstract: Background: Diffusion-weighted imaging is a fundamental tool integrated in MR protocols useful in differentiating benign from malignant mediastinal masses, assessing mediastinal lymphadenopathy and investigating central bronchogenic carcinoma. This ... ...

Abstract	Background: Diffusion-weighted imaging is a fundamental tool integrated in MR protocols useful in differentiating benign from malignant mediastinal masses, assessing mediastinal lymphadenopathy and investigating central bronchogenic carcinoma. This method is an excellent alternative to CT or PET/CT in the investigation of mediastinal masses. Current applications of diffusion MRI in malignancies include monitoring the treatment response and detecting recurrent cancer. Aim of the work: This study aims to assess the value of using MRI diffusion in differentiating benign and malignant mediastinal masses, differentiating central masses from post obstructive collapse and differentiating lymphoma versus sarcoidosis. Patients and methods: This study included 30 patients; 16 males and 14 females in the period from June 2013 to July 2014. The mean age was 49.3Â Â±Â 16.85 (range: 22â82Â years).Cases were referred for MRI assessment and were approved by the ethical committee in our department.The complaints varied between dyspnea, chest pain, cough, hemoptysis, fatigue and loss of weight. A superconducting 1.5Â T MRI machine with a four-channel body phased-array coil was used for the examination. Biopsy and histopathological assessment was done after that. Results: MRI examination with diffusion imaging was able to differentiate between benign and malignant mediastinal and hilar lesion confirmed by the biopsy and histopathology. Conclusion: MRI with diffusion weighted images can detect and stage lung cancer, differentiate benign from malignant mediastinal masses and differentiate lymphoma from sarcoidosis in mediastinal/hilar lymphadenopathy. Keywords: Magnetic resonance imaging, Diffusion, Sarcoidosis, Lymphoma, Bronchogenic carcinoma
Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CT chest for COVID-19, a multicenter study—experience with 220 Egyptian patients

Sabri, Youssriah Yahia / Nassef, Amr A. / Ibrahim, Iman Mohamed Hamdy / Abd El Mageed, Mohammed Raafat / Khairy, Mostafa Ahmed

Egyptian Journal of Radiology and Nuclear Medicine

2020 Volume 51, Issue 1

Keywords	covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2583928-7
ISSN	2090-4762 ; 0378-603X
ISSN (online)	2090-4762
ISSN	0378-603X
DOI	10.1186/s43055-020-00263-6
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CT findings of 795 COVID-19 positive cases

Youssriah Yahia Sabri / Mohamed Mohsen Tolba Fawzi / Eman Zaki Nossair / Safaa Mohamed El-Mandooh / Amira Aly Hegazy / Sally Fouad Tadros

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

a multicenter study in Egypt

2020 Volume 9

Abstract: Abstract Background Corona Virus Disease 2019 (COVID-19) outbreak was officially announced as a global pandemic by the WHO on March 11th 2020. Thorough understanding of CT imaging features of COVID-19 is essential for effective patient management; ... ...

Abstract	Abstract Background Corona Virus Disease 2019 (COVID-19) outbreak was officially announced as a global pandemic by the WHO on March 11th 2020. Thorough understanding of CT imaging features of COVID-19 is essential for effective patient management; rationalizing the need for relevant research. The aim of this study was to analyze the chest CT findings of patients with real-time polymerase chain reaction (RT-PCR) proved COVID-19 admitted to four Egyptian hospitals. The recently published RSNA expert consensus statement on reporting COVID-19 chest CT findings was taken into consideration. Results Normal CT “negative for COVID-19” was reported in 26.1% of our RT-PCR proved COVID-19 cases. In descending order of prevalence, imaging findings of the positive CT studies (73.9%) included GGO (69%), consolidation (49.7%), crazy paving (15.4%), and peri-lobular fibrosis (40.6%). These showed a dominantly bilateral (68.2%), peripheral (72.4%), and patchy (64.7%) distribution. Remarkably, thymic hyperplasia was identified in 14.3% of studies. According to the RSNA consensus, CT findings were classified as typical in 68.9%, indeterminate in 3.6%, and atypical in 1.4% of the evaluated CT studies. Conclusion Although COVID-19 cannot be entirely excluded by chest CT, it can be distinguished in more than two-thirds of cases; making CT a widely available, non-invasive, and rapid diagnostic tool.
Keywords	COVID-19 ;Chest CT ; Egypt ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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