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  1. Article ; Online: Paper-based uric acid assay in whole blood samples by Zn

    Jin, Xue / Liu, Jia / Wang, Jiaxi / Gao, Mingxia / Zhang, Xiangmin

    Analytical and bioanalytical chemistry

    2024  Volume 416, Issue 7, Page(s) 1589–1597

    Abstract: Uric acid (UA) is an important biomarker, as a high concentration in blood can lead to gout and further renal syndrome. Although several point-of-care testing (POCT) devices have been reported to detect UA, there are some limitations such as the ... ...

    Abstract Uric acid (UA) is an important biomarker, as a high concentration in blood can lead to gout and further renal syndrome. Although several point-of-care testing (POCT) devices have been reported to detect UA, there are some limitations such as the requirement for uricase and the complicated pretreatment of serum/plasma samples, which restricts their use at home or in undeveloped areas. In this work, we developed an approach by applying Zn
    MeSH term(s) Uric Acid ; Gold ; Colorimetry ; Hydrogen Peroxide ; Metal Nanoparticles ; Zinc
    Chemical Substances Uric Acid (268B43MJ25) ; Gold (7440-57-5) ; Hydrogen Peroxide (BBX060AN9V) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2024-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-024-05160-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oral verrucous xanthoma with oral lichen planus: a case report.

    Jia, Tingting / Zhang, Da / Qi, Xiangmin / Wang, Caijiao / Yan, Shiguo

    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

    2024  Volume 41, Issue 1, Page(s) 104–109

    Abstract: Verrucous xanthoma is a rare benign muco-cutaneous lesion, whereas oral lichen planus is a chronic inflammatory disease relatively common in the clinical setting. Verrucous xanthoma and oral lichen planus can reportedly coexist according to foreign ... ...

    Abstract Verrucous xanthoma is a rare benign muco-cutaneous lesion, whereas oral lichen planus is a chronic inflammatory disease relatively common in the clinical setting. Verrucous xanthoma and oral lichen planus can reportedly coexist according to foreign literature. Owing to the low incidence of verrucous xanthoma and the rarity of co-occurrence of these two diseases, the mechanism underlying the co-occurrence of the two diseases remains inconclusive. In this work, a case of oral verrucous xanthoma complicated with oral lichen planus was reported. Related literature was reviewed to discuss the clinical classification, pathological classification, and possible pathogenesis of the two diseases.
    MeSH term(s) Humans ; Lichen Planus, Oral ; Lichen Planus/complications ; Lichen Planus/pathology ; Carcinoma, Verrucous/complications ; Carcinoma, Verrucous/pathology ; Skin ; Xanthomatosis/complications ; Xanthomatosis/pathology
    Language Chinese
    Publishing date 2024-04-10
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 1202342-5
    ISSN 2618-0456 ; 1000-1182
    ISSN (online) 2618-0456
    ISSN 1000-1182
    DOI 10.7518/hxkq.2023.01.014
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  3. Article ; Online: An unusual case of thalassemia intermedia with inheritable complex repeats detected by single-molecule optical mapping.

    Zhang, Qianqian / Lin, Peng / Mao, Aiping / Liu, Yongqiong / Shang, Xuan / Wei, Xiaofeng / Li, Yuezhen / Lin, Bin / Xu, Xiangmin

    Haematologica

    2024  Volume 109, Issue 3, Page(s) 1000–1006

    MeSH term(s) Humans ; beta-Thalassemia/diagnosis ; beta-Thalassemia/genetics
    Language English
    Publishing date 2024-03-01
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.282902
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  4. Article ; Online: Enhanced Superconductivity and Critical Current Density Due to the Interaction of InSe

    Niu, Rui / Li, Jiayang / Zhen, Weili / Xu, Feng / Weng, Shirui / Yue, Zhilai / Meng, Xiangmin / Xia, Jing / Hao, Ning / Zhang, Changjin

    Journal of the American Chemical Society

    2024  Volume 146, Issue 2, Page(s) 1244–1249

    Abstract: Superconductivity was discovered in ( ... ...

    Abstract Superconductivity was discovered in (InSe
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c09756
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  5. Article ; Online: YBX1, Targeted By Microrna-382-5p, Promotes Laryngeal Squamous Cell Carcinoma Progression

    Zeng, Wen / Pan, Yiyun / Chen, Hailong / Lei, Xianhua / Zhang, Xiangmin

    Recent patents on anti-cancer drug discovery

    2024  Volume 19, Issue 2, Page(s) 176–187

    Abstract: Background: Laryngeal squamous cell carcinoma (LSCC) is the most common cancer of head and neck cancer. Y-box binding protein-1 (YBX1) has tumor-promoting effects in some types of cancers. However, its role in LSCC remains unknown. This study set out to ...

    Abstract Background: Laryngeal squamous cell carcinoma (LSCC) is the most common cancer of head and neck cancer. Y-box binding protein-1 (YBX1) has tumor-promoting effects in some types of cancers. However, its role in LSCC remains unknown. This study set out to identify the role of YBX1 in LSCC.
    Methods: Bioinformatics analysis of the Gene Expression Omnibus (GEO) database and our cohort data were used to explore the association of YBX1 expression with clinicopathological factors in LSCC. Then, cells with stably or transiently transfected with plasmid or siRNA were constructed to assess the effect of loss and gain of YBX1 on the biological phenotypes of LSCC cells in vitro. In addition, subcutaneous xenograft and orthotopic liver tumor mouse models were constructed for validation. The interrogated miRNA databases and subsequent luciferase reporter assays were used to confirm the miR-382-5p target of YBX1. At last, KEGG enrichment annotation from TGCA data was used for downstream analyses of miR-382-5p/YBX1 and verified by PCR and Western immunoblotting.
    Results: The results showed that significant upregulation of YBX1 in LSCC tumors was correlated with advanced TNM stage and poor prognosis. Knockdown of YBX1 markedly impaired the proliferative, invasive, and migratory activity of Tu212 cells. We confirmed that miR-382-5p targets YBX1 to mediate LSCC progression both in vitro and in vivo. We further confirmed that miR-382-5p/YBX1 modulated the Ras/MAPK signaling axis to regulate the progression of LSCC.
    Conclusion: Together, our results indicated that YBX1 is an important promoter of LSCC progression. And miR-382-5p/YBX1/RAS/MAPK signaling pathway can be perceived as a promising target in the treatment of LSCC.
    MeSH term(s) Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/metabolism ; Laryngeal Neoplasms/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Y-Box-Binding Protein 1/genetics ; Y-Box-Binding Protein 1/metabolism
    Chemical Substances MicroRNAs ; MIRN382 microRNA, human ; Y-Box-Binding Protein 1 ; YBX1 protein, human
    Language English
    Publishing date 2024-01-12
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2250820-X
    ISSN 2212-3970 ; 1574-8928
    ISSN (online) 2212-3970
    ISSN 1574-8928
    DOI 10.2174/1574892818666230207091720
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    Zs.A 6393: Show issues Location:
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  6. Article ; Online: Predictive Factors of Intestinal Ischaemia in Adhesive Small Bowel Obstruction.

    Li, Xiangmin / Tian, Min / Liu, Yulin / Zhang, Yongbo / Chen, Jingbo

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2024  Volume 34, Issue 2, Page(s) 146–150

    Abstract: Objective: To identify the predictive factors of intestinal ischaemia in adhesive small bowel obstruction (ASBO) and develop an intestinal ischaemia risk score.: Study design: Observational study. Place and Duration of the Study: Department of ... ...

    Abstract Objective: To identify the predictive factors of intestinal ischaemia in adhesive small bowel obstruction (ASBO) and develop an intestinal ischaemia risk score.
    Study design: Observational study. Place and Duration of the Study: Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China, from January 2017 to February 2022.
    Methodology: ASBO was determined by findings at laparotomy. The assessment of small bowel's viability was conducted through surgical inspection and subsequent histological examination of the surgical specimen. Univariate and multivariate analyses were conducted to ascertain the risk factors associated with intestinal ischaemia.
    Results: In total, 79 patients were included. Factors entered into multivariate analysis associated with intestinal ischaemia were; rebound tenderness (odds ratio (OR): 7.8, 95% confidence interval (CI):1.7-35.3; p=0.008), procalcitonin (PCT) >0.5 ng/mL (OR: 11.7, 95% CI: 2.3-58.1; p=0.003), and reduced bowel wall enhancement on computerised tomography (CT) scan (OR: 12.2, 95% CI:2.4-61.5; p=0.003). Among patients with 0, 1, 2, and 3 factors, the rate of intestinal ischaemia increased from 0% to 49%, 72%, and 100%, respectively. According to the number of risk factors, the area under the receiver operating characteristic curve for the determination of intestinal ischaemia was 0.848 (95% CI: 0.764-0.932).
    Conclusion: Rebound tenderness, PCT levels >0.5 ng/mL, and reduced bowel wall enhancement are risk factors of intestinal ischemic injury that require surgery within the context of ASBO. These factors need to be closely monitored that could assist clinicians in avoiding unnecessary laparotomies and selecting patients eligible for surgery.
    Key words: Intestinal obstruction, Ischaemia, Adhesions.
    MeSH term(s) Humans ; Abdominal Pain/etiology ; Intestinal Obstruction/complications ; Intestinal Obstruction/pathology ; Intestinal Obstruction/surgery ; Laparotomy ; Mesenteric Ischemia/etiology ; Mesenteric Ischemia/surgery ; Procalcitonin ; Retrospective Studies ; Tissue Adhesions/complications ; Tissue Adhesions/surgery ; Vascular System Injuries/etiology ; Vascular System Injuries/surgery
    Chemical Substances Procalcitonin
    Language English
    Publishing date 2024-02-12
    Publishing country Pakistan
    Document type Observational Study ; Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2024.02.146
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    Zs.A 6532: Show issues Location:
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  7. Article ; Online: In Situ Capturing and Counting Device for the Specific Depletion and Purification of Cancer-Derived Exosomes.

    Tai, Qunfei / Yu, Hailong / Gao, Mingxia / Zhang, Xiangmin

    Analytical chemistry

    2023  Volume 95, Issue 35, Page(s) 13113–13122

    Abstract: From metabolic waste to biological mediators, exosomes have emerged as the key player in a variety of pathological processes, particularly in oncogenesis. The exosome-mediated communication network involves nearly every step of cancer progression, ... ...

    Abstract From metabolic waste to biological mediators, exosomes have emerged as the key player in a variety of pathological processes, particularly in oncogenesis. The exosome-mediated communication network involves nearly every step of cancer progression, promoting the proliferation and immune escape of cancer cells. Therefore, the removal of cancer-derived exosomes has profound clinical significance. Current methods for exosome separation and enrichment are either for large-scale samples or require complex pretreatment processes, lacking effective methods for trace-volume exosome capture in situ. Herein, we have developed an in situ exosome capturing and counting device based on the antibody-functionalized capillary. Specific antibodies targeting exosome biomarkers were immobilized to the inner wall of the capillary via biotin-streptavidin interaction for direct cancer exosome capturing. Subsequent exosome staining enabled imaging and enumeration. Acceptable linearity and reproducibility were achieved with our device, with the capturing and detective range between 3.3 × 10
    MeSH term(s) Humans ; Exosomes ; Reproducibility of Results ; Neoplasms ; Carcinogenesis ; Adsorption ; Antibodies
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01670
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  8. Article ; Online: Quantitative proteomics investigating the intrinsic adaptation mechanism of Aeromonas hydrophila to streptomycin.

    Zhang, Shuangziying / Yang, Wenxiao / Xie, Yuyue / Zhao, Xinrui / Chen, Haoyu / Zhang, Lishan / Lin, Xiangmin

    Proteomics

    2024  , Page(s) e2300383

    Abstract: Aeromonas hydrophila, a prevalent pathogen in the aquaculture industry, poses significant challenges due to its drug-resistant strains. Moreover, residues of antibiotics like streptomycin, extensively employed in aquaculture settings, drive selective ... ...

    Abstract Aeromonas hydrophila, a prevalent pathogen in the aquaculture industry, poses significant challenges due to its drug-resistant strains. Moreover, residues of antibiotics like streptomycin, extensively employed in aquaculture settings, drive selective bacterial evolution, leading to the progressive development of resistance to this agent. However, the underlying mechanism of its intrinsic adaptation to antibiotics remains elusive. Here, we employed a quantitative proteomics approach to investigate the differences in protein expression between A. hydrophila under streptomycin (SM) stress and nonstress conditions. Notably, bioinformatics analysis unveiled the potential involvement of metal pathways, including metal cluster binding, iron-sulfur cluster binding, and transition metal ion binding, in influencing A. hydrophila's resistance to SM. Furthermore, we evaluated the sensitivity of eight gene deletion strains related to streptomycin and observed the potential roles of petA and AHA_4705 in SM resistance. Collectively, our findings enhance the understanding of A. hydrophila's response behavior to streptomycin stress and shed light on its intrinsic adaptation mechanism.
    Language English
    Publishing date 2024-05-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.202300383
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  9. Article ; Online: Five New Species of the Lichen-Forming Fungal Genus

    Yang, Qiuxia / Cheng, Xiangmin / Zhang, Tingting / Liu, Xinzhan / Wei, Xinli

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 2

    Abstract: ... The ... ...

    Abstract The genus
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8020134
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  10. Article: Discrimination for geographical origin of

    Pang, Shifeng / Piao, Xiangmin / Zhang, Xiaohao / Chen, Xiaolin / Zhang, Hao / Jin, Yinping / Li, Zheng / Wang, Yingping

    Food science & nutrition

    2023  Volume 11, Issue 8, Page(s) 4843–4852

    Abstract: American ginseng, ...

    Abstract American ginseng,
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3461
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