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  1. Article ; Online: Seasonal variation in azithromycin prescription.

    Danion, François / Margue, Magali / Ruch, Yvon / Séverac, François / Hansmann, Yves

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 3, Page(s) 277–278

    MeSH term(s) Humans ; Azithromycin ; Seasons ; Anti-Bacterial Agents/therapeutic use ; Prescriptions
    Chemical Substances Azithromycin (83905-01-5) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00009-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Re: real world clinical outcome of cefiderocol for treatment of multidrug-resistant non-fermenting gram-negative bacilli infections: author's response.

    Hoellinger, Baptiste / Danion, François / Hansmann, Yves / Schramm, Frederic / Ruch, Yvon

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 6, Page(s) 812–813

    MeSH term(s) Humans ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; Gram-Negative Bacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Cefiderocol
    Chemical Substances Cephalosporins ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.02.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Two cases of viral re-suppression after M184V + R263 K selection on DTG/3TC without treatment modification.

    Ursenbach, Axel / Ruch, Yvon / Hoellinger, Baptiste / Fuchs, Anne / Caspar, Stéphanie / Jegou, Frédérick / Rey, David / Fafi-Kremer, Samira / Mesplede, Thibault / Gantner, Pierre

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: DTG/3TC has a high genetic barrier against the development of HIV drug resistance. We report two cases of R263K + M184 V mutations during DTG/3TC failure followed by viral suppression after adherence intervention without treatment change that we ... ...

    Abstract DTG/3TC has a high genetic barrier against the development of HIV drug resistance. We report two cases of R263K + M184 V mutations during DTG/3TC failure followed by viral suppression after adherence intervention without treatment change that we attribute to residual drug activity, reduced viral fitness, and robust immune competence.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Case Report and Literature Review of Prosthetic Cardiovascular Mucormycosis.

    Hoellinger, Baptiste / Magnus, Louis / Ruch, Yvon / Ohana, Mickael / Hansmann, Yves / Letscher-Bru, Valérie / Lejay, Anne / Chakfé, Nabil / Danion, François

    Emerging infectious diseases

    2023  Volume 29, Issue 11, Page(s) 2388–2390

    Abstract: We report a rare case of aorto-bi-iliac prosthetic allograft mucormycosis in a 57-year-old immunocompetent patient in France. Outcome was favorable after surgery and dual antifungal therapy with liposomal amphotericin B and isavuconazole. In a literature ...

    Abstract We report a rare case of aorto-bi-iliac prosthetic allograft mucormycosis in a 57-year-old immunocompetent patient in France. Outcome was favorable after surgery and dual antifungal therapy with liposomal amphotericin B and isavuconazole. In a literature review, we identified 12 other cases of prosthetic vascular or heart valve mucormycosis; mortality rate was 38%.
    MeSH term(s) Humans ; Middle Aged ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Mucormycosis/microbiology ; Antifungal Agents/therapeutic use ; Rhizopus ; Transplantation, Homologous ; Lung
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Review ; Case Reports ; Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2911.230837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction to: Impact of 16S rDNA sequencing on clinical treatment decisions: a single center retrospective study.

    Ursenbach, Axel / Schramm, Frédéric / Séverac, François / Hansmann, Yves / Lefebvre, Nicolas / Ruch, Yvon / Argemi, Xavier

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 276

    Language English
    Publishing date 2021-03-18
    Publishing country England
    Document type Published Erratum
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-05938-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: HIV Productively Infects Highly Differentiated and Exhausted CD4+ T Cells During AIDS.

    Faua, Clayton / Ursenbach, Axel / Fuchs, Anne / Caspar, Stéphanie / Jegou, Frédérick / Ruch, Yvon / Hoellinger, Baptiste / Laugel, Elodie / Velay, Aurélie / Rey, David / Fafi-Kremer, Samira / Gantner, Pierre

    Pathogens & immunity

    2024  Volume 8, Issue 2, Page(s) 92–114

    Abstract: Background: Throughout HIV infection, productively infected cells generate billions of viral particles and are thus responsible for body-wide HIV dissemination, but their phenotype during AIDS is unknown. As AIDS is associated with immunological changes, ...

    Abstract Background: Throughout HIV infection, productively infected cells generate billions of viral particles and are thus responsible for body-wide HIV dissemination, but their phenotype during AIDS is unknown. As AIDS is associated with immunological changes, analyzing the phenotype of productively infected cells can help understand HIV production during this terminal stage.
    Methods: Blood samples from 15 untreated viremic participants (recent infection, n=5; long-term infection, n=5; active opportunistic AIDS-defining disease, n=5) and 5 participants virologically controlled on antiretroviral therapy (ART) enrolled in the Analysis of the Persistence, Reservoir and HIV Latency (APRIL) study (NCT05752318) were analyzed. Cells expressing the capsid protein p24 (p24+ cells) after 18 hours of resting or 24 hours of stimulation (HIV-Flow) revealed productively infected cells from viremic participants or translation-competent reservoir cells from treated participants, respectively.
    Results: The frequency of productively infected cells tended to be higher during AIDS in comparison with recent and long-term infections (median, 340, 72, and 32/million CD4+ T cells, respectively) and correlated with the plasma viral load at all stages of infection. Altogether, these cells were more frequently CD4
    Conclusions: In long-term infection and AIDS, productively infected cells were differentiated and exhausted. This could indicate that cells with these given features are responsible for HIV production and dissemination in an immune dysfunction environment occurring during the last stages of infection.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ISSN 2469-2964
    ISSN (online) 2469-2964
    DOI 10.20411/pai.v8i2.638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Organizational Benefits of Ultra-Low-Dose Chest CT Compared to Chest Radiography in the Emergency Department for the Diagnostic Workup of Community-Acquired Pneumonia: A Real-Life Retrospective Analysis.

    Kepka, Sabrina / Heimann, Charlène / Severac, François / Hoffbeck, Louise / Le Borgne, Pierrick / Bayle, Eric / Ruch, Yvon / Muller, Joris / Roy, Catherine / Sauleau, Erik André / Andres, Emmanuel / Ohana, Mickaël / Bilbault, Pascal

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 9

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Male ; Humans ; Aged ; Female ; Retrospective Studies ; Radiography ; Tomography, X-Ray Computed ; Pneumonia/diagnostic imaging ; Emergency Service, Hospital
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59091508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Revised version (INFD-D-20-00242): impact of 16S rDNA sequencing on clinical treatment decisions: a single center retrospective study.

    Ursenbach, Axel / Schramm, Frédéric / Séverac, François / Hansmann, Yves / Lefebvre, Nicolas / Ruch, Yvon / Argemi, Xavier

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 190

    Abstract: Background: PCRs targeting 16S ribosomal DNA (16S PCR) followed by Sanger's sequencing can identify bacteria from normally sterile sites and complement standard analyzes, but they are expensive. We conducted a retrospective study in the Strasbourg ... ...

    Abstract Background: PCRs targeting 16S ribosomal DNA (16S PCR) followed by Sanger's sequencing can identify bacteria from normally sterile sites and complement standard analyzes, but they are expensive. We conducted a retrospective study in the Strasbourg University Hospital to assess the clinical impact of 16S PCR sequencing on patients' treatments according to different sample types.
    Methods: From 2014 to 2018, 806 16S PCR samples were processed, and 191 of those were positive.
    Results: Overall, the test impacted the treatment of 62 of the 191 patients (32%). The antibiotic treatment was rationalized in 31 patients (50%) and extended in 24 patients (39%), and an invasive procedure was chosen for 7 patients (11%) due to the 16S PCR sequencing results. Positive 16S PCR sequencing results on cerebrospinal fluid (CSF) had a greater impact on patients' management than positive ones on cardiac valves (p = 0.044). The clinical impact of positive 16S PCR sequencing results were significantly higher when blood cultures were negative (p < 0.001), and this difference appeared larger when both blood and sample cultures were negative (p < 0.001). The diagnostic contribution of 16S PCR was higher in patients with previous antibiotic treatment (p < 0.001).
    Conclusion: In all, 16S PCR analysis has a significant clinical impact on patient management, particularly for suspected CSF infections, for patients with culture-negative samples and for those with previous antibiotic treatments.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacterial Infections/diagnosis ; Bacterial Infections/drug therapy ; Clinical Decision-Making ; Humans ; Molecular Diagnostic Techniques/methods ; Polymerase Chain Reaction ; RNA, Ribosomal, 16S/genetics ; Retrospective Studies ; Sequence Analysis, DNA
    Chemical Substances Anti-Bacterial Agents ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-05892-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: First Case of Bacteraemia Due to Carbapenem-Resistant

    Kaeuffer, Charlotte / Ruge, Tiffany / Diancourt, Laure / Romain, Benoît / Ruch, Yvon / Jaulhac, Benoît / Boyer, Pierre H

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Multidrug resistant (MDR) bacteria are increasingly observed in nosocomial and community-acquired settings. Anaerobes are no exception to this rule, but there are fewer reports of MDR in the scientific literature on anaerobes than there are for other ... ...

    Abstract Multidrug resistant (MDR) bacteria are increasingly observed in nosocomial and community-acquired settings. Anaerobes are no exception to this rule, but there are fewer reports of MDR in the scientific literature on anaerobes than there are for other bacteria. In this short case report, we describe the first case of bacteraemia caused by a multidrug-resistant
    Language English
    Publishing date 2021-03-19
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10030319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: High Incidence of Acute Kidney Injury in Patients Treated with High-Dose Amoxicillin and Cloxacillin Combination Therapy.

    Ruch, Yvon / Ursenbach, Axel / Danion, François / Reisz, Fanny / Nai, Thierry / Hoellinger, Baptiste / Hansmann, Yves / Lefebvre, Nicolas / Martzloff, Jonas

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 6

    Abstract: High-dose amoxicillin and cloxacillin combination therapy is recommended for the empiric treatment of selected patients with infective endocarditis despite a low level of evidence. The main objective of this study was to evaluate the renal tolerance of ... ...

    Abstract High-dose amoxicillin and cloxacillin combination therapy is recommended for the empiric treatment of selected patients with infective endocarditis despite a low level of evidence. The main objective of this study was to evaluate the renal tolerance of high-dose intravenous amoxicillin and cloxacillin combination. We studied 27 patients treated with amoxicillin and cloxacillin (≥100 mg/kg daily) for at least 48 h. The primary endpoint was the occurrence of acute kidney injury (AKI). The median patient age was 68 ± 8 years, and 16 (59%) were male. The indication for this combination therapy was suspected or confirmed endocarditis with no bacterial identification in 22 (81%) patients. The primary endpoint occurred in 16 (59%) patients after initiating this combination therapy within an average of 4.4 ± 3.6 days. Among them, seven (26%) patients developed severe AKI, including four (15%) patients who required hemodialysis. Other risk factors for AKI were identified in all patients, including injection of iodinated contrast media in 21 (78%), acute heart failure in 18 (67%), cardiac surgery in 11 (41%), and aminoglycoside use in 9 (33%) patients. This study reports an incidence of 59% of AKI after initiating amoxicillin and cloxacillin combination therapy in a population at high renal risk.
    Language English
    Publishing date 2022-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11060770
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