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  1. Article ; Online: Invited commentary: the incidentally discovered solid pancreatic mass: imaging and clinical observations.

    Charnsangavej, Chusilp

    Abdominal imaging

    2012  Volume 37, Issue 1, Page(s) 98–99

    MeSH term(s) Adenocarcinoma/diagnostic imaging ; Female ; Humans ; Incidental Findings ; Male ; Neuroendocrine Tumors/diagnostic imaging ; Pancreatic Neoplasms/diagnostic imaging ; Radiography
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1144553-1
    ISSN 1432-0509 ; 0942-8925
    ISSN (online) 1432-0509
    ISSN 0942-8925
    DOI 10.1007/s00261-011-9813-y
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  2. Article: Adjuvant perioperative hepatic arterial mitomycin C and floxuridine combined with surgical resection of metastatic colorectal cancer in the liver.

    Patt, Y Z / McBride, C M / Ames, F C / Claghorn, L J / Cleary, K R / Boddie, A W / Charnsangavej, C / Mavligit, G M

    Cancer

    1987  Volume 59, Issue 5, Page(s) 867–873

    Abstract: ... and adjuvant perioperative therapy that included hepatic arterial mitomycin C and floxuridine (FUDR ...

    Abstract Twenty patients with colon cancer metastatic to the liver underwent successful hepatic resection and adjuvant perioperative therapy that included hepatic arterial mitomycin C and floxuridine (FUDR). The median survival for all 20 patients was 51 months: 10 are still alive with a median postoperative follow-up of 49 months; 6 are disease-free with a median postoperative follow-up of 43 months. Among 10 patients in whom the surgical margins of the specimen contained tumor cells, the median survival was 52 months. This survival was comparable to that among 10 patients in whom the surgical margins were tumor free (P = 0.22). Neither the number of metastatic liver deposits nor the disease-free interval between the primary diagnosis of colorectal carcinoma and the development of liver metastases significantly affected survival. A transient chemical hepatitis which resolved before the next scheduled treatment was associated with 50% of arterial chemotherapy cycles (approximately 70% of the patients). Gastric or duodenal ulcerations occurred in 23% of the patients. Surgical complications were either pulmonary such as pleural effusion or atelectasis, or wound infections and subphrenic abscesses. Although these results compare favorably with the results in previously published series, this aggressive adjuvant chemotherapy appears to be particularly justified in patients with tumor positive surgical margins or those with multiple tumor masses and, therefore, are characterized by a poor prognosis.
    MeSH term(s) Adult ; Aged ; Carcinoembryonic Antigen/analysis ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/secondary ; Colonic Neoplasms/surgery ; Combined Modality Therapy ; Female ; Floxuridine/therapeutic use ; Hepatic Artery ; Humans ; Injections, Intra-Arterial ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Mitomycin ; Mitomycins/administration & dosage ; Mitomycins/therapeutic use ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/secondary ; Rectal Neoplasms/surgery
    Chemical Substances Carcinoembryonic Antigen ; Mitomycins ; Floxuridine (039LU44I5M) ; Mitomycin (50SG953SK6)
    Language English
    Publishing date 1987-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/1097-0142(19870301)59:5<867::aid-cncr2820590502>3.0.co;2-j
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  3. Article: Hepatic arterial infusion of floxuridine, leucovorin, doxorubicin, and cisplatin for hepatocellular carcinoma: effects of hepatitis B and C viral infection on drug toxicity and patient survival.

    Patt, Y Z / Charnsangavej, C / Yoffe, B / Smith, R / Lawrence, D / Chuang, V / Carrasco, H / Roh, M / Chase, J / Fischer, H

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    1994  Volume 12, Issue 6, Page(s) 1204–1211

    Abstract: ... hepatocellular cancer (HCC) confined to the liver and assess the effects of hepatitis B (HBV) and hepatitis C (HCV ...

    Abstract Purpose: To conduct a pilot trial of hepatic arterial infusion (HAI) of floxuridine (FUDR), leucovorin, Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH), and cisplatin (FLAP) in nonresectable hepatocellular cancer (HCC) confined to the liver and assess the effects of hepatitis B (HBV) and hepatitis C (HCV) viral markers on toxicity, response to treatment, and patient survival.
    Patients and methods: Of 31 HCC patients, 13 were HBV- and HCV-nonreactive, and 18 had evidence of either current or prior HBV and/or HCV infection. Treatment was delivered through percutaneous hepatic arterial catheters, and Infusaid pumps (Shiley Infusaid, Norwood, MA) were placed in responding patients. Cisplatin (100 mg/m2) and Adriamycin (30 to 35 mg/m2) were administered on day 1, followed by a continuous 24-hour HAI of an admixture of floxuridine (60 mg/m2) and leucovorin (15 mg/m2) daily for 4 days. Treatment was repeated every 5 weeks.
    Results: Twelve (41%) of 29 assessable patients had a partial response (PR), with a median time to disease progression of 13 months. Six (50%) of 12 HBV-negative (HBV-)/HCV-negative (HCV-) and six of 17 (35%) HBV-positive (HCV+) and/or HCV-positive (HCV+) patients achieved a PR. Eight patients have been maintained in remission for a median duration greater than 15.5 months. The median survival duration of all 31 patients was 15 months, 7.5 months among HBV+ and/or HCV+ patients, and significantly longer among hepatitis-non-reactive patients (P = .007). (A median has not yet been reached.) Granulocylopenia (< 0.1 x 10(3)/microL), thrombocytopenia (< 25 x 10(3)/microL), and hospitalizations for infectious complications were significantly more common among HBV-HCV-reactive than -nonreactive patients: 56%, 50%, and 67% versus 15%, 15%, and 8%, respectively (P < .05 for all).
    Conclusion: HAI of FLAP has induced long-term PR and has palliated extensive nonresectable HCC. Positive hepatitis serology appeared to increase bone marrow susceptibility to myelotoxic drugs. Conceivably, one or both viruses may have a direct inhibitory effect on bone marrow progenitors and thereby contribute to the observed myelotoxicity.
    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/mortality ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Doxorubicin/administration & dosage ; Doxorubicin/adverse effects ; Female ; Floxuridine/administration & dosage ; Floxuridine/adverse effects ; Hepatic Artery ; Hepatitis B/complications ; Hepatitis C/complications ; Humans ; Infusion Pumps ; Infusions, Intra-Arterial ; Leucovorin/administration & dosage ; Leucovorin/adverse effects ; Liver Neoplasms/complications ; Liver Neoplasms/drug therapy ; Liver Neoplasms/mortality ; Male ; Middle Aged ; Pilot Projects ; Survival Rate
    Chemical Substances Floxuridine (039LU44I5M) ; Doxorubicin (80168379AG) ; Cisplatin (Q20Q21Q62J) ; Leucovorin (Q573I9DVLP)
    Language English
    Publishing date 1994-06
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.1994.12.6.1204
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  4. Article: New imaging modalities for follow-up of colorectal carcinoma.

    Charnsangavej, C

    Cancer

    1993  Volume 71, Issue 12 Suppl, Page(s) 4236–4240

    Abstract: Recurrent disease after curative resection occurred in 37-44% of patients. The common sites of recurrent disease are at the anastomotic site, in the liver, in the lymph nodes, and in the peritoneal linings. Computed tomography (CT), barium enema, and ... ...

    Abstract Recurrent disease after curative resection occurred in 37-44% of patients. The common sites of recurrent disease are at the anastomotic site, in the liver, in the lymph nodes, and in the peritoneal linings. Computed tomography (CT), barium enema, and endoscopy detected local recurrent disease in 61-88% of the patients, whereas magnetic resonance imaging (MRI) detected 80-88% of the cases reported in some Phase 1 studies. CT and MRI are equally effective in the detection of hepatic metastases when lesions are larger than 2 cm, with detectability rate of 95-100%. They are fair (50-60% detectability rate) when tumors are between 1 and 2 cm and poor (less than 40%) when tumors are smaller than 1 cm. For recurrent nodal metastases and peritoneal deposits, CT is the modality of choice.
    MeSH term(s) Colonic Neoplasms/diagnosis ; Colonic Neoplasms/surgery ; Diagnostic Imaging ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/secondary ; Neoplasm Recurrence, Local/diagnosis ; Postoperative Care ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery
    Language English
    Publishing date 1993-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/1097-0142(19930615)71:12+<4236::aid-cncr2820711812>3.0.co;2-5
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  5. Article ; Online: Imaging of pancreatic neoplasms.

    Balachandran, Aparna / Bhosale, Priya R / Charnsangavej, Chuslip / Tamm, Eric P

    Surgical oncology clinics of North America

    2014  Volume 23, Issue 4, Page(s) 751–788

    Abstract: Ductal adenocarcinoma accounts for 85% to 90% of all solid pancreatic neoplasms, is increasing in incidence, and is the fourth leading cause of cancer-related deaths. There are currently no screening tests available for the detection of ductal ... ...

    Abstract Ductal adenocarcinoma accounts for 85% to 90% of all solid pancreatic neoplasms, is increasing in incidence, and is the fourth leading cause of cancer-related deaths. There are currently no screening tests available for the detection of ductal adenocarcinoma. The only chance for cure in pancreatic adenocarcinoma is surgery. Imaging has a crucial role in the identification of the primary tumor, vascular variants, identification of metastases, disease response assessment to treatment, and prediction of respectability. Pancreatic neuroendocrine neoplasms can have a distinctive appearance and pattern of spread, which should be recognized on imaging for appropriate management of these patients.
    MeSH term(s) Algorithms ; Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/epidemiology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Endosonography ; Gastrinoma/diagnosis ; Humans ; Insulinoma/diagnosis ; Magnetic Resonance Imaging ; Multimodal Imaging ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/epidemiology ; Pancreas/anatomy & histology ; Pancreatic Cyst/diagnosis ; Pancreatic Cyst/epidemiology ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Tomography, X-Ray Computed/methods
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2014.07.002
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  6. Article: Lymphoma of the genitourinary tract.

    Charnsangavej, C

    Radiologic clinics of North America

    1990  Volume 28, Issue 4, Page(s) 865–877

    Abstract: Lymphomatous involvement of the genitourinary tract is extremely rare when it presents as primary extranodal disease. It is more common in the advanced stage of disseminated disease. Computed tomography is the best diagnostic modality to detect the ... ...

    Abstract Lymphomatous involvement of the genitourinary tract is extremely rare when it presents as primary extranodal disease. It is more common in the advanced stage of disseminated disease. Computed tomography is the best diagnostic modality to detect the involvement of the genitourinary tract. Although the appearances are generally nonspecific, certain characteristics on computed tomography may suggest and allow for a proper approach to the diagnosis.
    MeSH term(s) Female ; Hodgkin Disease/diagnostic imaging ; Hodgkin Disease/pathology ; Humans ; Lymphoma, Non-Hodgkin/diagnostic imaging ; Lymphoma, Non-Hodgkin/pathology ; Male ; Radiography ; Urogenital Neoplasms/diagnostic imaging ; Urogenital Neoplasms/pathology
    Language English
    Publishing date 1990-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
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  7. Article ; Online: Perfusion CT findings in patients with metastatic carcinoid tumors undergoing bevacizumab and interferon therapy.

    Ng, Chaan S / Charnsangavej, Chuslip / Wei, Wei / Yao, James C

    AJR. American journal of roentgenology

    2011  Volume 196, Issue 3, Page(s) 569–576

    Abstract: Objective: The purpose of this article is to assess tumor changes on perfusion CT with bevacizumab and interferon (IFN) therapy in patients with metastatic carcinoid tumors and to evaluate perfusion CT differences between the two therapies.: Subjects ... ...

    Abstract Objective: The purpose of this article is to assess tumor changes on perfusion CT with bevacizumab and interferon (IFN) therapy in patients with metastatic carcinoid tumors and to evaluate perfusion CT differences between the two therapies.
    Subjects and methods: In a phase 2 clinical trial, 44 patients were randomized to receive monotherapy with bevacizumab or IFN for 18 weeks (stage 1), followed by dual-therapy with both drugs (stage 2). Twenty-four patients consented to have optional perfusion CT examinations, which were undertaken at baseline and 18 weeks and at intervening 2 days (bevacizumab arm) or 9 weeks (IFN arm), and subsequently at 2 days after the addition of bevacizumab (IFN arm) and 9 weeks after the addition of IFN (bevacizumab arm). Tumor blood flow, blood volume, and permeability were evaluated.
    Results: In the bevacizumab arm (n = 12), mean (± SD) blood flow reduced significantly after 2 days compared with baseline (16.2 ± 6.9 vs 32.3 ± 21.3 mL/min/100 g; p = 0.02), a 41.4% reduction (p < 0.0001) that was relatively fixed. Blood volume was similarly reduced from baseline values (2.8 ± 1.3 vs 4.3 ± 2.1 mL/100 g; p = 0.02), a 27.9% reduction (p < 0.02). Both measures remained essentially unchanged at 18 weeks. Similar changes in blood flow and blood volume were observed with the addition of bevacizumab in stage 2. No significant changes in blood flow or blood volume were detected in the IFN arm (n = 12), and no significant changes in permeability were detected in either arm.
    Conclusion: Perfusion CT detects significant changes in perfusion parameters in metastatic carcinoid tumors treated with bevacizumab. Such changes are apparent just 2 days into therapy, are sustained, and are significantly different from those associated with IFN treatment. Tumor blood flow decreased with bevacizumab treatment by a relatively fixed percentage relative to baseline measurements.
    MeSH term(s) Adult ; Aged ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Bevacizumab ; Carcinoid Tumor/diagnostic imaging ; Carcinoid Tumor/drug therapy ; Carcinoid Tumor/pathology ; Contrast Media ; Disease Progression ; Drug Therapy, Combination ; Female ; Humans ; Interferon-alpha/administration & dosage ; Interferon-alpha/therapeutic use ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Recombinant Proteins ; Tomography, X-Ray Computed/methods ; Triiodobenzoic Acids
    Chemical Substances Angiogenesis Inhibitors ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Contrast Media ; Interferon-alpha ; Recombinant Proteins ; Triiodobenzoic Acids ; Bevacizumab (2S9ZZM9Q9V) ; interferon alfa-2b (43K1W2T1M6) ; ioversol (N3RIB7X24K)
    Language English
    Publishing date 2011-03
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.10.4455
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  8. Article ; Online: Planning and follow-up after ablation of hepatic tumors: imaging evaluation.

    Boonsirikamchai, Piyaporn / Loyer, Evelyne M / Choi, Haesun / Charnsangavej, Chusilp

    Surgical oncology clinics of North America

    2011  Volume 20, Issue 2, Page(s) 301–15, viii

    Abstract: CTs or MRIs are essential for preablative therapy planning of hepatic tumors to identify accurate size, number, and location of tumors. Tumors larger than 5 cm and located near the major branches of the portal vein and hepatic vein have a higher ... ...

    Abstract CTs or MRIs are essential for preablative therapy planning of hepatic tumors to identify accurate size, number, and location of tumors. Tumors larger than 5 cm and located near the major branches of the portal vein and hepatic vein have a higher potential for incomplete ablation. Postablative imaging studies are needed to determine if the entire tumors are included in the treatment zone to minimize the risk of local tumor recurrences. Complications of ablative therapy can be identified on post-treatment imaging studies.
    MeSH term(s) Ablation Techniques ; Diagnostic Imaging ; Follow-Up Studies ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/surgery ; Research Design
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1196919-2
    ISSN 1558-5042 ; 1055-3207
    ISSN (online) 1558-5042
    ISSN 1055-3207
    DOI 10.1016/j.soc.2010.11.007
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  9. Article: Pancreatic cancer: current concepts in imaging for diagnosis and staging.

    Tamm, E / Charnsangavej, C

    Cancer journal (Sudbury, Mass.)

    2001  Volume 7, Issue 4, Page(s) 298–311

    Abstract: Because of its late clinical presentation, pancreatic cancer remains the fourth most common cause of cancer death. Surgery is the only option for cure, and advancements in surgical technique and neoadjuvant therapy have the potential to increase the ... ...

    Abstract Because of its late clinical presentation, pancreatic cancer remains the fourth most common cause of cancer death. Surgery is the only option for cure, and advancements in surgical technique and neoadjuvant therapy have the potential to increase the number of patients who could undergo surgery for potential cure. Accurate diagnosis and staging of pancreatic ductal carcinoma are therefore of great importance. This paper reviews the state of the art for such diagnostic modalities as computed tomography, magnetic resonance imaging, endoscopic ultrasound, positron emission tomography, and laparoscopic surgery and laparoscopic ultrasound for diagnosis and staging of pancreatic cancer. Currently, accurate diagnosis and staging probably require the use of a combination of techniques, including multiphase helical or multidetector computed tomography and/or dynamically enhanced magnetic resonance imaging with endoscopic ultrasound with fine-needle aspiration. The role of positron emission tomography still needs to be determined. The role of laparoscopic surgery and laparoscopic ultrasound may be limited in those institutions with state-of-the-art imaging techniques.
    MeSH term(s) Diagnosis, Differential ; Diagnostic Imaging/methods ; Humans ; Magnetic Resonance Imaging ; Neoplasm Metastasis ; Neoplasm Staging/instrumentation ; Neoplasm Staging/methods ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Tomography, Emission-Computed ; Tomography, X-Ray Computed ; Ultrasonography
    Language English
    Publishing date 2001-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2018400-1
    ISSN 1528-9117 ; 1081-4442
    ISSN 1528-9117 ; 1081-4442
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  10. Article: Are there predictors for failed expectant management of cervical intraepithelial neoplasia 1?

    Dunn, Terry S / Charnsangavej, Chutaporn / Wolf, Douglas

    The Journal of reproductive medicine

    2008  Volume 53, Issue 3, Page(s) 213–216

    Abstract: Objective: To identify the short-term natural history of cervical intraepithelial neoplasia (CIN) 1 and the potential risk factors for its progression, regression and persistence and to identify any characteristics of patients who were lost to follow-up. ...

    Abstract Objective: To identify the short-term natural history of cervical intraepithelial neoplasia (CIN) 1 and the potential risk factors for its progression, regression and persistence and to identify any characteristics of patients who were lost to follow-up.
    Study design: All colposcopic specimens from July 2001 through December 2004 were evaluated for the presence of CIN 1. Adequate follow-up was defined as 24 months of surveillance with Pap smears every 4-6 months. The chi2 and Student t test were performed for analysis.
    Results: Three hundred sixty women who had colposcopic specimens with the presence of CIN 1 were evaluated. Persistence of CIN 1 and progression to CIN 2 and 3 were associated with pregnancy at the time of colposcopy (p = 0.04), history of sexually transmitted diseases (p = 0.007) and age at first intercourse (p = 0.04). Age (p = 0.001) and no prior history of abnormal Pap smears (p = 0.001) were associated with the rate of loss to follow-up.
    Conclusion: Expectant management for the majority of patients with biopsy-proven CIN 1 is appropriate, but some risk factors might influence that decision. In this study, age at first intercourse was the only independent predictor of failure to resolve CIN 1 on multivariate analysis.
    MeSH term(s) Adult ; Age Factors ; Cervical Intraepithelial Neoplasia/pathology ; Coitus ; Colposcopy/methods ; Female ; Follow-Up Studies ; Humans ; Multivariate Analysis ; Pregnancy ; Prognosis ; Risk Factors ; Uterine Cervical Neoplasms/pathology
    Language English
    Publishing date 2008-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390916-5
    ISSN 1943-3565 ; 0024-7758
    ISSN (online) 1943-3565
    ISSN 0024-7758
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