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Article: Immune cholangitis related to anti-programmed cell death and programmed cell death ligand agents for the treatment of intrahepatic cholangiocarcinoma.

Huang, Wenpeng / Zhang, Yongbai / Liu, Yongshun / Sun, Zhaonan

Revista espanola de enfermedades digestivas

2024

Abstract: Anti-programmed cell death (anti-PD1) and anti-programmed cell death ligand (anti-PDL1) agents represent a burgeoning field of immunotherapy with an expanding array of indications. In this report, we present the observation of a patient with intrahepatic ...

Abstract	Anti-programmed cell death (anti-PD1) and anti-programmed cell death ligand (anti-PDL1) agents represent a burgeoning field of immunotherapy with an expanding array of indications. In this report, we present the observation of a patient with intrahepatic cholangiocarcinoma exhibiting features of immune-related cholangitis.
Language	English
Publishing date	2024-02-02
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2024.10284/2024
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Article ; Online: Dynamic behavior of the single-strand DNA molecules from the hydrophilic to hydrophobic regions on graphene oxide surface driven by heating.

Wu, Mengjiao / Huang, Yingying / Yang, Li / Song, Yongshun / Lei, Xiaoling

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 23, Page(s) 15807–15814

Abstract: Heating affects the interfacial properties of two-dimensional nanomaterials, especially when they interact with biomolecules. Here, we theoretically studied the dynamic processes driving single-strand DNA (ssDNA) molecules from the hydrophilic to ... ...

Abstract	Heating affects the interfacial properties of two-dimensional nanomaterials, especially when they interact with biomolecules. Here, we theoretically studied the dynamic processes driving single-strand DNA (ssDNA) molecules from the hydrophilic to hydrophobic regions on the graphene oxide (GO) surface by heating, as reported by recent experiments. This was accomplished by using multi-sample molecular dynamics simulations in the
MeSH term(s)	Heating ; DNA, Single-Stranded ; Water/chemistry ; Molecular Dynamics Simulation ; Graphite/chemistry ; Hydrophobic and Hydrophilic Interactions
Chemical Substances	graphene oxide ; DNA, Single-Stranded ; Water (059QF0KO0R) ; Graphite (7782-42-5)
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp00911d
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Article ; Online: Genome-Wide Identification and Analysis of

Liu, Yuqi / Wang, Mingyu / Huang, Yongshun / Zhu, Peng / Qian, Guangtao / Zhang, Yiming / Li, Lixin

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Soil saline-alkalization inhibits plant growth and development and seriously affects crop yields. Over their long-term evolution, plants have formed complex stress response systems to maintain species continuity. R2R3-MYB transcription factors are one of ...

Abstract	Soil saline-alkalization inhibits plant growth and development and seriously affects crop yields. Over their long-term evolution, plants have formed complex stress response systems to maintain species continuity. R2R3-MYB transcription factors are one of the largest transcription factor families in plants, widely involved in plant growth and development, metabolism, and stress response. Quinoa (
MeSH term(s)	Chenopodium quinoa/genetics ; Chenopodium quinoa/metabolism ; Amino Acid Sequence ; Plant Proteins/metabolism ; Genes, myb ; Arabidopsis/genetics ; Transcription Factors/metabolism ; Phylogeny ; Gene Expression Regulation, Plant
Chemical Substances	Plant Proteins ; Transcription Factors
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119132
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Article ; Online: Mass testing to support sustained containment of COVID-19.

Cheng, Weibin / Zhao, Na / Qin, Yiru / Tian, Junzhang / Huang, Yongshun

Journal of global health

2021 Volume 11, Page(s) 3114

MeSH term(s)	COVID-19 ; Humans ; Mass Screening ; SARS-CoV-2
Language	English
Publishing date	2021-10-02
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.11.03114
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Article ; Online: Genome-Wide Identification and Analysis of R2R3-MYB Genes Response to Saline–Alkali Stress in Quinoa

Yuqi Liu / Mingyu Wang / Yongshun Huang / Peng Zhu / Guangtao Qian / Yiming Zhang / Lixin Li

International Journal of Molecular Sciences, Vol 24, Iss 9132, p

2023 Volume 9132

Abstract: Soil saline–alkalization inhibits plant growth and development and seriously affects crop yields. Over their long-term evolution, plants have formed complex stress response systems to maintain species continuity. R2R3-MYB transcription factors are one of ...

Abstract	Soil saline–alkalization inhibits plant growth and development and seriously affects crop yields. Over their long-term evolution, plants have formed complex stress response systems to maintain species continuity. R2R3-MYB transcription factors are one of the largest transcription factor families in plants, widely involved in plant growth and development, metabolism, and stress response. Quinoa ( Chenopodium quinoa Willd.), as a crop with high nutritional value, is tolerant to various biotic and abiotic stress. In this study, we identified 65 R2R3-MYB genes in quinoa, which are divided into 26 subfamilies. In addition, we analyzed the evolutionary relationships, protein physicochemical properties, conserved domains and motifs, gene structure, and cis-regulatory elements of CqR2R3-MYB family members. To investigate the roles of CqR2R3-MYB transcription factors in abiotic stress response, we performed transcriptome analysis to figure out the expression file of CqR2R3-MYB genes under saline–alkali stress. The results indicate that the expression of the six CqMYB2R genes was altered significantly in quinoa leaves that had undergone saline–alkali stress. Subcellular localization and transcriptional activation activity analysis revealed that CqMYB2R09, CqMYB2R16, CqMYB2R25, and CqMYB2R62, whose Arabidopsis homologues are involved in salt stress response, are localized in the nucleus and exhibit transcriptional activation activity. Our study provides basic information and effective clues for further functional investigation of CqR2R3-MYB transcription factors in quinoa.
Keywords	transcription factors ; CqMYB2Rs ; stress response ; metabolism ; transcriptome analysis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Occupational noise and hypertension in Southern Chinese workers: a large occupational population-based study.

Zhou, Shanyu / Hu, Shijie / Ding, Kexin / Wen, Xianzhong / Li, Xudong / Huang, Yongshun / Chen, Jiabin / Chen, Dafang

BMC public health

2024 Volume 24, Issue 1, Page(s) 541

Abstract: Introduction: An increasing number of original studies suggested that occupational noise exposure might be associated with the risk of hypertension, but the results remain inconsistent and inconclusive. In addition, the attributable fraction (AF) of ... ...

Abstract	Introduction: An increasing number of original studies suggested that occupational noise exposure might be associated with the risk of hypertension, but the results remain inconsistent and inconclusive. In addition, the attributable fraction (AF) of occupational noise exposure has not been well quantified. We aimed to conduct a large-scale occupational population-based study to comprehensively investigate the relationship between occupational noise exposure and blood pressure and different hypertension subtypes and to estimate the AF for hypertension burden attributable to occupational noise exposure. Methods: A total of 715,135 workers aged 18-60 years were included in this study based on the Key Occupational Diseases Surveillance Project of Guangdong in 2020. Multiple linear regression was performed to explore the relationships of occupational noise exposure status, the combination of occupational noise exposure and binaural high frequency threshold on average (BHFTA) with systolic and diastolic blood pressure (SBP, DBP). Multivariable logistic regression was used to examine the relationshipassociation between occupational noise exposure status, occupational noise exposure combined with BHFTA and hypertension. Furthermore, the attributable risk (AR) was calculated to estimate the hypertension burden attributed to occupational exposure to noise. Results: The prevalence of hypertension among occupational noise-exposed participants was 13·7%. SBP and DBP were both significantly associated with the occupational noise exposure status and classification of occupational noise exposure combined with BHFTA in the crude and adjusted models (all P < 0·0001). Compared with workers without occupational noise exposure, the risk of hypertension was 50% greater among those exposed to occupational noise in the adjusted model (95% CI 1·42-1·58). For participants of occupational noise exposed with BHFTA normal, and occupational noise exposed with BHFTA elevated, the corresponding risks of hypertension were 48% (1·41-1·56) and 56% (1·46-1·63) greater than those of occupational noise non-exposed with BHFTA normal, respectively. A similar association was found in isolated systolic hypertension (ISH) and prehypertension. Subgroup analysis by sex and age showed that the positive associations between occupational noise exposure and hypertension remained statistically significant across all subgroups (all P < 0.001). Significant interactions between occupational noise status, classification of occupational noise exposure combined with BHFTA, and age in relation to hypertension risk were identified (all P for interaction < 0.001). The associations of occupational noise status, classification of occupational noise exposure combined with BHFTA and hypertension were most pronounced in the 18-29 age groups. The AR% of occupational noise exposure for hypertension was 28·05% in the final adjusted model. Conclusions: Occupational noise exposure was positively associated with blood pressure levels and the prevalence of hypertension, ISH, and prehypertension in a large occupational population-based study. A significantly increased risk of hypertension was found even in individuals with normal BHFTA exposed to occupational noise, with a further elevated risk observed in those with elevated BHFTA. Our findings provide epidemiological evidence for key groups associated with occupational noise exposure and hypertension, and more than one-fourth of hypertension cases would have been prevented by avoiding occupational noise exposure.
MeSH term(s)	Humans ; Noise, Occupational/adverse effects ; Prehypertension ; Cross-Sectional Studies ; Hypertension/epidemiology ; Hypertension/etiology ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; Occupational Diseases/epidemiology ; Hearing Loss, Noise-Induced/etiology ; China/epidemiology
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18040-9
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Article ; Online: Genome-Wide Identification and Analysis of Stress Response of Trehalose-6-Phosphate Synthase and Trehalose-6-Phosphate Phosphatase Genes in Quinoa.

Wang, Xiaoting / Wang, Mingyu / Huang, Yongshun / Zhu, Peng / Qian, Guangtao / Zhang, Yiming / Liu, Yuqi / Zhou, Jingwen / Li, Lixin

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: Saline-alkali stress seriously affects the yield and quality of crops, threatening food security and ecological security. Improving saline-alkali land and increasing effective cultivated land are conducive to sustainable agricultural development. ... ...

Abstract	Saline-alkali stress seriously affects the yield and quality of crops, threatening food security and ecological security. Improving saline-alkali land and increasing effective cultivated land are conducive to sustainable agricultural development. Trehalose, a nonreducing disaccharide, is closely related to plant growth and development and stress response. Trehalose 6-phosphate synthase (TPS) and trehalose-6-phosphate phosphatase (TPP) are key enzymes catalyzing trehalose biosynthesis. To elucidate the effects of long-term saline-alkali stress on trehalose synthesis and metabolism, we conducted an integrated transcriptome and metabolome analysis. As a result, 13
MeSH term(s)	Chenopodium quinoa/genetics ; Chenopodium quinoa/metabolism ; Trehalose/genetics ; Trehalose/metabolism ; Phylogeny ; Glucosyltransferases/genetics ; Glucosyltransferases/metabolism ; Gene Expression Regulation, Plant
Chemical Substances	trehalose-phosphatase (EC 3.1.3.12) ; trehalose-6-phosphate synthase (EC 2.4.1.15) ; Trehalose (B8WCK70T7I) ; Glucosyltransferases (EC 2.4.1.-)
Language	English
Publishing date	2023-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24086950
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Article ; Online: Characterization of metal resistance genes carried by waterborne free-living and particle-attached bacteria in the Pearl River Estuary.

Xie, Xiuqin / Yuan, Ke / Chen, Xin / Zhao, Zongshan / Huang, Yongshun / Hu, Ligang / Liu, Hongtao / Luan, Tiangang / Chen, Baowei

Environmental pollution (Barking, Essex : 1987)

2023 Volume 327, Page(s) 121547

Abstract: Toxic metals can substantially change the bacterial community and functions thereof in aquatic environments. Herein, metal resistance genes (MRGs) are the core genetic foundation for microbial responses to the threats of toxic metals. In this study, ... ...

Abstract	Toxic metals can substantially change the bacterial community and functions thereof in aquatic environments. Herein, metal resistance genes (MRGs) are the core genetic foundation for microbial responses to the threats of toxic metals. In this study, waterborne bacteria collected from the Pearl River Estuary (PRE) were separated into the free-living bacteria (FLB) and particle-attached bacteria (PAB), and analyzed using metagenomic approaches. MRGs were ubiquitous in the PRE water and mainly related to Cu, Cr, Zn, Cd and Hg. The levels of PAB MRGs in the PRE water ranged from 8.11 × 10
MeSH term(s)	Rivers/microbiology ; Estuaries ; RNA, Ribosomal, 16S/genetics ; Bacteria/genetics ; Metals, Heavy/toxicity ; Metals, Heavy/analysis ; Genes, Bacterial ; Water
Chemical Substances	RNA, Ribosomal, 16S ; Metals, Heavy ; Water (059QF0KO0R)
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121547
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Article ; Online: Superoxide anion generation response to wound in Arabidopsis hypocotyl cutting.

Ren, Xufang / Wang, Mengfang / Wang, Yongshun / Huang, Aixia

Plant signaling & behavior

2020 Volume 16, Issue 2, Page(s) 1848086

Abstract: Cutting is a frequently used model to study the process of adventitious root formation, and excision of cuttings leads to rapid wound response signaling. We recently showed that as a wound signal, reactive oxygen species (ROS, mainly hydrogen peroxide) ... ...

Abstract	Cutting is a frequently used model to study the process of adventitious root formation, and excision of cuttings leads to rapid wound response signaling. We recently showed that as a wound signal, reactive oxygen species (ROS, mainly hydrogen peroxide) participate in adventitious root induction of hypocotyl cuttings through regulation of auxin biosynthesis and transport. Here, superoxide anion (O
MeSH term(s)	Arabidopsis/drug effects ; Arabidopsis/metabolism ; Onium Compounds/pharmacology ; Plant Roots/drug effects ; Plant Roots/metabolism ; Reactive Oxygen Species/metabolism ; Superoxides/metabolism
Chemical Substances	Onium Compounds ; Reactive Oxygen Species ; Superoxides (11062-77-4) ; diphenyleneiodonium (6HJ411TU98)
Language	English
Publishing date	2020-11-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1559-2324
ISSN (online)	1559-2324
DOI	10.1080/15592324.2020.1848086
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Article ; Online: Lead activates neutrophil degranulation to induce early myocardial injury in mice.

Wu, Yanjun / Huang, Hongmei / Wu, Jiayun / Qin, Yiru / Zhao, Na / Chen, Baowei / Nong, Qiying / Huang, Yongshun / Hu, Ligang

Ecotoxicology and environmental safety

2023 Volume 268, Page(s) 115694

Abstract: Lead (Pb) is a pervasive toxic metal contaminant associated with a high risk of myocardial injury. However, the precise mechanism underlying Pb-induced myocardial injury has yet to be fully elucidated. In this study, a murine model of Pb exposure (0, 1, ... ...

Abstract	Lead (Pb) is a pervasive toxic metal contaminant associated with a high risk of myocardial injury. However, the precise mechanism underlying Pb-induced myocardial injury has yet to be fully elucidated. In this study, a murine model of Pb exposure (0, 1, 5, and 10 mg/kg) was employed to investigate the involvement of neutrophil degranulation in the induction of myocardial injury. Notably, serum levels of cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) increased significantly in Pb-exposed mice, whereas cTnI levels in cardiomyocytes decreased, suggesting that Pb exposure may cause early myocardial injury. Moreover, Pb exposure was found to promote neutrophil degranulation, as evidenced by elevated myeloperoxidase (MPO) and neutrophil elastase (NE) concentrations in both the serum of Pb-exposed workers and Pb-exposed mice, as well as the extracellular supernatant of neutrophils following exposure. However, we found that serum level of cTnI enhanced by Pb exposure is associated with increased NE levels in the serum, but not with MPO levels. Upon treatment with NE inhibitor (sivelestat), the serum level of cTnI markedly reduced in Pb-exposed mice, we found that early myocardial injury is associated with NE levels in the serum. At the molecular level, western blotting analysis revealed an upregulation of ERK1/2 expression in vitro following Pb exposure, suggesting that the activation of the ERK1/2 signaling pathway may underlie the participation of neutrophil degranulation in Pb-induced myocardial injury. In summary, our findings demonstrate that Pb exposure can initiate early myocardial injury by promoting the neutrophil degranulation process, thereby highlighting the potential role of this process in the pathogenesis of Pb-associated myocardial injury.
MeSH term(s)	Mice ; Animals ; Neutrophils/metabolism ; Lead/toxicity ; Myocytes, Cardiac/metabolism ; Leukocyte Elastase/metabolism
Chemical Substances	Lead (2P299V784P) ; Leukocyte Elastase (EC 3.4.21.37)
Language	English
Publishing date	2023-11-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.115694
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