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Article ; Online: D-dimer and Beyond: Harnessing the Potential of New Coagulation Indicators in COVID-19 Management.

Shibahashi, Eiji / Jujo, Kentaro

2023 Volume 62, Issue 20, Page(s) 2929–2930

MeSH term(s)	Humans ; COVID-19 ; Fibrin Fibrinogen Degradation Products ; Blood Coagulation ; Blood Coagulation Disorders/diagnosis ; Disseminated Intravascular Coagulation
Chemical Substances	fibrin fragment D ; Fibrin Fibrinogen Degradation Products
Language	English
Publishing date	2023-08-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2355-23
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Article ; Online: Leaving Nothing Is Leaving Unanswered Questions　- Drug-Coated Balloon Angioplasty for Femoropopliteal Artery.

Shibahashi, Eiji / Jujo, Kentaro

Circulation journal : official journal of the Japanese Circulation Society

2021 Volume 85, Issue 12, Page(s) 2157–2158

MeSH term(s)	Angioplasty, Balloon ; Femoral Artery/diagnostic imaging ; Femoral Artery/surgery ; Humans
Language	English
Publishing date	2021-10-28
Publishing country	Japan
Document type	Editorial ; Comment
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-21-0798
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Article ; Online: Myocardial bridging may shed light on one aspect of unexplained myocardial infarction with non-obstructive coronary arteries.

Abe, Takuro / Jujo, Kentaro / Matsukage, Takashi

European heart journal. Acute cardiovascular care

2022 Volume 11, Issue 6, Page(s) 508–509

MeSH term(s)	Coronary Angiography/methods ; Coronary Vessels/diagnostic imaging ; Humans ; MINOCA ; Myocardial Bridging/diagnosis ; Myocardial Bridging/diagnostic imaging ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis
Language	English
Publishing date	2022-06-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2663340-1
ISSN	2048-8734 ; 2048-8726
ISSN (online)	2048-8734
ISSN	2048-8726
DOI	10.1093/ehjacc/zuac074
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Article ; Online: Oral nutritional supplements in older outpatients with heart failure: rationale and design of the ALIMENT-HF trial.

Fujimoto, Yudai / Dotare, Taishi / Maekawa, Emi / Kamiya, Kentaro / Kitai, Takeshi / Kuwahara, Koichiro / Sugano, Teruyasu / Konishi, Masaaki / Ohtani, Tomohito / Sakamoto, Yoko / Jujo, Kentaro / Noda, Chiharu / Ako, Junya / Yanagisawa, Naotake / Matsue, Yuya

ESC heart failure

2024

Abstract: Aims: The ALIMENT-HF trial aims to determine whether high-calorie and high-protein oral nutritional supplements (ONS) are safe and beneficial for older adult outpatients with heart failure (HF).: Methods and results: This multicentre, single-arm, ... ...

Abstract	Aims: The ALIMENT-HF trial aims to determine whether high-calorie and high-protein oral nutritional supplements (ONS) are safe and beneficial for older adult outpatients with heart failure (HF). Methods and results: This multicentre, single-arm, interventional pilot trial is designed to evaluate the tolerance, efficacy, and safety of ONS in older adult outpatients with chronic HF, malnutrition, and anorexia. In total, 80 outpatients with HF regardless of their left ventricular ejection fraction will be treated with ONS, including high-energy (900 kcal/day) and high protein (36 g/day) supplementation, at eight sites in Japan. Inclusion criteria are as follows: age, ≥65 years; outpatients receiving maximally tolerated guideline-directed medical therapy for HF and without change in their diuretic dosage during the last 3 months; outpatients at risk of malnutrition, defined as a Malnutrition Universal Screening Tool score ≥1 point, and anorexia, defined using a Simplified Nutritional Appetite Questionnaire for the Japanese Elderly (SNAQ-JE) score of ≤14 points. Nutritional intervention will continue for up to 120 days, with an observational period lasting for a further 60 days. The primary outcome is a change in body weight between baseline and day 120. Conclusions: The ALIMENT-HF trial will evaluate the tolerance, efficacy, and safety of high-calorie and high-protein-rich ONS in older outpatients with HF co-morbid with malnutrition and anorexia and will provide insightful information for future randomized controlled trials.
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14800
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Article ; Online: Alternative Exercise Intervention for Patients With Severe Peripheral Artery Disease　- Akt1-Induced Blood Flow Recovery.

Jujo, Kentaro / Hagiwara, Nobuhisa

Circulation journal : official journal of the Japanese Circulation Society

2018 Volume 82, Issue 11, Page(s) 2705–2706

MeSH term(s)	Animals ; Exercise Therapy ; Heme Oxygenase-1 ; Hindlimb ; Humans ; Ischemia ; Peripheral Arterial Disease ; Proto-Oncogene Proteins c-akt
Chemical Substances	Heme Oxygenase-1 (EC 1.14.14.18) ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2018-10-06
Publishing country	Japan
Document type	Editorial ; Comment
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-18-1061
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Article ; Online: Recurrent takotsubo syndrome with worsening of left ventricular outflow obstruction during haemodialysis: a case report.

Takada, Takuma / Jujo, Kentaro / Ishida, Issei / Hagiwara, Nobuhisa

European heart journal. Case reports

2020 Volume 4, Issue 2, Page(s) 1–6

Abstract: Background: The recurrence rate of takotsubo syndrome (TS) has been reported as 1.8% per patient-year while left ventricular outflow tract (LVOT) obstruction is comorbid in 10-25% of all instances of TS. The clinical course of recurrent TS with ... ...

Abstract	Background: The recurrence rate of takotsubo syndrome (TS) has been reported as 1.8% per patient-year while left ventricular outflow tract (LVOT) obstruction is comorbid in 10-25% of all instances of TS. The clinical course of recurrent TS with associated LVOT while on haemodialysis has rarely been reported. Case summary: This case report involves a 60-year-old female patient receiving regular haemodialysis who was admitted for chest pain during ballroom dancing. Four years prior, she had suffered TS, and fully recovered after the hospitalization. An emergent coronary angiogram done during the second hospitalization showed no significant stenosis, and left ventriculography demonstrated mid-apical akinesia and basal hyperkinesia. Based on these findings, we diagnosed the recurrence of TS. Later in the admission, chest pain reappeared with the start of haemodialysis. A transthoracic echocardiogram demonstrated mean pressure gradient (PG) of LVOT was 58 mmHg, with systolic anterior motion of the mitral valve and basal-wall hyperkinesia. The main aetiology for her symptoms was considered as an exacerbation of LVOT obstruction due to removing intravascular volume by haemodialysis. After starting landiolol at 3 μg/kg/min, PG of LVOT and symptoms gradually improved with uptitration of landiolol. Finally, her chest pain resolved when mean PG of LVOT was down to 38 mmHg using 10 μg/kg/min of landiolol. Discussion: To our knowledge, this is the first report of a recurrent TS case comorbid with LVOT obstruction while on regular haemodialysis. Landiolol, the ultrashort-acting beta-blocker, may be a promising therapeutic option for rapid recovery of increased PG due to LVOT obstruction.
Language	English
Publishing date	2020-02-21
Publishing country	England
Document type	Journal Article
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytaa024
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Article ; Online: Prognostic Impact of Statins on Patients With Peripheral Artery Disease With Elevated C-Reactive Protein Levels.

Shibahashi, Eiji / Jujo, Kentaro / Mizobuchi, Keiko / Nakao, Masashi / Uchigata, Yasuko / Yamaguchi, Junichi

The American journal of cardiology

2022 Volume 186, Page(s) 142–149

Abstract: This study aimed to elucidate the prognostic influence of statins in relation to the degree of inflammation at the time of endovascular therapy (EVT) for patients with peripheral artery disease (PAD). This observational study included patients with PAD ... ...

Abstract	This study aimed to elucidate the prognostic influence of statins in relation to the degree of inflammation at the time of endovascular therapy (EVT) for patients with peripheral artery disease (PAD). This observational study included patients with PAD who underwent EVT, including 285 statin users and 275 statin non-users. They were assigned into four groups depending on C-reactive protein (CRP) level at the time of EVT: low CRP (<0.1 mg/dL), intermediate-low CRP (0.1-0.3 mg/dL), intermediate-high CRP (0.3-1.0 mg/dL), and high CRP (>1.0 mg/dL). A composite of death and major amputation as the primary endpoint was compared between statin users and non-users in each CRP category. Overall, statin users showed a lower event rate than non-users (log-rank, p=0.02). However, the event rates did not differ significantly between statin users and non-users in the low, intermediate-low, and intermediate-high CRP categories. In the high CRP category, statin users showed a lower event rate than non-users (p=0.002). In this population, multivariate Cox regression analysis revealed that statin use was independently associated with the primary endpoint (hazard ratio: 0.28 [95% confidence interval: 0.14-0.55]). Statins may exert favorable prognostic effects in PAD patients with highly elevated CRP levels, but not in those with low-to-moderate CRP levels.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Prognosis ; C-Reactive Protein/metabolism ; Peripheral Arterial Disease/drug therapy ; Amputation, Surgical ; Risk Factors
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2022.09.018
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Article ; Online: Review of Bleeding and Thrombotic Risks Associated With Antithrombotic Therapy After Transcatheter Structural Heart Interventions.

Kawashima, Hideyuki / Numasawa, Yohei / Hayakawa, Naoki / Asano, Taku / Tanaka, Shigemitsu / Torii, Sho / Ueshima, Daisuke / Hishikari, Keiichi / Hioki, Hirofumi / Watanabe, Yusuke / Mizutani, Kazuki / Matsuo, Yae / Hayashida, Kentaro / Jujo, Kentaro / Nakazawa, Gaku

JACC. Asia

2023 Volume 4, Issue 1, Page(s) 1–9

Abstract: Transcatheter structural heart interventions have drastically evolved over the past 2 decades. However, most catheterization procedures require the deployment of devices in the body; therefore, the adhesion of thrombi to those devices is a major problem, ...

Abstract	Transcatheter structural heart interventions have drastically evolved over the past 2 decades. However, most catheterization procedures require the deployment of devices in the body; therefore, the adhesion of thrombi to those devices is a major problem, resulting in the requirement of a period of postprocedural antithrombotic regimen. However, in recent years, bleeding associated with these antithrombotic therapies has also become a major concern, attracting the attention of investigators. This is complicated by the fact that patients at high thrombotic risk are also at high bleeding risk, making the issue of administrating antithrombotic therapy challenging. The objective of this review was to identify the important issues and summarize the current status of postoperative antithrombotic therapy and assessment of the bleeding risk following transcatheter structural heart interventions such as transcatheter aortic valve replacement, transcatheter edge-to-edge repair, and transcatheter left atrial appendage occlusion.
Language	English
Publishing date	2023-10-24
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2772-3747
ISSN (online)	2772-3747
DOI	10.1016/j.jacasi.2023.08.004
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Article ; Online: Bendopnea prevalence and prognostic value in older patients with heart failure: FRAGILE-HF-SONIC-HF post hoc analysis.

European journal of preventive cardiology

2024

Abstract: Aims: This study aimed to investigate the prevalence, clinical characteristics, and prognostic value of bendopnea in older patients hospitalized for heart failure.: Methods: This post hoc analysis was performed using two prospective, multicenter, ... ...

Abstract	Aims: This study aimed to investigate the prevalence, clinical characteristics, and prognostic value of bendopnea in older patients hospitalized for heart failure. Methods: This post hoc analysis was performed using two prospective, multicenter, observational studies: the FRAGILE-HF (main cohort) and SONIC-HF (validation cohort) cohorts. Patients were categorized based on the presence of bendopnea, which was evaluated before discharge. The primary endpoint was 2-year all-cause mortality after discharge. Results: Among the 1,243 patients (median age, 81 years; 57.2% male) in the FRAGILE-HF cohort and 225 (median age, 79 years; 58.2% men) in the SONIC-HF cohort, bendopnea was observed in 31 (2.5%) and 10 (4.4%) patients, respectively. Over a 2-year follow-up period, all-cause death occurred in 20.8% and 21.9% of the patients in the FRAGILE-HF and SONIC-HF cohorts, respectively. Kaplan-Meier survival curves demonstrated significantly higher mortality rates in patients with bendopnea than in those without bendopnea in the FRAGILE-HF (log-rank P = 0.006) and SONIC-HF cohorts (log-rank P = 0.014). Cox proportional hazard analysis identified bendopnea as an independent prognostic factor for all-cause mortality in both the FRAGILE-HF (hazard ratio [HR] 2.11, 95% confidence interval [CI] 1.18-3.78, P = 0.012) and SONIC-HF cohorts (HR 4.20, 95% CI 1.63-10.79, P = 0.003), even after adjusting for conventional risk factors. Conclusions: Bendopnea was observed in a relatively small proportion of older patients hospitalized for heart failure before discharge. However, its presence was significantly associated with an increased risk of all-cause mortality.
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwae128
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Article ; Online: Impact of Multidomain Frailty on the Mode of Death in Older Patients With Heart Failure: A Cohort Study.

Ohashi, Koichi / Matsue, Yuya / Maeda, Daichi / Fujimoto, Yudai / Kagiyama, Nobuyuki / Sunayama, Tsutomu / Dotare, Taishi / Jujo, Kentaro / Saito, Kazuya / Kamiya, Kentaro / Saito, Hiroshi / Ogasahara, Yuki / Maekawa, Emi / Konishi, Masaaki / Kitai, Takeshi / Iwata, Kentaro / Wada, Hiroshi / Hiki, Masaru / Kasai, Takatoshi /

Nagamatsu, Hirofumi / Ozawa, Tetsuya / Izawa, Katsuya / Yamamoto, Shuhei / Aizawa, Naoki / Wakaume, Kazuki / Oka, Kazuhiro / Momomura, Shin-Ichi / Minamino, Tohru

Circulation. Cardiovascular quality and outcomes

2024 , Page(s) e010416

Abstract: Background: Although frailty is strongly associated with mortality in patients with heart failure (HF), the risk of which specific cause of death is associated with being complicated with frailty is unclear. We aimed to clarify the association between ... ...

Abstract	Background: Although frailty is strongly associated with mortality in patients with heart failure (HF), the risk of which specific cause of death is associated with being complicated with frailty is unclear. We aimed to clarify the association between multidomain frailty and the causes of death in elderly patients hospitalized with HF. Methods: We analyzed data from the FRAGILE-HF cohort, where patients aged 65 years and older, hospitalized with HF, were prospectively registered between 2016 and 2018 in 15 Japanese hospitals before discharge and followed up for 2 years. All patients were assessed for physical, social, and cognitive dysfunction, and categorized into 3 groups based on their number of frailty domains (FDs, 0-1, 2, and 3). Kaplan-Meier survival analysis was used to evaluate the association between the number of FDs and all-cause mortality, whereas Fine-Gray competing risk regression analysis was used for assessing the impact on cause-specific mortality. Results: We analyzed 1181 patients with HF (81 years old in median, 57.4% were male), 530 (44.9%), 437 (37.0%), and 214 (18.1%) of whom were categorized into the FD 0 to 1, FD 2, and FD 3 groups, respectively. During the 2-year follow-up, 240 deaths were observed (99 HF deaths, 34 cardiovascular deaths, and 107 noncardiovascular deaths), and an increase in the number of FD was significantly associated with mortality (Log-rank: Conclusions: Although multidomain frailty is strongly associated with mortality in older patients with HF, it is mostly attributable to noncardiovascular death and not cardiovascular death, including HF death. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: UMIN000023929.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483197-9
ISSN	1941-7705 ; 1941-7713
ISSN (online)	1941-7705
ISSN	1941-7713
DOI	10.1161/CIRCOUTCOMES.123.010416
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