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  1. Article ; Online: Twentieth Anniversary of

    Teicher, Beverly A

    Molecular cancer therapeutics

    2021  Volume 20, Issue 11, Page(s) 2097

    MeSH term(s) Anniversaries and Special Events ; Female ; Humans ; Neoplasms/therapy
    Language English
    Publishing date 2021-10-31
    Publishing country United States
    Document type Editorial ; Portrait
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-21-0771
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5750: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Online: Cancer Drug Resistance

    Teicher, Beverly A.

    2006  

    Author's details edited by Beverly A. Teicher
    Keywords Oncology
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387098
    ISBN 978-1-588-29530-9 ; 978-1-597-45035-5 ; 1-588-29530-3 ; 1-597-45035-9
    DOI 10.1007/978-1-59745-035-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Book: Antiangiogenic agents in cancer therapy

    Teicher, Beverly A.

    (Cancer drug discovery and development)

    2008  

    Author's details ed. by Beverly A. Teicher
    Series title Cancer drug discovery and development
    Keywords Neoplasms / diagnosis ; Neovascularization, Pathologic / drug therapy ; Antineoplastic Agents / therapeutic use
    Language English
    Size XVIII, 559 S., [14] Bl. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015378633
    ISBN 978-1-58829-870-6 ; 1-58829-870-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 721 order for loan Magazin

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  4. Book: Cancer drug resistance

    Teicher, Beverly A.

    (Cancer drug discovery and development)

    2006  

    Author's details ed. by Beverly A. Teicher
    Series title Cancer drug discovery and development
    Keywords Drug Resistance, Neoplasm ; Antineoplastic Agents / therapeutic use
    Language English
    Size XVI, 617 S. : Ill., graph. Darst
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014565677
    ISBN 1-58829-530-3 ; 978-1-58829-530-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 2158 order for loan Magazin

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  5. Article ; Online: A Vision from the New Editor-in-Chief.

    Teicher, Beverly A

    Molecular cancer therapeutics

    2019  Volume 18, Issue 3, Page(s) 497

    MeSH term(s) Humans ; Neoplasms/genetics ; Peer Review, Research/trends
    Language English
    Publishing date 2019-01-18
    Publishing country United States
    Document type Editorial
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-19-0094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5750: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: TGFβ-Directed Therapeutics: 2020.

    Teicher, Beverly A

    Pharmacology & therapeutics

    2020  Volume 217, Page(s) 107666

    Abstract: The transforming growth factor-beta (TGFβ) pathway is essential during embryo development and in maintaining normal homeostasis. During malignancy, the TGFβ pathway is co-opted by the tumor to increase fibrotic stroma, to promote epithelial to ... ...

    Abstract The transforming growth factor-beta (TGFβ) pathway is essential during embryo development and in maintaining normal homeostasis. During malignancy, the TGFβ pathway is co-opted by the tumor to increase fibrotic stroma, to promote epithelial to mesenchymal transition increasing metastasis and producing an immune-suppressed microenvironment which protects the tumor from recognition by the immune system. Compelling preclinical data demonstrate the therapeutic potential of blocking TGFβ function in cancer. However, the TGFβ pathway cannot be described as a driver of malignant disease. Two small molecule kinase inhibitors which block the serine-threonine kinase activity of TGFβRI on TGFβRII, a pan-TGFβ neutralizing antibody, a TGFβ trap, a TGFβ antisense agent, an antibody which stabilizes the latent complex of TGFβ and a fusion protein which neutralizes TGFβ and binds PD-L1 are in clinical development. The challenge is how to most effectively incorporate blocking TGFβ activity alone and in combination with other therapeutics to improve treatment outcome.
    MeSH term(s) Animals ; B7-H1 Antigen/metabolism ; Epithelial-Mesenchymal Transition/physiology ; Humans ; Neoplasms/pathology ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Receptor, Transforming Growth Factor-beta Type II/metabolism ; Transforming Growth Factor beta/antagonists & inhibitors ; Transforming Growth Factor beta/metabolism ; Tumor Microenvironment/physiology
    Chemical Substances B7-H1 Antigen ; Transforming Growth Factor beta ; Receptor, Transforming Growth Factor-beta Type I (EC 2.7.11.30) ; Receptor, Transforming Growth Factor-beta Type II (EC 2.7.11.30) ; TGFBR1 protein, human (EC 2.7.11.30) ; TGFBR2 protein, human (EC 2.7.11.30)
    Language English
    Publishing date 2020-08-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2020.107666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Antibody-drug Conjugate Targets, Drugs, and Linkers.

    Teicher, Beverly A / Morris, Joel

    Current cancer drug targets

    2022  Volume 22, Issue 6, Page(s) 463–529

    Abstract: Antibody-drug conjugates offer the possibility of directing powerful cytotoxic agents to a malignant tumor while sparing normal tissue. The challenge is to select an antibody target expressed exclusively or at highly elevated levels on the surface of ... ...

    Abstract Antibody-drug conjugates offer the possibility of directing powerful cytotoxic agents to a malignant tumor while sparing normal tissue. The challenge is to select an antibody target expressed exclusively or at highly elevated levels on the surface of tumor cells and either not all or at low levels on normal cells. The current review explores 78 targets that have been explored as antibody-drug conjugate targets. Some of these targets have been abandoned, 9 or more are the targets of FDA-approved drugs, and most remain active clinical interest. Antibody-drug conjugates require potent cytotoxic drug payloads, several of these small molecules are discussed, as are the linkers between the protein component and small molecule components of the conjugates. Finally, conclusions regarding the elements for the successful antibody-drug conjugate are discussed.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/therapeutic use ; Humans ; Immunoconjugates/therapeutic use ; Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents ; Immunoconjugates
    Language English
    Publishing date 2022-02-24
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2064824-8
    ISSN 1873-5576 ; 1568-0096
    ISSN (online) 1873-5576
    ISSN 1568-0096
    DOI 10.2174/1568009622666220224110538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Audio / Video: Anticancer drug development guide

    Teicher, Beverly A.

    preclinical screening, clinical trials, and approval

    2004  

    Author's details ed. by Beverly A. Teicher
    Keywords Antineoplastic Agents / standards ; Drug Design ; Drug Evaluation, Preclinical ; Drug Approval ; Clinical Trials
    Language English
    Size 1 CD-ROM, 12 cm
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book ; Audio / Video
    Remark Kann auf Multimedia-PC (Lesesaal) installiert werden
    HBZ-ID HT014385478
    ISBN 1-59259-739-4 ; 978-1-59259-739-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 MO 428 order to use in reading room Magazin

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  9. Article ; Online: CD248: A therapeutic target in cancer and fibrotic diseases.

    Teicher, Beverly A

    Oncotarget

    2019  Volume 10, Issue 9, Page(s) 993–1009

    Abstract: CD248/endosialin/TEM1 is a type 1 transmembrane glycoprotein found on the plasma membrane of activated mesenchymal cells. CD248 functions during embryo development and is either not expressed or found at very low levels in adult tissues. CD248 is ... ...

    Abstract CD248/endosialin/TEM1 is a type 1 transmembrane glycoprotein found on the plasma membrane of activated mesenchymal cells. CD248 functions during embryo development and is either not expressed or found at very low levels in adult tissues. CD248 is expressed at high levels by malignant sarcoma cells, by the pericyte component of tumor vasculature and by mesenchymal cells in some fibrotic diseases. CD248 is being targeted by several experimental therapeutics including antibodies, antibody drug conjugates, as an antigen for CART cells and in therapeutic vaccines. Although the function of CD248 has yet to be fully elucidated, this protein is a potential broad scope therapeutic target.
    Language English
    Publishing date 2019-01-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Anticancer drug development guide

    Teicher, Beverly A.

    preclinical screening, clinical trials, and approval

    (Cancer drug discovery and development)

    2004  

    Author's details ed. by Beverly A. Teicher
    Series title Cancer drug discovery and development
    Keywords Antineoplastic Agents / standards ; Drug Design ; Drug Evaluation, Preclinical ; Clinical Trials ; Drug Approval
    Language English
    Size XIV, 450 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014354728
    ISBN 1-58829-228-2 ; 978-1-58829-228-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 2145 order for loan Magazin

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