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Article ; Online: Systemic isotretinoin has an impact on hemoglobin, ferritin, urea, ceruloplasmin, albumin, uric acid levels, and neutrophil to lymphocyte ratio in acne patients.

Hareedy, Mohammad Salem / Tawfik, Khaled Mohamed

2022

Abstract: Background: Patients suffering from moderate-to-severe acne are commonly treated with systemin isotretinoin; however, a great controverse about its safety had been raised. The aim of the present study is to evaluate the effects of isotretinoin on ... ...

Abstract	Background: Patients suffering from moderate-to-severe acne are commonly treated with systemin isotretinoin; however, a great controverse about its safety had been raised. The aim of the present study is to evaluate the effects of isotretinoin on hepatic, renal, and hematologic functions and to evaluate the potential oxidative stress in relation to isotretinoin therapy. Methods: Fifty-three female patients, treated from moderate-severe acne with isotretinoin (0.5 mg/kg/day), were included. Blood samples were taken for measuring low density lipoprotein (LDL), triglycerides, hemoglobin, erythrocyte sedimentation rate (ESR), bilirubin, total protein, albumin, globulin, blood urea nitrogen, ferritin, uric acid, creatinine, C-reactive protein (CRP), ceruloplasmin, alanine transaminase (ALT), aspartate transaminase (AST) levels, and red blood cells (RBC), white blood cells (WBCs), and platelet counts before starting isotretinoin treatment and 6 months later. Results: Isotretinoin was associated with increased levels of triglycerides, LDL, ESR, CRP, uric acid, and ferritin after 6 months of therapy (p < 0.0001), blood urea levels were significantly elevated from 3.681 ± 0.91 to 3.838 ± 0.877 (p = 0.014), ALT, AST, hemoglobin, globulin, and total proteins were significantly elevated after 6 months. Platelets, WBCs, albumin, albumin/globulin ratio, copper, ceruloplasmin, and neutrophil/lymphocyte ratio were significantly decreased after 6 months. Conclusion: Isotretinoin therapy could be associated with oxidative stress and hepatic, lipid, and blood abnormalities in patients with acne. Serum ferritin was elevated while serum ceruloplasmin was decreased. Isotretinoin could also affect immune regulation (decreasing neutrophil to lymphocyte ratio), isotretinoin was associated with a possible positive nitrogen balance (increasing proteins) and with elevations of blood urea nitrogen and uric acid levels.
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15199
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Zs.A 6539: Show issues

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Article ; Online: A feasible HPTLC method for concurrent quantitation of allopurinol-montelukast co-therapy in plasma and evaluation of their hepatic and renal effects in rats: Analytical, biochemical, and histopathological study.

Hosny, Noha M / Badary, Dalia M / Hareedy, Mohammad Salem

Journal of pharmaceutical and biomedical analysis

2023 Volume 233, Page(s) 115439

Abstract: Recent studies presented the crucial role of montelukast (MON, a leukotriene receptor antagonist) against gouty arthritis and its protective effect on drug-induced liver and kidney injury. Allopurinol (ALO, a selective xanthine oxidase inhibitor) is also ...

Abstract	Recent studies presented the crucial role of montelukast (MON, a leukotriene receptor antagonist) against gouty arthritis and its protective effect on drug-induced liver and kidney injury. Allopurinol (ALO, a selective xanthine oxidase inhibitor) is also used for treatment of hyperuricemia, however, it induces hepatotoxicity and acute kidney injury. Therefore, this study introduces the first analytical/biochemical/histopathological assay for MON-ALO co-therapy and aims to: inspect the hepatic and renal impacts of ALO, MON and their combination in rats via biochemical and histopathological examinations, propose and validate a facile HPTLC method for concurrent estimation of ALO-MON binary mixture in human plasma, and employ this method to attain the targeted drugs in real rat plasma. First, the cited drugs in human plasma were simultaneously separated utilizing silica gel G 60 F
MeSH term(s)	Humans ; Rats ; Male ; Animals ; Rats, Wistar ; Allopurinol/pharmacology ; Arthritis, Gouty/pathology ; Reproducibility of Results ; Kidney/pathology ; Liver
Chemical Substances	Allopurinol (63CZ7GJN5I) ; montelukast (MHM278SD3E)
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115439
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Article ; Online: Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment.

Salem Hareedy, Mohammad / Mahmoud, Waleed Ahmed / Tawfik, Khaled Mohamed

Clinical and experimental pharmacology & physiology

2021 Volume 48, Issue 10, Page(s) 1317–1326

Abstract: Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible ... ...

Abstract	Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible changes in thyroid-stimulating hormone (TSH), free thyroxin (fT4) and free triiodothyronine (fT3) levels during isotretinoin treatment and analyzing the possible factors which may contribute to such changes. In the present study, 47 patients received (0.5 mg/kg oral isotretinoin) for treatment of severe acne. TSH, fT4 and fT3 were measured at baseline, after 3 and 6 months. ANOVA tests were used for statistical analyses. The levels of fT4 and fT3 decreased significantly during isotretinoin treatment (from 0.85 ± 0.04 and 3.1 ± 0.26 at baseline to 0.81 ± 0.023 and 2.76 ± 0.2 after 6 months, respectively). The decrease was accompanied by significant elevation of TSH (0.66 ± 0.05 at baseline to 0.695 ± 0.05 after 6 months). The duration of therapy (but not the dose) has significantly affected all the hormonal changes. Previous incomplete or intermittent isotretinoin treatment had significantly influenced the changes in fT4 only, while gender affected the changes of TSH. Isotretinoin treatment can decrease fT4, fT3 and increase TSH. The pattern of these changes was affected by gender and previous isotretinoin therapy. Different doses of isotretinoin did not affect the hormonal changes, but the duration has been the major influencing factor.
MeSH term(s)	Acne Vulgaris/blood ; Acne Vulgaris/drug therapy ; Acne Vulgaris/pathology ; Adolescent ; Adult ; Dermatologic Agents/adverse effects ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Isotretinoin/adverse effects ; Isotretinoin/therapeutic use ; Male ; Thyroid Function Tests ; Thyroid Gland/drug effects ; Thyroid Gland/metabolism ; Thyrotropin/blood ; Thyroxine/blood ; Triiodothyronine/blood ; Young Adult
Chemical Substances	Dermatologic Agents ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Isotretinoin (EH28UP18IF) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2021-07-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	189277-0
ISSN	1440-1681 ; 0305-1870 ; 0143-9294
ISSN (online)	1440-1681
ISSN	0305-1870 ; 0143-9294
DOI	10.1111/1440-1681.13552
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Zs.A 990: Show issues

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Article ; Online: Celecoxib has Preventive and Therapeutic Benefits against Nephrotoxicity Caused by Gentamicin in Mice.

Abd-Eldayem, Ahmed M / Dahpy, Marwa A / Badary, Dalia M / Alnasser, Sulaiman Mohammed / Hareedy, Mohammad Salem

Drug research

2022 Volume 72, Issue 5, Page(s) 259–267

Abstract: It's crucial to comprehend the impact of oxidative stress and pro-inflammatory cytokines in the gentamicin-induced kidney injury mechanism. Celecoxib was administered orally either before or after intraperitoneal therapy with gentamicin in mice. The ... ...

Abstract	It's crucial to comprehend the impact of oxidative stress and pro-inflammatory cytokines in the gentamicin-induced kidney injury mechanism. Celecoxib was administered orally either before or after intraperitoneal therapy with gentamicin in mice. The serum levels of creatinine (SCr), blood urea nitrogen (BUN), IL-6, and TNF-α were measured by ELISA test, as well as the levels of the kidney tissue malondialdehyde (MDA), and glutathione (GSH) were also estimated spectrophotometrically. The renal expression of nuclear factor-κB (NF-κB), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and cyclooxygenase 2 (COX-2) mRNAs were evaluated by qPCR. Histopathological evaluation and Immunohistochemical examination of kidney NF-κB, IL-6, and COX-2 were also, performed. Celecoxib successfully prevented gentamicin-induced kidney damage as indicated by reducing blood BUN, SCr, and tissue MDA levels and increasing renal tissue GSH levels as well as lowering the blood IL-6 and TNF-α in comparison to mice received gentamicin. Furthermore, celecoxib has inhibited COX-2, NF-κB, IL-6, and TNF-α expression in the renal tissue. It is noteworthy that celecoxib therapy after gentamicin administration brought about substantially the same results as celecoxib treatment before gentamicin injection in mice. Our results showed the role of celecoxib as a therapeutic tool for gentamicin-induced nephrotoxicity as well as raised its beneficial prophylactic role in this medical challenge by attenuating oxidative stress and inflammation.
MeSH term(s)	Animals ; Celecoxib/pharmacology ; Cyclooxygenase 2/metabolism ; Gentamicins/toxicity ; Glutathione/metabolism ; Interleukin-6/metabolism ; Kidney/metabolism ; Mice ; NF-kappa B ; Oxidative Stress ; Renal Insufficiency/pathology ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Gentamicins ; Interleukin-6 ; NF-kappa B ; Tumor Necrosis Factor-alpha ; Cyclooxygenase 2 (EC 1.14.99.1) ; Glutathione (GAN16C9B8O) ; Celecoxib (JCX84Q7J1L)
Language	English
Publishing date	2022-03-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703847-6
ISSN	2194-9387 ; 2194-9379
ISSN (online)	2194-9387
ISSN	2194-9379
DOI	10.1055/a-1785-4005
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Uf I Zs.151: Show issues

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Article ; Online: Valproate attenuates hypertonic glycerol-induced rhabdomyolysis and acute kidney injury.

Hareedy, Mohammad Salem / Abdelzaher, Lobna A / Badary, Dalia M / Mohammed Alnasser, Sulaiman / Abd-Eldayem, Ahmed M

Nephrologie & therapeutique

2021 Volume 17, Issue 3, Page(s) 160–167

Abstract: Background and aim: The current study investigated the effects of treatment with 300 mg/kg valproic acid on rhabdomyolysis and acute kidney injury induced by intramuscular injection of hypertonic glycerol in rats.: Methods: Four groups of male wistar ...

Abstract	Background and aim: The current study investigated the effects of treatment with 300 mg/kg valproic acid on rhabdomyolysis and acute kidney injury induced by intramuscular injection of hypertonic glycerol in rats. Methods: Four groups of male wistar rats: control and hypertonic glycerol, valproic acid and valproic acid + hypertonic glycerol treated groups were used. Blood urea nitrogen, serum creatinine, creatinine kinase (CK) and CK MB, myoglobin and renal reduced glutathione (GSH) levels were measured. Histopathological examination of the kidneys was carried out to evaluate the degree of renal injury in each group. The expression of interleukin-1 beta "IL-1β" in renal tissue was detected using immunohistochemistry. Results: Hypertonic glycerol administration led to severe renal tubular damage with a significant elevation of blood urea nitrogen, serum creatinine, creatinine kinase, CK MB and myoglobin levels and overexpression of IL-1β compared to control group. Valproic acid administration attenuated both the muscle injury and the acute kidney injury induced by hypertonic glycerol, estimated through a significant reduction of creatinine kinase, myoglobin, and serum creatinine. Valproic acid administration caused a significant increase in GSH in the hypertonic glycerol + valproic acid group compared to the hypertonic glycerol group. A significant decrease in tubular necrosis grade, and expression of IL-1β in hypertonic glycerol + valproic acid group compared to the hypertonic glycerol group was observed. Conclusion: This study demonstrates, for the first time to the best of our knowledge, that valproic acid could ameliorate the rhabdomyolysis and the related acute kidney injury in rats.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/prevention & control ; Animals ; Glycerol ; Humans ; Kidney ; Male ; Rats ; Rhabdomyolysis/chemically induced ; Rhabdomyolysis/drug therapy ; Valproic Acid
Chemical Substances	Valproic Acid (614OI1Z5WI) ; Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2021-03-26
Publishing country	France
Document type	Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/j.nephro.2020.12.003
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Zs.A 6298: Show issues

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Article ; Online: Value of therapeutic drug monitoring of endoxifen in Egyptian premenopausal patients with breast cancer given tamoxifen adjuvant therapy: A pilot study.

El Desoky, Ehab S / Taha, Amira F / Mousa, Heba Salah / Ibrahim, Abeer / Saleh, Medhat A / Abdelrady, Mohamed A / Hareedy, Mohammad Salem

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2022 Volume 29, Issue 7, Page(s) 1673–1686

Abstract: Background: The complex metabolic profile of tamoxifen anticancer drug and polymorphism in its metabolizing enzymes particularly CYP2D6 contribute to the high-observed inter-individual variability in its main active metabolite endoxifen. Therapeutic ... ...

Abstract	Background: The complex metabolic profile of tamoxifen anticancer drug and polymorphism in its metabolizing enzymes particularly CYP2D6 contribute to the high-observed inter-individual variability in its main active metabolite endoxifen. Therapeutic drug monitoring of endoxifen may play a key role in optimizing tamoxifen therapy, and control of both adverse effects and cancer recurrence. This pilot study aims to assess the clinical benefits of applying endoxifen measurement during tamoxifen therapy in patients with breast cancer. Methods: Adult premenopausal breast cancer patients ≥ 18 years who received tamoxifen at a fixed dose of 20 mg daily were included. The primary endpoint was to identify the inter-subject variability in serum concentration of the drug and its metabolites especially endoxifen, through fixation of the tamoxifen dose. The secondary endpoint was to check the correlation between endoxifen metabolite concentration and the development of tamoxifen's adverse effects and cancer recurrence. Results: Sixty patients were included in the study with a mean age of 38.4 ± 0.6 years (range: 26-50). The mean concentration of tamoxifen and endoxifen was 181 ± 9.6 ng/mL and 31.49 ng/mL, respectively. The inter-individual variability in concentrations for the drug and its active metabolite as estimated by the coefficient of variation percentage was in 41% and 31%, respectively. Cancer recurrence was observed in a group of patients ( Conclusion: The measurement of the endoxifen active metabolite of tamoxifen in breast cancer patients can help dose optimization in light of the observed wide inter-individual variability in drug fixed-dose related concentration of the metabolite. Monitoring of serum concentration of endoxifen can help to reveal, reduce and control tamoxifen's adverse effects and cancer recurrence.
MeSH term(s)	Adult ; Female ; Humans ; Breast Neoplasms ; Pilot Projects ; Drug Monitoring ; Egypt ; Neoplasm Recurrence, Local/drug therapy ; Tamoxifen/therapeutic use ; Antineoplastic Agents, Hormonal/therapeutic use
Chemical Substances	4-hydroxy-N-desmethyltamoxifen (46AF8680RC) ; Tamoxifen (094ZI81Y45) ; Antineoplastic Agents, Hormonal
Language	English
Publishing date	2022-12-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552221146531
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Article: [No title information]

Abd-Eldayem, Ahmed M. / Dahpy, Marwa A. / Badary, Dalia M. / Alnasser, Sulaiman Mohammed / Hareedy, Mohammad Salem

Drug Research

2022 Volume 72, Issue 05, Page(s) 259–267

Abstract: It’s crucial to comprehend the impact of oxidative stress and pro-inflammatory cytokines in the gentamicin-induced kidney injury mechanism. Celecoxib was administered orally either before or after intraperitoneal ... ...

Abstract	It’s crucial to comprehend the impact of oxidative stress and pro-inflammatory cytokines in the gentamicin-induced kidney injury mechanism. Celecoxib was administered orally either before or after intraperitoneal therapy with gentamicin in mice. The serum levels of creatinine (SCr), blood urea nitrogen (BUN), IL-6, and TNF-α were measured by ELISA test, as well as the levels of the kidney tissue malondialdehyde (MDA), and glutathione (GSH) were also estimated spectrophotometrically. The renal expression of nuclear factor-κB (NF-κB), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and cyclooxygenase 2 (COX-2) mRNAs were evaluated by qPCR. Histopathological evaluation and Immunohistochemical examination of kidney NF-κB, IL-6, and COX-2 were also, performed. Celecoxib successfully prevented gentamicin-induced kidney damage as indicated by reducing blood BUN, SCr, and tissue MDA levels and increasing renal tissue GSH levels as well as lowering the blood IL-6 and TNF-α in comparison to mice received gentamicin. Furthermore, celecoxib has inhibited COX-2, NF-κB, IL-6, and TNF-α expression in the renal tissue. It is noteworthy that celecoxib therapy after gentamicin administration brought about substantially the same results as celecoxib treatment before gentamicin injection in mice. Our results showed the role of celecoxib as a therapeutic tool for gentamicin-induced nephrotoxicity as well as raised its beneficial prophylactic role in this medical challenge by attenuating oxidative stress and inflammation.
Keywords	Celecoxib ; Gentamicin ; Nephrotoxicity ; Oxidative stress ; Inflammatory markers ; Mice.
Language	English
Publishing date	2022-03-31
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2703847-6
ISSN	2194-9387 ; 2194-9379
ISSN (online)	2194-9387
ISSN	2194-9379
DOI	10.1055/a-1785-4005
Database	Thieme publisher's database

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Article ; Online: Frequency and impact of DHODH, ABCG2 and CYP2C19 SNPs on the therapeutic efficacy, tolerability and toxicity of leflunomide.

Makarem, Yasmine S / Hareedy, Mohammad Salem / Hassanien, Manal / Ahmed, Esraa A / Hetta, Helal F / Mohamed, Alaa Aa

Pharmacogenomics

2021 Volume 22, Issue 18, Page(s) 1201–1209

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Adult ; Aged ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/pharmacology ; Arthritis, Rheumatoid/diet therapy ; Arthritis, Rheumatoid/genetics ; Cytochrome P-450 CYP2C19/genetics ; Dihydroorotate Dehydrogenase/genetics ; Female ; Gene Frequency/genetics ; Genotype ; Humans ; Leflunomide/adverse effects ; Leflunomide/pharmacology ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; Pharmacogenetics/methods ; Polymorphism, Single Nucleotide/genetics ; Young Adult
Chemical Substances	ABCG2 protein, human ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Antirheumatic Agents ; Dihydroorotate Dehydrogenase ; Neoplasm Proteins ; CYP2C19 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Leflunomide (G162GK9U4W)
Language	English
Publishing date	2021-11-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2020-0146
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Article ; Online: CYP2D6 and CYP3A4 variants influence the risk and outcome of COVID-19 infection among rheumatoid arthritis patients maintained on hydroxychloroquine.

Salem Hareedy, Mohammad / Rashad, Sonya Mohamed / Hetta, Helal F / Hassanien, Sara Mahmoud / Abdellatif, Hebatallah / Hassanien, Manal

Drug metabolism and personalized therapy

2021

Abstract: Objectives: Hydroxychloroquine (HCQ) has been used as an off label for the management of coronavirus disease (Covid-19) infection with other drugs. However, different genetic variants can affect the metabolism of HCQ leading to inter-individual ... ...

Abstract	Objectives: Hydroxychloroquine (HCQ) has been used as an off label for the management of coronavirus disease (Covid-19) infection with other drugs. However, different genetic variants can affect the metabolism of HCQ leading to inter-individual differences in its efficacy. In this study, we investigated the effects of variants in CYP2D6, CYP3A4 and CYP3A5 on the risk of Covid-19 infection among patients receiving HCQ for controlling rheumatoid arthritis (RA). Methods: A total of 60 patients were genotyped for CYP2D62XN, CYP2D64, CYP3A41B and CYP3A52. They were receiving HCQ for the treatment of RA. The patients were evaluated clinically for fever and dry cough, radiologically via chest computed tomography (CT) and immunologically via anti-Covid-19 IgG and IgM titers. Results: Variants in CYP2D6 significantly affected the grade of ground glass (CYP2D64 AA carriers showed the higher risk for grade 3) and the risk of positive anti-Covid-19 IgM (CYP2D62XN CC and CYP3A41B AA had the lowest risk), the duration of HCQ, the use of corticosteroids or gender did not affect the Covid-19 status significantly. Conclusions:* In general, the outcome of the studied patients receiving HCQ was good (no deaths, no intubation needed). CYP2D6 variants could affect the outcome of Covid-19 infection.
Language	English
Publishing date	2021-03-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2822040-7
ISSN	2363-8915 ; 2363-8907
ISSN (online)	2363-8915
ISSN	2363-8907
DOI	10.1515/dmdi-2020-0164
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Article ; Online: Pregabalin administration and withdrawal affect testicular structure and functions in rats.

Salem Hareedy, Mohammad / Mohamed Tawfik, Khaled / Badary, Dalia M / Ahmed Mahmoud, Waleed / Mohamed Mohamed, Essam Elden

Andrologia

2020 Volume 52, Issue 11, Page(s) e13808

Abstract: The aim of this prospective experimental study was to investigate the effects of pregabalin (PG) administration and withdrawal on testicular structures and functions in rats. A total of 24 male Wistar rats were divided into two groups (n = 12 each): a ... ...

Abstract	The aim of this prospective experimental study was to investigate the effects of pregabalin (PG) administration and withdrawal on testicular structures and functions in rats. A total of 24 male Wistar rats were divided into two groups (n = 12 each): a control group received normal saline, and PG-treated group received 62 mg kg
MeSH term(s)	Animals ; Follicle Stimulating Hormone ; Male ; Pregabalin/administration & dosage ; Prospective Studies ; Rats ; Rats, Wistar ; Spermatogenesis ; Testis/drug effects ; Testosterone
Chemical Substances	Testosterone (3XMK78S47O) ; Pregabalin (55JG375S6M) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2020-09-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	7280-1
ISSN	1439-0272 ; 0303-4569
ISSN (online)	1439-0272
ISSN	0303-4569
DOI	10.1111/and.13808
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