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Article ; Online: Feeling pressured to talk about trauma: How pressure to disclose alters the association between trauma disclosure and posttraumatic growth.

Kimbley, Claire T / Cox, Daniel W / Kahn, Jeffrey H / Renshaw, Keith D

2023 Volume 36, Issue 3, Page(s) 567–578

Abstract: Talking with others about traumatic experiences (i.e., trauma disclosure) has been associated with increased posttraumatic growth (PTG). Although this association indicates the value of disclosing, there is evidence that external pressure to disclose can ...

Abstract	Talking with others about traumatic experiences (i.e., trauma disclosure) has been associated with increased posttraumatic growth (PTG). Although this association indicates the value of disclosing, there is evidence that external pressure to disclose can hinder the benefits of trauma disclosure. The aim of the current study was to examine the influence of pressure to disclose on the association between trauma disclosure and PTG. People who had experienced a traumatic event and disclosed their trauma to a close other were recruited using Amazon's Mechanical Turk (N = 208). Participants completed measures of trauma exposure, trauma disclosure, pressure to disclose, PTG, posttraumatic stress symptoms, and response to disclosure. The results indicated that the linear association between trauma disclosure and PTG was quadratically moderated by pressure to disclose, η
MeSH term(s)	Humans ; Disclosure ; Posttraumatic Growth, Psychological ; Stress Disorders, Post-Traumatic ; Emotions ; Survivors ; Adaptation, Psychological
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	639478-4
ISSN	1573-6598 ; 0894-9867
ISSN (online)	1573-6598
ISSN	0894-9867
DOI	10.1002/jts.22930
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Zs.A 2386: Show issues

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Article ; Online: Modeling a Ca(2+) channel/BKCa channel complex at the single-complex level.

Cox, Daniel H

Biophysical journal

2014 Volume 107, Issue 12, Page(s) 2797–2814

Abstract: BKCa-channel activity often affects the firing properties of neurons, the shapes of neuronal action potentials (APs), and in some cases the extent of neurotransmitter release. It has become clear that BKCa channels often form complexes with voltage-gated ...

Abstract	BKCa-channel activity often affects the firing properties of neurons, the shapes of neuronal action potentials (APs), and in some cases the extent of neurotransmitter release. It has become clear that BKCa channels often form complexes with voltage-gated Ca(2+) channels (CaV channels) such that when a CaV channel is activated, the ensuing influx of Ca(2+) activates its closely associated BKCa channel. Thus, in modeling the electrical properties of neurons, it would be useful to have quantitative models of CaV/BKCa complexes. Furthermore, in a population of CaV/BKCa complexes, all BKCa channels are not exposed to the same Ca(2+) concentration at the same time. Thus, stochastic rather than deterministic models are required. To date, however, no such models have been described. Here, however, I present a stochastic model of a CaV2.1/BKCa(α-only) complex, as might be found in a central nerve terminal. The CaV2.1/BKCa model is based on kinetic modeling of its two component channels at physiological temperature. Surprisingly, The CaV2.1/BKCa model predicts that although the CaV channel will open nearly every time during a typical cortical AP, its associated BKCa channel is expected to open in only 30% of trials, and this percentage is very sensitive to the duration of the AP, the distance between the two channels in the complex, and the presence of fast internal Ca(2+) buffers. Also, the model predicts that the kinetics of the BKCa currents of a population of CaV2.1/BKCa complexes will not be limited by the kinetics of the CaV2.1 channel, and during a train of APs, the current response of the complex is expected to faithfully follow even very rapid trains. Aside from providing insight into how these complexes are likely to behave in vivo, the models presented here could also be of use more generally as components of higher-level models of neural function.
MeSH term(s)	Animals ; Calcium Channels, N-Type/chemistry ; Calcium Channels, N-Type/metabolism ; Humans ; Large-Conductance Calcium-Activated Potassium Channels/chemistry ; Large-Conductance Calcium-Activated Potassium Channels/metabolism ; Mice ; Protein Binding ; Protein Multimerization ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Rats
Chemical Substances	Calcium Channels, N-Type ; Large-Conductance Calcium-Activated Potassium Channels ; Protein Subunits
Language	English
Publishing date	2014-12-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2014.10.069
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Zs.A 235: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Durability of the moderate-to-heavy-intensity transition is related to the effects of prolonged exercise on severe-intensity performance.

Hamilton, Kate / Kilding, Andrew E / Plews, Daniel J / Mildenhall, Mathew J / Waldron, Mark / Charoensap, Thanchanok / Cox, Tobias H / Brick, Matthew J / Leigh, Warren B / Maunder, Ed

European journal of applied physiology

2024

Abstract: Purpose: Power output at the moderate-to-heavy-intensity transition decreases during prolonged exercise, and resilience to this has been termed 'durability'. The purpose of this study was to assess the relationship between durability and the effect of ... ...

Abstract	Purpose: Power output at the moderate-to-heavy-intensity transition decreases during prolonged exercise, and resilience to this has been termed 'durability'. The purpose of this study was to assess the relationship between durability and the effect of prolonged exercise on severe-intensity performance, and explore intramuscular correlates of durability. Methods: On separate days, 13 well-trained cyclists and triathletes (V̇O Results: Prolonged exercise reduced power output at VT Conclusion: These data provide the first direct support that durability of the moderate-to-heavy-intensity transition is an important performance parameter, as more durable athletes exhibited smaller reductions in 5-min TT performance following prolonged exercise. We did not find relationships between durability and vastus lateralis carnosine content, citrate synthase activity, or complex I activity.
Language	English
Publishing date	2024-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-024-05459-6
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Uc I Zs.195: Show issues

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Article ; Online: Syndemic Factors and Lifetime Bidirectional Intimate Partner Violence Among Gay, Bisexual, and Other Sexual Minority Men.

Kirschbaum, Allison L / Metheny, Nicholas / Skakoon-Sparling, Shayna / Grace, Daniel / Yakubovich, Alexa R / Cox, Joseph / Palachi, Aaron / Sang, Jordan M / O'Campo, Patricia / Tan, Darrell H S / Hart, Trevor A

LGBT health

2023 Volume 10, Issue S1, Page(s) S89–S97

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Male ; Humans ; Child ; Alcoholism ; Syndemic ; Canada/epidemiology ; Sexual and Gender Minorities ; Intimate Partner Violence ; Ethanol
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2727303-9
ISSN	2325-8306 ; 2325-8292
ISSN (online)	2325-8306
ISSN	2325-8292
DOI	10.1089/lgbt.2023.0117
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Article: CCT and Cullin1 regulate the TORC1 pathway to promote dendritic arborization in health and disease.

Lottes, Erin N / Ciger, Feyza H / Bhattacharjee, Shatabdi / Timmins-Wilde, Emily A / Tete, Benoit / Tran, Tommy / Matta, Jais / Patel, Atit A / Cox, Daniel N

bioRxiv : the preprint server for biology

2023

Abstract: The development of cell-type-specific dendritic arbors is integral to the proper functioning of neurons within their circuit networks. In this study, we examine the regulatory relationship between the cytosolic chaperonin CCT, key insulin pathway genes, ... ...

Abstract	The development of cell-type-specific dendritic arbors is integral to the proper functioning of neurons within their circuit networks. In this study, we examine the regulatory relationship between the cytosolic chaperonin CCT, key insulin pathway genes, and an E3 ubiquitin ligase (Cullin1) in homeostatic dendritic development. CCT loss of function (LOF) results in dendritic hypotrophy in
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.31.551324
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Article ; Online: Ca(2+)-regulated ion channels.

Cox, Daniel H

BMB reports

2011 Volume 44, Issue 10, Page(s) 635–646

Abstract: Due to its high external and low internal concentration the Ca(2+) ion is used ubiquitously as an intracellular signaling molecule, and a great many Ca(2+)-sensing proteins have evolved to receive and propagate Ca(2+) signals. Among them are ion channel ... ...

Abstract	Due to its high external and low internal concentration the Ca(2+) ion is used ubiquitously as an intracellular signaling molecule, and a great many Ca(2+)-sensing proteins have evolved to receive and propagate Ca(2+) signals. Among them are ion channel proteins, whose Ca(2+) sensitivity allows internal Ca(2+) to influence the electrical activity of cell membranes and to feedback-inhibit further Ca(2+) entry into the cytoplasm. In this review I will describe what is understood about the Ca(2+) sensing mechanisms of the three best studied classes of Ca(2+)-sensitive ion channels: Large-conductance Ca(2+)-activated K(+) channels, small-conductance Ca(2+)-activated K(+) channels, and voltage- gated Ca(2+) channels. Great strides in mechanistic understanding have be made for each of these channel types in just the past few years.
MeSH term(s)	Calcium/metabolism ; Cell Membrane/metabolism ; Ion Channel Gating/physiology ; Ion Channels/metabolism ; Membrane Potentials/physiology ; Potassium/metabolism
Chemical Substances	Ion Channels ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2011-10
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
DOI	10.5483/BMBRep.2011.44.10.635
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Zs.A 4202: Show issues

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Article ; Online: Problematic alcohol use among gay, bisexual, and other men who have sex with men in Canada: the role of proximal stressors and anxiety.

Zahran, Adhm / Dermody, Sarah S / Berlin, Graham W / Palma, Paolo A / Skakoon-Sparling, Shayna / Noor, Syed W / Lachowsky, Nathan J / Grace, Daniel / Cox, Joseph / Moore, David M / Lambert, Gilles / Zhang, Terri H / Dvorakova, Milada / Jollimore, Jody / Lal, Allan / Hart, Trevor A

Substance abuse treatment, prevention, and policy

2024 Volume 19, Issue 1, Page(s) 16

Abstract: Background: Gay, bisexual, and other men who have sex with men (GBM) report high rates of problematic alcohol use, anxiety, and depression. This may, in part, be due to stressors related to their sexual identity (i.e., minority stressors). However, few ... ...

Abstract	Background: Gay, bisexual, and other men who have sex with men (GBM) report high rates of problematic alcohol use, anxiety, and depression. This may, in part, be due to stressors related to their sexual identity (i.e., minority stressors). However, few studies have examined both distal and proximal stressors, as well as the specific psychological mechanisms by which these stressors may be related to alcohol use outcomes, in a representative sample of GBM. We explored the relationship between distal and proximal stressors and alcohol use outcomes, as well as the role of anxiety and depression as potential mediators of these relationships. Methods: We analyzed the baseline data of 2,449 GBM from Engage, a cohort study of sexually active GBM recruited using respondent-driven sampling (RDS) in Montreal, Toronto, and Vancouver from February 2017 to August 2019. Using structural equation modeling, we examined the associations between distal minority stressors (i.e., experiences of heterosexist harassment, rejection, and discrimination), proximal minority stressors (i.e., internalized homonegativity, concerns about acceptance, concealment, and lack of affirmation), anxiety and depression, and alcohol consumption and alcohol use problems. RDS-adjusted analyses controlled for age, income, sexual orientation, ethnicity, recruitment city, and HIV serostatus. Results: There were positive direct associations between distal stress and proximal stress, anxiety, and depression, but not alcohol use outcomes. Proximal stress had a positive direct association with anxiety, depression, and alcohol use problems, but not alcohol consumption. Anxiety was positively associated with alcohol consumption and alcohol use problems. Depression was negatively associated with alcohol consumption but not alcohol use problems. Regarding indirect effects, distal stress was associated with alcohol use outcomes via proximal stress and anxiety, but not via depression. Conclusions: We found support for a minority stress model as it relates to alcohol use outcomes among GBM. Findings suggest that proximal minority stress and anxiety differentially impact the problematic alcohol use among GBM who experience heterosexist discrimination. Clinical providers should consider incorporating the treatment of proximal minority stressors and anxiety into existing alcohol interventions for GBM.
MeSH term(s)	Humans ; Male ; Female ; Sexual and Gender Minorities ; Homosexuality, Male/psychology ; Cohort Studies ; Sexual Behavior ; Anxiety/epidemiology ; Anxiety/psychology ; Canada/epidemiology ; Alcohol Drinking/epidemiology
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2222956-5
ISSN	1747-597X ; 1747-597X
ISSN (online)	1747-597X
ISSN	1747-597X
DOI	10.1186/s13011-024-00597-8
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Article ; Online: 'It's not as good as the face-to-face contact': A sociomaterialist analysis of the use of virtual care among Canadian gay, bisexual and queer men during the COVID-19 pandemic.

Daroya, Emerich / Grey, Cornel / Klassen, Ben / Lessard, David / Skakoon-Sparling, Shayna / Perez-Brumer, Amaya / Adam, Barry / Cox, Joseph / Lachowsky, Nathan J / Hart, Trevor A / Gervais, Jessie / Tan, Darrell H S / Grace, Daniel

Sociology of health & illness

2023 Volume 46, Issue 1, Page(s) 19–38

Abstract: The COVID-19 pandemic led to the widespread adoption of virtual care-the use of communication technologies to receive health care at home. We explored the differential impacts of the rapid transition to virtual care during the COVID-19 pandemic on health- ...

Abstract	The COVID-19 pandemic led to the widespread adoption of virtual care-the use of communication technologies to receive health care at home. We explored the differential impacts of the rapid transition to virtual care during the COVID-19 pandemic on health-care access and delivery for gay, bisexual and queer men (GBQM), a population that disproportionately experiences sexual and mental health disparities in Canada. Adopting a sociomaterial theoretical perspective, we analysed 93 semi-structured interviews with GBQM (n = 93) in Montreal, Toronto and Vancouver, Canada, conducted between November 2020 and February 2021 (n = 42) and June-October 2021 (n = 51). We focused on explicating how the dynamic relations of humans and non-humans in everyday virtual care practices have opened or foreclosed different care capacities for GBQM. Our analysis revealed that the rapid expansion and implementation of virtual care during the COVID-19 pandemic enacted disruptions and challenges while providing benefits to health-care access among some GBQM. Further, virtual care required participants to change their sociomaterial practices to receive health care effectively, including learning new ways of communicating with providers. Our sociomaterial analysis provides a framework that helps identify what works and what needs to be improved when delivering virtual care to meet the health needs of GBQM and other diverse populations.
MeSH term(s)	Humans ; Canada/epidemiology ; Pandemics ; COVID-19 ; Sexual Behavior ; Sexual and Gender Minorities
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	795552-2
ISSN	1467-9566 ; 0141-9889
ISSN (online)	1467-9566
ISSN	0141-9889
DOI	10.1111/1467-9566.13686
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Zs.A 2727: Show issues

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Article ; Online: Exploring the dynamics of the 2022 mpox outbreak in Canada.

Milwid, Rachael M / Li, Michael / Fazil, Aamir / Maheu-Giroux, Mathieu / Doyle, Carla M / Xia, Yiqing / Cox, Joseph / Grace, Daniel / Dvorakova, Milada / Walker, Steven C / Mishra, Sharmistha / Ogden, Nicholas H

Journal of medical virology

2023 Volume 95, Issue 12, Page(s) e29256

Abstract: The 2022 mpox outbreak predominantly impacted gay, bisexual, and other men who have sex with men (gbMSM). Two models were developed to support situational awareness and management decisions in Canada. A compartmental model characterized epidemic drivers ... ...

Abstract	The 2022 mpox outbreak predominantly impacted gay, bisexual, and other men who have sex with men (gbMSM). Two models were developed to support situational awareness and management decisions in Canada. A compartmental model characterized epidemic drivers at national/provincial levels, while an agent-based model (ABM) assessed municipal-level impacts of vaccination. The models were parameterized and calibrated using empirical case and vaccination data between 2022 and 2023. The compartmental model explored: (1) the epidemic trajectory through community transmission, (2) the potential for transmission among non-gbMSM, and (3) impacts of vaccination and the proportion of gbMSM contributing to disease transmission. The ABM incorporated sexual-contact data and modeled: (1) effects of vaccine uptake on disease dynamics, and (2) impacts of case importation on outbreak resurgence. The calibrated, compartmental model followed the trajectory of the epidemic, which peaked in July 2022, and died out in December 2022. Most cases occurred among gbMSM, and epidemic trajectories were not consistent with sustained transmission among non-gbMSM. The ABM suggested that unprioritized vaccination strategies could increase the outbreak size by 47%, and that consistent importation (≥5 cases per 10 000) is necessary for outbreak resurgence. These models can inform time-sensitive situational awareness and policy decisions for similar future outbreaks.
MeSH term(s)	Male ; Humans ; Homosexuality, Male ; Sexual and Gender Minorities ; Mpox (monkeypox) ; Canada/epidemiology ; Disease Outbreaks
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29256
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Article ; Online: Experimental Modeling of Horizontal and Vertical Wave Forces on an Elevated Coastal Structure.

Park, Hyoungsu / Tomiczek, Tori / Cox, Daniel T / van de Lindt, John W / Lomonaco, Pedro

Coastal engineering

2023 Volume 128, Issue October 2017, Page(s) 58–74

Abstract: A large-scale physical model was created in Oregon State University's Large Wave Flume to collect an extensive dataset measuring wave-induced horizontal and vertical forces on an idealized coastal structure. Water depth was held constant while wave ... ...

Abstract	A large-scale physical model was created in Oregon State University's Large Wave Flume to collect an extensive dataset measuring wave-induced horizontal and vertical forces on an idealized coastal structure. Water depth was held constant while wave conditions included regular, irregular, and transient (tsunami-like) waves with different significant wave heights and peak periods for each test. The elevation of the base of the test specimen with respect to the stillwater depth (air gap) was also varied from at-grade to 0.28 m above the stillwater level to better understand the effects of raising or lowering a nearshore structure on increasing or decreasing the horizontal and vertical wave forces. Results indicate that while both horizontal and vertical forces tend to increase with increasing significant wave height, the maximum and top 0.4% of forces increased disproportionally to other characteristic values such as the mean or top 10%. As expected, the horizontal force increased as the test specimen was more deeply submerged and decreased as the structure was elevated to larger air gaps above the stillwater level. However, this trend was not true for the vertical force, which was maximized when the elevation of the base of the structure was equal to the elevation of the stillwater depth. Small wave heights were characterized by low horizontal to vertical force ratios, highlighting the importance of considering vertical wave forces in addition to horizontal wave forces in the design of coastal structures. The findings and data presented here may be used by city planners, engineers, and numerical modelers, for future analyses, informed coastal design, and numerical benchmarking to work toward enabling more resilient nearcoast structures.
Language	English
Publishing date	2023-11-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2019650-7
ISSN	1872-7379 ; 0378-3839
ISSN (online)	1872-7379
ISSN	0378-3839
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