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  1. Article ; Online: The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases.

    D'Angelo, Donato / Rizzuto, Rosario

    Biomolecules

    2023  Volume 13, Issue 9

    Abstract: ... Calcium ( ... ...

    Abstract Calcium (Ca
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13091304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Imaging living cells

    Rizzuto, Rosario

    (Springer lab manual)

    1999  

    Author's details Rosario Rizzuto ... (eds.)
    Series title Springer lab manual
    Keywords Zelle ; Konfokale Mikroskopie ; Fluoreszenzmikroskopie
    Subject Konfokalmikroskopie ; Confocal laser scanning microsopy ; CLSM
    Language English
    Size XXI, 394 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT010402198
    ISBN 3-540-65051-2 ; 978-3-540-65051-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 2987 order for loan Magazin

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  3. Article ; Online: CoQ

    Gherardi, Gaia / Corbioli, Giovanni / Ruzza, Filippo / Rizzuto, Rosario

    Nutrients

    2022  Volume 14, Issue 20

    Abstract: Mitochondria participate in the maintenance of cellular homeostasis. Firstly, mitochondria regulate energy metabolism through oxidative phosphorylation. In addition, they are involved in cell fate decisions by activating the apoptotic intrinsic pathway. ... ...

    Abstract Mitochondria participate in the maintenance of cellular homeostasis. Firstly, mitochondria regulate energy metabolism through oxidative phosphorylation. In addition, they are involved in cell fate decisions by activating the apoptotic intrinsic pathway. Finally, they work as intracellular signaling hubs as a result of their tight regulation of ion and metabolite concentrations and other critical signaling molecules such as ROS. Aging is a multifactorial process triggered by impairments in different cellular components. Among the various molecular pathways involved, mitochondria are key regulators of longevity. Indeed, mitochondrial deterioration is a critical signature of the aging process. In this scenario, we will focus specifically on the age-related decrease in CoQ levels, an essential component of the electron transport chain (ETC) and an antioxidant, and how CoQ supplementation could benefit the aging process. Generally, any treatment that improves and sustains mitochondrial functionality is a good candidate to counteract age-related mitochondrial dysfunctions. In recent years, heightened attention has been given to natural compounds that modulate mitochondrial function. One of the most famous is resveratrol due to its ability to increase mitochondrial biogenesis and work as an antioxidant agent. This review will discuss recent clinical trials and meta-analyses based on resveratrol and CoQ supplementation, focusing on how these compounds could improve mitochondrial functionality during aging.
    MeSH term(s) Resveratrol/pharmacology ; Resveratrol/metabolism ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Reactive Oxygen Species/metabolism ; Mitochondria/metabolism ; Oxidative Phosphorylation ; Oxidative Stress
    Chemical Substances Resveratrol (Q369O8926L) ; Antioxidants ; Reactive Oxygen Species
    Language English
    Publishing date 2022-10-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14204326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mitochondrial Ca

    De Mario, Agnese / Trevellin, Elisabetta / Piazza, Ilaria / Vindigni, Vincenzo / Foletto, Mirto / Rizzuto, Rosario / Vettor, Roberto / Mammucari, Cristina

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8469

    Abstract: Obesity is associated with increased risk and worse prognosis of many tumours including those of the breast and of the esophagus. Adipokines released from the peritumoural adipose tissue promote the metastatic potential of cancer cells, suggesting the ... ...

    Abstract Obesity is associated with increased risk and worse prognosis of many tumours including those of the breast and of the esophagus. Adipokines released from the peritumoural adipose tissue promote the metastatic potential of cancer cells, suggesting the existence of a crosstalk between the adipose tissue and the surrounding tumour. Mitochondrial Ca
    MeSH term(s) Humans ; Adipose Tissue/pathology ; Adipocytes ; Obesity/complications ; Subcutaneous Fat/pathology ; Neoplasms/pathology
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55650-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: From the Identification to the Dissection of the Physiological Role of the Mitochondrial Calcium Uniporter: An Ongoing Story.

    Pallafacchina, Giorgia / Zanin, Sofia / Rizzuto, Rosario

    Biomolecules

    2021  Volume 11, Issue 6

    Abstract: The notion of mitochondria being involved in the decoding and shaping of intracellular ... ...

    Abstract The notion of mitochondria being involved in the decoding and shaping of intracellular Ca
    MeSH term(s) Animals ; Calcium/history ; Calcium/metabolism ; Calcium Channels/history ; Calcium Channels/metabolism ; Calcium Signaling ; Calcium-Binding Proteins/history ; Calcium-Binding Proteins/metabolism ; Cation Transport Proteins/history ; Cation Transport Proteins/metabolism ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Ion Transport ; Mitochondria/metabolism ; Mitochondrial Membrane Transport Proteins/history ; Mitochondrial Membrane Transport Proteins/metabolism
    Chemical Substances Calcium Channels ; Calcium-Binding Proteins ; Cation Transport Proteins ; MICU1 protein, human ; Mitochondrial Membrane Transport Proteins ; mitochondrial calcium uniporter ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-05-23
    Publishing country Switzerland
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11060786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The mitochondrial ATP-dependent potassium channel (mitoK

    Di Marco, Giulia / Gherardi, Gaia / De Mario, Agnese / Piazza, Ilaria / Baraldo, Martina / Mattarei, Andrea / Blaauw, Bert / Rizzuto, Rosario / De Stefani, Diego / Mammucari, Cristina

    Cell death & disease

    2024  Volume 15, Issue 1, Page(s) 58

    Abstract: ... ...

    Abstract MitoK
    MeSH term(s) Adenosine Triphosphate/metabolism ; Potassium Channels/metabolism ; Mitochondria/metabolism ; Muscle, Skeletal/metabolism ; Mitochondria, Heart/metabolism
    Chemical Substances mitochondrial K(ATP) channel ; Adenosine Triphosphate (8L70Q75FXE) ; Potassium Channels
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-024-06426-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Skeletal muscle mitochondria in health and disease.

    De Mario, Agnese / Gherardi, Gaia / Rizzuto, Rosario / Mammucari, Cristina

    Cell calcium

    2021  Volume 94, Page(s) 102357

    Abstract: Mitochondrial activity warrants energy supply to oxidative myofibres to sustain endurance workload. The maintenance of mitochondrial homeostasis is ensured by the control of fission and fusion processes and by the mitophagic removal of aberrant ... ...

    Abstract Mitochondrial activity warrants energy supply to oxidative myofibres to sustain endurance workload. The maintenance of mitochondrial homeostasis is ensured by the control of fission and fusion processes and by the mitophagic removal of aberrant organelles. Many diseases are due to or characterized by dysfunctional mitochondria, and altered mitochondrial dynamics or turnover trigger myopathy per se. In this review, we will tackle the role of mitochondrial dynamics, turnover and metabolism in skeletal muscle, both in health and disease.
    Language English
    Publishing date 2021-01-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2021.102357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The Mitochondrial Ca

    Gherardi, Gaia / Monticelli, Halenya / Rizzuto, Rosario / Mammucari, Cristina

    Frontiers in physiology

    2020  Volume 11, Page(s) 554904

    Abstract: Recently, the role of mitochondrial activity in high-energy demand organs and in the orchestration of whole-body metabolism has received renewed attention. In mitochondria, pyruvate oxidation, ensured by efficient mitochondrial pyruvate entry and matrix ... ...

    Abstract Recently, the role of mitochondrial activity in high-energy demand organs and in the orchestration of whole-body metabolism has received renewed attention. In mitochondria, pyruvate oxidation, ensured by efficient mitochondrial pyruvate entry and matrix dehydrogenases activity, generates acetyl CoA that enters the TCA cycle. TCA cycle activity, in turn, provides reducing equivalents and electrons that feed the electron transport chain eventually producing ATP. Mitochondrial Ca
    Language English
    Publishing date 2020-10-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.554904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Aldosterone Biosynthesis Is Potently Stimulated by Perfluoroalkyl Acids: A Link between Common Environmental Pollutants and Arterial Hypertension.

    Caroccia, Brasilina / Seccia, Teresa Maria / Pallafacchina, Giorgia / Piazza, Maria / Caputo, Ilaria / Zamberlan, Stefania / Rizzuto, Rosario / Rossi, Gian Paolo

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: The large environmental contamination of drinking water by perfluoroalkyl substances (PFAS) markedly increased the plasma levels of pentadecafluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in a Northern Italy population with a high ... ...

    Abstract The large environmental contamination of drinking water by perfluoroalkyl substances (PFAS) markedly increased the plasma levels of pentadecafluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in a Northern Italy population with a high prevalence of arterial hypertension and cardiovascular disease. As the link between PFAS and arterial hypertension is unknown, we investigated if they enhance the biosynthesis of the well-known pressor hormone aldosterone. We found that PFAS increased aldosterone synthase (
    MeSH term(s) Humans ; Aldosterone/metabolism ; Environmental Pollutants/toxicity ; Cytochrome P-450 CYP11B2/genetics ; Cytochrome P-450 CYP11B2/metabolism ; Reactive Oxygen Species ; Hypertension/chemically induced ; Alkanesulfonic Acids/toxicity ; Fluorocarbons/toxicity ; Adrenal Cortex Neoplasms
    Chemical Substances Aldosterone (4964P6T9RB) ; Environmental Pollutants ; Cytochrome P-450 CYP11B2 (EC 1.14.15.4) ; Reactive Oxygen Species ; Alkanesulfonic Acids ; Fluorocarbons
    Language English
    Publishing date 2023-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Myonecrosis Induction by Intramuscular Injection of CTX.

    Feno, Simona / Munari, Fabio / Gherardi, Gaia / Reane, Denis Vecellio / D'Angelo, Donato / Viola, Antonella / Rizzuto, Rosario / Raffaello, Anna

    Bio-protocol

    2023  Volume 13, Issue 1, Page(s) e4587

    Abstract: Skeletal muscle, one of the most abundant tissue in the body, is a highly regenerative tissue. Indeed, compared to other tissues that are not able to regenerate after injury, skeletal muscle can fully regenerate upon mechanically, chemically, and ... ...

    Abstract Skeletal muscle, one of the most abundant tissue in the body, is a highly regenerative tissue. Indeed, compared to other tissues that are not able to regenerate after injury, skeletal muscle can fully regenerate upon mechanically, chemically, and infection-induced trauma. Several injury models have been developed to thoroughly investigate the physiological mechanisms regulating skeletal muscle regeneration. This protocol describes how to induce muscle regeneration by taking advantage of a cardiotoxin (CTX)-induced muscle injury model. The overall steps include CTX injection of tibialis anterior (TA) muscles of BL6N mice, collection of regenerating muscles at different time points after CTX injury, and histological characterization of regenerating muscles. Our protocol, compared with others such as those for freeze-induced injury models, avoids laceration or infections of the muscles since it involves neither surgery nor suture. In addition, our protocol is highly reproducible, since it causes homogenous myonecrosis of the whole muscle, and further reduces animal pain and stress. Graphical abstract.
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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