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Article ; Online: John H. Wigmore on the abolition of partisan experts.

Weiss, Kenneth J

The journal of the American Academy of Psychiatry and the Law

2015 Volume 43, Issue 1, Page(s) 21–31

Abstract: ... Commenting on the case, John H. Wigmore, Dean of Northwestern Law School and authority on evidence, critiqued ...

Abstract	The American justice system traditionally has relied on expert witnesses hired by adverse parties, resulting in the appearance of dueling hired guns. There have been attempts to reform the system through court-appointed impartial experts, but trial attorneys have resisted them. Celebrated cases have brought the problem to the forefront--for example, the 1924 murder trial of Richard Loeb and Nathan Leopold, Jr, in Chicago. These young men were on trial for kidnapping and killing a teenage boy. That there was no motive but thrill-seeking incensed citizens, who called for their death. Several psychiatrists testified at the penalty phase. The judge sentenced the defendants to life in prison, ostensibly because of their age. Commenting on the case, John H. Wigmore, Dean of Northwestern Law School and authority on evidence, critiqued the system of partisan experts. This article contains a reprint of his editorial and a discussion of it in the context of evolving expert testimony standards. My conclusion is that a robust but honest airing of opinions is most helpful in criminal cases and that court-appointed experts may be more appropriate in civil and domestic relations matters.
MeSH term(s)	Conflict of Interest/legislation & jurisprudence ; Expert Testimony/legislation & jurisprudence ; Forensic Psychiatry/history ; History, 20th Century ; Homicide/history ; Humans ; Male ; United States ; Young Adult
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	1381489-8
ISSN	1943-3662 ; 0091-634X ; 1093-6793
ISSN (online)	1943-3662
ISSN	0091-634X ; 1093-6793
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Article: Editorial: Excitotoxicity Turns 50. The Death That Never Dies.

Granzotto, Alberto / Weiss, John H / Sensi, Stefano L

Frontiers in neuroscience

2022 Volume 15, Page(s) 831809

Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.831809
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Article: Stable Law Densities and Linear Relaxation Phenomena.

Dishon, Menachem / Weiss, George H / Bendler, John T

Journal of research of the National Bureau of Standards (1977)

2021 Volume 90, Issue 1, Page(s) 27–39

Abstract: Stable law distributions occur in the description of the linear dielectric behavior of polymers, the motion of carriers in semi-conductors, the statistical behavior of neurons, and many other phenomena. No accurate tables of these distributions or ... ...

Abstract	Stable law distributions occur in the description of the linear dielectric behavior of polymers, the motion of carriers in semi-conductors, the statistical behavior of neurons, and many other phenomena. No accurate tables of these distributions or algorithms for estimating the parameters in these relaxation models exist. In this paper we present tables of the functions
Language	English
Publishing date	2021-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2602408-1
ISSN	0160-1741 ; 0034-530X ; 0091-0635
ISSN	0160-1741 ; 0034-530X ; 0091-0635
DOI	10.6028/jres.090.002
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Article ; Online: Trainees Are Change Agents: An Introduction to This Year's Trainee-Authored Letters to the Editor.

Blyton, Laura / Forrest, Lala L / Coverdale, John H / Roberts, Laura Weiss

Academic medicine : journal of the Association of American Medical Colleges

2022 Volume 97, Issue 6, Page(s) 761–763

Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000004677
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Article ; Online: Zn

Ji, Sung G / Weiss, John H

Experimental neurology

2018 Volume 302, Page(s) 181–195

Abstract: Excitotoxic ... ...

Abstract	Excitotoxic Zn
MeSH term(s)	Animals ; Calcium/metabolism ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology ; Cell Death/drug effects ; Cells, Cultured ; Cerebral Cortex/cytology ; Cytosol/drug effects ; Cytosol/metabolism ; Embryo, Mammalian ; Membrane Potential, Mitochondrial/physiology ; Mice ; Mice, Inbred ICR ; Mitochondria/metabolism ; N-Methylaspartate/pharmacology ; Neurons/cytology ; Neurons/drug effects ; Neurons/metabolism ; Oligonucleotides/pharmacology ; Potassium/pharmacology ; Proton Ionophores/pharmacology ; Pyridines/pharmacology ; Reactive Oxygen Species/metabolism ; Zinc/metabolism ; Zinc/pharmacology
Chemical Substances	2-diphenylphosphinopyridine ; Oligonucleotides ; Proton Ionophores ; Pyridines ; Reactive Oxygen Species ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (370-86-5) ; N-Methylaspartate (6384-92-5) ; Zinc (J41CSQ7QDS) ; Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2018.01.012
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Article ; Online: Establishing the Early Psychosis Intervention Clinic, New Orleans (EPIC-NOLA): Sustainability Challenges Threaten Clinical Success.

Weiss, Ashley / Chaudhry, Serena / Cahill, John Danie / Srihari, Vinod H

Journal of health care for the poor and underserved

2021 Volume 32, Issue 1, Page(s) 8–17

Abstract: This paper describes the implementation of the first coordinated specialty care clinic for first episode psychosis in New Orleans, Louisiana (Early Psychosis Intervention Clinic-New Orleans), a historically underserved area. Successes, lessons, and ... ...

Abstract	This paper describes the implementation of the first coordinated specialty care clinic for first episode psychosis in New Orleans, Louisiana (Early Psychosis Intervention Clinic-New Orleans), a historically underserved area. Successes, lessons, and challenges will be explored in the context of a mission to provide highest quality clinical care in the current insurance reimbursement systems.
MeSH term(s)	Ambulatory Care Facilities ; Early Intervention, Educational ; Humans ; Medicine ; New Orleans ; Psychotic Disorders/therapy
Language	English
Publishing date	2021-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1142637-8
ISSN	1548-6869 ; 1049-2089
ISSN (online)	1548-6869
ISSN	1049-2089
DOI	10.1353/hpu.2021.0003
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Article ; Online: Examining Sex Differences in Autism Heritability.

Sandin, Sven / Yip, Benjamin H K / Yin, Weiyao / Weiss, Lauren A / Dougherty, Joseph D / Fass, Stuart / Constantino, John N / Hailin, Zhu / Turner, Tychele N / Marrus, Natasha / Gutmann, David H / Sanders, Stephan J / Christoffersson, Benjamin

JAMA psychiatry

2024

Abstract: Importance: Autism spectrum disorder (ASD) is a neurodevelopmental disorder more prevalent in males than in females. The cause of ASD is largely genetic, but the association of genetics with the skewed sex ratio is not yet understood. To our knowledge, ... ...

Abstract	Importance: Autism spectrum disorder (ASD) is a neurodevelopmental disorder more prevalent in males than in females. The cause of ASD is largely genetic, but the association of genetics with the skewed sex ratio is not yet understood. To our knowledge, no large population-based study has provided estimates of heritability by sex. Objective: To estimate the sex-specific heritability of ASD. Design, setting, and participants: This was a population-based, retrospective analysis using national health registers of nontwin siblings and cousins from Sweden born between January 1, 1985, and December 31, 1998, with follow-up to 19 years of age. Data analysis occurred from August 2022 to November 2023. Main outcomes and measures: Models were fitted to estimate the relative variance in risk for ASD occurrence owing to sex-specific additive genetics, shared environmental effects, and a common residual term. The residual term conceptually captured other factors that promote individual behavioral variation (eg, maternal effects, de novo variants, rare genetic variants not additively inherited, or gene-environment interactions). Estimates were adjusted for differences in prevalence due to birth year and maternal and paternal age by sex. Results: The sample included 1 047 649 individuals in 456 832 families (538 283 males [51.38%]; 509 366 females [48.62%]). Within the entire sample, 12 226 (1.17%) received a diagnosis of ASD, comprising 8128 (1.51%) males and 4098 (0.80%) females. ASD heritability was estimated at 87.0% (95% CI, 81.4%-92.6%) for males and 75.7% (95% CI, 68.4%-83.1%) for females with a difference in heritability estimated at 11.3% (95% CI, 1.0%-21.6%). There was no support for shared environmental contributions. Conclusions and relevance: These findings suggest that the degree of phenotypic variation attributable to genetic differences (heritability) differs between males and females, indicating that some of the underlying causes of the condition may differ between the 2 sexes. The skewed sex ratio in ASD may be partly explained by differences in genetic variance between the sexes.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701203-7
ISSN	2168-6238 ; 2168-622X
ISSN (online)	2168-6238
ISSN	2168-622X
DOI	10.1001/jamapsychiatry.2024.0525
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Article ; Online: PACE: randomized, controlled, multicentre, multinational, phase III study of PLX-PAD for critical limb ischaemia in patients unsuitable for revascularization: randomized clinical trial.

Norgren, Lars / Weiss, Norbert / Nikol, Sigrid / Lantis, John C / Patel, Manesh R / Hinchliffe, Robert J / Reinecke, Holger / Volk, Hans Dieter / Reinke, Petra / Fadini, Gian Paolo / Ofir, Racheli / Rothenstein, Daniel / Halevy, Nitsan / Karagjozov, Mitko / Rundback, John H

The British journal of surgery

2024 Volume 111, Issue 2

Abstract: Background: Revascularization is the primary treatment modality for chronic limb-threatening ischaemia (CLTI), but is not feasible in all patients. PLX-PAD is an off-the-shelf, placental-derived, mesenchymal stromal cell-like cell therapy. This study ... ...

Abstract	Background: Revascularization is the primary treatment modality for chronic limb-threatening ischaemia (CLTI), but is not feasible in all patients. PLX-PAD is an off-the-shelf, placental-derived, mesenchymal stromal cell-like cell therapy. This study aimed to evaluate whether PLX-PAD would increase amputation-free survival in people with CLTI who were not candidates for revascularization. Methods: People with CLTI and minor tissue loss (Rutherford 5) who were unsuitable for revascularization were entered into a randomized, parallel-group, placebo-controlled, multinational, blinded, trial, in which PLX-PAD was compared with placebo (2 : 1 randomization), with 30 intramuscular injections (0.5 ml each) into the index leg on days 0 and 60. Planned follow-up was 12-36 months, and included vital status, amputations, lesion size, pain and quality-of-life assessments, haemodynamic parameters, and adverse events. Results: Of 213 patients enrolled, 143 were randomized to PLX-PAD and 70 to placebo. Demographics and baseline characteristics were balanced. Most patients were Caucasian (96.2%), male (76.1%), and ambulatory (85.9%). Most patients (76.6%) reported at least one adverse event, which were mostly expected events in CLTI, such as skin ulcer or gangrene. The probability of major amputation or death was similar for placebo and PLX-PAD (33 and 28.6% respectively; HR 0.93, 95% c.i. 0.53 to 1.63; P = 0.788). Revascularization and complete wound healing rates were similar in the two groups. A post hoc analysis of a subpopulation of 121 patients with a baseline haemoglobin A1c level below 6.5% showed improved 12-month amputation-free survival (HR 0.46, 0.21 to 0.99; P = 0.048). Conclusion: Although there was no evidence that PLX-PAD reduced amputation-free survival in the entire study population, benefit was observed in patients without diabetes mellitus or whose diabetes was well controlled; this requires confirmation in further studies. Trial registration: NCT03006770 (http://www.clinicaltrials.gov); 2015-005532-18 (EudraCT Clinical Trials register - Search for 2015-005532-18).
MeSH term(s)	Humans ; Male ; Female ; Pregnancy ; Chronic Limb-Threatening Ischemia ; Peripheral Arterial Disease/therapy ; Ischemia ; Placenta/metabolism ; Vascular Surgical Procedures ; Treatment Outcome
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Multicenter Study ; Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znad437
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Article ; Online: Letter to the Editor. Gamma Knife radiosurgery for Cushing's disease after prior resection.

Weiss, Martin H / Zada, Gabriel / Carmichael, John D / Couldwell, William T

Journal of neurosurgery

2020 Volume 134, Issue 3, Page(s) 1012–1014

MeSH term(s)	Humans ; Pituitary ACTH Hypersecretion/surgery ; Pituitary Neoplasms/surgery ; Radiosurgery ; Treatment Outcome
Language	English
Publishing date	2020-07-31
Publishing country	United States
Document type	Journal Article ; Letter ; Comment
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2020.6.JNS202134
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Article ; Online: Institutional experience report on the target contouring workflow in the radiotherapy department for stereotactic arrhythmia radioablation delivered on conventional linear accelerators.

Rosu-Bubulac, Mihaela / Trankle, Cory R / Mankad, Pranav / Grizzard, John D / Ellenbogen, Kenneth A / Jordan, Jennifer H / Weiss, Elisabeth

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

2023 Volume 200, Issue 1, Page(s) 83–96

Abstract: Purpose: In stereotactic arrhythmia radioablation (STAR), the target is defined using multiple imaging studies and a multidisciplinary team consisting of electrophysiologist, cardiologist, cardiac radiologist, and radiation oncologist collaborate to ... ...

Abstract	Purpose: In stereotactic arrhythmia radioablation (STAR), the target is defined using multiple imaging studies and a multidisciplinary team consisting of electrophysiologist, cardiologist, cardiac radiologist, and radiation oncologist collaborate to identify the target and delineate it on the imaging studies of interest. This report describes the workflow employed in our radiotherapy department to transfer the target identified based on electrophysiology and cardiology imaging to the treatment planning image set. Methods: The radiotherapy team was presented with an initial target in cardiac axes orientation, contoured on a wideband late gadolinium-enhanced (WB-LGE) cardiac magnetic resonance (CMR) study, which was subsequently transferred to the computed tomography (CT) scan used for treatment planning-i.e., the average intensity projection (AIP) image set derived from a 4D CT-via an axial CMR image set, using rigid image registration focused on the target area. The cardiac and the respiratory motion of the target were resolved using ciné-CMR and 4D CT imaging studies, respectively. Results: The workflow was carried out for 6 patients and resulted in an internal target defined in standard anatomical orientation that encompassed the cardiac and the respiratory motion of the initial target. Conclusion: An image registration-based workflow was implemented to render the STAR target on the planning image set in a consistent manner, using commercial software traditionally available for radiation therapy.
MeSH term(s)	Humans ; Workflow ; Radiotherapy Planning, Computer-Assisted/methods ; Four-Dimensional Computed Tomography ; Particle Accelerators ; Arrhythmias, Cardiac
Language	English
Publishing date	2023-10-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84983-2
ISSN	1439-099X ; 0179-7158 ; 0039-2073
ISSN (online)	1439-099X
ISSN	0179-7158 ; 0039-2073
DOI	10.1007/s00066-023-02159-6
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