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Article ; Online: Cerium Oxide Nanoparticles Improve Lifespan of Stored Blood.

Rzigalinski, Beverly A / Giovinco, Holly M / Cheatham, Byron J

2020 Volume 185, Issue Suppl 1, Page(s) 103–109

Abstract: Introduction: Blood is a precious commodity, with storage limited to 42 days under refrigeration. Degradative changes in red blood cells (RBCs) begin as early as 11-21 days after collection, and compromise their function. Materials that extend the life ... ...

Abstract	Introduction: Blood is a precious commodity, with storage limited to 42 days under refrigeration. Degradative changes in red blood cells (RBCs) begin as early as 11-21 days after collection, and compromise their function. Materials that extend the life of RBCs will improve blood utilization in the field, as well as in hospital settings. Cerium oxide nanoparticles (CeONPs) are widely used in the materials industry to counteract oxidative stress and improve oxygen storage. We have previously shown that CeONPs extended the lifespan of cells in culture and counteract oxidative stress in vitro and in vivo. Here, we test the hypothesis that CeONPs extend the lifespan of RBCs in whole stored blood. Materials and methods: Rat whole blood was collected with sodium citrate and stored at 4°C. Groups consisted of control (no CeONPs), and 10 and 100 nM CeONPs (average particle size 10 nm) added. Aliquots of stored blood were removed weekly and analyzed for different blood parameters. Results: Results demonstrate that CeONPs improve storage and functional lifespan of RBCs in stored whole blood. Conclusions: This work suggests that CeONPs may be a promising additive for extending storage and function of blood and blood products.
MeSH term(s)	Animals ; Blood/drug effects ; Cell Survival/drug effects ; Cell Survival/physiology ; Cerium/pharmacology ; Cerium/therapeutic use ; Disease Models, Animal ; Drug Storage/methods ; Drug Storage/statistics & numerical data ; Longevity/drug effects ; Nanoparticles/therapeutic use ; Rats
Chemical Substances	Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
Language	English
Publishing date	2020-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usz210
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Article ; Online: Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety.

Rzigalinski, Beverly A / Carfagna, Charles S / Ehrich, Marion

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2016 Volume 9, Issue 4

Abstract: Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative antioxidant properties. Given that the brain is one of the most highly oxidative ... ...

Abstract	Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative antioxidant properties. Given that the brain is one of the most highly oxidative organs in the body, it is subject to some of the greatest levels of oxidative stress, particularly in neurodegenerative disease. Therefore, cerium oxide nanoparticles are currently being investigated for efficacy in several neurodegenerative disorders and have shown promising levels of neuroprotection. This review discusses the basis for cerium oxide nanoparticle use in neurodegenerative disease and its hypothesized mechanism of action. The review focuses on an up-to-date summary of in vivo work with cerium oxide nanoparticles in animal models of neurodegenerative disease. Additionally, we examine the current state of information regarding biodistribution, toxicity, and safety for cerium oxide nanoparticles at the in vivo level. Finally, we discuss future directions that are necessary if this nanopharmaceutical is to move up from the bench to the bedside. WIREs Nanomed Nanobiotechnol 2017, 9:e1444. doi: 10.1002/wnan.1444 For further resources related to this article, please visit the WIREs website.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Cerium/pharmacology ; Humans ; Nanoparticles/chemistry ; Neurodegenerative Diseases/drug therapy ; Neuroprotection ; Oxidative Stress ; Tissue Distribution
Chemical Substances	Antioxidants ; Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
Language	English
Publishing date	2016-11-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.1444
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Article: Nanoparticles and cell longevity.

Rzigalinski, Beverly A

Technology in cancer research & treatment

2005 Volume 4, Issue 6, Page(s) 651–659

Abstract: The field of engineering has made substantial strides in nanotechnology, in the realm of materials science and construction of nanoscale devices. Nanomedicine encompasses application of cutting edge engineered nanostructures to biological systems and ... ...

Abstract	The field of engineering has made substantial strides in nanotechnology, in the realm of materials science and construction of nanoscale devices. Nanomedicine encompasses application of cutting edge engineered nanostructures to biological systems and development of novel strategies for disease intervention. In the current review, we discuss the pharmacological application of nanoparticles as free radical scavengers and the capacity of nanoparticles to promote cell and organismal longevity.
MeSH term(s)	Cell Survival ; Cellular Senescence ; Drug Delivery Systems ; Drug Design ; Free Radicals ; Genetic Therapy ; Humans ; Nanostructures ; Neoplasms/diagnosis ; Neoplasms/therapy
Chemical Substances	Free Radicals
Language	English
Publishing date	2005-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2146365-7
ISSN	1533-0338 ; 1533-0346
ISSN (online)	1533-0338
ISSN	1533-0346
DOI	10.1177/153303460500400609
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Article ; Online: Genomic divergence and adaptive convergence in

Kang, Lin / Rashkovetsky, Eugenia / Michalak, Katarzyna / Garner, Harold R / Mahaney, James E / Rzigalinski, Beverly A / Korol, Abraham / Nevo, Eviatar / Michalak, Pawel

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 24, Page(s) 11839–11844

Abstract: Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent microclimate conditions can be ... ...

Abstract	Biodiversity refugia formed by unique features of the Mediterranean arid landscape, such as the dramatic ecological contrast of "Evolution Canyon," provide a natural laboratory in which local adaptations to divergent microclimate conditions can be investigated. Significant insights have been provided by studies of
MeSH term(s)	Animals ; Behavior, Animal/physiology ; Biodiversity ; Drosophila melanogaster/genetics ; Drosophila simulans/genetics ; Evolution, Molecular ; Genome/genetics ; Genomics/methods ; Israel ; Membrane Proteins/genetics ; Polymorphism, Genetic/genetics
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2019-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1720938116
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Article ; Online: Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots.

Rzigalinski, Beverly A / Strobl, Jeannine S

Toxicology and applied pharmacology

2009 Volume 238, Issue 3, Page(s) 280–288

Abstract: The field of nanotechnology is rapidly expanding with the development of novel nanopharmaceuticals that have potential for revolutionizing medical treatment. The rapid pace of expansion in this field has exceeded the pace of pharmacological and ... ...

Abstract	The field of nanotechnology is rapidly expanding with the development of novel nanopharmaceuticals that have potential for revolutionizing medical treatment. The rapid pace of expansion in this field has exceeded the pace of pharmacological and toxicological research on the effects of nanoparticles in the biological environment. The development of cadmium-containing nanoparticles, known as quantum dots, show great promise for treatment and diagnosis of cancer and targeted drug delivery, due to their size-tunable fluorescence and ease of functionalization for tissue targeting. However, information on pharmacology and toxicology of quantum dots needs much further development, making it difficult to assess the risks associated with this new nanotechnology. Further, nanotechnology poses yet another risk for toxic cadmium, which will now enter the biological realm in nano-form. In this review, we discuss cadmium-containing quantum dots and their physicochemical properties at the nano-scale. We summarize the existing work on pharmacology and toxicology of cadmium-containing quantum dots and discuss perspectives in their utility in disease treatment. Finally, we identify critical gaps in our knowledge of cadmium quantum dot toxicity, and how these gaps need to be assessed to enable quantum dot nanotechnology to transit safely from bench to bedside.
MeSH term(s)	Animals ; Cadmium/pharmacokinetics ; Cadmium/therapeutic use ; Cadmium/toxicity ; Diagnostic Imaging/adverse effects ; Dose-Response Relationship, Drug ; Environmental Pollutants/toxicity ; Humans ; Metal Nanoparticles ; Nanotechnology ; Neoplasms/chemically induced ; Particle Size ; Quantum Dots ; Risk Assessment
Chemical Substances	Environmental Pollutants ; Cadmium (00BH33GNGH)
Language	English
Publishing date	2009-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2009.04.010
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Article ; Online: Malathion/oxon and lead acetate increase gene expression and protein levels of transient receptor potential canonical channel subunits TRPC1 and TRPC4 in rat endothelial cells of the blood-brain barrier.

Balbuena, Pergentino / Li, Wen / Rzigalinski, Beverly A / Ehrich, Marion

International journal of toxicology

2012 Volume 31, Issue 3, Page(s) 238–249

Abstract: This study examined the effects of malathion and lead on transient receptor potential canonical channel TRPC1/TRPC4 channels in rat brain endothelial cells as a mechanism to explain previously noted blood-brain barrier (BBB) permeability induced by these ...

Abstract	This study examined the effects of malathion and lead on transient receptor potential canonical channel TRPC1/TRPC4 channels in rat brain endothelial cells as a mechanism to explain previously noted blood-brain barrier (BBB) permeability induced by these compounds. Lead, malathion, malaoxon and combinations of these were assessed for protein levels and gene expression of TRPC1/C4 at 2, 4, 8, 16, and 24 hours after exposure. Changes in intracellular free calcium dynamics were also assessed. Compounds increased TRPC1 and TRPC4 protein levels as well as gene expression within 4 hours after exposure. Basal levels of intracellular free calcium were also elevated. Increases in gene and protein expression may be associated with an increase in the numbers of TRP channels, and the increases in intracellular calcium may be associated with activation of such channels. Therefore, upregulation and activation of the TRPC1/TRPC4 may be a mechanism by which these neurotoxicants affect BBB permeability.
MeSH term(s)	Animals ; Blood-Brain Barrier/cytology ; Calcium/metabolism ; Cell Line ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Gene Expression Regulation/drug effects ; Insecticides/toxicity ; Malathion/analogs & derivatives ; Malathion/toxicity ; Organometallic Compounds/toxicity ; Rats ; TRPC Cation Channels/biosynthesis ; TRPC Cation Channels/genetics
Chemical Substances	Insecticides ; Organometallic Compounds ; TRPC Cation Channels ; TRPC4 ion channel ; transient receptor potential cation channel, subfamily C, member 1 ; malaoxon (2439JYF84Q) ; lead acetate (RX077P88RY) ; Calcium (SY7Q814VUP) ; Malathion (U5N7SU872W)
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1379845-5
ISSN	1092-874X ; 1091-5818
ISSN (online)	1092-874X
ISSN	1091-5818
DOI	10.1177/1091581812442688
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Article ; Online: Dopamine stimulates propagation of Toxoplasma gondii tachyzoites in human fibroblast and primary neonatal rat astrocyte cell cultures.

Strobl, Jeannine S / Goodwin, David G / Rzigalinski, Beverly A / Lindsay, David S

The Journal of parasitology

2012 Volume 98, Issue 6, Page(s) 1296–1299

Abstract: Toxoplasma gondii is an obligate intracellular parasite often found in the brain of humans. Research has shown a correlation between prevalence of antibody titers to T. gondii and psychological illness in humans. Recent studies indicate that individuals ... ...

Abstract	Toxoplasma gondii is an obligate intracellular parasite often found in the brain of humans. Research has shown a correlation between prevalence of antibody titers to T. gondii and psychological illness in humans. Recent studies indicate that individuals seropositive for T. gondii antibodies are more likely to develop psychotic disorders including schizophrenia, which is associated with changes in the dopamine neurotransmitter system. Dopamine in the brain may play a role in proliferation, chemoattraction, infection efficiency, or stage conversion of T. gondii . Because tachyzoites are the first developmental stage to reach the brain, the present study was conducted to determine the effects of dopamine on their development in vitro. In human fibroblast host cells, dopamine was added at either 100 nM or 250 nM to cell culture media, and the numbers of tachyzoites produced at 48 hr were determined and compared to vehicle-treated controls. An increase of tachyzoite numbers and increased destruction in cell monolayer were observed at both concentrations of dopamine. Dopamine used at 250 nM caused a significant (P < 0.05) increase in tachyzoites counts compared to controls. Dopamine antagonists (10 μM) did not significantly alter dopamine-stimulated tachyzoite production in human fibroblasts. In primary neonatal rat astrocyte cell cultures, dopamine (200 μM) significantly (P < 0.05) increased numbers of intracellular tachyzoites after 24 hr. The role that this increase plays in tachyzoite production under the stimulus of dopamine in the modulation of neural infection in humans awaits further studies.
MeSH term(s)	Animals ; Animals, Newborn ; Astrocytes/drug effects ; Astrocytes/parasitology ; Cells, Cultured ; Dopamine/pharmacology ; Dopamine Antagonists/pharmacology ; Fibroblasts/drug effects ; Fibroblasts/parasitology ; Humans ; Rats ; Rats, Sprague-Dawley ; Schizophrenia/complications ; Schizophrenia/metabolism ; Sympathomimetics/pharmacology ; Toxoplasma/drug effects ; Toxoplasma/growth & development ; Toxoplasmosis, Cerebral/complications ; Toxoplasmosis, Cerebral/metabolism ; Toxoplasmosis, Cerebral/psychology
Chemical Substances	Dopamine Antagonists ; Sympathomimetics ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2012-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	300870-8
ISSN	1937-2345 ; 0022-3395
ISSN (online)	1937-2345
ISSN	0022-3395
DOI	10.1645/GE-2760.1
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Article: A novel bridge wire model of blast traumatic brain injury - biomed 2013.

Hampton, Carolyn E / Thorpe, Chevon N / Sholar, Christopher A / Rzigalinski, Beverly A / VandeVord, Pamela J

Biomedical sciences instrumentation

2013 Volume 49, Page(s) 312–319

Abstract: Research into the mechanics of blast-induced traumatic brain injury requires a device capable of reproducing pressures of the same magnitude and time scale as a blast wave. A blast simulator based on the exploding bridge wire mechanism was created with ... ...

Abstract	Research into the mechanics of blast-induced traumatic brain injury requires a device capable of reproducing pressures of the same magnitude and time scale as a blast wave. A blast simulator based on the exploding bridge wire mechanism was created with these capabilities. Peak blast pressures in the range of 5 29 psi were generated with a positive phase duration less than 20 µs. A series of experiments using 0.008 inch diameter wires (10-20 psi) were used to demonstrate the ability of the blast simulator to injure in vitro primary brain cell cultures at 1, 24, and 48 hours following blast. Blast exposure caused a rapid loss of cells which was significant over controls. Propidium iodide uptake indicated limited injury to cellular membranes but the cytoskeletal structure showed signs of degeneration 1 hour following blast. These results indicate that the bridge wire blast simulator can serve as a suitable in vitro model of blast injury.
Language	English
Publishing date	2013
Publishing country	United States
Document type	Journal Article
ISSN	0067-8856 ; 0077-3565 ; 1054-0032
ISSN	0067-8856 ; 0077-3565 ; 1054-0032
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Article: Development of an improved injury device for neural cell cultures.

Webster, Gregory D / Rzigalinski, Beverly A / Gabler, Hampton C

Biomedical sciences instrumentation

2008 Volume 44, Page(s) 483–488

Abstract: Traumatic Brain Injury is hypothesized to occur as a function of the strain and strain rate experienced by neural tissues during a traumatic event. In vitro studies of TBI at the cellular level have used a variety of methods to subject neural cell ... ...

Abstract	Traumatic Brain Injury is hypothesized to occur as a function of the strain and strain rate experienced by neural tissues during a traumatic event. In vitro studies of TBI at the cellular level have used a variety of methods to subject neural cell cultures to potentially injurious strains and strain rates. A device used in previous investigations of neural cell injury was limited in its ability to control strain and strain rate independently or simulate quick repetitive loading. Here we present the design of an improved cell injury controller based on an experimental setup previously used. The new device has the ability to independently control strain and strain rate and can strain cell cultures grown on a stretchable membrane from 0.1 to 0.60 at rates up to 25 s-1.
Language	English
Publishing date	2008
Publishing country	United States
Document type	Journal Article
ISSN	0067-8856 ; 0077-3565 ; 1054-0032
ISSN	0067-8856 ; 0077-3565 ; 1054-0032
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Article: Treatment of neurodegenerative disorders with radical nanomedicine.

Singh, Neeraj / Cohen, Courtney A / Rzigalinski, Beverly A

Annals of the New York Academy of Sciences

2007 Volume 1122, Page(s) 219–230

Abstract: In engineering and materials science, nanotechnology has provided many advances that effectively reduce oxidative damage generated by free radical production. Despite such advances, there has been little application to biomedical problems. Increased ... ...

Abstract	In engineering and materials science, nanotechnology has provided many advances that effectively reduce oxidative damage generated by free radical production. Despite such advances, there has been little application to biomedical problems. Increased oxidative stress and free radical production are associated with neurodegenerative conditions, including aging, trauma, Alzheimer's and Parkinson's diseases, and many others. The antioxidant properties of cerium oxide nanoparticles show promise in the treatment of such diseases. Here, we summarize the work on the biological antioxidant actions of cerium oxide nanoparticles in extension of cell and organism longevity, protection against free radical insult, and protection against trauma-induced neuronal damage. We discuss establishment of effective dosing parameters, along with the physicochemical properties that regulate the pharmacological action of these new nanomaterials. Taken together, these studies suggest that nanotechnology can take pharmacological treatment to a new level, with a novel generation of nanopharmaceuticals.
MeSH term(s)	Animals ; Cerium/therapeutic use ; Free Radicals/toxicity ; Humans ; Nanomedicine/methods ; Neurodegenerative Diseases/therapy ; Neuroprotective Agents/therapeutic use
Chemical Substances	Free Radicals ; Neuroprotective Agents ; Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
Language	English
Publishing date	2007-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1196/annals.1403.015
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