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  1. Article: NEKL-4 regulates microtubule stability and mitochondrial health in

    Power, Kaiden M / Nguyen, Ken C / Silva, Andriele / Singh, Shaneen / Hall, David H / Rongo, Christopher / Barr, Maureen M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-onset ... ...

    Abstract Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-onset neurodegeneration. In
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.14.580304
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  2. Article ; Online: Middle Age Has Its Advantages.

    Barr, Maureen M

    PLoS genetics

    2016  Volume 12, Issue 12, Page(s) e1006426

    MeSH term(s) Animals ; Caenorhabditis elegans ; Cilia ; Humans ; Middle Aged ; Recovery of Function
    Language English
    Publishing date 2016-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1006426
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  3. Article ; Online: The tubulin code specializes neuronal cilia for extracellular vesicle release.

    Akella, Jyothi S / Barr, Maureen M

    Developmental neurobiology

    2020  Volume 81, Issue 3, Page(s) 231–252

    Abstract: Cilia are microtubule-based organelles that display diversity in morphology, ultrastructure, protein composition, and function. The ciliary microtubules of C. elegans sensory neurons exemplify this diversity and provide a paradigm to understand ... ...

    Abstract Cilia are microtubule-based organelles that display diversity in morphology, ultrastructure, protein composition, and function. The ciliary microtubules of C. elegans sensory neurons exemplify this diversity and provide a paradigm to understand mechanisms driving ciliary specialization. Only a subset of ciliated neurons in C. elegans are specialized to make and release bioactive extracellular vesicles (EVs) into the environment. The cilia of extracellular vesicle releasing neurons have distinct axonemal features and specialized intraflagellar transport that are important for releasing EVs. In this review, we discuss the role of the tubulin code in the specialization of microtubules in cilia of EV releasing neurons.
    MeSH term(s) Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Cilia/metabolism ; Extracellular Vesicles/metabolism ; Sensory Receptor Cells/metabolism ; Tubulin/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; Tubulin
    Language English
    Publishing date 2020-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22787
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    Zs.A 853: Show issues Location:
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  4. Article: Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular vesicle release from sensory neurons.

    Wang, Juan / Saul, Josh / Nikonorova, Inna A / Cruz, Carlos Nava / Power, Kaiden M / Nguyen, Ken C / Hall, David H / Barr, Maureen M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cilia-derived extracellular vesicles (EVs) contain signaling proteins and act in intercellular communication. Polycystin-2 (PKD-2), a transient receptor potential channel, is a conserved ciliary EVs cargo. ...

    Abstract Cilia-derived extracellular vesicles (EVs) contain signaling proteins and act in intercellular communication. Polycystin-2 (PKD-2), a transient receptor potential channel, is a conserved ciliary EVs cargo.
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.01.565151
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  5. Article ; Online: C. elegans male mating behavior. Introduction.

    Barr, Maureen M

    Seminars in cell & developmental biology

    2014  Volume 33, Page(s) 1–2

    MeSH term(s) Animals ; Caenorhabditis elegans/physiology ; Male ; Reproduction ; Sexual Behavior, Animal
    Language English
    Publishing date 2014-06-12
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2014.06.006
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    Zs.A 2918: Show issues Location:
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  6. Article ; Online: Cell-cell communication via ciliary extracellular vesicles: clues from model systems.

    Wang, Juan / Barr, Maureen M

    Essays in biochemistry

    2018  Volume 62, Issue 2, Page(s) 205–213

    Abstract: In this short review, we will focus on the uniqueness of ciliary extracellular vesicles (EVs). In particular, we will review what has been learned regarding EVs produced by cilia of model organisms. Model systems ... ...

    Abstract In this short review, we will focus on the uniqueness of ciliary extracellular vesicles (EVs). In particular, we will review what has been learned regarding EVs produced by cilia of model organisms. Model systems including
    MeSH term(s) Animals ; Caenorhabditis elegans/physiology ; Cell Communication ; Chlamydomonas/physiology ; Cilia/physiology ; Humans ; Mice ; Models, Biological
    Language English
    Publishing date 2018-05-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1744-1358 ; 0071-1365
    ISSN (online) 1744-1358
    ISSN 0071-1365
    DOI 10.1042/EBC20170085
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  7. Article ; Online: What about the males? the

    Walsh, Jonathon D / Boivin, Olivier / Barr, Maureen M

    Journal of neurogenetics

    2020  Volume 34, Issue 3-4, Page(s) 323–334

    Abstract: Sexual dimorphism is a device that supports genetic diversity while providing selective pressure against speciation. This phenomenon is at the core of sexually reproducing organisms. ...

    Abstract Sexual dimorphism is a device that supports genetic diversity while providing selective pressure against speciation. This phenomenon is at the core of sexually reproducing organisms.
    MeSH term(s) Animal Structures/growth & development ; Animal Structures/innervation ; Animal Structures/ultrastructure ; Animals ; CRISPR-Cas Systems ; Caenorhabditis elegans/anatomy & histology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/physiology ; Cell Cycle Proteins/genetics ; Cilia/chemistry ; DNA-Binding Proteins/physiology ; Disease Models, Animal ; Extracellular Vesicles/physiology ; Hermaphroditic Organisms/physiology ; Hermaphroditic Organisms/ultrastructure ; Humans ; Interneurons/physiology ; Male ; Nervous System/anatomy & histology ; Nervous System/growth & development ; Neuronal Plasticity ; Neurons/classification ; Neurons/physiology ; Neurons/ultrastructure ; Neurotransmitter Agents/physiology ; Nondisjunction, Genetic ; Polycystic Kidney, Autosomal Dominant/genetics ; Sex Characteristics ; Sexual Behavior, Animal/physiology ; TRPP Cation Channels/genetics ; Transcription Factors/physiology
    Chemical Substances Caenorhabditis elegans Proteins ; Cell Cycle Proteins ; DNA-Binding Proteins ; HIM-5 protein, C elegans ; Neurotransmitter Agents ; TRPP Cation Channels ; Transcription Factors ; polycystic kidney disease 1 protein ; polycystic kidney disease 2 protein ; tra-1 protein, C elegans
    Language English
    Publishing date 2020-07-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605543-6
    ISSN 1563-5260 ; 0167-7063
    ISSN (online) 1563-5260
    ISSN 0167-7063
    DOI 10.1080/01677063.2020.1789978
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    Zs.A 1878: Show issues Location:
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  8. Article ; Online: Centring the health of women across the HIV research continuum.

    Barr, Elizabeth / Marshall, Leslie J / Collins, Lauren F / Godfrey, Catherine / St Vil, Noelle / Stockman, Jamila K / Davey, Dvora L Joseph / Dong, Krista / Temkin, Sarah M / Glenshaw, Mary T / Byrd, Corette / Clayton, Janine A / Goodenow, Maureen M

    The lancet. HIV

    2024  Volume 11, Issue 3, Page(s) e186–e194

    Abstract: Despite tremendous advances in HIV research, women and gender diverse people-particularly women from racial and ethnic groups under-represented in research, transgender women, and young women-remain disproportionately affected by HIV. Women and gender ... ...

    Abstract Despite tremendous advances in HIV research, women and gender diverse people-particularly women from racial and ethnic groups under-represented in research, transgender women, and young women-remain disproportionately affected by HIV. Women and gender diverse people face unique challenges and have been under-represented in HIV research. The National Institutes of Health (NIH) is tasked to apply fundamental knowledge about the nature and behaviour of living systems to enhance health, lengthen life, and reduce disability. Rigorous exploration of-and interventions for-the individual, social, biological, structural, and environmental factors that influence HIV prevention, transmission, treatment, and cure is crucial to advance research for women, girls, and gender diverse people across the lifespan. In this Position Paper, we introduce a framework for an intersectional, equity-informed, data-driven approach to research on HIV and women and highlight selected issues for women and gender diverse people, including HIV prevention, HIV cure, ageing with HIV, substance use and misuse, violence, pregnancy, and breastfeeding or chestfeeding. This framework underlines a new HIV and Women Signature Programme from the NIH Office of AIDS Research and Office of Research on Women's Health that advances the NIH vision for women's health, in which all women receive evidence-based HIV prevention, treatment, and care across their lifespan tailored to their unique needs, circumstances, and goals. The time is now to centre the health of women, girls, and gender diverse people across the HIV research continuum.
    MeSH term(s) Humans ; Female ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Acquired Immunodeficiency Syndrome ; Women's Health ; Gender Identity ; Violence
    Language English
    Publishing date 2024-02-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(24)00004-3
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  9. Article ; Online: Sexual Dimorphism and Sex Differences in

    Barr, Maureen M / García, L Rene / Portman, Douglas S

    Genetics

    2018  Volume 208, Issue 3, Page(s) 909–935

    Abstract: As fundamental features of nearly all animal species, sexual dimorphisms and sex differences have particular relevance for the development and function of the nervous system. The unique advantages of the ... ...

    Abstract As fundamental features of nearly all animal species, sexual dimorphisms and sex differences have particular relevance for the development and function of the nervous system. The unique advantages of the nematode
    MeSH term(s) Animals ; Caenorhabditis elegans/anatomy & histology ; Caenorhabditis elegans/physiology ; Cell Differentiation ; Cell Lineage ; Neurogenesis ; Neurons/metabolism ; Organogenesis ; Sex Characteristics ; Sexual Behavior, Animal ; Sexual Development
    Language English
    Publishing date 2018-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.117.300294
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    Zs.B 767: Show issues Location:
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  10. Article ; Online: Ciliary Extracellular Vesicles: Txt Msg Organelles.

    Wang, Juan / Barr, Maureen M

    Cellular and molecular neurobiology

    2016  Volume 36, Issue 3, Page(s) 449–457

    Abstract: Cilia are sensory organelles that protrude from cell surfaces to monitor the surrounding environment. In addition to its role as sensory receiver, the cilium also releases extracellular vesicles (EVs). The release of sub-micron sized EVs is a conserved ... ...

    Abstract Cilia are sensory organelles that protrude from cell surfaces to monitor the surrounding environment. In addition to its role as sensory receiver, the cilium also releases extracellular vesicles (EVs). The release of sub-micron sized EVs is a conserved form of intercellular communication used by all three kingdoms of life. These extracellular organelles play important roles in both short and long range signaling between donor and target cells and may coordinate systemic responses within an organism in normal and diseased states. EV shedding from ciliated cells and EV-cilia interactions are evolutionarily conserved phenomena, yet remarkably little is known about the relationship between the cilia and EVs and the fundamental biology of EVs. Studies in the model organisms Chlamydomonas and Caenorhabditis elegans have begun to shed light on ciliary EVs. Chlamydomonas EVs are shed from tips of flagella and are bioactive. Caenorhabditis elegans EVs are shed and released by ciliated sensory neurons in an intraflagellar transport-dependent manner. Caenorhabditis elegans EVs play a role in modulating animal-to-animal communication, and this EV bioactivity is dependent on EV cargo content. Some ciliary pathologies, or ciliopathies, are associated with abnormal EV shedding or with abnormal cilia-EV interactions. Until the 21st century, both cilia and EVs were ignored as vestigial or cellular junk. As research interest in these two organelles continues to gain momentum, we envision a new field of cell biology emerging. Here, we propose that the cilium is a dedicated organelle for EV biogenesis and EV reception. We will also discuss possible mechanisms by which EVs exert bioactivity and explain how what is learned in model organisms regarding EV biogenesis and function may provide insight to human ciliopathies.
    MeSH term(s) Animals ; Biological Transport ; Cilia/metabolism ; Ciliopathies/metabolism ; Ciliopathies/pathology ; Exosomes/metabolism ; Extracellular Vesicles/metabolism ; Humans ; Organelles/metabolism
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-016-0345-4
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