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  1. Article ; Online: Reproductive Maternal and Newborn Health Providers' Assessment of Facility Preparedness and Its Determinants during the COVID-19 Pandemic in Lagos, Nigeria.

    Ameh, Charles / Banke-Thomas, Aduragbemi / Balogun, Mobolanle / Makwe, Christian Chigozie / Afolabi, Bosede Bukola

    The American journal of tropical medicine and hygiene

    2021  Volume 104, Issue 4, Page(s) 1495–1506

    Abstract: The global COVID-19 pandemic is predicted to compromise the achievement of global reproductive, maternal, and newborn health (RMNH) targets. The objective of this study was to determine the health facility (HF) preparedness for RMNH service delivery ... ...

    Abstract The global COVID-19 pandemic is predicted to compromise the achievement of global reproductive, maternal, and newborn health (RMNH) targets. The objective of this study was to determine the health facility (HF) preparedness for RMNH service delivery during the outbreak from the perspective of RMNH providers and to determine what factors significantly predict this. An anonymous cross-sectional online survey of RMNH providers was conducted from to July 1-21, 2020 in Lagos State, Nigeria. We conducted a descriptive and ordinal regression analysis, with RMNH worker perception of HF preparedness for RMNH service delivery during the outbreak as the dependent variable. In all, 256 RMNH workers participated, 35.2% reported that RMNH services were unavailable at some time since March 2020, 87.1% felt work-related burnout, 97.7% were concerned about the availability of personal protective equipment (PPE) and related guidelines, and only 11.7% were satisfied with the preparedness of their HFs. Our final model was a statistically significant predictor of RMNH worker perception of HF preparedness explaining 54.7% of the variation observed. The most significant contribution to the model was communication by HF management (likelihood ratio chi-square [LRCS]: 87.94, P < 0.001) and the availability of PPE and COVID-19 guidelines (LRCS: 15.43, P < 0.001). A one-unit increase in the level of concern about the availability of PPE and COVID-19 guidelines would increase the odds of observing a higher category of satisfaction with HF COVID-19 preparedness. Adequate support of RMNH providers, particularly provision of PPE and guidelines, and appropriate communications about COVID-19 should be prioritized as part of HF preparedness.
    MeSH term(s) Adult ; Aged ; Burnout, Professional/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; Female ; Health Facilities ; Health Personnel ; Humans ; Infant Health ; Male ; Maternal Health Services ; Middle Aged ; Nigeria/epidemiology ; Personal Protective Equipment ; SARS-CoV-2 ; Young Adult
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-1324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Human papillomavirus (HPV) infection and vaccines

    Christian Chigozie Makwe / Rose Ihuoma Anorlu / Kofoworola Abimbola Odeyemi

    Journal of Epidemiology and Global Health, Vol 2, Iss

    Knowledge, attitude and perception among female students at the University of Lagos, Lagos, Nigeria

    2019  Volume 4

    Abstract: Aim: This study sought to determine knowledge of and attitude towards human papillomavirus (HPV) infection, HPV-related diseases and HPV vaccines among female undergraduate students at the University of Lagos. Methods: A self-administered questionnaire ... ...

    Abstract Aim: This study sought to determine knowledge of and attitude towards human papillomavirus (HPV) infection, HPV-related diseases and HPV vaccines among female undergraduate students at the University of Lagos. Methods: A self-administered questionnaire was administered between May and July 2010, to 368 female students aged 16–29 years, who were selected from two faculties of the University of Lagos using two-stage sampling method. Data collected included: socio-demographic characteristics, sexual history, awareness and knowledge of HPV infection, cervical cancer and genital warts, and HPV vaccine; the perceived risk of acquiring genital HPV infection and developing cervical cancer or genital warts, and the willingness to receive an HPV vaccine. Results: Only 64 (17.7%) and 52 (14.4%) of the students had ever heard of HPV infection and HPV vaccines respectively. The median HPV knowledge on a 15-item score was 2. Overall, only 11.1% knew that genital HPV infection can cause cervical cancer. Fourteen (6.9%) of those who were aware of cervical cancer agreed they were at risk of developing the disease. Of the 52 students who had heard of the HPV vaccine, 24 (46.2%) knew it was given for cervical cancer prevention and 30 (57.7%) expressed their willingness to receive the vaccine. Conclusion: The knowledge of and the perceived susceptibility to HPV infection and HPV-related diseases among female students in the University of Lagos were generally low. The need for a well-designed HPV-educational program to bridge the knowledge gap cannot be overemphasized.
    Keywords Female students ; Human papillomavirus ; HPV vaccine ; Knowledge ; Nigeria ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Springer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Ovarian reserve in nigerian women with sickle cell anaemia: a cross- sectional study.

    Garba, Sunusi Rimi / Makwe, Christian Chigozie / Osunkalu, Vincent Oluseye / Kalejaiye, Olufunto Olufela / Soibi-Harry, Adaiah Priscillia / Aliyu, Amina Umar / Afolabi, Bosede Bukola

    Journal of ovarian research

    2021  Volume 14, Issue 1, Page(s) 174

    Abstract: Introduction: Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in ... ...

    Abstract Introduction: Sickle cell disease is the most common monogenetic disorder worldwide. There have been reports of endocrine dysfunction and gonadal failure among affected individuals, especially in males. The findings on ovarian reserve and failure in women with sickle anaemia have been inconsistent.
    Aim and objective: The aim of this study was to determine and compare the ovarian reserve of Nigerian women with and without sickle cell anaemia attending a University Teaching Hospital.
    Study design: This cross-sectional study was carried out at the Adult Sickle Cell Clinic and the Community Health Clinic of the Lagos University Teaching Hospital.
    Methodology: A total of 166 participants who met the selection criteria, were recruited for the study. The study population consisted of two groups of women matched for age: 83 women with HbSS and 83 women with HbAA. The haemoglobin phenotype of each participant was determined on alkaline electrophoresis (pH 8.4) before analysis. Serum Anti-Mullerian Hormone (AMH) was determined using Enzyme-linked immunosorbent assay (ELISA) method (Calbiotech Inc. USA, Catalog no AM448T).
    Results: The mean ± SD of serum AMH level in women with HbSS was 3.64 ± 0.65 ng/mL and was lower than that of women with HbAA 7.35 ±1.19 ng/mL (p < 0.001). Serum AMH negatively correlated with age in both study groups (HbAA and HbSS). Also, a significant negative correlation was found between serum AMH and BMI in women with HbAA.
    Conclusion: The study showed diminished ovarian reserve in women with HbSS when compared to age-matched women with HbAA.
    MeSH term(s) Adult ; Anemia, Sickle Cell/blood ; Anti-Mullerian Hormone/blood ; Cross-Sectional Studies ; Female ; Hemoglobins/analysis ; Humans ; Nigeria ; Ovarian Reserve ; Phenotype ; Young Adult
    Chemical Substances Hemoglobins ; Anti-Mullerian Hormone (80497-65-0)
    Language English
    Publishing date 2021-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2455679-8
    ISSN 1757-2215 ; 1757-2215
    ISSN (online) 1757-2215
    ISSN 1757-2215
    DOI 10.1186/s13048-021-00927-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hysterosalpingography findings of female partners of infertile couple attending fertility clinic at Lagos University Teaching Hospital.

    Makwe, Christian Chigozie / Ugwu, Aloy Okechukwu / Sunmonu, Oyebola Halimah / Yusuf-Awesu, Salimat Abisoye / Ani-Ugwu, Nneoma Kwemtochukwu / Olumakinwa, Olayemi Emmanuel

    The Pan African medical journal

    2021  Volume 40, Page(s) 223

    Abstract: Introduction: Hysterosalpingography (HSG) is an outpatient fluoroscopic method for the evaluation of the uterine cavity, fallopian tubes, and the surrounding peritoneal cavity. Female fertility depends greatly on normal female reproductive organs; hence ...

    Abstract Introduction: Hysterosalpingography (HSG) is an outpatient fluoroscopic method for the evaluation of the uterine cavity, fallopian tubes, and the surrounding peritoneal cavity. Female fertility depends greatly on normal female reproductive organs; hence tubal abnormalities may contribute significantly to female infertility. HSG is an invaluable screening tool in the evaluation of women with suspected tubal factor infertility. This study aims to review the HSG findings of women who sought fertility treatment at the Lagos University Teaching Hospital, Lagos (LUTH).
    Methods: this was a retrospective study of the pattern of HSG findings among female partners of infertile couples seeking fertility treatment at the LUTH, over a 2-year period, from January 2018 to December 2019.
    Results: a total of 266 medical records and HSG results were reviewed and included in the data analysis. The mean age (± standard deviation) was 38.4 (± 0.3) years with a range of 24 to 50 years. Most (80.5%) of the participants have secondary infertility and majority (65.4%) were nulliparous. Tubal pathology was the commonest abnormality detected on HSG in 54.9% of women. About one-third (30.8%) of women had bilateral tubal occlusion on HSG. With regards to the right fallopian tube, 43.2% of the participants had tubal occlusion, which differs from 41.7% on the left fallopian tube. Similarly, 10.2% of the women had hydrosalpinx on the left tube when compared with 9% on the right tube. Age (OR 1.055; 95% CI: 1.006, 1.106, p-value 0.028), and previous salpingectomy [OR 6.151; 95% CI: 1.335, 28.349] and myomectomy [OR 4.6; 95% CI: 1.814, 11.67] were identified as risk factors for tubal pathologies on HSG.
    Conclusion: tubal abnormalities are common findings on HSG and the identifiable risk factors for tubal pathologies include age, salpingectomy, and myomectomy. HSG remains a vital screening tool in the evaluation of tubal-factor infertility in Nigeria.
    MeSH term(s) Adult ; Fallopian Tube Diseases/diagnostic imaging ; Fallopian Tubes ; Female ; Fertility Clinics ; Hospitals, Teaching ; Humans ; Hysterosalpingography ; Infertility, Female ; Middle Aged ; Nigeria ; Retrospective Studies ; Universities ; Young Adult
    Language English
    Publishing date 2021-12-14
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2021.40.223.29890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Biochemical Assessment of Renal and Liver Function among Preeclamptics in Lagos Metropolis.

    Ekun, Oloruntoba Ayodele / Olawumi, Oluwatumininu Mary / Makwe, Christian Chigozie / Ogidi, Nkeiruka Ogochukwu

    International journal of reproductive medicine

    2018  Volume 2018, Page(s) 1594182

    Abstract: Objectives: Preeclampsia is a pregnancy specific syndrome. Studies have shown that preeclampsia has multiorgan dysfunction effects. This study evaluated biomarkers of renal and liver function among preeclamptic Nigerian women.: Study design: This was ...

    Abstract Objectives: Preeclampsia is a pregnancy specific syndrome. Studies have shown that preeclampsia has multiorgan dysfunction effects. This study evaluated biomarkers of renal and liver function among preeclamptic Nigerian women.
    Study design: This was a cross-sectional study conducted among 49 preeclamptic women and 50 normotensive healthy pregnant women.
    Method: The baseline data comprising age, gestational age, and blood pressure were obtained. Venous blood and spot urine samples were collected from each participant. Plasma obtained from blood samples taken into lithium heparinized vacutainer bottles was assayed for electrolytes, urea, creatinine, total protein, albumin, and uric acid, while sera samples from blood samples taken into serum separation tube- (SST-) gel vacutainer were assayed for aspartate transaminase and alanine transaminase using ion selective electrode technique and Cobas autoanalyzer. Spot urine samples were assayed for protein and creatinine using Pyrogallol's reagent and Jaffe's methods, respectively. Microalbuminuria (protein/creatinine ratio) was generated from spot urine protein and creatinine data.
    Result: The plasma sodium, total protein, and albumin in preeclamptic group were significantly decreased (p<0.05) when compared with control. There was statistically significant increase (p<0.05) in microalbuminuria, plasma potassium, urea, creatinine, uric acid levels, serum AST, and ALT activities in preeclamptic group. A positive association (p<0.05) between alanine aminotransferase and biomarkers of renal function was observed.
    Conclusion: Preeclampsia has deleterious effects on renal and liver function as shown by alteration of these parameters.
    Language English
    Publishing date 2018-07-31
    Publishing country Egypt
    Document type Journal Article
    ISSN 2356-7104
    ISSN 2356-7104
    DOI 10.1155/2018/1594182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Utilization cost of maternity services for childbirth amongst pregnant women with COVID-19 in Nigeria’s epicenter

    Banke-Thomas, Aduragbemi / Chigozie Makwe, Christian / Balogun, Mobolanle / Afolabi, Bosede Bukola / Amaogechukwu Alex-Nwangwu, Theresa

    2020  

    Keywords HQ The family. Marriage. Woman ; HV Social pathology. Social and public welfare. Criminology ; RA0421 Public health. Hygiene. Preventive Medicine ; RG Gynecology and obstetrics ; covid19
    Language English
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Utilization cost of maternity services for childbirth among pregnant women with COVID‐19 in Nigeria’s epicenter

    Banke‐Thomas, Aduragbemi / Chigozie Makwe, Christian / Balogun, Mobolanle / Bukola Afolabi, Bosede / Amaogechukwu Alex‐Nwangwu, Theresa / Anawo Ameh, Charles

    International Journal of Gynecology & Obstetrics ; ISSN 0020-7292 1879-3479

    2020  

    Keywords Obstetrics and Gynaecology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/ijgo.13436
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Use of exchange blood transfusion in the management of severe COVID-19 infection in pregnancy: experience from Lagos, Nigeria.

    Afolabi, Bosede Bukola / Makwe, Christian Chigozie / Okunade, Kehinde Sharafadeen / Akanmu, Olanrewaju Nurudeen / Akase, Iorhen Ephraim / Otokiti, Oluwakemi / Bolarinwa, Abiola / Ezenwankwo, Francis / Oyeleke, Gabriel Olalekan / Ezenwa, Beatrice Nkolika / Martins-Akinlose, Oluwaseun / Ogundare, Titus / Iloka, Augustine / Akanmu, Alani Sulaimon

    African health sciences

    2022  Volume 22, Issue 2, Page(s) 75–78

    Abstract: Coronavirus disease 2019 (COVID-19) presents with symptoms that may be mild or severe. The individual with the severe form of the disease usually presents with a constellation of respiratory symptoms typical of acute respiratory distress syndrome. In ... ...

    Abstract Coronavirus disease 2019 (COVID-19) presents with symptoms that may be mild or severe. The individual with the severe form of the disease usually presents with a constellation of respiratory symptoms typical of acute respiratory distress syndrome. In this report, we present our experience of the successful management of an oxygen-dependent pregnant woman with severe COVID-19 infection who had 2 sessions of partial exchange blood transfusion. We discussed the principles that informed this intervention and the need to adopt this novel approach in the care of severe COVID-19 infection.
    MeSH term(s) Humans ; Pregnancy ; Female ; Nigeria ; COVID-19/therapy ; Exchange Transfusion, Whole Blood ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-11-04
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2240308-5
    ISSN 1729-0503 ; 1680-6905
    ISSN (online) 1729-0503
    ISSN 1680-6905
    DOI 10.4314/ahs.v22i2.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Utilization cost of maternity services for childbirth among pregnant women with coronavirus disease 2019 in Nigeria's epicenter.

    Banke-Thomas, Aduragbemi / Makwe, Christian Chigozie / Balogun, Mobolanle / Afolabi, Bosede Bukola / Alex-Nwangwu, Theresa Amaogechukwu / Ameh, Charles Anawo

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2020  Volume 152, Issue 2, Page(s) 242–248

    Abstract: Objective: To estimate utilization costs of spontaneous vaginal delivery (SVD) and cesarean delivery (CD) for pregnant women with coronavirus disease 2019 (COVID-19) at the largest teaching hospital in Lagos, the pandemic's epicenter in Nigeria.: ... ...

    Abstract Objective: To estimate utilization costs of spontaneous vaginal delivery (SVD) and cesarean delivery (CD) for pregnant women with coronavirus disease 2019 (COVID-19) at the largest teaching hospital in Lagos, the pandemic's epicenter in Nigeria.
    Methods: We collected facility-based and household costs of all nine pregnant women with COVID-19 managed at the hospital. We compared their mean facility-based costs with those paid by pregnant women pre-COVID-19, identifying cost-drivers. We also estimated what would have been paid without subsidies, testing assumptions with a sensitivity analysis.
    Results: Total utilization costs ranged from US $494 for SVD with mild COVID-19 to US $4553 for emergency CD with severe COVID-19. Though 32%-66% of facility-based cost were subsidized, costs of SVD and CD during the pandemic have doubled and tripled, respectively, compared with those paid pre-COVID-19. Of the facility-based costs, cost of personal protective equipment was the major cost-driver (50%). Oxygen was the major driver for women with severe COVID-19 (48%). Excluding treatment costs for COVID-19, mean facility-based costs were US $228 (SVD) and US $948 (CD).
    Conclusion: Despite cost exemptions and donations, utilization costs remain prohibitive. Regulation of personal protective equipment and medical oxygen supply chains and expansion of advocacy for health insurance enrollments are needed in order to minimize catastrophic health expenditure.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/economics ; Cesarean Section/economics ; Delivery, Obstetric/economics ; Female ; Hospitals, Teaching ; Humans ; Maternal Health Services/economics ; Nigeria ; Parturition ; Pregnancy ; Pregnancy Complications, Infectious/economics ; Pregnancy Complications, Infectious/virology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.13436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Selenium status and infant birth weight among HIV-positive and HIV-negative pregnant women in Lagos, Nigeria.

    Makwe, Christian Chigozie / Nwabua, Francis Izuegbunam / Anorlu, Rose Ihuoma

    Nigerian quarterly journal of hospital medicine

    2015  Volume 25, Issue 3, Page(s) 209–215

    Abstract: Background: During pregnancy, selenium deficiency and reduced antioxidant activities may result in adverse perinatal outcome such as low birthweight, which is associated with significant perinatal morbidity and mortality. Many studies have reported ... ...

    Abstract Background: During pregnancy, selenium deficiency and reduced antioxidant activities may result in adverse perinatal outcome such as low birthweight, which is associated with significant perinatal morbidity and mortality. Many studies have reported conflicting findings on the relationship between maternal selenium status and infant birth weight.
    Objective: This study is to determine the relationship between maternal serum selenium concentration and infant birthweight in HIV-positive and HIV-negative pregnant women at term.
    Methods: A cross-sectional study carried out among HIV-positive and HIV-negative pregnant women at term. Participants were recruited from the antenatal clinic at the Lagos University Teaching Hospital. After obtaining an informed consent, participants were interviewed using a structured questionnaire. Five milliliters of venous blood sample was collected from each participant for estimation of selenium levels using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method. At delivery, the infant birth weights were measured using a standard infant weighing scale.
    Results: Of the 240 participants, data were complete for analysis in 214 (89.2%) of the participants. HIV-positive women had significantly lower mean serum selenium concentration when compared with HIV-negative women (33.7 +/- 22.2 pg/L versus 83.6 +/- 18.7 pg/L; p<0.01). Compared with HIV-negative women, the mean birth weight of infants of HIV positive women was significantly lower (2952 +/- 572 g versus 3392 +/- 452 g; p<0.01). There was no significant association between maternal serum selenium levels at term and infant birth weight in both groups.
    Conclusion: HIV-positive pregnant women had a lower mean serum selenium level and their infants had a lower mean birth weight, when compared to HIV-negative pregnant women. However, no significant association was found between maternal serum selenium concentration and birth weight in both groups.
    MeSH term(s) Adult ; Birth Weight ; Cross-Sectional Studies ; Female ; HIV Seronegativity ; HIV Seropositivity ; Humans ; Infant, Newborn ; Male ; Nigeria ; Pregnancy ; Pregnancy Outcome ; Selenium/deficiency ; Surveys and Questionnaires
    Chemical Substances Selenium (H6241UJ22B)
    Language English
    Publishing date 2015-07
    Publishing country Nigeria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0189-2657
    ISSN 0189-2657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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