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  1. Article ; Online: 2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section.

    Fenton, Robert A / Ellison, David H

    American journal of physiology. Renal physiology

    2024  

    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00086.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perspective on G protein-coupled receptors in renal physiology.

    Pluznick, Jennifer L / Fenton, Robert A

    American journal of physiology. Renal physiology

    2023  Volume 325, Issue 6, Page(s) F683–F684

    MeSH term(s) Receptors, G-Protein-Coupled ; Signal Transduction ; Urinary Tract Physiological Phenomena
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00307.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: USE OF A STATEWIDE SOLID ORGAN INJURY PROCOTCOL TO OPTIMIZE TRIAGE, TREATMENT, AND TRANSFER FOR PEDIATRIC ABDOMINAL TRAUMA.

    Swendiman, Robert A / Russell, Katie W / Larsen, Kezlyn / Eyre, Matthew / Fenton, Stephen J

    The journal of trauma and acute care surgery

    2024  

    Abstract: Background: The Utah Pediatric Trauma Network (UPTN) is a non-competitive collaboration of all 51 hospitals in the state of Utah with the purpose of improving pediatric trauma care. Created in 2019, UPTN has implemented evidence-based guidelines based ... ...

    Abstract Background: The Utah Pediatric Trauma Network (UPTN) is a non-competitive collaboration of all 51 hospitals in the state of Utah with the purpose of improving pediatric trauma care. Created in 2019, UPTN has implemented evidence-based guidelines based on hospital resources and capabilities with quarterly review of data collected in a network-specific database. A blunt solid organ injury (SOI) protocol was developed to optimize treatment of these injuries statewide. The purpose of this study was to review the effectiveness of the SOI guideline.
    Methods: The UPTN REDCap® database was retrospectively reviewed from 2021 through 2022. We compared admissions from the Level 1 pediatric trauma center (PED1) to non-pediatric hospitals (non-PED1) of children with low grade (I-II) and high grade (III-V) SOIs.
    Results: In 2 years, 172 patients were treated for blunt SOI, with or without concomitant injuries. There were 48 (28%) low grade and 124 (72%) high grade SOIs. 33 (69%) patients were triaged with low grade SOI injuries at a non-PED1 center, and 17 (35%) were transferred to the PED1 hospital. Most had multiple injuries, but 7 (44%) were isolated, and none required a transfusion or any procedure/operation at either hospital. Of the 124 patients with high grade injuries, 41 (33%) primarily presented to the PED1 center, and 44 (35%) were transferred there. Of these, 2 required a splenectomy and none required angiography. 39 children were treated at non-PED1 centers without transfer, and 4 required splenectomy and 6 underwent angiography/embolization procedures. No patient with an isolated SOI died.
    Conclusions: Implementation of SOI guidelines across UPTN successfully allowed non-pediatric hospitals to safely admit children with low grade isolated SOI, keeping families closer to home, while standardizing pediatric triage for blunt abdominal trauma in the state.
    Level of evidence: III - Retrospective study.
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000004261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Potassium homeostasis: sensors, mediators, and targets.

    McDonough, Alicia A / Fenton, Robert A

    Pflugers Archiv : European journal of physiology

    2022  Volume 474, Issue 8, Page(s) 853–867

    Abstract: Transmembrane potassium (K) gradients are key determinants of membrane potential that can modulate action potentials, control muscle contractility, and influence ion channel and transporter activity. Daily K intake is normally equal to the amount of K in ...

    Abstract Transmembrane potassium (K) gradients are key determinants of membrane potential that can modulate action potentials, control muscle contractility, and influence ion channel and transporter activity. Daily K intake is normally equal to the amount of K in the entire extracellular fluid (ECF) creating a critical challenge - how to maintain ECF [K] and membrane potential in a narrow range during feast and famine. Adaptations to maintain ECF [K] include sensing the K intake, sensing ECF [K] vs. desired set-point and activating mediators that regulate K distribution between ECF and ICF, and regulate renal K excretion. In this focused review, we discuss the basis of these adaptions, including (1) potential mechanisms for rapid feedforward signaling to kidney and muscle after a meal (before a rise in ECF [K]), (2) how skeletal muscles sense and respond to changes in ECF [K], (3) effects of K on aldosterone biosynthesis, and (4) how the kidney responds to changes in ECF [K] to modify K excretion. The concepts of sexual dimorphisms in renal K handling adaptation are introduced, and the molecular mechanisms that can account for the benefits of a K-rich diet to maintain cardiovascular health are discussed. Although the big picture of K homeostasis is becoming more clear, we also highlight significant pieces of the puzzle that remain to be solved, including knowledge gaps in our understanding of initiating signals, sensors and their connection to homeostatic adjustments of ECF [K].
    MeSH term(s) Extracellular Fluid/metabolism ; Homeostasis/physiology ; Kidney/metabolism ; Muscle, Skeletal/metabolism ; Potassium/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Chemical Substances Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2022-06-21
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-022-02718-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Regulation of the water channel Aquaporin-2 by Cullin E3 ubiquitin ligases.

    Murali, Sathish K / McCormick, James A / Fenton, Robert A

    American journal of physiology. Renal physiology

    2024  

    Abstract: Aquaporin 2 (AQP2) is a vasopressin (VP) regulated water channel in the renal collecting duct. Phosphorylation and ubiquitylation of AQP2 play essential roles in controlling the cellular abundance of AQP2 and its accumulation on the plasma membrane in ... ...

    Abstract Aquaporin 2 (AQP2) is a vasopressin (VP) regulated water channel in the renal collecting duct. Phosphorylation and ubiquitylation of AQP2 play essential roles in controlling the cellular abundance of AQP2 and its accumulation on the plasma membrane in response to VP. Cullin-RING ubiquitin ligases (CRLs) are multi-subunit E3 ligases involved in ubiquitylation and degradation of their target proteins, eight of which are expressed in the collecting duct. Here, we utilized an established cell model of the collecting duct (mpkCCD14 cells) to study the role of Cullins in modulating AQP2. Western blotting identified Cul-1 to -5 in mpkCCD14 cells. Treatment of cells for 4 h with a pan-cullin inhibitor (MLN4924) decreased AQP2 abundance, prevented a VP-induced reduction in AQP2 Ser
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00049.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Central nervous system nocardiosis mimicking recurrence of diffuse large B cell lymphoma with cerebral involvement.

    Fenton, Graeme A / Banfill, Grant / Gera, Kriti / Seifert, Robert P / Heldermon, Coy D

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 134, Page(s) 133–134

    MeSH term(s) Humans ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology ; Central Nervous System ; Nocardia
    Language English
    Publishing date 2023-06-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.06.005
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    Zs.A 4516: Show issues Location:
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  7. Article ; Online: Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease.

    Geurts, Frank / Chaker, Layal / van der Burgh, Anna C / Cronin-Fenton, Deirdre / Fenton, Robert A / Hoorn, Ewout J

    Journal of the American Heart Association

    2024  Volume 13, Issue 4, Page(s) e032835

    Abstract: Background: Inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs is associated with cardiovascular mortality and kidney disease. This study hypothesizes that urinary prostaglandin E2 (PGE2) and PGE2 metabolite (PGEM) excretions ... ...

    Abstract Background: Inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs is associated with cardiovascular mortality and kidney disease. This study hypothesizes that urinary prostaglandin E2 (PGE2) and PGE2 metabolite (PGEM) excretions are markers of cardiovascular and kidney health, because they reflect both systemic and kidney-derived PGE2 production.
    Methods and results: PGE2 and PGEM were measured in spot urine samples from 2291 participants (≥55 years old) of the population-based Rotterdam Study. Urinary PGE2 and PGEM excretions were analyzed using linear regression analyses to identify cross-sectional associations with cardiovascular risk factors and baseline estimated glomerular filtration rate (eGFR). Longitudinal associations with cardiovascular mortality and kidney outcomes (eGFR <60 or <45 mL/min per 1.73 m
    Conclusions: Urinary PGE2 and PGEM excretions are novel markers for the presence and progression of cardiovascular and kidney disease. Future studies should address whether these associations are causal and can be targeted to improve cardiovascular and kidney outcomes.
    MeSH term(s) Humans ; Middle Aged ; Dinoprostone ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Kidney Diseases/diagnosis ; Kidney Diseases/epidemiology ; Kidney Diseases/complications ; Kidney ; Glomerular Filtration Rate/physiology ; Albuminuria/urine ; Risk Factors
    Chemical Substances Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.032835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Proteomic approaches in kidney disease biomarker discovery.

    Fenton, Robert A

    American journal of physiology. Renal physiology

    2018  Volume 315, Issue 6, Page(s) F1817–F1821

    Abstract: Biomarkers have the potential to greatly facilitate diagnosis and treatment of patients with various forms of kidney disease. State-of-the-art mass spectrometry-based methods possess the capability, on a proteome scale and in an unbiased manner, to ... ...

    Abstract Biomarkers have the potential to greatly facilitate diagnosis and treatment of patients with various forms of kidney disease. State-of-the-art mass spectrometry-based methods possess the capability, on a proteome scale and in an unbiased manner, to detect alterations in protein abundances and/or posttranslational modifications in plasma, urine, or tissue. Such approaches can provide a large, unbiased database to facilitate identification of potential biomarkers. In the diagnosis of kidney diseases, urine is usually a more favorable specimen than plasma and kidney tissue due to its noninvasive collection and simplicity of processing. However, whether analysis of proteins in urine faithfully reflects their changes in the kidney tissue remains unclear. The use of proteomics to analyze kidney tissue samples collected during late-stage kidney diseases has also recently gathered pace. The goal of this minireview is to provide an overview of the proteomic technologies currently applied to studies of kidney and their limitations, present existing kidney and urine proteome databases, and highlight a few applications of such approaches in kidney disease biomarker discovery.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Biomarkers/urine ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/metabolism ; Kidney Diseases/urine ; Predictive Value of Tests ; Prognosis ; Proteomics/methods ; Urinalysis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00421.2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Urinary proteomics for kidney dysfunction: insights and trends.

    Wu, Qi / Fenton, Robert A

    Expert review of proteomics

    2021  Volume 18, Issue 6, Page(s) 437–452

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Biomarkers ; Humans ; Kidney ; Kidney Diseases/diagnosis ; Mass Spectrometry ; Proteomics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2299100-1
    ISSN 1744-8387 ; 1478-9450
    ISSN (online) 1744-8387
    ISSN 1478-9450
    DOI 10.1080/14789450.2021.1950535
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    Zs.A 6686: Show issues Location:
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  10. Article ; Online: NHE3 in the thick ascending limb is required for sustained but not acute furosemide-induced urinary acidification.

    Xue, Jianxiang / Thomas, Linto / Dominguez Rieg, Jessica A / Fenton, Robert A / Rieg, Timo

    American journal of physiology. Renal physiology

    2022  Volume 323, Issue 2, Page(s) F141–F155

    Abstract: ... ...

    Abstract Na
    MeSH term(s) Alkalosis ; Animals ; Furosemide/pharmacology ; Hydrogen-Ion Concentration ; Mice ; Sodium/metabolism ; Sodium-Hydrogen Exchanger 3/genetics ; Sodium-Hydrogen Exchangers/genetics ; Sodium-Hydrogen Exchangers/metabolism
    Chemical Substances Sodium-Hydrogen Exchanger 3 ; Sodium-Hydrogen Exchangers ; Furosemide (7LXU5N7ZO5) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00013.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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