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Article: On logical difficulties, philosophy, and the T.C.E. explanation of the firm

Nash, Stephen / Rybak, Liza

Review of social economy : publication of the Association for Social Economics Bd. LXVIII.2010, 3 (Sep.), S. 339-368

2010

Author's details	Stephen Nash and Liza Rybak
Keywords	Transaktionskosten ; Theorie der Unternehmung ; Wirtschaftsphilosophie
Language	English
Publisher	Routledge
Publishing place	London [u.a.]
Document type	Article
ZDB-ID	280967-9 ; 2007774-9
ISSN	1470-1162 ; 0034-6764
ISSN (online)	1470-1162
ISSN	0034-6764
Database	ECONomics Information System

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Article ; Online: Correction: Normative Intercorrelations between EEG Microstate Characteristics.

Kleinert, Tobias / Nash, Kyle / Koenig, Thomas / Wascher, Edmund

Brain topography

2023 Volume 37, Issue 2, Page(s) 270

Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1078442-1
ISSN	1573-6792 ; 0896-0267
ISSN (online)	1573-6792
ISSN	0896-0267
DOI	10.1007/s10548-023-01012-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: On the Reliability of the EEG Microstate Approach.

Kleinert, Tobias / Koenig, Thomas / Nash, Kyle / Wascher, Edmund

Brain topography

2023 Volume 37, Issue 2, Page(s) 271–286

Abstract: ... characteristics (i.e., durations, occurrences, percentage coverage, and transitions) may serve as neural markers ...

Abstract	EEG microstates represent functional brain networks observable in resting EEG recordings that remain stable for 40-120ms before rapidly switching into another network. It is assumed that microstate characteristics (i.e., durations, occurrences, percentage coverage, and transitions) may serve as neural markers of mental and neurological disorders and psychosocial traits. However, robust data on their retest-reliability are needed to provide the basis for this assumption. Furthermore, researchers currently use different methodological approaches that need to be compared regarding their consistency and suitability to produce reliable results. Based on an extensive dataset largely representative of western societies (2 days with two resting EEG measures each; day one: n = 583; day two: n = 542) we found good to excellent short-term retest-reliability of microstate durations, occurrences, and coverages (average ICCs = 0.874-0.920). There was good overall long-term retest-reliability of these microstate characteristics (average ICCs = 0.671-0.852), even when the interval between measures was longer than half a year, supporting the longstanding notion that microstate durations, occurrences, and coverages represent stable neural traits. Findings were robust across different EEG systems (64 vs. 30 electrodes), recording lengths (3 vs. 2 min), and cognitive states (before vs. after experiment). However, we found poor retest-reliability of transitions. There was good to excellent consistency of microstate characteristics across clustering procedures (except for transitions), and both procedures produced reliable results. Grand-mean fitting yielded more reliable results compared to individual fitting. Overall, these findings provide robust evidence for the reliability of the microstate approach.
MeSH term(s)	Humans ; Electroencephalography/methods ; Reproducibility of Results ; Brain ; Brain Mapping/methods ; Rest
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1078442-1
ISSN	1573-6792 ; 0896-0267
ISSN (online)	1573-6792
ISSN	0896-0267
DOI	10.1007/s10548-023-00982-9
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Article ; Online: Normative Intercorrelations Between EEG Microstate Characteristics.

Kleinert, Tobias / Nash, Kyle / Koenig, Thomas / Wascher, Edmund

Brain topography

2023 Volume 37, Issue 2, Page(s) 265–269

Abstract: EEG microstates are brief, recurring periods of stable brain activity that reflect the activation of large-scale neural networks. The temporal characteristics of these microstates, including their average duration, number of occurrences, and percentage ... ...

Abstract	EEG microstates are brief, recurring periods of stable brain activity that reflect the activation of large-scale neural networks. The temporal characteristics of these microstates, including their average duration, number of occurrences, and percentage contribution have been shown to serve as biomarkers of mental and neurological disorders. However, little is known about how microstate characteristics of prototypical network types relate to each other. Normative intercorrelations among these parameters are necessary to help researchers better understand the functions and interactions of underlying networks, interpret and relate results, and generate new hypotheses. Here, we present a systematic analysis of intercorrelations between EEG microstate characteristics in a large sample representative of western working populations (n = 583). Notably, we find that microstate duration is a general characteristic that varies across microstate types. Further, microstate A and B show mutual reinforcement, indicating a relationship between auditory and visual sensory processing at rest. Microstate C appears to play a special role, as it is associated with longer durations of all other microstate types and increased global field power, suggesting a relationship of these parameters with the anterior default mode network. All findings could be confirmed using independent EEG recordings from a retest-session (n = 542).
MeSH term(s)	Humans ; Brain/physiology ; Electroencephalography/methods ; Visual Perception ; Sensation
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1078442-1
ISSN	1573-6792 ; 0896-0267
ISSN (online)	1573-6792
ISSN	0896-0267
DOI	10.1007/s10548-023-00988-3
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Article ; Online: Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina.

Rodriguez, Derek / Church, Kaira A / Smith, Chelsea T / Vanegas, Difernando / Cardona, Sandra M / Muzzio, Isabel A / Nash, Kevin R / Cardona, Astrid E

International journal of molecular sciences

2024 Volume 25, Issue 3

Abstract: Diabetic retinopathy (DR)-associated vision loss is a devastating disease affecting the working-age population. Retinal pathology is due to leakage of serum components into retinal tissues, activation of resident phagocytes (microglia), and vascular and ... ...

Abstract	Diabetic retinopathy (DR)-associated vision loss is a devastating disease affecting the working-age population. Retinal pathology is due to leakage of serum components into retinal tissues, activation of resident phagocytes (microglia), and vascular and neuronal damage. While short-term interventions are available, they do not revert visual function or halt disease progression. The impact of microglial inflammatory responses on the neurovascular unit remains unknown. In this study, we characterized microglia-vascular interactions in an experimental model of DR. Early diabetes presents activated retinal microglia, vascular permeability, and vascular abnormalities coupled with vascular tortuosity and diminished astrocyte and endothelial cell-associated tight-junction (TJ) and gap-junction (GJ) proteins. Microglia exclusively bind to the neuronal-derived chemokine fractalkine (FKN) via the CX3CR1 receptor to ameliorate microglial activation. Using neuron-specific recombinant adeno-associated viruses (rAAVs), we therapeutically overexpressed soluble (sFKN) or membrane-bound (mFKN) FKN using intra-vitreal delivery at the onset of diabetes. This study highlights the neuroprotective role of rAAV-sFKN, reducing microglial activation, vascular tortuosity, fibrin(ogen) deposition, and astrogliosis and supporting the maintenance of the GJ connexin-43 (Cx43) and TJ zonula occludens-1 (ZO-1) molecules. The results also show that microglia-vascular interactions influence the vascular width upon administration of rAAV-sFKN and rAAV-mFKN. Administration of rAAV-sFKN improved visual function without affecting peripheral immune responses. These findings suggest that overexpression of rAAV-sFKN can mitigate vascular abnormalities by promoting glia-neural signaling. sFKN gene therapy is a promising translational approach to reverse vision loss driven by vascular dysfunction.
MeSH term(s)	Chemokine CX3CL1/pharmacology ; Chemokine CX3CL1/therapeutic use ; Diabetes Mellitus/metabolism ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/metabolism ; Microglia/metabolism ; Retina/metabolism ; Signal Transduction ; Diabetes Complications/drug therapy ; Animals ; Mice
Chemical Substances	Chemokine CX3CL1
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25031727
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The TSANZ and Lung Foundation Australia 2023 landscape survey of lung cancer care across Australia and Aotearoa New Zealand.

Nash, Jessica / Leong, Tracy / Dawkins, Paul / Stone, Emily / Marshall, Henry / Brims, Fraser

Respirology (Carlton, Vic.)

2024 Volume 29, Issue 5, Page(s) 405–412

Abstract: Background and objective: Unwarranted variations in lung cancer care have been well described in both Australia and Aotearoa New Zealand, with shortfalls in hospital-based workforce and infrastructure previously demonstrated. A survey of lung cancer ... ...

Abstract	Background and objective: Unwarranted variations in lung cancer care have been well described in both Australia and Aotearoa New Zealand, with shortfalls in hospital-based workforce and infrastructure previously demonstrated. A survey of lung cancer clinicians was performed to gain an updated understanding of current workforce and infrastructure. Methods: An online Qualtrics survey included questions on institutional demographics, estimated lung cancer case load, multidisciplinary team (MDT) characteristics including workforce and local infrastructure. We sought to obtain one response from every institution treating lung cancer in Australia and Aotearoa New Zealand. Results: Responses were received from 89 institutions, estimated to include 85% centres treating lung cancer in Australia and 100% of public hospitals in Aotearoa New Zealand. Lung cancer nurse specialist and Nuclear Medicine are poorly represented in multidisciplinary teams (MDTs) with just 34/88 (38%) institutions fulfilling recommended core workforce for MDT meetings. Case presentation is low with 32/88 (36%) regularly discussing all lung cancer patients at MDT. Metropolitan institutions appear to have a more comprehensive range of services on site, compared to non-metropolitan institutions. Few (4/88) institutions have embedded smoking cessation services. Compared to the previous 2021 Landscape Survey, thoracic surgery representation and core MDT workforce have improved, with modest change in specialist nurse numbers. Conclusion: This wide-reaching survey has identified persistent deficiencies and variations in lung cancer workforce and gaps in infrastructure. Multidisciplinary collaboration and care coordination are needed to ensure all patients can access timely and equitable lung cancer care.
MeSH term(s)	Humans ; Lung Neoplasms/epidemiology ; Lung Neoplasms/therapy ; New Zealand/epidemiology ; Surveys and Questionnaires ; Lung ; Australia/epidemiology
Language	English
Publishing date	2024-03-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14693
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Article ; Online: Clinical trials: A plea to cooperative groups, consortia, pharmaceutical companies, and lead investigators for reasonable imaging protocols.

Trout, Andrew T / Norris, Robin E / de Blank, Peter M K / Backus, Lori R / Towbin, Alexander J / Nash, Jaylynn M

Pediatric blood & cancer

2023 Volume 70, Issue 10, Page(s) e30362

MeSH term(s)	Humans ; Clinical Trials as Topic ; Drug Industry
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Editorial
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30362
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Article ; Online: Learning from the End of the Public-Private Partnership for Lesotho's National Referral Hospital Network.

McGuire, Chelsea M / Kaiser, Jeanette L / Vian, Taryn / Nkabane-Nkholongo, Elizabeth / Nash, Tshema / Jack, Brian W / Scott, Nancy A

Annals of global health

2024 Volume 90, Issue 1, Page(s) 19

Abstract: Background: Public-private partnerships (PPP) are one strategy to finance and deliver healthcare in lower-resourced settings. Lesotho's Queen 'Mamohato Memorial Hospital Integrated Network (QMMH-IN) was sub-Saharan Africa's first and largest integrated ... ...

Abstract	Background: Public-private partnerships (PPP) are one strategy to finance and deliver healthcare in lower-resourced settings. Lesotho's Queen 'Mamohato Memorial Hospital Integrated Network (QMMH-IN) was sub-Saharan Africa's first and largest integrated healthcare PPP. Objective: We assessed successes and challenges to performance of the QMMH-IN PPP. Methods: We conducted 26 semi-structured interviews among QMMH-IN executive leadership and staff in early 2020. Questions were guided by the WHO Health System Building Blocks Framework. We conducted a thematic analysis. Findings: Facilitators of performance included: 1) PPP leadership commitment to quality improvement supported by protocols, monitoring, and actions; 2) high levels of accountability and discipline; and 3) well-functioning infrastructure, core systems, workflows, and internal referral network. Barriers to performance included: 1) human resource management challenges and 2) broader health system and referral network limitations. Respondents anticipated the collapse of the PPP and suggested better investing in training incoming managerial staff, improving staffing, and expanding QMMH-IN's role as a training facility. Conclusions: The PPP contract was terminated approximately five years before its anticipated end date; in mid-2021 the government of Lesotho assumed management of QMMH-IN. Going forward, the Lesotho government and others making strategic planning decisions should consider fostering a culture of quality improvement and accountability; ensuring sustained investments in human resource management; and allocating resources in a way that recognizes the interdependency of healthcare facilities and overall system strengthening. Contracts for integrated healthcare PPPs should be flexible to respond to changing external conditions and include provisions to invest in people as substantively as infrastructure, equipment, and core systems over the full length of the PPP. Healthcare PPPs, especially in lower-resource settings, should be developed with a strong understanding of their role in the broader health system and be implemented in conjunction with efforts to ensure and sustain adequate capacity and resources throughout the health system.
MeSH term(s)	Humans ; Public-Private Sector Partnerships ; Lesotho ; Delivery of Health Care ; Hospitals ; Referral and Consultation
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821756-1
ISSN	2214-9996 ; 2214-9996
ISSN (online)	2214-9996
ISSN	2214-9996
DOI	10.5334/aogh.4377
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phosphate Coordination to Metal-Organic Layer Secondary Building Units Prolongs Drug Retention for Synergistic Chemoradiotherapy.

Luo, Taokun / Jiang, Xiaomin / Li, Jinhong / Nash, Geoffrey T / Yuan, Eric / Albano, Luciana / Tillman, Langston / Lin, Wenbin

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 16, Page(s) e202319981

Abstract: Chemoradiotherapy combines radiotherapy with concurrent chemotherapy to potentiate antitumor activity but exacerbates toxicities and causes debilitating side effects in cancer patients. Herein, we report the use of a nanoscale metal-organic layer (MOL) ... ...

Abstract	Chemoradiotherapy combines radiotherapy with concurrent chemotherapy to potentiate antitumor activity but exacerbates toxicities and causes debilitating side effects in cancer patients. Herein, we report the use of a nanoscale metal-organic layer (MOL) as a 2D nanoradiosensitizer and a reservoir for the slow release of chemotherapeutics to amplify the antitumor effects of radiotherapy. Coordination of phosphate-containing drugs to MOL secondary building units prolongs their intratumoral retention, allowing for continuous release of gemcitabine monophosphate (GMP) for effective localized chemotherapy. In the meantime, the MOL sensitizes cancer cells to X-ray irradiation and provides potent radiotherapeutic effects. GMP-loaded MOL (GMP/MOL) enhances cytotoxicity by 2-fold and improves radiotherapeutic effects over free GMP in vitro. In a colon cancer model, GMP/MOL retains GMP in tumors for more than four days and, when combined with low-dose radiotherapy, inhibits tumor growth by 98 %. The synergistic chemoradiotherapy enabled by GMP/MOL shows a cure rate of 50 %, improves survival, and ameliorates cancer-proliferation histological biomarkers.
MeSH term(s)	Humans ; Phosphates ; Gemcitabine ; Chemoradiotherapy ; Neoplasms/drug therapy
Chemical Substances	Phosphates ; Gemcitabine
Language	English
Publishing date	2024-03-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202319981
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Article ; Online: The effect of rehabilitation therapies on quality of life and function in individuals with phantom limb pain after lower-limb amputation: A systematic review.

Gane, Elise / Petersen, Phoebe / Killalea, Taylor / Glavinovic, Paige / Nash, Isabel / Batten, Heather

Prosthetics and orthotics international

2023

Abstract: Purpose: To evaluate the existing evidence surrounding the effect of rehabilitation therapies on quality of life (QOL) and function of individuals with a lower-limb amputation and experiencing phantom limb pain (PLP).: Methods: This review followed ... ...

Abstract	Purpose: To evaluate the existing evidence surrounding the effect of rehabilitation therapies on quality of life (QOL) and function of individuals with a lower-limb amputation and experiencing phantom limb pain (PLP). Methods: This review followed Preferred Reporting Items for Systematic reviews and Meta-Analyses methodology. Four databases were searched with key terms that covered 4 broad areas: phantom limb, lower-limb amputation, rehabilitation interventions, and randomized controlled trial (no date limits). Outcomes of either function or QOL in people receiving rehabilitation for PLP were included. The RoB2.0 risk-of-bias tool was used to rate quality. Results: Five studies were included, reporting on QOL (n = 5) and function (n = 3), using interventions including mirror therapy, phantom exercises, and muscle relaxation. The evidence was mixed in direction and significance, and this was likely attributed to by the heterogeneity of interventions and types of outcomes as well as incomplete reporting. There was very low certainty in the effect of these rehabilitation interventions to affect QOL or function. Conclusion: The overall effect of rehabilitation interventions on QOL and function is inconclusive because of the variable results across the included randomized controlled trials. More research is needed to explore the impact of interventions beyond the outcome of pain and to establish a clearer conclusion. Including measures of QOL and function as well as pain in studies with people with PLP is encouraged.
Language	English
Publishing date	2023-09-14
Publishing country	France
Document type	Journal Article
ZDB-ID	753382-2
ISSN	1746-1553 ; 0309-3646
ISSN (online)	1746-1553
ISSN	0309-3646
DOI	10.1097/PXR.0000000000000288
Database	MEDical Literature Analysis and Retrieval System OnLINE

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