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  1. Article: Periarrestrhythmen – ein schmaler Grat. Teil I: der bradykarde Periarrest

    Kraft, Maximilian / Rusnak, Jonas / Biener, Moritz / Weilbacher, Frank

    NOTARZT

    2024  Volume 40, Issue 02, Page(s) 105–108

    Keywords Kreislaufstillstand ; Früherkennung ; Bradykardie ; kardiale Arrhythmien ; Schrittmachertherapie ; cardiac arrest ; early diagnosis ; bradycardia ; arrhythmias, cardiac ; cardiac pacing, artificial
    Language German
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2039417-2
    ISSN 1438-8693 ; 0177-2309
    ISSN (online) 1438-8693
    ISSN 0177-2309
    DOI 10.1055/a-2278-8542
    Database Thieme publisher's database

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  2. Article: Chirurgische Therapie der Adipositas

    Stroh, C. / Luderer, D. / Arnold, F. / Rusnak, R.

    Herzmedizin

    2022  Volume 38, Issue 5, Page(s) 32

    Language German
    Document type Article
    ZDB-ID 561578-1
    ISSN 0171-9238
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2206: Show issues Location:
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  3. Article: Attacks on Ukrainian healthcare facilities during the first year of the full-scale Russian invasion of Ukraine.

    Barten, Dennis G / Tin, Derrick / Granholm, Fredrik / Rusnak, Diana / van Osch, Frits / Ciottone, Gregory

    Conflict and health

    2023  Volume 17, Issue 1, Page(s) 57

    Abstract: Background: Although the Geneva Conventions and Rome Statute demand protections for healthcare facilities during war, breaches of these protections are frequently reported. The ongoing war in Ukraine is no exception, with several healthcare attacks ... ...

    Abstract Background: Although the Geneva Conventions and Rome Statute demand protections for healthcare facilities during war, breaches of these protections are frequently reported. The ongoing war in Ukraine is no exception, with several healthcare attacks eliciting widespread condemnation. The Ukrainian Healthcare Center (UHC) has been collecting, verifying and documenting attacks on health infrastructure since the Russia-Ukraine War was launched. The aim of this study was to assess UHC documented healthcare facility attacks during the first year (24 February 2022 to 25 February 2023) of the full-scale Russian invasion of Ukraine.
    Methods: The Berkeley Protocol on Digital Open Source Investigations was used to document healthcare attacks. Data collection included temporal factors, location, facility type, attack and weapon type, number of killed and injured healthcare personnel and civilians, and whether facilities were damaged, destroyed or attacked more than once.
    Results: There were 334 documented attacks on 267 Ukrainian healthcare facilities, with 230 facilities being damaged and 37 destroyed. General hospitals, primary care clinics, emergency departments and children's hospitals were most frequently targeted. The majority of attacks took place during the first three months and in eastern Ukrainian oblasts. Heavy weaponry was employed in almost all attacks. The total number of casualties included 97 fatalities and 114 injuries.
    Conclusions: During the first year of the full-scale Russian invasion of Ukraine, there were 334 attacks on 267 Ukrainian healthcare facilities documented by the UHC. Heavy weaponry was commonly used, and the direct impact of attacks was considerable in terms of facility damage and casualty tolls.
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2273783-2
    ISSN 1752-1505
    ISSN 1752-1505
    DOI 10.1186/s13031-023-00557-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Obesity Paradox in Heart Failure with Mildly Reduced Ejection Fraction.

    Reinhardt, Marielen / Schupp, Tobias / Abumayyaleh, Mohammad / Lau, Felix / Schmitt, Alexander / Abel, Noah / Akin, Muharrem / Rusnak, Jonas / Akin, Ibrahim / Behnes, Michael

    Pragmatic and observational research

    2024  Volume 15, Page(s) 31–43

    Abstract: Objective: The study investigates the prognostic impact of body mass index (BMI) in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF).: Background: Limited data regarding the prognostic impact of BMI in patients ... ...

    Abstract Objective: The study investigates the prognostic impact of body mass index (BMI) in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF).
    Background: Limited data regarding the prognostic impact of BMI in patients with HFmrEF is available.
    Methods: Consecutive patients with HFmrEF (ie, left ventricular ejection fraction 41-49% and signs and/or symptoms of HF) were retrospectively included at one institution from 2016 to 2022. Risk stratification was performed according to WHO-defined BMI groups. The primary endpoint was all-cause mortality at 30 months (median follow-up). Kaplan-Meier, uni- and multivariable Cox proportional regression analyses were applied for statistics.
    Results: 1832 consecutive patients with HFmrEF were included with a median BMI of 26.7 kg/m
    Conclusion: In patients hospitalized with HFmrEF, lower BMI was associated with increased risk of all-cause mortality at 30 months, suggesting an obesity paradox in HFmrEF.
    Language English
    Publishing date 2024-03-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2586661-8
    ISSN 1179-7266
    ISSN 1179-7266
    DOI 10.2147/POR.S444361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Alterations in the localization of F-actin, fibronectin, and thrombospondin occur prior to neoplastic transformation in rat tracheal epithelial cells.

    Carter, C A / Doherty, M M / Rusnak, D W / Nettesheim, P / Ferriola, P C

    Experimental cell research

    1994  Volume 212, Issue 1, Page(s) 141–150

    Abstract: ... alterations in cell architecture. Localization of fibronectin (Fn), thrombospondin (Tsp), and F-actin was ... scanning microscope. Primary RTE cells display organized F-actin stress fibers, perinuclear Fn and Tsp, and ... exhibit few cell surface extensions. F-actin stress fibers are reduced in these immortalized cells. F ...

    Abstract Structural glycoproteins and cytoskeletal proteins play a major role in the regulation of cellular organization and function. Changes in the structure and function of these proteins are involved in the cascade of events which lead to neoplastic transformation. We evaluated RNA levels, protein localization, and organization of selected proteins in an in vitro model system of respiratory carcinogenesis to examine alterations in cell architecture. Localization of fibronectin (Fn), thrombospondin (Tsp), and F-actin was examined in (1) primary rat tracheal epithelial (RTE) cells; (2) spontaneously immortalized nonneoplastic cells (SPOC-1); and (3) neoplastic cells (EGV5T) derived from tumors arising following transplantation of an N-methyl-N'-nitro-N-nitrosoguanidine-transformed RTE cell line into nude mice. Proteins were stained with fluorescein-labeled antibodies or phalloidin compound and analysis was performed with a confocal laser scanning microscope. Primary RTE cells display organized F-actin stress fibers, perinuclear Fn and Tsp, and pericellular Fn in fibrillar arrays. In larger colonies, Tsp occurs between cells and occasionally in fibrillar arrays. SPOC-1 cells, unlike primary RTE cells and neoplastic EGV5T cells, seldom form junctions and exhibit few cell surface extensions. F-actin stress fibers are reduced in these immortalized cells. F-actin in SPOC-1 cells occurs in the perinuclear region, scattered diffusely throughout the cell and in punctate adhesions. Fn and Tsp are localized to the perinuclear region with Fn staining more intensely. EGV5T neoplastic cells also display a dramatic loss of stress fibers and F-actin is concentrated mainly near the cell periphery. Perinuclear staining of Fn and Tsp occurs in some cells within the colony. Levels of Tsp RNA and Fn RNA and protein are significantly reduced in both cell lines compared to primary RTE cells. We conclude that structural protein disruptions are early events in the transformation of these respiratory epithelial cells.
    MeSH term(s) Actins/isolation & purification ; Animals ; Cell Compartmentation ; Cell Division ; Cell Transformation, Neoplastic ; Cells, Cultured ; Epithelial Cells ; Fibronectins/genetics ; Fibronectins/isolation & purification ; Fluorescent Antibody Technique ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/isolation & purification ; RNA, Messenger/analysis ; Rats ; Thrombospondins ; Trachea/cytology
    Chemical Substances Actins ; Fibronectins ; Membrane Glycoproteins ; RNA, Messenger ; Thrombospondins
    Language English
    Publishing date 1994-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1493-x
    ISSN 1090-2422 ; 0014-4827
    ISSN (online) 1090-2422
    ISSN 0014-4827
    DOI 10.1006/excr.1994.1128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Development of forest industry of Northern Bukovyna and Khotyn region in the interwar period

    Oleksandr Rusnak / Vasyl Tomash

    Науковий вісник Чернівецького національного університету імені Юрія Федьковича. Історія, Iss

    2021  Volume 54

    Abstract: ... region, which operated between the two world wars were: Joint-Stock Company f. Wood Industry «Goetz», «Forestiera», E.H ...

    Abstract Forest resources of Northern Bukovyna and Khotyn County have long played an important role in the life of the local population. During 1918–1940, the forest branch of the region occupied one of the leading positions in all industry. In particular, during the investigated period there was an expansion of production and an increase in the number of enterprises (from 32 to 48). Among the most important enterprises in the logging, sawmilling, furniture, pulp and paper subsectors of Northern Bukovyna and Khotyn region, which operated between the two world wars were: Joint-Stock Company f. Wood Industry «Goetz», «Forestiera», E.H. Friedmann, Engel & Glasberg Sawmill, a furniture factory «Ant», «Nikolaus Zajacskowski & Sons, Barrels Factory with Electric Power», a factory for the production of wooden nails «Astra», a paper factory «Biedermann and Kindler», Wallpaper and Paper Bags Factory «Tapa» Limited Liability Company in Chernivtsi.
    Keywords Northern Bukovyna ; Khotyn region ; interwar period ; forest industry ; factory ; woodworking ; History (General) and history of Europe ; D
    Subject code 941
    Language German
    Publishing date 2021-12-01T00:00:00Z
    Publisher Yuriy Fedkovych Chernivtsi National University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Polyethylene Glycol Impacts Conformation and Dynamics of

    Liebau, Jessica / Laatsch, Bethany F / Rusnak, Joshua / Gunderson, Keegan / Finke, Brianna / Bargender, Kassandra / Narkiewicz-Jodko, Alex / Weeks, Katelyn / Williams, Murphi T / Shulgina, Irina / Musier-Forsyth, Karin / Bhattacharyya, Sudeep / Hati, Sanchita

    Biochemistry

    2024  

    Abstract: Polyethylene glycol (PEG) is a flexible, nontoxic polymer commonly used in biological and medical research, and it is generally regarded as biologically inert. PEG molecules of variable sizes are also used as crowding agents to mimic intracellular ... ...

    Abstract Polyethylene glycol (PEG) is a flexible, nontoxic polymer commonly used in biological and medical research, and it is generally regarded as biologically inert. PEG molecules of variable sizes are also used as crowding agents to mimic intracellular environments. A recent study with PEG crowders revealed decreased catalytic activity of
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Prediction Model of the Resulting Dimensions of Welded Stamped Parts.

    Kadnár, Milan / Káčer, Peter / Harničárová, Marta / Valíček, Jan / Gombár, Mirek / Kušnerová, Milena / Tóth, František / Boržan, Marian / Rusnák, Juraj

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 11

    Abstract: The combination of stamping and subsequent welding of components is an important area of the automotive industry. Stamping inaccuracies affect the final size of the stamping and the welded part. In this article, we deal with a specific component that is ... ...

    Abstract The combination of stamping and subsequent welding of components is an important area of the automotive industry. Stamping inaccuracies affect the final size of the stamping and the welded part. In this article, we deal with a specific component that is produced by such a procedure and is also a common part of the geometry of a car. We focused on the possibility of using a negative phenomenon-deformation during welding-on the partial elimination of inaccuracies arising during stamping. Based on the planned experiment, we created a prediction model for the selected part and its production, with the help of which it is possible to determine suitable welding parameters for a specific dimension of the stamping and the required monitored dimension of the welded part. The article also includes the results of additional experimental measurements verifying the accuracy of the model and prediction maps for practice.
    Language English
    Publishing date 2021-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14113062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Out-of-

    Müller, Michael P / Ganter, Julian / Busch, Hans-Jörg / Trummer, Georg / Sahlmann, Jörg / Brettner, Florian / Reden, Maria / Elschenbroich, Daniel / Preusch, Michael / Rusnak, Jonas / Katzenschlager, Stephan / Nauheimer, Dirk / Wunderlich, Robert / Pooth, Jan-Steffen

    Resuscitation plus

    2024  Volume 17, Page(s) 100564

    Abstract: Background: Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called "life-saving systems". These systems include smartphone alerting systems (SAS), which enable dispatch centres to alert first ... ...

    Abstract Background: Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called "life-saving systems". These systems include smartphone alerting systems (SAS), which enable dispatch centres to alert first responders via smartphone applications, who are in proximity of a suspected out-of-hospital cardiac arrest (OHCA). However, the effect of SAS on survival remains unknown.
    Aim: The aim is to assess the rate of survival to hospital discharge in adult patients with OHCA not witnessed by emergency medical services (EMS): before and after SAS implementation.
    Design: Multicentre, prospective, observational, intention-to-treat, pre-post design clinical trial.
    Population: Adults (aged ≥ 18 years), OHCA not witnessed by EMS, no traumatic cause for cardiac arrest, cardiopulmonary resuscitation initiated or continued by EMS.
    Setting: Dispatch-centre-based.
    Outcomes: Primary: survival to hospital discharge. Secondary: time to first compression, rate of basic life support measures before EMS arrival, rate of patients with shockable rhythm at EMS arrival, Cerebral Performance Category at hospital discharge, and duration of hospital stay.
    Sample size: Assuming an absolute difference in survival rates to hospital discharge of 4% in the two groups (11% before implementation of the SAS versus 15% after) and 80% power, and a type 1 error rate of 0.05, the required sample size is
    Conclusions: The HEROES trial will investigate the effects of a SAS on the survival rate after OHCA.
    Trial registration: German Clinical Trials Register (DRKS, ID: DRKS00032920).
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-5204
    ISSN (online) 2666-5204
    DOI 10.1016/j.resplu.2024.100564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prognostic Implications of Septal Hypertrophy in Patients with Heart Failure with Mildly Reduced Ejection Fraction.

    Abel, Noah / Schupp, Tobias / Abumayyaleh, Mohammad / Schmitt, Alexander / Reinhardt, Marielen / Lau, Felix / Ayoub, Mohamed / Mashayekhi, Kambis / Akin, Muharrem / Rusnak, Jonas / Akin, Ibrahim / Behnes, Michael

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Cardiac remodeling is frequently observed in patients with heart failure (HF) and serves as an indicator of disease progression and severity. Septal hypertrophy represents an aspect of remodeling that can be easily assessed via an echocardiographic ... ...

    Abstract Cardiac remodeling is frequently observed in patients with heart failure (HF) and serves as an indicator of disease progression and severity. Septal hypertrophy represents an aspect of remodeling that can be easily assessed via an echocardiographic measurement of the interventricular septal end diastole (IVSd), but it has not been evaluated for its prognostic value, particularly in patients with heart failure with mildly reduced ejection fraction (HFmrEF). We retrospectively included 1881 consecutive patients hospitalized with HFmrEF (i.e., a left ventricular ejection fraction of 41-49% and signs and/or symptoms of HF) at one institution during a study period from 2016 to 2022. Septal hypertrophy, defined as an IVSd > 12 mm, was prevalent in 34% of the HFmrEF patients. Although septal hypertrophy was not associated with all-cause mortality at 30 months (median follow-up) (HR = 1.067; 95% CI: 0.898-1.267;
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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