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  1. Book ; Conference proceedings: Examining developments in multicancer early detection: highlights of new clinical data from recent conferences

    Beer, Tomasz M.

    (The American journal of managed care ; vol. 27, no. 19, sup. (December 2021))

    2021  

    Author's details Tomasz M. Beer, MD
    Series title The American journal of managed care ; vol. 27, no. 19, sup. (December 2021)
    Collection
    Language English
    Size Seite S345-S356, Illustrationen, Diagramme
    Publisher Managed Care & Healthcare Communications, LLC
    Publishing place Plainsboro, NJ
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT021299547
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 5353 -27,19,Sup.- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Examining developments in multicancer early detection: highlights of new clinical data from recent conferences.

    Beer, Tomasz M

    The American journal of managed care

    2022  Volume 27, Issue 19 Suppl, Page(s) S347–S355

    Abstract: Cancer remains the second leading cause of death in the United States despite decades of treatment advances. While death rates have fallen for breast, cervical, and colorectal cancers, death rates remain high for the majority of malignancies, primarily ... ...

    Abstract Cancer remains the second leading cause of death in the United States despite decades of treatment advances. While death rates have fallen for breast, cervical, and colorectal cancers, death rates remain high for the majority of malignancies, primarily given the late stage at which they are diagnosed. The US Preventive Services Task Force currently recommends routine screening for just 4 cancers: breast, cervical, colorectal, and lung (for high-risk individuals); for prostate cancer, recommendations support individual decision making. However, cancers without recommended screening tests account for 71% of cancer deaths in the United States. In addition, screening rates remain below national goals, with numerous barriers to population-based screening. Recently, initial results of studies on blood-based multicancer early detection tests, which rely on measurement of a range of analytes, demonstrate the potential to identify multiple cancers in a single blood test and detect many cancers for which no screening tests are currently recommended. Blood-based tests have the potential to be more accessible and easier to disseminate than organ-specific tests. However, it remains unclear if their use can reduce deaths from these cancers. Other issues include cost-effectiveness, the impact of false-positive and false-negative results on patients and costs, and uptake among individuals and clinicians. Research and development of blood-based multicancer early detection tests continue.
    MeSH term(s) Cost-Benefit Analysis ; Early Detection of Cancer ; Humans ; Male ; Mass Screening ; Prostatic Neoplasms ; United States
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2021.88801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Promise of Multicancer Early Detection.

    Klein, Eric A / Beer, Tomasz M / Seiden, Michael

    The American journal of medicine

    2023  Volume 136, Issue 3, Page(s) e46–e47

    MeSH term(s) Humans ; Neoplasms ; Risk Factors ; Early Detection of Cancer
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Novel blood-based early cancer detection: diagnostics in development.

    Beer, Tomasz M

    The American journal of managed care

    2020  Volume 26, Issue 14 Suppl, Page(s) S292–S299

    Abstract: Cancer affects millions of Americans, and the number of cases is steadily rising. The increase in diagnosis of cancer cases comes with an associated increase in personal and economic burden. Earlier detection can improve treatment outcomes and may reduce ...

    Abstract Cancer affects millions of Americans, and the number of cases is steadily rising. The increase in diagnosis of cancer cases comes with an associated increase in personal and economic burden. Earlier detection can improve treatment outcomes and may reduce the burden of cancer. Screening for cervical cancer is a good example of the potential of effective screening methods to dramatically reduce the morbidity and mortality associated with cancer. However, many current screening methods have high false-positive rates, increasing the concern for overdiagnosis and overtreatment. Blood-based tests capable of detecting multiple types of cancer represent an emerging approach to early cancer detection. Although there are several single-cancer detection tests in development, multicancer screening tests have greater potential to allow for widespread screening in the general population. Three multicancer screening tests are being validated in ongoing clinical trials, including the CancerSEEK assay, the Galleri test, and the PanSeer assay, all of which show high specificity in preliminary findings. Further validation is required before multicancer detection tests are incorporated into general population cancer screening.
    MeSH term(s) Early Detection of Cancer ; Female ; Humans ; Mass Screening ; Medical Overuse ; Uterine Cervical Neoplasms/diagnosis
    Language English
    Publishing date 2020-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2020.88533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Multicancer early detection.

    Klein, Eric A / Beer, Tomasz M / Seiden, Michael

    Clinical chemistry and laboratory medicine

    2022  Volume 60, Issue 5, Page(s) e119–e120

    MeSH term(s) Biopsy ; Early Detection of Cancer ; Humans ; Mass Screening ; Neoplasms/diagnosis
    Language English
    Publishing date 2022-02-03
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2022-0058
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  6. Article: The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm.

    Klein, Eric A / Beer, Tomasz M / Seiden, Michael

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 5

    Abstract: Multicancer Early Detection (MCED) represents a new and exciting paradigm for the early detection of cancer, which is the leading cause of death worldwide. Current screening tests, recommended for only five cancer types (breast, lung, colon, cervical, ... ...

    Abstract Multicancer Early Detection (MCED) represents a new and exciting paradigm for the early detection of cancer, which is the leading cause of death worldwide. Current screening tests, recommended for only five cancer types (breast, lung, colon, cervical, and prostate), are limited by a lack of complete adherence to guideline-based use and by the fact that they have cumulative high false positive rates. MCED tests agnostically detect cancer signals in the blood with good sensitivity and low false positive rates, can predict the cancer site of origin with high accuracy, can detect highly lethal cancers that have no current screening tests, and promise to improve cancer screening by improving efficiency and reducing the overall number needed to screen. Herein we outline this promise and clarify several published misconceptions about this field.
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12051243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Management of Castration-Resistant, Taxane-Resistant Prostate Cancer.

    Beer, Tomasz M

    Oncology (Williston Park, N.Y.)

    2017  Volume 31, Issue 8, Page(s) 633–636

    Abstract: Metastatic castration-resistant prostate cancer that is progressing despite docetaxel chemotherapy is difficult to treat and often aggressive. If not previously used, modern androgen signaling inhibitors have established clinical activity in this setting. ...

    Abstract Metastatic castration-resistant prostate cancer that is progressing despite docetaxel chemotherapy is difficult to treat and often aggressive. If not previously used, modern androgen signaling inhibitors have established clinical activity in this setting. Cabazitaxel and radium-223 have also been shown to extend survival in appropriately selected patients. Carboplatin-containing chemotherapy regimens have not been studied in randomized trials with a survival endpoint, but they have demonstrated activity in phase II trials and are occasionally considered in the post-docetaxel setting. Recent identification of potentially exploitable targets in the molecular makeup of advanced prostate cancer has created opportunities for clinical trials of novel targeted agents, with poly(ADP-ribose) polymerase inhibitors yielding compelling early results in molecularly selected patients. Much remains to be done to improve the lot of patients with docetaxel-unresponsive metastatic castration-resistant prostate cancer.
    MeSH term(s) Clinical Trials as Topic ; Drug Resistance, Neoplasm ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Taxoids/therapeutic use
    Chemical Substances Taxoids ; docetaxel (15H5577CQD) ; cabazitaxel (51F690397J)
    Language English
    Publishing date 2017--15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3168: Show issues Location:
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    Zs.MO 372: Show issues

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  8. Article ; Online: The Promise of Multicancer Early Detection. Comment on Pons-Belda et al. Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm. Diagnostics 2021, 11 , 2171

    Eric A. Klein / Tomasz M. Beer / Michael Seiden

    Diagnostics, Vol 12, Iss 1243, p

    2022  Volume 1243

    Abstract: Multicancer Early Detection (MCED) represents a new and exciting paradigm for the early detection of cancer, which is the leading cause of death worldwide. Current screening tests, recommended for only five cancer types (breast, lung, colon, cervical, ... ...

    Abstract Multicancer Early Detection (MCED) represents a new and exciting paradigm for the early detection of cancer, which is the leading cause of death worldwide. Current screening tests, recommended for only five cancer types (breast, lung, colon, cervical, and prostate), are limited by a lack of complete adherence to guideline-based use and by the fact that they have cumulative high false positive rates. MCED tests agnostically detect cancer signals in the blood with good sensitivity and low false positive rates, can predict the cancer site of origin with high accuracy, can detect highly lethal cancers that have no current screening tests, and promise to improve cancer screening by improving efficiency and reducing the overall number needed to screen. Herein we outline this promise and clarify several published misconceptions about this field.
    Keywords multicancer early detection ; methylation ; circulating cell-free genome atlas ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Combining options in metastatic prostate cancer.

    Kopp, Ryan P / Beer, Tomasz M

    Nature reviews. Urology

    2019  Volume 16, Issue 10, Page(s) 569–570

    MeSH term(s) Clinical Trials as Topic ; Drug Therapy, Combination ; Humans ; Male ; Neoplasm Metastasis ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology
    Language English
    Publishing date 2019-07-17
    Publishing country England
    Document type News
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-019-0217-z
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  10. Article: Building on Last Year's Advances.

    Beer, Tomasz M

    Oncology (Williston Park, N.Y.)

    2015  Volume 29, Issue 7, Page(s) 504–506

    MeSH term(s) Humans ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/mortality
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3168: Show issues Location:
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