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  1. Article ; Online: Calcium pyrophosphate deposition and crowned dens syndrome.

    Rosenthal, Ann K

    Cleveland Clinic journal of medicine

    2021  Volume 88, Issue 4, Page(s) 206–207

    MeSH term(s) Calcinosis/diagnostic imaging ; Calcium Pyrophosphate ; Humans ; Neck Pain/etiology ; Syndrome
    Chemical Substances Calcium Pyrophosphate (X69NU20D19)
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.88a.21008
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  2. Article ; Online: Daniel J McCarty, MD: A Giant of Rheumatology.

    Rosenthal, Ann K / Csuka, Mary E / Halverson, Paul

    Rheumatic diseases clinics of North America

    2023  Volume 50, Issue 1, Page(s) 15–23

    Abstract: There is no doubt that Dr Daniel J McCarty warrants inclusion among the giants of rheumatology. He has made major contributions to both clinical and scientific knowledge in our field, and his impact has been long-lasting and paradigm shifting. He is ... ...

    Abstract There is no doubt that Dr Daniel J McCarty warrants inclusion among the giants of rheumatology. He has made major contributions to both clinical and scientific knowledge in our field, and his impact has been long-lasting and paradigm shifting. He is perhaps best known for his pioneering work in crystal arthritis, but as an astute clinician, he is also responsible for describing several other novel rheumatic conditions and developing innovative treatment protocols.
    MeSH term(s) Male ; Humans ; Synovitis/drug therapy ; Rheumatology ; Edema
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2023.08.001
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  3. Article ; Online: Pathogenesis of calcium pyrophosphate deposition disease.

    Williams, Charlene J / Rosenthal, Ann K

    Best practice & research. Clinical rheumatology

    2021  Volume 35, Issue 4, Page(s) 101718

    Abstract: Calcium pyrophosphate deposition disease is defined by the presence of calcium pyrophosphate (CPP) crystals in articular cartilage and is the fourth most common type of arthritis in adults. Despite its high prevalence, the etiology of CPPD disease ... ...

    Abstract Calcium pyrophosphate deposition disease is defined by the presence of calcium pyrophosphate (CPP) crystals in articular cartilage and is the fourth most common type of arthritis in adults. Despite its high prevalence, the etiology of CPPD disease remains unclear and no specific therapies currently exist. It has been known for several decades that abnormalities of cartilage pyrophosphate metabolism are common in patients with CPPD disease, and this classic work will be reviewed here. Recent studies of rare familial forms of CPPD disease have provided additional novel information about its pathophysiology. This work suggests that CPPD disease occurs through at least two unique and potentially intertwined biomolecular pathways. We are hopeful that a detailed understanding of the components and regulation of these pathways will lead to improved therapies for this common disease.
    MeSH term(s) Adult ; Calcium Pyrophosphate ; Cartilage, Articular ; Chondrocalcinosis/etiology ; Humans
    Chemical Substances Calcium Pyrophosphate (X69NU20D19)
    Language English
    Publishing date 2021-10-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2021.101718
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  4. Article ; Online: Basic calcium phosphate crystal-associated musculoskeletal syndromes: an update.

    Rosenthal, Ann K

    Current opinion in rheumatology

    2017  Volume 30, Issue 2, Page(s) 168–172

    Abstract: Purpose of review: Basic calcium phosphate (BCP) crystals are associated with two important musculoskeletal syndromes. Deposition of BCP crystals in tendons, bursae, and other soft tissues around joints causes calcific periarthritis, whereas intra- ... ...

    Abstract Purpose of review: Basic calcium phosphate (BCP) crystals are associated with two important musculoskeletal syndromes. Deposition of BCP crystals in tendons, bursae, and other soft tissues around joints causes calcific periarthritis, whereas intra-articular BCP crystals contribute to osteoarthritis and cause the highly destructive arthritis known as Milwaukee Shoulder Syndrome. The epidemiology and natural history of these syndromes are poorly understood, and because the pathogenesis remains unclear, few targeted therapies are available. I will review new developments in this field.
    Recent findings: I will discuss a case collection of calcific periarthritis of the hip, and evidence-based management strategies for shoulder calcific periarthritis that might be applied to calcific periarthritis at other locations. I will summarize several recent articles addressing mechanisms of crystal formation and identifying pathways through which BCP crystals produce tissue damage and explore some newly identified risk factors for pathologic mineralization.
    Summary: We are making slow, but steady progress in understanding the clinical presentation of calcific periarthritis in sites other than the shoulder. A growing appreciation of the mechanisms through which BCP crystals mediate tissue damage should lead to the development of novel management strategies for these common musculoskeletal syndromes.
    MeSH term(s) Calcinosis/complications ; Calcinosis/metabolism ; Calcium Phosphates/adverse effects ; Calcium Phosphates/metabolism ; Crystal Arthropathies/etiology ; Crystal Arthropathies/metabolism ; Humans ; Musculoskeletal Diseases/etiology ; Musculoskeletal Diseases/metabolism ; Osteoarthritis/etiology ; Osteoarthritis/metabolism ; Syndrome
    Chemical Substances Calcium Phosphates
    Language English
    Publishing date 2017-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000477
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  5. Article ; Online: Fractures in Patients With Acute Calcium Pyrophosphate Crystal Arthritis Versus Matched Comparators in a Large Cohort Study.

    Tedeschi, Sara K / Hayashi, Keigo / Rosenthal, Ann / Gill, Muneet / Marrugo, Javier / Fukui, Sho / Gravallese, Ellen / Solomon, Daniel H

    Arthritis & rheumatology (Hoboken, N.J.)

    2024  

    Abstract: Objective: Calcium pyrophosphate deposition (CPPD) disease was associated with osteopenia in two cross-sectional studies. We compared fracture risks in patients with acute calcium pyrophosphate (CPP) crystal arthritis versus matched comparators.: ... ...

    Abstract Objective: Calcium pyrophosphate deposition (CPPD) disease was associated with osteopenia in two cross-sectional studies. We compared fracture risks in patients with acute calcium pyrophosphate (CPP) crystal arthritis versus matched comparators.
    Methods: We performed a longitudinal cohort study using electronic health record data from a single large academic health system, with data from 1991 to 2023. Patients with one or more episodes of acute CPP crystal arthritis were matched to comparators on the index date (first documentation of "pseudogout" or synovial fluid CPP crystals or matched encounter) and first encounter in the health system. The primary outcome was first fracture at the humerus, wrist, hip, or pelvis. We excluded patients with fracture before the index date. Covariates included demographics, body mass index, smoking, comorbidities, health care use, glucocorticoids, and osteoporosis treatments. We estimated incidence rates and adjusted hazard ratios for fracture. Sensitivity analyses excluded patients prescribed glucocorticoids, patients prescribed osteoporosis treatments, or patients with rheumatoid arthritis and additionally adjusted for chronic kidney disease.
    Results: We identified 1,148 patients with acute CPP crystal arthritis matched to 3,730 comparators, with a mean age of 73 years. Glucocorticoids and osteoporosis treatments were more frequent in the acute CPP crystal arthritis cohort. Fracture incidence rates were twice as high in the acute CPP crystal arthritis cohort (11.7 per 1,000 person-years) versus comparators (5.5 per 1,000 person-years). After multivariable adjustment, fracture relative risk was twice as high in the acute CPP crystal arthritis cohort (hazard ratio 1.8 [95% confidence interval 1.3-2.3]); results were similar in sensitivity analyses.
    Conclusion: In this first published study of fractures and CPPD, fracture risk was nearly doubled in patients with acute CPP crystal arthritis.
    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42798
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  6. Article ; Online: Editorial: Community Health Workers Practice From Recruitment to Integration.

    St John, Julie Ann / Fox, Durrell J / Rosenthal, E Lee / Lee, Lily K

    Frontiers in public health

    2022  Volume 10, Page(s) 841081

    MeSH term(s) Community Health Workers ; Humans
    Language English
    Publishing date 2022-02-17
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.841081
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  7. Article ; Online: Accelerated mafic weathering in Southeast Asia linked to late Neogene cooling.

    Bayon, Germain / Patriat, Martin / Godderis, Yves / Trinquier, Anne / De Deckker, Patrick / Kulhanek, Denise K / Holbourn, Ann / Rosenthal, Yair

    Science advances

    2023  Volume 9, Issue 13, Page(s) eadf3141

    Abstract: Arc-continent collision in Southeast Asia during the Neogene may have driven global cooling through chemical weathering of freshly exposed ophiolites resulting in atmospheric ... ...

    Abstract Arc-continent collision in Southeast Asia during the Neogene may have driven global cooling through chemical weathering of freshly exposed ophiolites resulting in atmospheric CO
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adf3141
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  8. Article ; Online: Articular cartilage vesicles and calcium crystal deposition diseases.

    Rosenthal, Ann K

    Current opinion in rheumatology

    2015  Volume 28, Issue 2, Page(s) 127–132

    Abstract: Purpose of review: Articular cartilage vesicles (ACVs) are small extracellular vesicles that serve as foci of pathologic calcium crystal deposition in articular cartilage matrix. In this review, I have summarized the role of ACVs in calcium crystal ... ...

    Abstract Purpose of review: Articular cartilage vesicles (ACVs) are small extracellular vesicles that serve as foci of pathologic calcium crystal deposition in articular cartilage matrix. In this review, I have summarized the role of ACVs in calcium crystal formation and discuss recent findings that impact our understanding of the content, behavior, and origin of ACVs in healthy and diseased joints. The burgeoning interest in extracellular vesicles in other fields renders this a timely and relevant topic.
    Recent findings: I have highlighted recent studies demonstrating that some ACVs originate in the autophagic pathway in healthy articular chondrocytes. I have reviewed accumulating evidence that nonmineralizing functions of ACVs contribute to osteoarthritis. I have also discussed new work supporting a role for extracellular vesicles in interleukin-1β-induced mineralization and in mediating the catabolic effects of synovial inflammation in osteoarthritis.
    Summary: We are making slow and steady progress in understanding the origin and function of ACVs and other relevant extracellular vesicles in arthritis. Further work in this interesting area is warranted.
    MeSH term(s) Calcinosis/metabolism ; Calcinosis/pathology ; Calcium/metabolism ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Chondrocytes/metabolism ; Crystallization ; Extracellular Space/metabolism ; Humans ; Interleukin-1beta/metabolism ; Osteoarthritis/metabolism ; Osteoarthritis/pathology
    Chemical Substances Interleukin-1beta ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2015-12-30
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000244
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  9. Article ; Online: Editorial

    Julie Ann St. John / Durrell J. Fox / E. Lee Rosenthal / Lily K. Lee

    Frontiers in Public Health, Vol

    Community Health Workers Practice From Recruitment to Integration

    2022  Volume 10

    Keywords Community Health Workers (CHWs) ; integration ; recruitment ; training ; sustainability ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Identification of Common Pathogenic Pathways Involved in Hemochromatosis Arthritis and Calcium Pyrophosphate Deposition Disease: a Review.

    Mitton-Fitzgerald, Elizabeth / Gohr, Claudia M / Williams, Charlene M / Rosenthal, Ann K

    Current rheumatology reports

    2022  Volume 24, Issue 2, Page(s) 40–45

    Abstract: Objectives: Arthritis is a common clinical manifestation of hereditary hemochromatosis (HH), and HH is one of a handful of conditions linked to calcium pyrophosphate deposition (CPPD) in joints. The connection between these two types of arthritis has ... ...

    Abstract Objectives: Arthritis is a common clinical manifestation of hereditary hemochromatosis (HH), and HH is one of a handful of conditions linked to calcium pyrophosphate deposition (CPPD) in joints. The connection between these two types of arthritis has not yet been fully elucidated. In light of new pathogenic pathways recently implicated in CPPD involving bone, we reviewed the literature on the etiology of hemochromatosis arthropathy (HHA) seeking shared pathogenic mechanisms.
    Results: Clinical observations reinforce striking similarities between HHA and CPPD even in the absence of CPP crystals. They share a similar joint distribution, low grade synovial inflammation, and generalized bone loss. Excess iron damages chondrocytes and bone cells in vitro. While direct effects of iron on cartilage are not consistently seen in animal models of HH, there is decreased osteoblast alkaline phosphatase activity, and increased osteoclastogenesis. These abnormalities are also seen in CPPD. Joint repair processes may also be impaired in both CPPD and HHA.
    Conclusions: Possible shared pathogenic pathways relate more to bone and abnormal damage/repair mechanisms than direct damage to articular cartilage. While additional work is necessary to fully understand the pathogenesis of arthritis in HH and to firmly establish causal links with CPPD, this review provides some plausible hypotheses explaining the overlap of these two forms of arthritis.
    MeSH term(s) Animals ; Calcinosis ; Calcium Pyrophosphate ; Cartilage, Articular/pathology ; Chondrocalcinosis/pathology ; Hemochromatosis/complications ; Hemochromatosis/genetics ; Hemochromatosis/metabolism ; Humans ; Iron/metabolism ; Joint Diseases/complications
    Chemical Substances Iron (E1UOL152H7) ; Calcium Pyrophosphate (X69NU20D19)
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-022-01054-w
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