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Article: Editorial: Fostering sustainable career throughout lifespan of employees.

Savanevičienė, Asta / Peters, Pascale / Manuti, Amelia / Cabral-Cardoso, Carlos / Karman, Agnieszka

2023 Volume 14, Page(s) 1161624

Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1161624
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Article ; Online: Call for open science in sports medicine.

Bullock, Garrett S / Ward, Patrick / Peters, Scott / Arundale, Amelia Joanna Hanford / Murray, Andrew / Impellizzeri, Franco M / Kluzek, Stefan

British journal of sports medicine

2022

Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Editorial
ZDB-ID	600592-5
ISSN	1473-0480 ; 0306-3674
ISSN (online)	1473-0480
ISSN	0306-3674
DOI	10.1136/bjsports-2022-105719
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Article ; Online: Five Reliable Nerve Transfers for the Treatment of Isolated Upper Extremity Nerve Injuries.

Peters, Blair R / Van Handel, Amelia C / Russo, Stephanie A / Moore, Amy M

Plastic and reconstructive surgery

2021 Volume 147, Issue 5, Page(s) 830e–845e

Abstract: Learning objectives: After studying this article and accompanying videos, the participant should be able to: 1. Understand and apply the principles of nerve transfer surgery for nerve injuries. 2. Discuss important considerations when performing nerve ... ...

Abstract	Learning objectives: After studying this article and accompanying videos, the participant should be able to: 1. Understand and apply the principles of nerve transfer surgery for nerve injuries. 2. Discuss important considerations when performing nerve transfers, such as aspects of surgical technique and perioperative decision-making. 3. Understand indications for end-to-end versus supercharged reverse end-to-side nerve transfers. 4. Understand an algorithm for treating nerve injuries to include the indications and surgical techniques of five nerve transfers commonly performed for the treatment of isolated upper extremity nerve injuries. 5. Understand the outcomes and postoperative management of the discussed nerve transfers. Summary: Nerve transfers are gaining wide acceptance because of their superior results in the management of many nerve injuries of the upper extremity. This article presents five nerve transfers for the treatment of isolated nerve injuries in the authors' upper extremity nerve practice that offer reliable results. Indications, surgical techniques, outcomes, and postoperative management are reviewed. To maximize functional outcomes in patients with nerve injuries, the treatment should be individualized to the patient, and the principles for nerve transfers as described herein should be considered.
MeSH term(s)	Humans ; Nerve Transfer/methods ; Peripheral Nerve Injuries/surgery ; Upper Extremity/innervation
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000007865
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Article ; Online: The one hour human proteome.

Molecular & cellular proteomics : MCP

2024 , Page(s) 100760

Abstract: We describe deep analysis of the human proteome in less than one hour. We achieve this expedited proteome characterization by leveraging state-of-the-art sample preparation, chromatographic separations, data analysis tools, and by using the new Orbitrap ... ...

Abstract	We describe deep analysis of the human proteome in less than one hour. We achieve this expedited proteome characterization by leveraging state-of-the-art sample preparation, chromatographic separations, data analysis tools, and by using the new Orbitrap Astral mass spectrometer equipped with a quadrupole mass filter, a high-field Orbitrap mass analyzer, and an asymmetric track lossless (Astral) mass analyzer. The system offers high MS/MS acquisition speed of 200 Hz and detects hundreds of peptide sequences per second within data independent- or data-dependent acquisition modes of operation. The fast-switching capabilities of the new quadrupole complement the sensitivity and fast ion scanning of the Astral analyzer to enable narrow-bin data-independent analysis (DIA) methods. Over a 30-minute active chromatographic method consuming a total analysis time of 56 minutes, the Q-Orbitrap-Astral hybrid MS collects an average of 4,319 MS
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075924-1
ISSN	1535-9484 ; 1535-9476
ISSN (online)	1535-9484
ISSN	1535-9476
DOI	10.1016/j.mcpro.2024.100760
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Article ; Online: A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse.

Heinsbroek, Jasper A / Furbish, Amelia B / Peters, Jamie

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2018 Volume 43, Issue 7, Page(s) 1492–1497

Abstract: Kappa opioid receptor (KOR) agonists have known anti-addiction properties and can reduce drug seeking. Their potential for clinical use has largely been daunted by their aversive properties mediated through p38 MAPK signaling. Here we examined the ... ...

Abstract	Kappa opioid receptor (KOR) agonists have known anti-addiction properties and can reduce drug seeking. Their potential for clinical use has largely been daunted by their aversive properties mediated through p38 MAPK signaling. Here we examined the therapeutic potential of the KOR agonist U50,488 (U50) to reduce cocaine seeking in a self-administration model. Following cocaine self-administration and 7 days of forced home-cage abstinence, rats were administered a single dose of U50 (5 mg/kg, i.p.) 30 min prior to the first extinction training session, wherein cocaine and the discrete cocaine-paired cues were no longer available. U50 reduced cocaine seeking on this first extinction session, but did not alter extinction training over subsequent days. 2 weeks after U50 treatment, rats underwent a test of cue-induced reinstatement, and rats that had received U50 reinstated less than controls. Central inhibition of p38 MAPK at the time of U50 administration prevented its long-term therapeutic effect on reinstatement, but not its acute reduction in drug seeking on extinction day 1. The long-term therapeutic effect of U50 required operant extinction during U50 exposure, extended to cocaine-primed reinstatement, and was not mimicked by another aversive drug, lithium chloride (LiCl). These data suggest U50 elicits its long-term anti-relapse effects through a KOR-p38 MAPK-specific aversive counterconditioning of the operant cocaine-seeking response. A single, albeit aversive treatment that is able to reduce relapse long-term warrants further consideration of the therapeutic potential of KOR agonists in the treatment of addiction.
MeSH term(s)	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology ; Animals ; Cocaine/pharmacology ; Cocaine-Related Disorders/drug therapy ; Cocaine-Related Disorders/prevention & control ; Conditioning, Operant/drug effects ; Cues ; Drug-Seeking Behavior/drug effects ; Extinction, Psychological/drug effects ; Imidazoles/administration & dosage ; Imidazoles/pharmacology ; Infusions, Intraventricular ; Lithium Chloride/pharmacology ; Male ; Pyridines/administration & dosage ; Pyridines/pharmacology ; Rats ; Receptors, Opioid, kappa/agonists ; Recurrence ; Self Administration ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Chemical Substances	Imidazoles ; Pyridines ; Receptors, Opioid, kappa ; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer (67198-13-4) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Lithium Chloride (G4962QA067) ; Cocaine (I5Y540LHVR) ; SB 203580 (OU13V1EYWQ)
Language	English
Publishing date	2018-02-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-017-0006-4
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Article: AKT Regulation of ORAI1-Mediated Calcium Influx in Breast Cancer Cells.

Bong, Alice Hui Li / Hua, Trinh / So, Choon Leng / Peters, Amelia A / Robitaille, Mélanie / Tan, Yin Yi / Roberts-Thomson, Sarah J / Monteith, Gregory R

Cancers

2022 Volume 14, Issue 19

Abstract: Although breast cancer cells often exhibit both abnormal AKT signaling and calcium signaling, the association between these two pathways is unclear. Using a combination of pharmacological tools, siRNA and CRISPR/Cas9 gene silencing techniques, we ... ...

Abstract	Although breast cancer cells often exhibit both abnormal AKT signaling and calcium signaling, the association between these two pathways is unclear. Using a combination of pharmacological tools, siRNA and CRISPR/Cas9 gene silencing techniques, we investigated the association between PTEN, AKT phosphorylation and calcium signaling in a basal breast cancer cell line. We found that siRNA-mediated PTEN silencing promotes AKT phosphorylation and calcium influx in MDA-MB-231 cells. This increase in AKT phosphorylation and calcium influx was phenocopied by the pharmacological AKT activator, SC79. The increased calcium influx associated with SC79 is inhibited by silencing AKT2, but not AKT1. This increase in calcium influx is suppressed when the store-operated calcium channel, ORAI1 is silenced. The results from this study open a novel avenue for therapeutic targeting of cancer cells with increased AKT activation. Given the association between ORAI1 and breast cancer, ORAI1 is a possible therapeutic target in cancers with abnormal AKT signaling.
Language	English
Publishing date	2022-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14194794
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Article ; Online: ORAI1-Regulated Gene Expression in Breast Cancer Cells: Roles for STIM1 Binding, Calcium Influx and Transcription Factor Translocation.

Robitaille, Mélanie / Chan, Shao Ming / Peters, Amelia A / Dai, Limin / So, Choon Leng / Bong, Alice H L / Sadras, Francisco / Roberts-Thomson, Sarah J / Monteith, Gregory R

International journal of molecular sciences

2022 Volume 23, Issue 11

Abstract: A remodeling of calcium homeostasis, including calcium influx via store-operated calcium entry (SOCE), is a feature of breast cancers. SOCE is critical to maintain calcium balance in the endoplasmic reticulum calcium store and is an important mechanism ... ...

Abstract	A remodeling of calcium homeostasis, including calcium influx via store-operated calcium entry (SOCE), is a feature of breast cancers. SOCE is critical to maintain calcium balance in the endoplasmic reticulum calcium store and is an important mechanism for calcium signaling in a variety of cell types, including breast cancer cells. The canonical mechanism of SOCE is stromal interacting molecule 1 (STIM1)-mediated activation of ORAI. Elevated ORAI1 expression is a feature of basal breast cancer cells. However, the role of ORAI1 in the regulation of transcription in breast cancer cells of the basal molecular subtype is still unclear. Using CRISPR-Cas9 gene editing, ORAI1 protein expression was disrupted in MDA-MB-231 and MDA-MB-468 basal breast cancer cells. The ORAI1 wild-type and mutants were reintroduced into ORAI1 knockout cells to study the role of ORAI1 in gene transcriptional regulation. In the absence of calcium store depletion, ORAI1 regulated
MeSH term(s)	Breast Neoplasms/genetics ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling/physiology ; Calcium, Dietary ; Female ; Gene Expression ; Gene Expression Regulation ; Humans ; Neoplasm Proteins/metabolism ; ORAI1 Protein/genetics ; ORAI1 Protein/metabolism ; Stromal Interaction Molecule 1/genetics ; Stromal Interaction Molecule 1/metabolism ; Transcription Factors/metabolism
Chemical Substances	Calcium Channels ; Calcium, Dietary ; Neoplasm Proteins ; ORAI1 Protein ; ORAI1 protein, human ; STIM1 protein, human ; Stromal Interaction Molecule 1 ; Transcription Factors ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23115867
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Article ; Online: ORAI1-Regulated Gene Expression in Breast Cancer Cells

Mélanie Robitaille / Shao Ming Chan / Amelia A. Peters / Limin Dai / Choon Leng So / Alice H. L. Bong / Francisco Sadras / Sarah J. Roberts-Thomson / Gregory R. Monteith

International Journal of Molecular Sciences, Vol 23, Iss 5867, p

Roles for STIM1 Binding, Calcium Influx and Transcription Factor Translocation

2022 Volume 5867

Abstract	A remodeling of calcium homeostasis, including calcium influx via store-operated calcium entry (SOCE), is a feature of breast cancers. SOCE is critical to maintain calcium balance in the endoplasmic reticulum calcium store and is an important mechanism for calcium signaling in a variety of cell types, including breast cancer cells. The canonical mechanism of SOCE is stromal interacting molecule 1 (STIM1)-mediated activation of ORAI. Elevated ORAI1 expression is a feature of basal breast cancer cells. However, the role of ORAI1 in the regulation of transcription in breast cancer cells of the basal molecular subtype is still unclear. Using CRISPR-Cas9 gene editing, ORAI1 protein expression was disrupted in MDA-MB-231 and MDA-MB-468 basal breast cancer cells. The ORAI1 wild-type and mutants were reintroduced into ORAI1 knockout cells to study the role of ORAI1 in gene transcriptional regulation. In the absence of calcium store depletion, ORAI1 regulated PTGS2 in MDA-MB-231 cells, and this was dependent on ORAI1 pore function and STIM1 binding. The activation of SOCE by thapsigargin resulted in ORAI1-dependent increases in IL6 transcription in MDA-MB-468 cells; this was also dependent on ORAI1 pore function and STIM1 binding and was associated with the translocation of NFAT1. Given the upregulation of ORAI1 in basal breast cancer cells, our results provide further evidence that ORAI1 may contribute to cancer progression through regulation of gene expression.
Keywords	ORAI1 ; calcium signaling ; breast cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Service-level barriers to and facilitators of accessibility to treatment for problematic alcohol use: a scoping review.

Frontiers in public health

2023 Volume 11, Page(s) 1296239

Abstract: Introduction: Services to treat problematic alcohol use (PAU) should be highly accessible to optimize treatment engagement. We conducted a scoping review to map characteristics of services for the treatment of PAU that have been reported in the ... ...

Abstract	Introduction: Services to treat problematic alcohol use (PAU) should be highly accessible to optimize treatment engagement. We conducted a scoping review to map characteristics of services for the treatment of PAU that have been reported in the literature to be barriers to or facilitators of access to treatment from the perspective of individuals with PAU. Methods: A protocol was developed Results: One-hundred-and-nine included studies reported an extensive array of unique service-level barriers that could act alone or together to prevent treatment accessibility. These included but were not limited to lack of an obvious entry point, complexity of the care pathway, high financial cost, unacceptably long wait times, lack of geographically accessible treatment, inconvenient appointment hours, poor cultural/demographic sensitivity, lack of anonymity/privacy, lack of services to treat concurrent PAU and mental health problems. Discussion: Barriers generally aligned with recent reviews of the substance use disorder literature. Ranking of barriers may be explored in a future discrete choice experiment of PAU service users. The rich qualitative findings of this review may support the design of new or modification of existing services for people with PAU to improve accessibility. Systematic review registration: Open Science Framework doi: 10.17605/OSF.IO/S849R.
MeSH term(s)	Adult ; Humans ; Substance-Related Disorders/therapy ; Alcoholism/therapy ; Health Services Accessibility
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1296239
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Article: Altered Calcium Influx Pathways in Cancer-Associated Fibroblasts.

Sadras, Francisco / Stewart, Teneale A / Robitaille, Mélanie / Peters, Amelia A / Croft, Priyakshi Kalita-de / Soon, Patsy S / Saunus, Jodi M / Lakhani, Sunil R / Roberts-Thomson, Sarah J / Monteith, Gregory R

Biomedicines

2021 Volume 9, Issue 6

Abstract: Cancer-associated fibroblasts (CAFs) represent an important component of the tumour microenvironment and are implicated in disease progression. Two outstanding questions in cancer biology are how CAFs arise and how they might be targeted therapeutically. ...

Abstract	Cancer-associated fibroblasts (CAFs) represent an important component of the tumour microenvironment and are implicated in disease progression. Two outstanding questions in cancer biology are how CAFs arise and how they might be targeted therapeutically. The calcium signal also has an important role in tumorigenesis. To date, the role of calcium signalling pathways in the induction of the CAF phenotype remains unexplored. A CAF model was generated through exogenous transforming growth factor beta 1 (TGFβ1) stimulation of the normal human mammary fibroblast cell line, HMF3S (HMF3S-CAF), and changes in calcium signalling were investigated. Functional changes in HMF3S-CAF calcium signalling pathways were assessed using a fluorescent indicator, gene expression, gene-silencing and pharmacological approaches. HMF3S-CAF cells demonstrated functionally altered calcium influx pathways with reduced store-operated calcium entry. In support of a calcium signalling switch, two voltage-gated calcium channel (VGCC) family members, Ca
Language	English
Publishing date	2021-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9060680
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