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Article ; Online: Primary Sjögren's syndrome as independent risk factor for subclinical atherosclerosis.

Novella-Navarro, Marta / Cabrera-Alarcón, José Luis / Rosales-Alexander, José Luis / González-Martín, Jorge Juan / Carrión, Ofelia / Peña, Paloma García de la

European journal of rheumatology

2022 Volume 9, Issue 1, Page(s) 20–25

Abstract: Objective: To assess the prevalence of subclinical atherosclerosis in patients with primary Sjögren's syndrome (pSS) and its possible association with clinical and analytical parameters of the disease.: Methods: In this cross-sectional study, 38 ... ...

Abstract	Objective: To assess the prevalence of subclinical atherosclerosis in patients with primary Sjögren's syndrome (pSS) and its possible association with clinical and analytical parameters of the disease. Methods: In this cross-sectional study, 38 consecutive patients with pSS were compared with 38 age and sex healthy controls. Demographic variables and classic cardiovascular risk factors (CVRFs): Hypertension, dyslipidemia, diabetes mellitus, obesity, and smoking habit were assessed in both groups, and also disease-related features were collected in pSS group. The presence of subclinical atherosclerosis was assessed by carotid ultrasound, with carotid intima-media thickness (CIMT) measurement and determination of the presence of atheromatous plaques. Results: Subclinical atherosclerosis presence was remarkably greater in patients with pSS than in healthy controls (OR = 4.17, 95%CI [1.27-16.54]), as well as CIMT values (0.79 ± 0.43mm vs. 0.66 ± 0.27mm; P = .02). No differences for classic CVRFs were found between both groups. An association of subclinical atherosclerosis with erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF) was observed in patients with pSS. Conclusion: This cohort showed a greater prevalence of subclinical atherosclerosis in patients with pSS, indicating this disease as an independent risk factor for presence of early vascular damage.
Language	English
Publishing date	2022-01-26
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2873727-1
ISSN	2148-4279 ; 2147-9720
ISSN (online)	2148-4279
ISSN	2147-9720
DOI	10.5152/eurjrheum.2021.20093
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Calcium pyrophosphate crystal deposition disease: diagnosis and treatment.

Rosales-Alexander, José Luis / Balsalobre Aznar, Jerónimo / Magro-Checa, César

Open access rheumatology : research and reviews

2014 Volume 6, Page(s) 39–47

Abstract: Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) is an inflammatory arthritis produced by the deposition of calcium pyrophosphate (CPP) crystals in the synovium and periarticular soft tissues. It is the third most common inflammatory ... ...

Abstract	Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) is an inflammatory arthritis produced by the deposition of calcium pyrophosphate (CPP) crystals in the synovium and periarticular soft tissues. It is the third most common inflammatory arthritis. Diagnosis is suspected on the basis of the clinical picture and radiographic/laboratory findings. The reference standard for the diagnosis of CPPD is based on the identification of CPP crystals in synovial fluid by light microscopy, compensated polarized light microscopy, or phase contrast microscopy. Most treatment approaches for CPPD are based upon clinical experience and not upon controlled trials. They range - depending on the subtype and the characteristics of symptoms - from no treatment to interleukin-1 blockade antibodies or specific therapy for an underlying disease. This review summarizes all we know so far about the diagnosis and management of CPPD.
Language	English
Publishing date	2014-05-08
Publishing country	New Zealand
Document type	Review ; Journal Article
ZDB-ID	2508169-X
ISSN	1179-156X
ISSN	1179-156X
DOI	10.2147/OARRR.S39039
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Article ; Online: Drug survival of anti-tumour necrosis factor α therapy in spondyloarthropathies: results from the Spanish emAR II Study.

Rosales-Alexander, José Luis / Balsalobre Aznar, Jerónimo / Pérez-Vicente, Sabina / Magro-Checa, César

Rheumatology (Oxford, England)

2015 Volume 54, Issue 8, Page(s) 1459–1463

Abstract: Objective: To assess drug survival and the reasons for switching anti-TNF-α therapy in SpA patients in a Spanish nationwide study.: Methods: A cross-sectional study was performed. Sample size was calculated to represent all regions and hospitals ... ...

Abstract	Objective: To assess drug survival and the reasons for switching anti-TNF-α therapy in SpA patients in a Spanish nationwide study. Methods: A cross-sectional study was performed. Sample size was calculated to represent all regions and hospitals throughout the country. Demographic data, patient characteristics and disease activity parameters were obtained. Drug survival and reasons for switching anti-TNF therapy were also recorded. Results: A total of 467 SpA patients receiving at least one anti-TNF agent were identified. Among patients who received a first, second and third anti-TNF course, 39.4%, 37.4% and 23.1% discontinued treatment, respectively. The main reasons for switching anti-TNF agents in the first course were lack or loss of efficacy (LOE) and adverse events (AEs) in 40% and 30% of switchers, respectively. Similarly, reasons for switching during the second anti-TNF course were LOE in 48% and AEs in 28% of switchers. Of the 467 SpA patients starting anti-TNF therapy, 28% switched to a second and 8% switched to a third therapy. Mean drug survival for the first, second and third anti-TNF courses were 84.4 (95% CI 78.4, 90.5), 70.2 (95% CI 61.6, 78.9) and 64.8 (95% CI 51.1, 78.5) months, respectively (P = 0.315). Conclusion: Twenty-eight per cent of SpA patients starting anti-TNF therapy switched to a second anti-TNF agent. Drug survival did not differ among anti-TNF courses. The main reason for switching anti-TNF therapy was LOE. Switchers were more frequently women and had higher disease activity parameters at the time of the study than non-switchers.
MeSH term(s)	Adult ; Aged ; Antirheumatic Agents/therapeutic use ; Cross-Sectional Studies ; Drug Substitution/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Sex Factors ; Spain/epidemiology ; Spondylarthropathies/diagnosis ; Spondylarthropathies/drug therapy ; Spondylarthropathies/epidemiology ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Chemical Substances	Antirheumatic Agents ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kev001
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Zs.MO 497: Show issues

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Article: Cost-Effective Cultivation of Native PGPB

Manzano-Gómez, Luis Alberto / Rincón-Rosales, Reiner / Flores-Felix, José David / Gen-Jimenez, Adriana / Ruíz-Valdiviezo, Víctor Manuel / Ventura-Canseco, Lucia María Cristina / Rincón-Molina, Francisco Alexander / Villalobos-Maldonado, Juan José / Rincón-Molina, Clara Ivette

Bioengineering (Basel, Switzerland)

2023 Volume 10, Issue 8

Abstract: The implementation of bioreactor systems for the production of bacterial inoculants as biofertilizers has become very important in recent decades. However, it is essential to know the bacterial growth optimal conditions to optimize the production and ... ...

Abstract	The implementation of bioreactor systems for the production of bacterial inoculants as biofertilizers has become very important in recent decades. However, it is essential to know the bacterial growth optimal conditions to optimize the production and efficiency of bioinoculants. The aim of this work was to identify the best nutriment and mixing conditions to improve the specific cell growth rates (µ) of two PGPB (plant growth-promoting bacteria) rhizobial strains at the bioreactor level. For this purpose, the strains
Language	English
Publishing date	2023-08-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering10080960
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Article: Bacterial Community with Plant Growth-Promoting Potential Associated to Pioneer Plants from an Active Mexican Volcanic Complex.

Rincón-Molina, Clara Ivette / Martínez-Romero, Esperanza / Aguirre-Noyola, José Luis / Manzano-Gómez, Luis Alberto / Zenteno-Rojas, Adalberto / Rogel, Marco Antonio / Rincón-Molina, Francisco Alexander / Ruíz-Valdiviezo, Víctor Manuel / Rincón-Rosales, Reiner

Microorganisms

2022 Volume 10, Issue 8

Abstract: Microorganisms in extreme volcanic environments play an important role in the development of plants on newly exposed substrates. In this work, we studied the structure and diversity of a bacterial community associated ... ...

Abstract	Microorganisms in extreme volcanic environments play an important role in the development of plants on newly exposed substrates. In this work, we studied the structure and diversity of a bacterial community associated to
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10081568
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Article ; Online: Back pain and headaches in a patient with rheumatoid arthritis and Marfan's syndrome.

Magro-Checa, César / Rosales-Alexander, José Luis / Salvatierra, Juan / Raya-Álvarez, Enrique

Joint bone spine

2012 Volume 79, Issue 6, Page(s) 626

MeSH term(s)	Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/epidemiology ; Back Pain/etiology ; Comorbidity ; Female ; Headache/etiology ; Humans ; Marfan Syndrome/complications ; Marfan Syndrome/diagnostic imaging ; Marfan Syndrome/epidemiology ; Middle Aged ; Tomography, X-Ray Computed
Language	English
Publishing date	2012-06-29
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2012.04.007
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Article: Enhance of tomato production and induction of changes on the organic profile mediated by

Gen-Jiménez, Adriana / Flores-Félix, José David / Rincón-Molina, Clara Ivette / Manzano-Gomez, Luis Alberto / Rogel, Marco Antonio / Ruíz-Valdiviezo, Víctor Manuel / Rincón-Molina, Francisco Alexander / Rincón-Rosales, Reiner

Frontiers in microbiology

2023 Volume 14, Page(s) 1235930

Abstract: Introduction: The extensive use of chemical fertilizers has served as a response to the increasing need for crop production in recent decades. While it addresses the demand for food, it has resulted in a decline in crop productivity and a heightened ... ...

Abstract	Introduction: The extensive use of chemical fertilizers has served as a response to the increasing need for crop production in recent decades. While it addresses the demand for food, it has resulted in a decline in crop productivity and a heightened negative environmental impact. In contrast, plant probiotic bacteria (PPB) offer a promising alternative to mitigate the negative consequences of chemical fertilizers. PPB can enhance nutrient availability, promote plant growth, and improve nutrient uptake efficiency, thereby reducing the reliance on chemical fertilizers. Methods: This study aimed to evaluate the impact of native Results: The results showed that the rhizobial strains LBP2-1, NSJP1-1 and SJP1-2 had the ability to solubilize dicalcium phosphate, produce siderophores, synthesize indole acetic acid, cellulose production, biofilm production, and root colonization. Inoculation of tomato plants with native Discussion: Our findings demonstrate the potential that native
Language	English
Publishing date	2023-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1235930
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Article ; Online: Recommendations by the Spanish Society of Rheumatology on the Use of Biological Therapies in Axial Spondyloarthritis.

Gratacós, Jordi / Díaz Del Campo Fontecha, Petra / Fernández-Carballido, Cristina / Juanola Roura, Xavier / Linares Ferrando, Luis Francisco / de Miguel Mendieta, Eugenio / Muñoz Fernández, Santiago / Rosales-Alexander, Jose Luis / Zarco Montejo, Pedro / Guerra Rodríguez, Mercedes / Navarro Compán, Victoria

Reumatologia clinica

2017 Volume 14, Issue 6, Page(s) 320–333

Abstract: Objective: Recent data published on biological therapy in axial spondyloarthritis (axSpA) since the last publication of the recommendations of the Spanish Society of Rheumatology (SER) has led to the generation of a review of these recommendations based ...

Title translation	Recomendaciones de la Sociedad Española de Reumatología sobre el uso de terapias biológicas en espondiloartritis axial.
Abstract	Objective: Recent data published on biological therapy in axial spondyloarthritis (axSpA) since the last publication of the recommendations of the Spanish Society of Rheumatology (SER) has led to the generation of a review of these recommendations based on the best possible evidence. These recommendations should be a reference for rheumatologists and those involved in the treatment of patients with axSpA. Methods: Recommendations were drawn up following a nominal group methodology and based on systematic reviews. The level of evidence and grade of recommendation were classified according to the model proposed by the Centre for Evidence Based Medicine at Oxford. The level of agreement was established through the Delphi technique. Results: In this review, we did an update of the evaluation of disease activity and treatment objectives. We included the new drugs with approved therapeutic indication for axSpA. We reviewed both the predictive factors of the therapeutic response and progression of radiographic damage. Finally, we drafted some recommendations for the treatment of patients refractory to anti-tumor necrosis factor, as well as for the possible optimization of biological therapy. The document also includes a table of recommendations and a treatment algorithm. Conclusions: We present an update of the SER recommendations for the use of biological therapy in patients with axSpA.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Antirheumatic Agents/therapeutic use ; Biological Therapy/methods ; Biological Therapy/standards ; Delphi Technique ; Humans ; Spain ; Spondylarthritis/diagnosis ; Spondylarthritis/drug therapy ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal ; Antirheumatic Agents
Language	Spanish
Publishing date	2017-10-16
Publishing country	Spain
Document type	Journal Article ; Practice Guideline
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reuma.2017.08.008
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Article: Life-threatening vasculo-Behçet following discontinuation of infliximab after three years of complete remission.

Magro-Checa, César / Salvatierra, Juan / Rosales-Alexander, José Luis / Orgaz-Molina, Jacinto / Raya-Álvarez, Enrique

Clinical and experimental rheumatology

2013 Volume 31, Issue 3 Suppl 77, Page(s) 96–98

Abstract: Behçet's disease (BD) is a chronic, complex multisystem vasculitis of unknown cause characterised for its ability to involve blood vessels of all sizes on both the arterial and venous sides of the circulation. It has been suggested that TNF-alpha plays a ...

Abstract	Behçet's disease (BD) is a chronic, complex multisystem vasculitis of unknown cause characterised for its ability to involve blood vessels of all sizes on both the arterial and venous sides of the circulation. It has been suggested that TNF-alpha plays a main role in the pathogenesis of BD. This hypothesis is supported by the efficacy of TNF-blocking antibodies in these patients, which have been shown to be very powerful in the induction of remission and as maintenance treatment on different BD manifestations, including severe vascular involvement. However, little is known about when and how to stop IFX after long-standing complete remission of these patients to avoid relapses. We describe a case of BD without previous vascular involvement that developed myocardial infarction and severe venous thromboses only four months after discontinuation of infliximab (IFX) after more than three years of complete remission. The patient did not respond to corticosteroids and intravenous cyclophosphamide and only recovered completely after reintroducing IFX.
MeSH term(s)	Adult ; Antibodies, Monoclonal/administration & dosage ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Behcet Syndrome/immunology ; Electrocardiography ; Humans ; Immunosuppressive Agents/administration & dosage ; Infliximab ; Male ; Myocardial Infarction/diagnosis ; Myocardial Infarction/drug therapy ; Myocardial Infarction/etiology ; Recurrence ; Remission Induction ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/metabolism ; Venous Thrombosis/diagnosis ; Venous Thrombosis/drug therapy ; Venous Thrombosis/etiology
Chemical Substances	Antibodies, Monoclonal ; Immunosuppressive Agents ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2013-05
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article: Bacterial Community with Plant Growth-Promoting Potential Associated to Pioneer Plants from an Active Mexican Volcanic Complex

Microorganisms. 2022 Aug. 04, v. 10, no. 8

2022

Abstract	Microorganisms in extreme volcanic environments play an important role in the development of plants on newly exposed substrates. In this work, we studied the structure and diversity of a bacterial community associated to Andropogon glomeratus and Cheilanthes aemula at El Chichón volcano. The genetic diversity of the strains was revealed by genomic fingerprints and by 16S rDNA gene sequencing. Furthermore, a metagenomic analysis of the rhizosphere samples was carried out for pioneer plants growing inside and outside the volcano. Multifunctional biochemical tests and plant inoculation assays were evaluated to determine their potential as plant growth-promoting bacteria (PGPB). Through metagenomic analysis, a total of 33 bacterial phyla were identified from A. glomeratus and C. aemula rhizosphere samples collected inside the volcano, and outside the volcano 23 bacterial phyla were identified. For both rhizosphere samples, proteobacteria was the most abundant phylum. With a cultivable approach, 174 bacterial strains were isolated from the rhizosphere and tissue of plants growing outside the volcanic complex. Isolates were classified within the genera Acinetobacter, Arthrobacter, Bacillus, Burkholderia, Cupriavidus, Enterobacter, Klebsiella, Lysinibacillus, Pantoea, Pseudomonas, Serratia, Stenotrophomonas and Pandoraea. The evaluated strains were able to produce indole compounds, solubilize phosphate, synthesize siderophores, showed ACC deaminase and nitrogenase activity, and they had a positive effect on the growth and development of Capsicum chinense. The wide diversity of bacteria associated to pioneer plants at El Chichón volcano with PGPB qualities represent an alternative for the recovery of eroded environments, and they can be used efficiently as biofertilizers for agricultural crops growing under adverse conditions.
Keywords	1-aminocyclopropane-1-carboxylate deaminase ; Acinetobacter ; Andropogon ; Arthrobacter ; Burkholderia ; Capsicum chinense ; Cheilanthes ; Cupriavidus ; Enterobacter ; Klebsiella ; Lysinibacillus ; Pandoraea ; Pantoea ; Pseudomonas ; Serratia ; Stenotrophomonas ; bacterial communities ; biofertilizers ; genes ; genetic variation ; growth and development ; indoles ; metagenomics ; nitrogenase ; phosphates ; rhizosphere ; siderophores
Language	English
Dates of publication	2022-0804
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10081568
Database	NAL-Catalogue (AGRICOLA)

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