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  1. Book ; Online ; E-Book: Ion and molecule transport in lysosomes

    Gasnier, Bruno / Zhu, Michael X.

    (Methods in signal transduction series)

    2020  

    Author's details edited by Bruno Gasnier, Michael X. Zhu
    Series title Methods in signal transduction series
    Keywords Lysosomes ; Ion channels ; Lysosomal storage diseases
    Subject code 571.655
    Language English
    Size 1 Online-Ressource (vii, 240 Seiten), Illustrationen
    Edition First edition
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020546608
    ISBN 9781351361132 ; 9781351361149 ; 9781351361125 ; 9780203711590 ; 9781138560390 ; 1351361139 ; 1351361147 ; 1351361120 ; 0203711599 ; 1138560391
    DOI 10.1201/b22460
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: High resolution cryo-EM structures of TRPC5-Gα

    Zhu, Michael X

    Cell calcium

    2023  Volume 113, Page(s) 102767

    Abstract: Transient receptor potential canonical 4 and 5 (TRPC4 and TRPC5) are ... ...

    Abstract Transient receptor potential canonical 4 and 5 (TRPC4 and TRPC5) are Ca
    MeSH term(s) Cryoelectron Microscopy ; TRPC Cation Channels/metabolism ; Guanosine Triphosphate
    Chemical Substances TRPC Cation Channels ; Guanosine Triphosphate (86-01-1)
    Language English
    Publishing date 2023-06-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2023.102767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1596: Show issues Location:
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  3. Book: TRP channels

    Zhu, Michael X.

    (Methods in signal transduction series)

    2011  

    Author's details ed. by Michael X. Zhu
    Series title Methods in signal transduction series
    Keywords Transient Receptor Potential Channels
    Language English
    Size XXII, 473 S., [2] Bl. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016752672
    ISBN 978-1-4398-1860-2 ; 1-4398-1860-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 2095 order for loan Magazin

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  4. Article ; Online: Transient Receptor Potential Channels in Cardiovascular and Renal Diseases.

    Ma, Shuangtao / Zhu, Michael X

    Cells

    2022  Volume 11, Issue 24

    Abstract: Transient receptor potential (TRP) channels belong to a superfamily of integral membrane proteins with diverse functions in sensory perception and cellular physiology [ ... ]. ...

    Abstract Transient receptor potential (TRP) channels belong to a superfamily of integral membrane proteins with diverse functions in sensory perception and cellular physiology [...].
    Language English
    Publishing date 2022-12-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11243960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: NAADP-Dependent TPC Current.

    Wang, Qiaochu / Zhu, Michael X

    Handbook of experimental pharmacology

    2022  Volume 278, Page(s) 35–56

    Abstract: Two-pore channels, TPC1 and TPC2, are ... ...

    Abstract Two-pore channels, TPC1 and TPC2, are Ca
    MeSH term(s) Animals ; Humans ; Calcium Channels/metabolism ; NADP/metabolism ; Signal Transduction ; Lysosomes/metabolism ; Calcium/metabolism ; Calcium Signaling ; Mammals/metabolism
    Chemical Substances Calcium Channels ; NAADP (5502-96-5) ; NADP (53-59-8) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-07-27
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2022_606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  6. Article ; Online: A well-known potassium channel plays a critical role in lysosomes.

    Zhu, Michael X

    The Journal of cell biology

    2017  Volume 216, Issue 6, Page(s) 1513–1515

    Abstract: Whole-endolysosome patch clamping presents new opportunities to identify and characterize channels pivotal for these acidic organelles. In this issue (Wang et al., 2017. ...

    Abstract Whole-endolysosome patch clamping presents new opportunities to identify and characterize channels pivotal for these acidic organelles. In this issue (Wang et al., 2017.
    MeSH term(s) Calcium ; Humans ; Lysosomes ; Membrane Potentials ; Organelles ; Patch-Clamp Techniques ; Potassium Channels ; Potassium Channels, Calcium-Activated
    Chemical Substances Potassium Channels ; Potassium Channels, Calcium-Activated ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2017-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201704017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Readiness of nociceptor cell bodies to generate spontaneous activity results from background activity of diverse ion channels and high input resistance.

    Tian, Jinbin / Bavencoffe, Alexis G / Zhu, Michael X / Walters, Edgar T

    Pain

    2023  Volume 165, Issue 4, Page(s) 893–907

    Abstract: Abstract: Nociceptor cell bodies generate "spontaneous" discharge that can promote ongoing pain in persistent pain conditions. Little is known about the underlying mechanisms. Recordings from nociceptor cell bodies (somata) dissociated from rodent and ... ...

    Abstract Abstract: Nociceptor cell bodies generate "spontaneous" discharge that can promote ongoing pain in persistent pain conditions. Little is known about the underlying mechanisms. Recordings from nociceptor cell bodies (somata) dissociated from rodent and human dorsal root ganglia have shown that previous pain in vivo is associated with low-frequency discharge controlled by irregular depolarizing spontaneous fluctuations of membrane potential (DSFs), likely produced by transient inward currents across the somal input resistance. Using mouse nociceptors, we show that DSFs are associated with high somal input resistance over a wide range of membrane potentials, including depolarized levels where DSFs approach action potential (AP) threshold. Input resistance and both the amplitude and frequency of DSFs were increased in neurons exhibiting spontaneous activity. Ion substitution experiments indicated that the depolarizing phase of DSFs is generated by spontaneous opening of channels permeable to Na + or Ca 2+ and that Ca 2+ -permeable channels are especially important for larger DSFs. Partial reduction of the amplitude or frequency of DSFs by perfusion of pharmacological inhibitors indicated small but significant contributions from Nav1.7, Nav1.8, TRPV1, TRPA1, TRPM4, and N-type Ca 2+ channels. Less specific blockers suggested a contribution from NALCN channels, and global knockout suggested a role for Nav1.9. The combination of high somal input resistance plus background activity of diverse ion channels permeable to Na + or Ca 2+ produces DSFs that are poised to reach AP threshold if resting membrane potential depolarizes, AP threshold decreases, or DSFs become enhanced-all of which can occur under painful neuropathic and inflammatory conditions.
    MeSH term(s) Rats ; Mice ; Animals ; Humans ; Nociceptors ; Rats, Sprague-Dawley ; Cell Body ; Pain/metabolism ; Action Potentials/physiology ; Ion Channels/metabolism ; Ganglia, Spinal/metabolism ; TRPM Cation Channels/metabolism
    Chemical Substances Ion Channels ; TRPM4 protein, mouse ; TRPM Cation Channels ; TRPM4 protein, rat
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000003091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1158: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: TRPC4 as a coincident detector of G

    Jeon, Jaepyo / Tian, Jin-Bin / Zhu, Michael X

    Current opinion in physiology

    2020  Volume 17, Page(s) 34–41

    Abstract: TRPC channels are ... ...

    Abstract TRPC channels are Ca
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2918626-2
    ISSN 2468-8673 ; 2468-8681
    ISSN (online) 2468-8673
    ISSN 2468-8681
    DOI 10.1016/j.cophys.2020.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Movement Behaviors and Mental Health of Catholic Priests in the Eastern United States.

    Kostick, Michael D / Zhu, Xihe

    Journal of religion and health

    2023  

    Abstract: The purpose of this observational study was to examine (a) the proportion of Catholic priests in the United States that have anxiety/depression and meet the Canadian 24-Hour of Movement Guidelines, and (b) the association of meeting these guidelines with ...

    Abstract The purpose of this observational study was to examine (a) the proportion of Catholic priests in the United States that have anxiety/depression and meet the Canadian 24-Hour of Movement Guidelines, and (b) the association of meeting these guidelines with the likelihood of anxiety and depression. A sample of (arch)diocesan priests (n = 335) completed demographic and behavior survey, International Physical Activity Questionnaire (IPAQ-SF), and Hospital Anxiety and Depression Scale (HADS). Results indicated that 21.1% of priests surveyed met all three movement guidelines (physical activity, sleep, and screentime) and 7.8% met none. Priests who reported excessive recreational screentime (≥ 3 h/day) were more likely to have anxiety (OR = 3.17) and depression (OR = 2.91), and who were physically inactive (< 150 min/week) were more likely to have depression (OR = 8.89). Data from this study addresses a gap in the literature regarding Catholic priests, movement behavior, and mental wellbeing.
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2017250-3
    ISSN 1573-6571 ; 0022-4197
    ISSN (online) 1573-6571
    ISSN 0022-4197
    DOI 10.1007/s10943-023-01894-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Doxycycline Promotes Graft Healing and Attenuates Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Reconstruction in a Rat Model.

    Cao, Mingde / Yao, Shiyi / Zhu, Xiaobo / Ong, Michael T Y / Yung, Patrick S H / Jiang, Yangzi

    The American journal of sports medicine

    2023  Volume 51, Issue 2, Page(s) 461–475

    Abstract: Background: Doxycycline (Doxy) has been shown to facilitate tendon healing by reducing on-site matrix metalloproteinase (MMP) activity, but its effect on graft healing after anterior cruciate ligament reconstruction (ACLR) has not been investigated, and ...

    Abstract Background: Doxycycline (Doxy) has been shown to facilitate tendon healing by reducing on-site matrix metalloproteinase (MMP) activity, but its effect on graft healing after anterior cruciate ligament reconstruction (ACLR) has not been investigated, and the therapeutic effect of Doxy in preventing ACLR-induced posttraumatic osteoarthritis (PTOA) is unclear.
    Hypothesis: Doxy promotes graft healing and alleviates the progression of PTOA after ACLR.
    Study design: Controlled laboratory study.
    Methods: Sprague Dawley rats (n = 74; age, 12-13 weeks; male) that underwent ACLR were divided into untreated control and Doxy treatment (50 mg/kg/d orally until sacrifice) groups. At 2 and 6 weeks after surgery, graft healing was assessed by biomechanical testing, histology, immunohistochemical staining, and micro-computed tomography (μCT). The progression of PTOA was evaluated at 6 weeks by histology, the Mankin score, and immunofluorescence staining of the tibial plateau, and osteophyte formation was evaluated by μCT. Hindlimb weight distribution was evaluated at 6 weeks, and gait patterns were evaluated at 2 and 6 weeks. Intra-articular MMP activity was evaluated at 6 weeks in vivo using an MMP-activatable near-infrared fluorescent probe.
    Results: Graft healing was enhanced by Doxy treatment, and the ultimate failure load (
    Conclusion: The oral administration of Doxy was able to synchronously promote graft healing and attenuate PTOA in an ACLR rat model.
    Clinical relevance: Our results indicated that Doxy, a widely used drug, is potentially beneficial to patients after ACLR.
    MeSH term(s) Rats ; Male ; Animals ; Doxycycline ; Rats, Sprague-Dawley ; X-Ray Microtomography ; Fluorescent Dyes ; Osteophyte ; Osteoarthritis/surgery ; Collagen ; Anterior Cruciate Ligament Reconstruction/methods ; Anterior Cruciate Ligament Injuries/surgery
    Chemical Substances Doxycycline (N12000U13O) ; Fluorescent Dyes ; Collagen (9007-34-5)
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/03635465221145015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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