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Article: Clinical Cases: Cannabis-In Effects of Post-partum Hemorrhage; Acid. Mur.-Diarrhœa; Natr. M., Canth., Rhus Tox. and Merc.-Gleet.

Berridge, E W

The Homoeopathic physician

2023 Volume 1, Issue 9, Page(s) 446–452

Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article
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Article: Hemopoietic cell transformation is associated with failure to downregulate glucose uptake during the G2/M phase of the cell cycle.

Kansara, Maya / Berridge, Michael V

Experimental cell research

2004 Volume 293, Issue 2, Page(s) 321–330

Abstract: ... transformed 32D cells and Jurkat cells. Cells were enriched in the G1, S and G2/M phases of the cell cycle ... uptake at G2/M, with the highest specific activity of transporters in the S phase. In contrast, src ... transformed 32D cells and Jurkat cells showed increased 2-deoxyglucose uptake from S to G2/M, with the highest ...

Abstract	Growth factors and cytokines initiate multiple signal transduction pathways that lead to cell survival, cell cycle progression or differentiation. A common feature of these pathways is increased cellular metabolism and glucose uptake. Furthermore, the energy requirements of many cancers and transformed cell lines are met by constitutive upregulation of glucose uptake. Relationships among transforming events, glucose uptake and cell cycle progression are not well understood. Here we investigated the regulation of glucose transport during the cell cycle of growth factor-dependent 32D cells, primary T-cells, src-transformed 32D cells and Jurkat cells. Cells were enriched in the G1, S and G2/M phases of the cell cycle, and glucose transporter expression and 2-deoxyglucose uptake were measured. Glucose transporter expression increased with cell volume as cells progressed through the cell cycle. Growth factor-dependent 32D cells and T-lymphocytes were characterised by increased 2-deoxyglucose uptake from G1 to S and reduced uptake at G2/M, with the highest specific activity of transporters in the S phase. In contrast, src-transformed 32D cells and Jurkat cells showed increased 2-deoxyglucose uptake from S to G2/M, with the highest glucose transporter specific activity in G2/M. Our results show that glucose transport is regulated in a cell cycle-dependent manner and suggest that this regulation may be altered in transformed cells.
MeSH term(s)	Animals ; Cell Cycle/physiology ; Cell Transformation, Neoplastic/metabolism ; Deoxyglucose/metabolism ; Deoxyglucose/pharmacokinetics ; Down-Regulation/physiology ; Energy Metabolism/physiology ; G2 Phase/physiology ; Glucose/metabolism ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Jurkat Cells ; Mice ; Mice, Inbred C57BL ; Mitosis/physiology ; Monosaccharide Transport Proteins/metabolism ; Neoplasms/metabolism ; S Phase/physiology ; Up-Regulation/physiology
Chemical Substances	Monosaccharide Transport Proteins ; Deoxyglucose (9G2MP84A8W) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2004-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2003.10.027
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Zs.A 563: Show issues

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Article ; Online: Advocating for Generalizability: Accepting Inherent Variability in Translation of Animal Research Outcomes.

Hankenson, F C / Prager, E M / Berridge, B R

Annual review of animal biosciences

2024 Volume 12, Page(s) 391–410

Abstract: Advancing scientific discovery requires investigators to embrace research practices that increase transparency and disclosure about materials, methods, and outcomes. Several research advocacy and funding organizations have produced guidelines and ... ...

Abstract	Advancing scientific discovery requires investigators to embrace research practices that increase transparency and disclosure about materials, methods, and outcomes. Several research advocacy and funding organizations have produced guidelines and recommended practices to enhance reproducibility through detailed and rigorous research approaches; however, confusion around vocabulary terms and a lack of adoption of suggested practices have stymied successful implementation. Although reproducibility of research findings cannot be guaranteed due to extensive inherent variables in attempts at experimental repetition, the scientific community can advocate for generalizability in the application of data outcomes to ensure a broad and effective impact on the comparison of animals to translation within human research. This report reviews suggestions, based upon work with National Institutes of Health advisory groups, for improving rigor and transparency in animal research through aspects of experimental design, statistical assessment, and reporting factors to advocate for generalizability in the application of comparative outcomes between animals and humans.
MeSH term(s)	Humans ; Animals ; Reproducibility of Results ; Animal Experimentation ; Research Design
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2700164-7
ISSN	2165-8110 ; 2165-8102
ISSN (online)	2165-8110
ISSN	2165-8102
DOI	10.1146/annurev-animal-021022-043531
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Article ; Online: Incentive motivation: 'wanting' roles of central amygdala circuitry.

Warlow, Shelley M / Berridge, Kent C

Behavioural brain research

2021 Volume 411, Page(s) 113376

Abstract: The central nucleus of amygdala (CeA) mediates positively-valenced reward motivation as well as negatively-valenced fear. Optogenetic or neurochemical stimulation of CeA circuitry can generate intense incentive motivation to pursue and consume a paired ... ...

Abstract	The central nucleus of amygdala (CeA) mediates positively-valenced reward motivation as well as negatively-valenced fear. Optogenetic or neurochemical stimulation of CeA circuitry can generate intense incentive motivation to pursue and consume a paired natural food, sex, or addictive drug reward, and even create maladaptive 'wanting what hurts' such as attraction to a shock rod. Evidence indicates CeA stimulations selectively amplify incentive motivation ('wanting') but not hedonic impact ('liking') of the same reward. Further, valence flips can occur for CeA contributions to motivational salience. That is, CeA stimulation can promote either incentive motivation or fearful motivation, even in the same individual, depending on situation. These findings may carry implications for understanding CeA roles in neuropsychiatric disorders involving aberrant motivational salience, ranging from addiction to paranoia and anxiety disorders.
MeSH term(s)	Amygdala/metabolism ; Amygdala/physiology ; Animals ; Behavior, Addictive ; Central Amygdaloid Nucleus/metabolism ; Central Amygdaloid Nucleus/physiology ; Cues ; Emotions/physiology ; Fear ; Humans ; Motivation/physiology ; Reward
Language	English
Publishing date	2021-05-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2021.113376
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Zs.A 1599: Show issues

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Article: Companion robots to mitigate loneliness among older adults: Perceptions of benefit and possible deception.

Berridge, Clara / Zhou, Yuanjin / Robillard, Julie M / Kaye, Jeffrey

Frontiers in psychology

2023 Volume 14, Page(s) 1106633

Abstract: Objective: Given growing interest in companion robots to mitigate loneliness, large-scale studies are needed to understand peoples' perspectives on the use of robots to combat loneliness and attendant ethical issues. This study examines opinions about ... ...

Abstract	Objective: Given growing interest in companion robots to mitigate loneliness, large-scale studies are needed to understand peoples' perspectives on the use of robots to combat loneliness and attendant ethical issues. This study examines opinions about artificial companion (AC) robots regarding deception with dementia and impact on loneliness. Methods: Data are from a survey of 825 members of the OHSU Research via Internet Technology and Experience cohort (response rate = 45%). Sixty percent ( Results: Most participants (68.7%) did not think an AC robot would make them feel less lonely and felt somewhat-to-very uncomfortable (69.3%) with the idea of being allowed to believe that an artificial companion is human. In adjusted models, one additional year of age was associated with lower likelihood of perceived benefit of reducing loneliness [Odds Ratio (OR) = 0.98; (0.97-0.99), Discussion: There was not strong support for AC robots to mitigate loneliness. Most participants were uncomfortable with this form of deception, indicating need for design solutions for those who want to avoid this possibility, as well as greater attentiveness to desirability and comfort across age and gender.
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1106633
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Article ; Online: Cognition-enhancing and cognition-impairing doses of psychostimulants exert opposing actions on frontostriatal neural coding of delay in working memory.

Spencer, Robert C / Martin, Andrea J / Devilbiss, David M / Berridge, Craig W

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2023 Volume 49, Issue 5, Page(s) 837–844

Abstract: The prefrontal cortex (PFC) and extended frontostriatal circuitry play a critical role in executive cognitive processes that guide goal-directed behavior. Dysregulation of frontostriatal-dependent cognition is implicated in a variety of cognitive/ ... ...

Abstract	The prefrontal cortex (PFC) and extended frontostriatal circuitry play a critical role in executive cognitive processes that guide goal-directed behavior. Dysregulation of frontostriatal-dependent cognition is implicated in a variety of cognitive/behavioral disorders, including addiction and attention deficit hyperactivity disorder (ADHD). Psychostimulants exert dose-dependent and opposing actions on frontostriatal cognitive function. Specifically, low and clinically-relevant doses improve, while higher doses associated with abuse and addiction impair, frontostriatal-dependent cognitive function. Frontostriatal cognition is supported by the coordinated activity of neurons across this circuit. To date, the neural coding mechanisms that support the diverse cognitive actions of psychostimulants are unclear. This represents a significant deficit in our understanding of the neurobiology of frontostriatal cognition and limits the development of novel treatments for frontostriatal cognitive impairment. The current studies examined the effects of cognition-enhancing and cognition-impairing doses of methylphenidate (MPH) on the spiking activity of dorsomedial PFC (dmPFC) and dorsomedial striatal (dmSTR) neurons in 17 male rats engaged in a working memory task. Across this frontostriatal circuit, we observed opposing actions of low- and high-dose MPH on the population-based representation of delay: low-dose strengthened, while high-dose weakened, representation of this event. MPH elicited a more complex pattern of actions on reward-related signaling, that were highly dose-, region- and neuron-dependent. These observations provide novel insight into the neurophysiological mechanisms that support the cognitive actions of psychostimulants.
MeSH term(s)	Rats ; Male ; Animals ; Memory, Short-Term ; Rats, Sprague-Dawley ; Central Nervous System Stimulants/pharmacology ; Central Nervous System Stimulants/therapeutic use ; Methylphenidate/pharmacology ; Methylphenidate/therapeutic use ; Cognition ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Prefrontal Cortex
Chemical Substances	Central Nervous System Stimulants ; Methylphenidate (207ZZ9QZ49)
Language	English
Publishing date	2023-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-023-01738-6
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Zs.A 2379: Show issues

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Article ; Online: Bioethical, Reproducibility, and Translational Challenges of Animal Models.

Landi, Margaret / Everitt, Jeffrey / Berridge, B

ILAR journal

2022 Volume 62, Issue 1-2, Page(s) 60–65

Abstract: There is no prescribed stage or standardized point at which an animal model protocol is reviewed for reproducibility and translatability. The method of review for a reproducible and translatable study is not consistently documented in peer literature, ... ...

Abstract	There is no prescribed stage or standardized point at which an animal model protocol is reviewed for reproducibility and translatability. The method of review for a reproducible and translatable study is not consistently documented in peer literature, and this is a major challenge for those working with animal models of human diseases. If the study is ill designed, it is impossible to perform an accurate harm/benefit analysis. In addition, there may be an ethical challenge if the work is not reproducible and translatable. Animal welfare regulations and other documents of control clearly state the role of the Institutional Animal Care and Use Committees are to look at science justification within the context of animal welfare. This article, concentrating on models not governed by regulations, outlines issues and offers recommendations for refining animal model review with a goal to improve study reproducibility and translatability.
MeSH term(s)	Animal Care Committees ; Animal Experimentation ; Animal Welfare ; Animals ; Models, Animal ; Reproducibility of Results
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2192062-X
ISSN	1930-6180 ; 1084-2020
ISSN (online)	1930-6180
ISSN	1084-2020
DOI	10.1093/ilar/ilaa027
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Article ; Online: Discontinuation of methylphenidate after long-term exposure in nonhuman primates.

Zhang, X / Berridge, M S / Apana, S M / Slikker, W / Paule, M G / Talpos, John

Neurotoxicology and teratology

2023 Volume 97, Page(s) 107173

Abstract: Attention-deficit hyperactivity disorder (ADHD) is a common human neurobehavioral disorder that usually begins in early childhood. Methylphenidate (MPH) has been used extensively as a first-line medicine for the treatment of ADHD. Since ADHD is often ... ...

Abstract	Attention-deficit hyperactivity disorder (ADHD) is a common human neurobehavioral disorder that usually begins in early childhood. Methylphenidate (MPH) has been used extensively as a first-line medicine for the treatment of ADHD. Since ADHD is often diagnosed in early childhood and can persist for the entire lifespan, individuals may take MPH for many years. Given that in the course of one's lifetime a person may stop taking MPH for periods of time, or may implement lifestyle changes that may reduce the need for MPH entirely, it is important to understand how cessation of MPH affects the adult brain following long-term use of MPH. The blockage of the dopamine transporter (DAT) and the norepinephrine transporter (NET) by MPH may help with ADHD symptoms by boosting monoamine levels in the synapse. In the present study, microPET/CT was used to investigate possible neurochemical alterations in the cerebral dopamine system after cessation of long-term MPH administration in nonhuman primates. MicroPET/CT images were collected from adult male rhesus monkeys 6 months after they stopped receiving vehicle or MPH following 12 years of chronic treatment. The neurochemical status of brain dopaminergic systems was evaluated using the vesicular monoamine transporter 2 (VMAT2) ligand [
MeSH term(s)	Child, Preschool ; Adult ; Animals ; Male ; Humans ; Methylphenidate ; Central Nervous System Stimulants ; Dopamine ; Fluorodeoxyglucose F18/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy
Chemical Substances	Methylphenidate (207ZZ9QZ49) ; Central Nervous System Stimulants ; Dopamine (VTD58H1Z2X) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; florbenazine F 18 (KM31LBX59H) ; 3-N-(2-fluoroethyl)spiperone (106114-42-5)
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	639165-5
ISSN	1872-9738 ; 0892-0362
ISSN (online)	1872-9738
ISSN	0892-0362
DOI	10.1016/j.ntt.2023.107173
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Zs.A 1626: Show issues

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Article ; Online: The Role of Trust in Older Adult Service Provision at the Onset of the COVID-19 Pandemic.

Turner, Natalie R / Freitag, Callie / Johnson, Ian / Parsey, Carolyn M / Ramirez, Magaly / Berridge, Clara

Journal of gerontological social work

2023 Volume 66, Issue 6, Page(s) 739–762

Abstract: The COVID-19 pandemic caused near immediate service delivery adaptation among social service and healthcare sectors. Findings from in-depth interviews with 45 senior leaders of social services and healthcare organizations serving older adults in ... ...

Abstract	The COVID-19 pandemic caused near immediate service delivery adaptation among social service and healthcare sectors. Findings from in-depth interviews with 45 senior leaders of social services and healthcare organizations serving older adults in Washington State elucidate the role of trust in service provision at the onset of the pandemic. First, a history of trust facilitated service adaptation. Intentional outreach, programs, and culturally responsive services sustained trust with service recipients. Providing services and information in an older adult's preferred language built trust. Community networks facilitated and reflected trust between organizations and older adults. Finally, mistrust was prevalent for clients who perceived a high risk of experiencing negative consequences from accessing services. Our findings support the need for culturally and linguistically diverse services. To improve trust, the aging network should strengthen and expand partnerships with community-based organizations who have established trust through history, intentionality, and relevance to their service populations..
MeSH term(s)	Humans ; Aged ; Pandemics ; Health Services Accessibility ; Trust ; COVID-19/epidemiology ; Community Networks
Language	English
Publishing date	2023-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	779365-0
ISSN	1540-4048 ; 0163-4372
ISSN (online)	1540-4048
ISSN	0163-4372
DOI	10.1080/01634372.2022.2164821
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Zs.A 4324: Show issues

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Article: Bioenergetic and Metabolic Adaptation in Tumor Progression and Metastasis.

Herst, Patries M / Carson, Georgia M / Eccles, David A / Berridge, Michael V

Frontiers in oncology

2022 Volume 12, Page(s) 857686

Abstract: The ability of cancer cells to adjust their metabolism in response to environmental changes is a well-recognized hallmark of cancer. Diverse cancer and non-cancer cells within tumors compete for metabolic resources. Metabolic demands change frequently ... ...

Abstract	The ability of cancer cells to adjust their metabolism in response to environmental changes is a well-recognized hallmark of cancer. Diverse cancer and non-cancer cells within tumors compete for metabolic resources. Metabolic demands change frequently during tumor initiation, progression and metastasis, challenging our quest to better understand tumor biology and develop novel therapeutics. Vascularization, physical constraints, immune responses and genetic instability promote tumor evolution resulting in immune evasion, opportunities to breach basement membrane barriers and spread through the circulation and lymphatics. In addition, the unfolded protein response linked to the ubiquitin proteasome system is a key player in addressing stoichiometric imbalances between nuclear and mitochondrially-encoded protein subunits of respiratory complexes, and nuclear-encoded mitochondrial ribosomal protein subunits. While progressive genetic changes, some of which affect metabolic adaptability, contribute to tumorigenesis and metastasis through clonal expansion, epigenetic changes are also important and more dynamic in nature. Understanding the role of stromal and immune cells in the tumor microenvironment in remodeling cancer cell energy metabolism has become an increasingly important area of research. In this perspective, we discuss the adaptations made by cancer cells to balance mitochondrial and glycolytic energy metabolism. We discuss how hypoxia and nutrient limitations affect reductive and oxidative stress through changes in mitochondrial electron transport activity. We propose that integrated responses to cellular stress in cancer cells are central to metabolic flexibility in general and bioenergetic adaptability in particular and are paramount in tumor progression and metastasis.
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.857686
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