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Article ; Online: Determination of growth and maintenance coefficients by calorespirometry.

Matheson, Sannali / Ellingson, Derek J / McCarlie, V Wallace / Smith, Bruce N / Criddle, Richard S / Rodier, Laurence / Hansen, Lee D

Functional plant biology : FPB

2020 Volume 31, Issue 9, Page(s) 929–939

Abstract: This study describes a calorespirometric method for determining the coefficients of the correlation of specific respiration and growth rates. To validate the calorespirometric method, coefficients obtained from calorespirometric data are compared with ... ...

Abstract	This study describes a calorespirometric method for determining the coefficients of the correlation of specific respiration and growth rates. To validate the calorespirometric method, coefficients obtained from calorespirometric data are compared with coefficients obtained from mass and elongation growth rates measured at three temperatures on oat (Avena sativa L.) shoots. Calorespirometric measurements were also made on leaf tissue of varying age from Verbascum thapsus L., Convolvulus arvensis L., and Helianthus tuberosus Nutt. Measurements on A. sativa, C. arvensis and H. tuberosus at several temperatures show maintenance coefficients generally increase with temperature, but, in disagreement with accepted theory, growth coefficients for C. arvensis and A. sativa vary with temperature. A comparison of rates expressed as intensive and extensive quantities showed that the decline in specific respiration and growth rates with age is caused by dilution-by-growth, not down-regulation of respiration rate by reduced demand. The ratio of heat rate to CO
Language	English
Publishing date	2020-07-21
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2071582-1
ISSN	1445-4416 ; 1445-4408
ISSN (online)	1445-4416
ISSN	1445-4408
DOI	10.1071/FP03029
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Article ; Online: Microbial biomanufacturing for space-exploration-what to take and when to make.

Averesch, Nils J H / Berliner, Aaron J / Nangle, Shannon N / Zezulka, Spencer / Vengerova, Gretchen L / Ho, Davian / Casale, Cameran A / Lehner, Benjamin A E / Snyder, Jessica E / Clark, Kevin B / Dartnell, Lewis R / Criddle, Craig S / Arkin, Adam P

Nature communications

2023 Volume 14, Issue 1, Page(s) 2311

Abstract: As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase resilience, flexibility, and ... ...

Abstract	As renewed interest in human space-exploration intensifies, a coherent and modernized strategy for mission design and planning has become increasingly crucial. Biotechnology has emerged as a promising approach to increase resilience, flexibility, and efficiency of missions, by virtue of its ability to effectively utilize in situ resources and reclaim resources from waste streams. Here we outline four primary mission-classes on Moon and Mars that drive a staged and accretive biomanufacturing strategy. Each class requires a unique approach to integrate biomanufacturing into the existing mission-architecture and so faces unique challenges in technology development. These challenges stem directly from the resources available in a given mission-class-the degree to which feedstocks are derived from cargo and in situ resources-and the degree to which loop-closure is necessary. As mission duration and distance from Earth increase, the benefits of specialized, sustainable biomanufacturing processes also increase. Consequentially, we define specific design-scenarios and quantify the usefulness of in-space biomanufacturing, to guide techno-economics of space-missions. Especially materials emerged as a potentially pivotal target for biomanufacturing with large impact on up-mass cost. Subsequently, we outline the processes needed for development, testing, and deployment of requisite technologies. As space-related technology development often does, these advancements are likely to have profound implications for the creation of a resilient circular bioeconomy on Earth.
MeSH term(s)	Humans ; Space Flight ; Moon ; Biotechnology ; Mars
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37910-1
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Article: Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis

Yang, Xinmin / Yao, Linbo / Yuan, Mei / Zhang, Xiaoying / Jakubowska, Monika A / Ferdek, Pawel E / Dai, Lei / Yang, Jingyu / Jin, Tao / Deng, Lihui / Fu, Xianghui / Du, Dan / Liu, Tingting / Criddle, David N / Sutton, Robert / Huang, Wei / Xia, Qing

Frontiers in pharmacology

2022 Volume 13, Page(s) 896523

Abstract: Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide and worse clinical outcomes compared to AP of other etiologies. Chaiqin chengqi decoction (CQCQD), a Chinese herbal formula, has long been used for the clinical ... ...

Abstract	Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide and worse clinical outcomes compared to AP of other etiologies. Chaiqin chengqi decoction (CQCQD), a Chinese herbal formula, has long been used for the clinical management of AP but its therapeutic actions and the underlying mechanisms have not been fully elucidated. This study has investigated the pharmacological mechanisms of CQCQD in a novel mouse model of obesity-related alcohol-induced AP (OA-AP). The mouse OA-AP model was induced by a high-fat diet for 12 weeks and subsequently two intraperitoneal injections of ethanol, CQCQD was administered 2 h after the first injection of ethanol. The severity of OA-AP was assessed and correlated with changes in transcriptomic profiles and network pharmacology in the pancreatic and adipose tissues, and further docking analysis modeled the interactions between compounds of CQCQD and their key targets. The results showed that CQCQD significantly reduced pancreatic necrosis, alleviated systemic inflammation, and decreased the parameters associated with multi-organ dysfunction. Transcriptomics and network pharmacology analysis, as well as further experimental validation, have shown that CQCQD induced Nrf2/HO-1 antioxidant protein response and decreased Akt phosphorylation in the pancreatic and adipose tissues.
Language	English
Publishing date	2022-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.896523
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Article ; Online: Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1.

Ouyang, Yulin / Wen, Li / Armstrong, Jane A / Chvanov, Michael / Latawiec, Diane / Cai, Wenhao / Awais, Mohammad / Mukherjee, Rajarshi / Huang, Wei / Gough, Peter J / Bertin, John / Tepikin, Alexei V / Sutton, Robert / Criddle, David N

Cells

2021 Volume 10, Issue 5

Abstract: Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1), a key component of programmed necrosis ( ... ...

Abstract	Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1), a key component of programmed necrosis (Necroptosis), is unclear in AP. We assessed the effects of RIPK1 inhibitor Necrostatin-1 (Nec-1) and RIPK1 modification (RIPK1
MeSH term(s)	Acinar Cells/metabolism ; Alcohols ; Animals ; Bile Acids and Salts ; Calcium/metabolism ; Ceruletide ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Indoles/pharmacology ; Indoles/therapeutic use ; Male ; Mice, Inbred C57BL ; Pancreas/pathology ; Pancreatitis/chemically induced ; Pancreatitis/drug therapy ; Pancreatitis/enzymology ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Reactive Oxygen Species/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Mice
Chemical Substances	Alcohols ; Bile Acids and Salts ; Imidazoles ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Indoles ; Protective Agents ; Reactive Oxygen Species ; necrostatin-1 ; Ceruletide (888Y08971B) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Ripk1 protein, mouse (EC 2.7.11.1) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-04-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10051035
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Article ; Online: Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis.

Chvanov, Michael / Voronina, Svetlana / Zhang, Xiaoying / Telnova, Svetlana / Chard, Robert / Ouyang, Yulin / Armstrong, Jane / Tanton, Helen / Awais, Muhammad / Latawiec, Diane / Sutton, Robert / Criddle, David N / Tepikin, Alexei V

Cells

2020 Volume 9, Issue 6

Abstract: Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the molecular mechanisms of acute pancreatitis is essential for the development of new therapeutics. Several inducers of acute pancreatitis trigger sustained ... ...

Abstract	Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the molecular mechanisms of acute pancreatitis is essential for the development of new therapeutics. Several inducers of acute pancreatitis trigger sustained Ca
MeSH term(s)	Acinar Cells/metabolism ; Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling ; Cytosol/metabolism ; Disease Models, Animal ; Flavin-Adenine Dinucleotide/metabolism ; Mice, Knockout ; Mitochondria/metabolism ; NAD/metabolism ; Pancreas/pathology ; Pancreatitis/metabolism ; Pancreatitis/pathology ; Severity of Illness Index
Chemical Substances	Calcium Channels ; mitochondrial calcium uniporter ; NAD (0U46U6E8UK) ; Flavin-Adenine Dinucleotide (146-14-5) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-06-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9061407
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Article ; Online: A microRNA checkpoint for Ca

Molecular therapy : the journal of the American Society of Gene Therapy

2022 Volume 30, Issue 4, Page(s) 1754–1774

Abstract: Acute pancreatitis (AP) is a common digestive disease without specific treatment, and its pathogenesis features multiple deleterious amplification loops dependent on translation, triggered by cytosolic ... ...

Abstract	Acute pancreatitis (AP) is a common digestive disease without specific treatment, and its pathogenesis features multiple deleterious amplification loops dependent on translation, triggered by cytosolic Ca
MeSH term(s)	Acinar Cells/metabolism ; Acute Disease ; Animals ; Calcium/metabolism ; Calcium Signaling ; Humans ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Pancreatitis/genetics ; Pancreatitis/metabolism ; Pancreatitis/pathology
Chemical Substances	MicroRNAs ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-01-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2022.01.033
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Article ; Online: Protective effects of flavonoids from Coreopsis tinctoria Nutt. on experimental acute pancreatitis via Nrf-2/ARE-mediated antioxidant pathways.

Du, Dan / Yao, Linbo / Zhang, Rui / Shi, Na / Shen, Yan / Yang, Xinmin / Zhang, Xiaoying / Jin, Tao / Liu, Tingting / Hu, Liqiang / Xing, Zhihua / Criddle, David N / Xia, Qing / Huang, Wei / Sutton, Robert

Journal of ethnopharmacology

2018 Volume 224, Page(s) 261–272

Abstract: ... in reducing necrotic cell death pathway activation with 0.5 mM C1, (2 R,3 R)-taxifolin 7-O-β-D-glucopyranoside ...

Abstract	Ethnopharmacological relevance: Oxidative stress is a prominent feature of clinical acute pancreatitis (AP). Coreopsis tinctoria has been used traditionally to treat pancreas disorders like diabetes mellitus in China and Portugal and its flavonoid-rich fraction contain the main phytochemicals that have antioxidant and anti-inflammatory activities. Aim of the study: To investigate the effects of flavonoids isolated from C. tinctoria on experimental AP and explore the potential mechanism. Materials and methods: LC-MS based online technique was used to analyse and isolate targeted flavonoids from C. tinctoria. Freshly isolated mouse pancreatic acinar cells were treated with taurocholic acid sodium salt hydrate (NaT, 5 mM) with or without flavonoids. Fluorescence microscopy and a plate reader were used to determine necrotic cell death pathway activation (propidium iodide), reactive oxygen species (ROS) production (H2-DCFDA) and ATP depletion (luminescence) where appropriate. AP was induced by 7 repeated intraperitoneal caerulein injections (50 μg/kg) at hourly interval in mice or retrograde infusion of taurolithocholic acid 3-sulfate disodium salt (TLCS; 5 mM, 50 μL) into the pancreatic duct in mice or infusion of NaT (3.5%, 1 mL/kg) in rats. A flavonoid was intraperitoneally administered at 0, 4, and 8 h after the first caerulein injection or post-operation. Disease severity, oxidative stress and antioxidant markers were determined. Results: Total flavonoids extract and flavonoids 1-6 (C1-C6) exhibited different capacities in reducing necrotic cell death pathway activation with 0.5 mM C1, (2 R,3 R)-taxifolin 7-O-β-D-glucopyranoside, having the best effect. C1 also significantly reduced NaT-induced ROS production and ATP depletion. C1 at 12.5 mg/kg and 8.7 mg/kg (equivalent to 12.5 mg/kg for mice) significantly reduced histopathological, biochemical and immunological parameters in the caerulein-, TLCS- and NaT-induced AP models, respectively. C1 administration increased pancreatic nuclear factor erythroid 2-related factor 2 (Nrf2) and Nrf2-medicated haeme oxygenase-1 expression and elevated pancreatic antioxidant enzymes superoxide dismutase and glutathione peroxidase levels. Conclusions: Flavonoid C1 from C. tinctoria was protective in experimental AP and this effect may at least in part be attributed to its antioxidant effects by activation of Nrf2-mediated pathways. These results suggest the potential utilisation of C. tinctoria to treat AP.
MeSH term(s)	Acinar Cells/drug effects ; Acute Disease ; Adenosine Triphosphate/metabolism ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antioxidant Response Elements/drug effects ; Coreopsis ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Glutathione Peroxidase/metabolism ; Heme Oxygenase-1/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; NF-E2-Related Factor 2/metabolism ; Pancreas/drug effects ; Pancreas/metabolism ; Pancreas/pathology ; Pancreatitis/drug therapy ; Pancreatitis/metabolism ; Pancreatitis/pathology ; Phytotherapy ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Flavonoids ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; Adenosine Triphosphate (8L70Q75FXE) ; Glutathione Peroxidase (EC 1.11.1.9) ; Heme Oxygenase-1 (EC 1.14.14.18) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2018-06-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2018.06.003
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Article: Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine.

Zhang, Xiaoying / Jin, Tao / Shi, Na / Yao, Linbo / Yang, Xinmin / Han, Chenxia / Wen, Li / Du, Dan / Szatmary, Peter / Mukherjee, Rajarshi / Liu, Tingting / Xia, Qing / Criddle, David N / Huang, Wei / Chvanov, Michael / Sutton, Robert

Frontiers in physiology

2019 Volume 9, Page(s) 1922

Abstract: ... cell death caused by L-histidine, but not L-arginine or L-ornithine. Cyclophilin D knock-out (Ppif ...

Abstract	Pancreatic acinar cells require high rates of amino acid uptake for digestive enzyme synthesis, but excessive concentrations can trigger acute pancreatitis (AP) by mechanisms that are not well understood. We have used three basic natural amino acids L-arginine, L-ornithine, and L-histidine to determine mechanisms of amino acid-induced pancreatic injury and whether these are common to all three amino acids. Caffeine markedly inhibited necrotic cell death pathway activation in isolated pancreatic acinar cells induced by L-arginine, but not L-ornithine, whereas caffeine accelerated L-histidine-induced cell death. Both necroptosis inhibitors of RIPK1 and RIPK3 and a necroptosis activator/apoptosis inhibitor z-VAD increased cell death caused by L-histidine, but not L-arginine or L-ornithine. Cyclophilin D knock-out (Ppif
Language	English
Publishing date	2019-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2018.01922
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Article ; Online: Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift.

Armstrong, Jane A / Cash, Nicole J / Ouyang, Yulin / Morton, Jack C / Chvanov, Michael / Latawiec, Diane / Awais, Muhammad / Tepikin, Alexei V / Sutton, Robert / Criddle, David N

The Journal of biological chemistry

2018 Volume 293, Issue 21, Page(s) 8032–8047

Abstract: Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli induce ... ...

Abstract	Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli induce Ca
MeSH term(s)	Acinar Cells/metabolism ; Acinar Cells/pathology ; Adenosine Triphosphate/metabolism ; Animals ; Apoptosis ; Calcium/metabolism ; Cells, Cultured ; Peptidyl-Prolyl Isomerase F ; Cyclophilins/physiology ; Energy Metabolism ; Membrane Potential, Mitochondrial ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/physiology ; Mitochondrial Membrane Transport Proteins/physiology ; Mitochondrial Permeability Transition Pore ; Necrosis ; Oxidative Stress ; Pancreas/metabolism ; Pancreas/pathology ; Reactive Oxygen Species/metabolism
Chemical Substances	Peptidyl-Prolyl Isomerase F ; Mitochondrial Membrane Transport Proteins ; Mitochondrial Permeability Transition Pore ; PPIF protein, mouse ; Reactive Oxygen Species ; Adenosine Triphosphate (8L70Q75FXE) ; Cyclophilins (EC 5.2.1.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA118.003200
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Article ; Online: LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells.

De Faveri, Francesca / Chvanov, Michael / Voronina, Svetlana / Moore, Danielle / Pollock, Liam / Haynes, Lee / Awais, Muhammad / Beckett, Alison J / Mayer, Ulrike / Sutton, Robert / Criddle, David N / Prior, Ian A / Wileman, Tom / Tepikin, Alexei V

Autophagy

2019 Volume 16, Issue 7, Page(s) 1314–1331

Abstract: Activation of trypsinogen (formation of trypsin) inside the pancreas is an early pathological event in the development of acute pancreatitis. In our previous studies we identified the activation of trypsinogen within endocytic vacuoles (EVs), cellular ... ...

Abstract	Activation of trypsinogen (formation of trypsin) inside the pancreas is an early pathological event in the development of acute pancreatitis. In our previous studies we identified the activation of trypsinogen within endocytic vacuoles (EVs), cellular organelles that appear in pancreatic acinar cells treated with the inducers of acute pancreatitis. EVs are formed as a result of aberrant compound exocytosis and subsequent internalization of post-exocytic structures. These organelles can be up to 12 μm in diameter and can be actinated (i.e. coated with F-actin). Notably, EVs can undergo intracellular rupture and fusion with the plasma membrane, providing trypsin with access to cytoplasmic and extracellular targets. Unraveling the mechanisms involved in cellular processing of EVs is an interesting cell biological challenge with potential benefits for understanding acute pancreatitis. In this study we have investigated autophagy of EVs and discovered that it involves a non-canonical LC3-conjugation mechanism, reminiscent in its properties to LC3-associated phagocytosis (LAP); in both processes LC3 was recruited to single, outer organellar membranes. Trypsinogen activation peptide was observed in approximately 55% of LC3-coated EVs indicating the relevance of the described process to the early cellular events of acute pancreatitis. We also investigated relationships between actination and non-canonical autophagy of EVs and concluded that these processes represent sequential steps in the evolution of EVs. Our study expands the known roles of LAP and indicates that, in addition to its well-established functions in phagocytosis and macropinocytosis, LAP is also involved in the processing of post-exocytic organelles in exocrine secretory cells. Abbreviations: AP: acute pancreatitis; CCK: cholecystokinin; CLEM: correlative light and electron microscopy; DPI: diphenyleneiodonium; EV: endocytic vacuole; LAP: LC3-associate phagocytosis; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PACs: pancreatic acinar cells; PFA: paraformaldehyde; PtdIns3K: phosphatidylinositol 3-kinase; PtdIns3P: phosphatidylinositol 3-phosphate; Res: resveratrol; TAP: trypsinogen activation peptide; TEM: transmission electron microscopy; TLC-S: taurolithocholic acid 3-sulfate; TRD: Dextran Texas Red 3000 MW Neutral; ZGs: zymogen granules.
MeSH term(s)	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt/pharmacology ; Acinar Cells/drug effects ; Acinar Cells/metabolism ; Acinar Cells/ultrastructure ; Actins/metabolism ; Animals ; Autophagy/drug effects ; Autophagy-Related Protein-1 Homolog/antagonists & inhibitors ; Autophagy-Related Protein-1 Homolog/metabolism ; Autophagy-Related Proteins/chemistry ; Autophagy-Related Proteins/metabolism ; Chloroquine/pharmacology ; Cholecystokinin/pharmacology ; Endocytosis ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/metabolism ; Onium Compounds/pharmacology ; Pancreas/cytology ; Phagocytosis/drug effects ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Domains ; Protein Kinase Inhibitors/pharmacology ; Reactive Oxygen Species/metabolism ; Resveratrol/pharmacology ; Taurolithocholic Acid/analogs & derivatives ; Trypsinogen/metabolism ; Vacuolar Proton-Translocating ATPases/antagonists & inhibitors ; Vacuolar Proton-Translocating ATPases/metabolism ; Vacuoles/drug effects ; Vacuoles/metabolism
Chemical Substances	Actins ; Atg16l1 protein, mouse ; Autophagy-Related Proteins ; Map1lc3b protein, mouse ; Microtubule-Associated Proteins ; Onium Compounds ; Protein Kinase Inhibitors ; Reactive Oxygen Species ; taurolithocholic acid 3-sulfate (15324-65-9) ; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt (4X87R5T106) ; Taurolithocholic Acid (516-90-5) ; diphenyleneiodonium (6HJ411TU98) ; Chloroquine (886U3H6UFF) ; Trypsinogen (9002-08-8) ; Cholecystokinin (9011-97-6) ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-) ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2019-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2019.1679514
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