LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 17

Search options

  1. Article ; Online: Association of lewy bodies, hippocampal sclerosis and amyloid angiopathy with dementia in community-dwelling elderly: A systematic review and meta-analysis.

    Avan, Abolfazl / Amiri, Amin / Mokhber, Naghmeh / Erfanian, Mahdiyeh / Cipriano, Lauren E / Stranges, Saverio / Shojaeianbabaei, Golnaz / Abootalebi, Shahram / Azarpazhooh, M Reza

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2021  Volume 90, Page(s) 124–131

    Abstract: Introduction: We measured the proportion of Lewy body pathology (LB), hippocampal sclerosis (HS), and cerebral amyloid angiopathy (CAA) among community-dwelling people with and without dementia.: Methods: We searched for community-based cohorts with ... ...

    Abstract Introduction: We measured the proportion of Lewy body pathology (LB), hippocampal sclerosis (HS), and cerebral amyloid angiopathy (CAA) among community-dwelling people with and without dementia.
    Methods: We searched for community-based cohorts with postmortem brain autopsy until 1 January 2020. We calculated the summary risk difference and 95% confidence interval (95% CI) using a random-effects model in R.
    Results: We found 12 articles, comprising 2197 demented and 2104 non-demented participants. LB, HS, CAA were prevalent lesions among community-dwelling elderly (15%, 10%, and 24%, respectively). These significantly increased the risk of dementia (LB: risk difference 38%, 95% CI 20-56%, HS: 34%, 24-44%, CAA: 19%, 3-34%). 20% of cases with neocortical LB, 17% with bilateral HS, and 42% with moderate/severe CAA pathology remained non-demented by death.
    Discussion: LB or HS or CAA are common neuropathologies among community-dwelling elderly. Although these lesions independently are associated with dementia, many remain non-demented, by death.
    MeSH term(s) Aged ; Aged, 80 and over ; Cerebral Amyloid Angiopathy/complications ; Cerebral Amyloid Angiopathy/epidemiology ; Cerebral Amyloid Angiopathy/pathology ; Dementia/etiology ; Dementia/pathology ; Female ; Hippocampus/pathology ; Humans ; Independent Living ; Lewy Bodies/pathology ; Male ; Prevalence ; Sclerosis/epidemiology ; Sclerosis/pathology
    Language English
    Publishing date 2021-06-07
    Publishing country Scotland
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2021.05.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: The upgoing thumb sign: An interobserver/intraobserver reliability study.

    Abootalebi, Shahram / Azarpazhooh, Mahmoud Reza / Sposato, Luciano / Hachinski, Vladimir

    Neurology. Clinical practice

    2017  Volume 7, Issue 6, Page(s) 483–487

    Abstract: Background: The upgoing thumb sign as a subtle clinical finding of upper motor neuron involvement has been frequently reported in patients with TIAs and minor strokes. This study was designed to show the method of examination and interpretation and the ... ...

    Abstract Background: The upgoing thumb sign as a subtle clinical finding of upper motor neuron involvement has been frequently reported in patients with TIAs and minor strokes. This study was designed to show the method of examination and interpretation and the interobserver/intraobserver reliability.
    Methods: The thumb sign was elicited in TIA/minor strokes or stroke mimics. After obtaining the participant's permission, the examinations were recorded. Two independent neurologists reviewed all patients for the possibility of an upgoing thumb sign. After 1 hour education about the definition of an upgoing thumb sign to a group of stroke fellows, nurse practitioners, and a research secretary, the videos were reviewed and the participants rated the thumb sign independently. The intraobserver reliability was assessed after 3 months by rating the same videos.
    Results: The interobserver reliability among 9 raters showed an overall agreement of 0.83 and fixed-marginal kappa of 0.66. The same videos were reviewed by the observers after 3 months with a similar level of agreement (percent of overall agreement 0.84, fixed-marginal kappa 0.66) and a substantial to almost perfect level of intraobserver concordance (mean 0.86; SD 0.08; median 0.90; interquartile range 25-75, 0.8, 0.95).
    Conclusions: The upgoing thumb sign is a subtle upper limb neurologic finding, with a high level of interobserver and intraobserver reliability. The test is easy to perform and can be interpreted accurately.
    Language English
    Publishing date 2017-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000398
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Goodbye neurological examination, hello history?

    Soros, Peter / Abootalebi, Shahram / Hachinski, Vladimir

    Annals of neurology

    2012  Volume 72, Issue 6, Page(s) 983

    MeSH term(s) Humans ; Neurologic Examination ; Research
    Language English
    Publishing date 2012-12
    Publishing country United States
    Document type Comment ; Letter ; Research Support, N.I.H., Intramural
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.23742
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Secular trends of ischaemic heart disease, stroke, and dementia in high-income countries from 1990 to 2017: the Global Burden of Disease Study 2017.

    Morovatdar, Negar / Avan, Abolfazl / Azarpazhooh, M Reza / Di Napoli, Mario / Stranges, Saverio / Kapral, Moira K / Rezayat, Arash Akhavan / Shariatzadeh, Aidin / Abootalebi, Shahram / Mokhber, Naghmeh / Spence, J David / Hachinski, Vladimir

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2021  Volume 43, Issue 1, Page(s) 255–264

    Abstract: Background: We assessed secular trends in the burden of ischaemic heart disease (IHD), stroke, and dementia in the Organization for Economic Co-operation and Development (OECD) countries.: Methods: Using the Global Burden of Disease (GBD) Study 2017, ...

    Abstract Background: We assessed secular trends in the burden of ischaemic heart disease (IHD), stroke, and dementia in the Organization for Economic Co-operation and Development (OECD) countries.
    Methods: Using the Global Burden of Disease (GBD) Study 2017, we compared sex-specific and age-standardized rates of disability-adjusted life years (DALY); mortality, incidence, and prevalence of IHD and stroke; and dementia per 100,000 people, in the world, OECD countries, and Canada.
    Results: From 1990 to 2017, the crude incidence number of IHD, stroke, and dementia increased 52%, 76%, and 113%, respectively. Likewise, the prevalence of IHD (75%), stroke (95%), and dementia (119%) increased worldwide. In addition during the study period, the crude global number of deaths of IHD increased 52%, stroke by 41%, and dementia by 146% (9, 6, and 3 million deaths in 2017, respectively). Despite an increase in the crude number of these diseases, the global age-standardized incidence rate of IHD, stroke, and dementia decreased by -27%, - 11%, and - 5%, respectively. Moreover, there was a decline in their age-standardized DALY rates (- 1.17%, - 1.32%, and - 0.23% per year, respectively) and death rates (- 1.29%, - 1.46%, and - 0.17% per year, respectively), with sharper downward trends in Canada and OECD countries. Almost all trends flattened during the last decade.
    Conclusions: From 1990 to 2017, the age-standardized burden of IHD, stroke, and dementia decreased, more prominently in OECD countries than the world. However, their rising crude numbers mainly due to population growth and ageing require urgent identification of reversible risk and protective factors.
    MeSH term(s) Dementia/epidemiology ; Developed Countries ; Disability-Adjusted Life Years ; Female ; Global Burden of Disease ; Global Health ; Humans ; Male ; Myocardial Ischemia/epidemiology ; Stroke/epidemiology
    Language English
    Publishing date 2021-05-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-021-05259-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Validity of Modified Ashworth Scale as a Measure of Wrist Spasticity in Stroke Patients

    Mohammad Heidari / Shahram Abootalebi / Seyed Ali Hosseini

    Iranian Rehabilitation Journal, Vol 9, Iss 1, Pp 26-

    2011  Volume 30

    Abstract: Objectives: There are some controversies about the value of modified Ashworth Scale (MAS) for assessing spasticity. The goal of this study was to investigate if there is any correlation between scores obtained from MAS for wrist spasticity and ... ...

    Abstract Objectives: There are some controversies about the value of modified Ashworth Scale (MAS) for assessing spasticity. The goal of this study was to investigate if there is any correlation between scores obtained from MAS for wrist spasticity and electrophysiological recordings as the objective measure of spasticity. Methods: In this cross-sectional study, 34 stroke patients were employed. Wrist spasticity was clinically measured by means of MAS. Also, an electromyogram (EMG) machine was used to elicit Hmax and Mmax from the flexor carpi radialis muscle. Spearman’s correlation coefficient test was used to investigate potential correlation between clinically and electrophysiologically measures of spasticity. Results: The observed relation between MAS and EMG recordings was not statistically significant (rho=0.183, P>0.05). Discussion: Our findings suggest that MAS may be a useful tool for grading hypertonia, but it is not a valid measure of spasticity in selected patients.
    Keywords Validity ; Modified ashworth scale ; Spasticity ; Stroke ; Medicine ; R ; Vocational rehabilitation. Employment of people with disabilities ; HD7255-7256
    Subject code 150
    Language English
    Publishing date 2011-04-01T00:00:00Z
    Publisher Negah Institute for Scientific Communication
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Book ; Online: Call to action

    Abootalebi, Shahram / Aertker, Benjamin M / Andalibi, Mohammad Sobhan / Asdaghi, Negar / Aykac, Ozlem / Azarpazhooh, M Reza / Bahit, M Cecilia / Barlinn, Kristian / Basri, Hamidon / Wasay, Mohammad

    Section of Neurology

    SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)

    2020  

    Abstract: Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and ... ...

    Abstract Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic.Methods: This is an international, multicenter, hospital-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hospital mortality) in 2020 during COVID-19 pandemic, comparing them with the corresponding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center.Conclusion: The proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities.
    Keywords COVID-19 ; Health policy ; Incidence ; Mortality ; National crisis ; Pandemic ; SARS-CoV-2 ; Stroke ; Neurology ; covid19
    Publishing date 2020-09-01T07:00:00Z
    Publisher eCommons@AKU
    Publishing country pk
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  7. Article: Comparison of modified Ashworth scale and Hoffmann reflex in study of spasticity.

    Kohan, Amir Hassan / Abootalebi, Shahram / Khoshnevisan, Alireza / Rahgozar, Mehdi

    Acta medica Iranica

    2010  Volume 48, Issue 3, Page(s) 154–157

    Abstract: Spasticity is one of the common complications in upper motor neuron lesions and without appropriate treatment it causes disturbances in movement pattern. Assessments of patients are effective in patient's management. Modified Ashworth scale (MAS) is one ... ...

    Abstract Spasticity is one of the common complications in upper motor neuron lesions and without appropriate treatment it causes disturbances in movement pattern. Assessments of patients are effective in patient's management. Modified Ashworth scale (MAS) is one of the criteria in qualitative assessment of spasticity, and there are lots of controversies about its validity. The purpose of this study is to compare MAS with electrophysiological indices of spasticity. The spasticity of upper limb muscles in patients with hemiplegic cerebral palsy are measured and recorded by MAS. Then electrophysiological indices of Hoffmann reflex (H reflex) and ratio of maximum range of action potential of combined movement of flexor carpi radialis (FCR) for upper limb and soleus for lower limb were estimated. Data of 11 patients with age range 4 to 6 were analyzed. There is no significant correlation between degree of spasticity and electrophysiological indices.
    MeSH term(s) Action Potentials/physiology ; Cerebral Palsy/complications ; Cerebral Palsy/physiopathology ; Child ; Child, Preschool ; Female ; H-Reflex/physiology ; Hemiplegia/physiopathology ; Humans ; Lower Extremity/physiopathology ; Male ; Muscle Spasticity/etiology ; Muscle Spasticity/physiopathology ; Muscle, Skeletal/physiopathology ; Severity of Illness Index ; Upper Extremity/physiopathology
    Language English
    Publishing date 2010-05
    Publishing country Iran
    Document type Comparative Study ; Journal Article
    ZDB-ID 603042-7
    ISSN 0044-6025
    ISSN 0044-6025
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Comparison of Modified Ashworth Scale and Hoffmann Reflex in Study of Spasticity

    Amir Hassan Kohan / Shahram Abootalebi / Alireza Khoshnevisan / Mehdi Rahgozar

    Acta Medica Iranica, Vol 48, Iss 3, Pp 154-

    2010  Volume 157

    Abstract: nSpasticity is one of the common complications in upper motor neuron lesions and without appropriate treatment it causes disturbances in movement pattern. Assessments of patients are effective in patient`s management. Modified Ashworth scale (MAS) is ... ...

    Abstract "nSpasticity is one of the common complications in upper motor neuron lesions and without appropriate treatment it causes disturbances in movement pattern. Assessments of patients are effective in patient`s management. Modified Ashworth scale (MAS) is one of the criteria in qualitative assessment of spasticity, and there are lots of controversies about its validity. The purpose of this study is to compare MAS with electrophysiological indices of spasticity. The spasticity of upper limb muscles in patients with hemiplegic cerebral palsy are measured and recorded by MAS. Then electrophysiological indices of Hoffmann reflex (H reflex) and ratio of maximum range of action potential of combined movement of flexor carpi radialis (FCR) for upper limb and soleus for lower limb were estimated. Data of 11 patients with age range 4 to 6 were analyzed. There is no significant correlation between degree of spasticity and electrophysiological indices.
    Keywords Cerebral palsy ; muscle spasticity ; reflex ; abnormal ; motor neurons ; Medicine (General) ; R5-920
    Language English
    Publishing date 2010-05-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  9. Article ; Online: Comparison of Modified Ashworth Scale and Hoffmann Reflex in Study of Spasticity

    Amir Hassan Kohan / Shahram Abootalebi / Alireza Khoshnevisan / Mehdi Rahgozar

    Acta Medica Iranica, Vol 48, Iss

    2010  Volume 3

    Abstract: Spasticity is one of the common complications in upper motor neuron lesions and without appropriate treatment it causes disturbances in movement pattern. Assessments of patients are effective in patient`s management. Modified Ashworth scale (MAS) is one ... ...

    Abstract Spasticity is one of the common complications in upper motor neuron lesions and without appropriate treatment it causes disturbances in movement pattern. Assessments of patients are effective in patient`s management. Modified Ashworth scale (MAS) is one of the criteria in qualitative assessment of spasticity, and there are lots of controversies about its validity. The purpose of this study is to compare MAS with electrophysiological indices of spasticity. The spasticity of upper limb muscles in patients with hemiplegic cerebral palsy are measured and recorded by MAS. Then electrophysiological indices of Hoffmann reflex (H reflex) and ratio of maximum range of action potential of combined movement of flexor carpi radialis (FCR) for upper limb and soleus for lower limb were estimated. Data of 11 patients with age range 4 to 6 were analyzed. There is no significant correlation between degree of spasticity and electrophysiological indices.
    Keywords Cerebral palsy ; muscle spasticity ; reflex ; abnormal ; motor neurons ; Medicine (General) ; R5-920
    Language English
    Publishing date 2010-06-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  10. Article ; Online: Stroke Care Trends During COVID-19 Pandemic in Zanjan Province, Iran. From the CASCADE Initiative: Statistical Analysis Plan and Preliminary Results.

    Ghoreishi, Abdoreza / Arsang-Jang, Shahram / Sabaa-Ayoun, Ziad / Yassi, Nawaf / Sylaja, P N / Akbari, Yama / Divani, Afshin A / Biller, Jose / Phan, Thanh / Steinwender, Sandy / Silver, Brian / Zand, Ramin / Basri, Hamidon Bin / Iqbal, Omer M / Ranta, Annemarei / Ruland, Sean / Macri, Elizabeth / Ma, Henry / Nguyen, Thanh N /
    Abootalebi, Shahram / Gupta, Animesh / Alet, Matias / Lattanzi, Simona / Desai, Masoom / Gagliardi, Rubens J / Girotra, Tarun / Inoue, Manabu / Yoshimoto, Takeshi / Isaac, Cristian Flavo / Mayer, Stephan A / Morovatdar, Negar / Nilanont, Yongchai / Nobleza, Christa O'Hana S / Saber, Hamidreza / Kamenova, Saltanat / Kondybayeva, Aida / Krupinski, Jerzy / Siegler, James E / Stranges, Saverio / Torbey, Michel T / Yorio, Diana / Zurrú, María Cristina / Rubinos, Clio Aracelli / Shahripour, Reza Bavarsad / Borhani-Haghighi, Afshin / Napoli, Mario Di / Azarpazhooh, M Reza

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2020  Volume 29, Issue 12, Page(s) 105321

    Abstract: Background: The emergence of the COVID-19 pandemic has significantly impacted global healthcare systems and this may affect stroke care and outcomes. This study examines the changes in stroke epidemiology and care during the COVID-19 pandemic in Zanjan ... ...

    Abstract Background: The emergence of the COVID-19 pandemic has significantly impacted global healthcare systems and this may affect stroke care and outcomes. This study examines the changes in stroke epidemiology and care during the COVID-19 pandemic in Zanjan Province, Iran.
    Methods: This study is part of the CASCADE international initiative. From February 18, 2019, to July 18, 2020, we followed ischemic and hemorrhagic stroke hospitalization rates and outcomes in Valiasr Hospital, Zanjan, Iran. We used a Bayesian hierarchical model and an interrupted time series analysis (ITS) to identify changes in stroke hospitalization rate, baseline stroke severity [measured by the National Institutes of Health Stroke Scale (NIHSS)], disability [measured by the modified Rankin Scale (mRS)], presentation time (last seen normal to hospital presentation), thrombolytic therapy rate, median door-to-needle time, length of hospital stay, and in-hospital mortality. We compared in-hospital mortality between study periods using Cox-regression model.
    Results: During the study period, 1,026 stroke patients were hospitalized. Stroke hospitalization rates per 100,000 population decreased from 68.09 before the pandemic to 44.50 during the pandemic, with a significant decline in both Bayesian [Beta: -1.034; Standard Error (SE): 0.22, 95% CrI: -1.48, -0.59] and ITS analysis (estimate: -1.03, SE = 0.24, p < 0.0001). Furthermore, we observed lower admission rates for patients with mild (NIHSS < 5) ischemic stroke (p < 0.0001). Although, the presentation time and door-to-needle time did not change during the pandemic, a lower proportion of patients received thrombolysis (-10.1%; p = 0.004). We did not see significant changes in admission rate to the stroke unit and in-hospital mortality rate; however, disability at discharge increased (p < 0.0001).
    Conclusion: In Zanjan, Iran, the COVID-19 pandemic has significantly impacted stroke outcomes and altered the delivery of stroke care. Observed lower admission rates for milder stroke may possibly be due to fear of exposure related to COVID-19. The decrease in patients treated with thrombolysis and the increased disability at discharge may indicate changes in the delivery of stroke care and increased pressure on existing stroke acute and subacute services. The results of this research will contribute to a similar analysis of the larger CASCADE dataset in order to confirm findings at a global scale and improve measures to ensure the best quality of care for stroke patients during the COVID-19 pandemic.
    MeSH term(s) Aged ; Aged, 80 and over ; Bayes Theorem ; Brain Ischemia/diagnosis ; Brain Ischemia/mortality ; Brain Ischemia/therapy ; COVID-19/epidemiology ; Female ; Hospital Mortality/trends ; Hospitalization/trends ; Humans ; Interrupted Time Series Analysis ; Intracranial Hemorrhages/diagnosis ; Intracranial Hemorrhages/mortality ; Intracranial Hemorrhages/therapy ; Iran/epidemiology ; Length of Stay/trends ; Male ; Middle Aged ; Outcome and Process Assessment, Health Care/trends ; Recovery of Function ; Stroke/diagnosis ; Stroke/mortality ; Stroke/therapy ; Thrombolytic Therapy/trends ; Time Factors ; Time-to-Treatment/trends ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2020.105321
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top