Article ; Online: Association of lewy bodies, hippocampal sclerosis and amyloid angiopathy with dementia in community-dwelling elderly: A systematic review and meta-analysis.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2021 Volume 90, Page(s) 124–131
Abstract: Introduction: We measured the proportion of Lewy body pathology (LB), hippocampal sclerosis (HS), and cerebral amyloid angiopathy (CAA) among community-dwelling people with and without dementia.: Methods: We searched for community-based cohorts with ... ...
Abstract | Introduction: We measured the proportion of Lewy body pathology (LB), hippocampal sclerosis (HS), and cerebral amyloid angiopathy (CAA) among community-dwelling people with and without dementia. Methods: We searched for community-based cohorts with postmortem brain autopsy until 1 January 2020. We calculated the summary risk difference and 95% confidence interval (95% CI) using a random-effects model in R. Results: We found 12 articles, comprising 2197 demented and 2104 non-demented participants. LB, HS, CAA were prevalent lesions among community-dwelling elderly (15%, 10%, and 24%, respectively). These significantly increased the risk of dementia (LB: risk difference 38%, 95% CI 20-56%, HS: 34%, 24-44%, CAA: 19%, 3-34%). 20% of cases with neocortical LB, 17% with bilateral HS, and 42% with moderate/severe CAA pathology remained non-demented by death. Discussion: LB or HS or CAA are common neuropathologies among community-dwelling elderly. Although these lesions independently are associated with dementia, many remain non-demented, by death. |
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MeSH term(s) | Aged ; Aged, 80 and over ; Cerebral Amyloid Angiopathy/complications ; Cerebral Amyloid Angiopathy/epidemiology ; Cerebral Amyloid Angiopathy/pathology ; Dementia/etiology ; Dementia/pathology ; Female ; Hippocampus/pathology ; Humans ; Independent Living ; Lewy Bodies/pathology ; Male ; Prevalence ; Sclerosis/epidemiology ; Sclerosis/pathology |
Language | English |
Publishing date | 2021-06-07 |
Publishing country | Scotland |
Document type | Journal Article ; Meta-Analysis ; Systematic Review |
ZDB-ID | 1193674-5 |
ISSN | 1532-2653 ; 0967-5868 |
ISSN (online) | 1532-2653 |
ISSN | 0967-5868 |
DOI | 10.1016/j.jocn.2021.05.044 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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