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Article: Calreticulin in Essential Thrombocythemia: StressINg OUT the Megakaryocyte Nucleus.

Iborra, Francisco Jose / Papadopoulos, Petros

2017 Volume 7, Page(s) 103

Abstract: Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F ... ...

Abstract	Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F mutation has stirred an intensive research interest about the molecular functions of CALR and its mutants in myeloproliferative neoplasms (MPNs) and its diagnostic/prognostic value. The recently characterized protein-protein interaction of CALR mutants and MPL receptor has advanced our knowledge on the functional role of CALR mutants in thrombocythemia but it has also uncovered limitations of the current established research models. Human cell lines and mouse models provide useful information but they lack the advantages provided by ex vivo primary cultures of physiologically relevant to the disease cell types [i.e., megakaryocytes (MKs), platelets]. The results from gene expression and chromatin occupancy analysis have focused on the JAK-STAT pathway activated in both JAK2 V617F- and CALR-mutated MPN patient groups, although a more complete analysis is needed to be performed in MKs. Stress related processes seem to be affected in CALR mutant ET-MKs, but the precise mechanism is not known yet. Herein, we describe a culture method for human MKs from peripheral blood progenitors, which could help further toward an unbiased characterization of the role of CALR in ET and MK differentiation.
Language	English
Publishing date	2017-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2017.00103
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Splanchnic Vein Thrombosis in Inflammatory Bowel Disease: An Observational Study from the ENEIDA Registry and Systematic Review.

Puig, Maria / Masnou, Helena / Mesonero, Francisco / Menchén, Luís / Bujanda, Luís / Castro, Jesús / González-Partida, Irene / Vicente, Raquel / González-Muñoza, Carlos / Iborra, Marisa / Sierra, Mónica / Huguet, José María / García, María José / De Francisco, Ruth / García-Alonso, Francisco Javier / Mañosa, Míriam / Domènech, Eugeni / On Behalf Of Eneida-Geteccu Registry

Journal of clinical medicine

2023 Volume 12, Issue 23

Abstract: Background: Thromboembolic events are frequent among patients with inflammatory bowel disease (IBD). However, there is little information on the prevalence, features and outcomes of splanchnic vein thrombosis (SVT) in patients with IBD.: Aims: To ... ...

Abstract	Background: Thromboembolic events are frequent among patients with inflammatory bowel disease (IBD). However, there is little information on the prevalence, features and outcomes of splanchnic vein thrombosis (SVT) in patients with IBD. Aims: To describe the clinical features and outcomes of SVT in patients with IBD and to perform a systematic review of these data with published cases and series. Methods: A retrospective observational study from the Spanish nationwide ENEIDA registry was performed. A systematic search of the literature was performed to identify studies with at least one case of SVT in IBD patients. Results: A new cohort of 49 episodes of SVT from the Eneida registry and 318 IBD patients with IBD identified from the literature review (sixty studies: two multicentre, six single-centre and fifty-two case reports or case series) were analysed. There was a mild predominance of Crohn's disease and the most frequent clinical presentation was abdominal pain with or without fever followed by the incidental finding in cross-sectional imaging techniques. The most frequent SVT location was the main portal trunk in two-thirds of the cases, followed by the superior mesenteric vein. Anticoagulation therapy was prescribed in almost 90% of the cases, with a high rate of radiologic resolution of SVT. Thrombophilic conditions other than IBD itself were found in at least one-fifth of patients. Conclusions: SVT seems to be a rare (or underdiagnosed) complication in IBD patients. SVT is mostly associated with disease activity and evolves suitably when anticoagulation therapy is started.
Language	English
Publishing date	2023-11-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12237366
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Article ; Online: Splanchnic Vein Thrombosis in Inflammatory Bowel Disease

Maria Puig / Helena Masnou / Francisco Mesonero / Luís Menchén / Luís Bujanda / Jesús Castro / Irene González-Partida / Raquel Vicente / Carlos González-Muñoza / Marisa Iborra / Mónica Sierra / José María Huguet / María José García / Ruth De Francisco / Francisco Javier García-Alonso / Míriam Mañosa / Eugeni Domènech / on behalf of ENEIDA-GETECCU Registry

Journal of Clinical Medicine, Vol 12, Iss 23, p

An Observational Study from the ENEIDA Registry and Systematic Review

2023 Volume 7366

Abstract	Background: Thromboembolic events are frequent among patients with inflammatory bowel disease (IBD). However, there is little information on the prevalence, features and outcomes of splanchnic vein thrombosis (SVT) in patients with IBD. Aims: To describe the clinical features and outcomes of SVT in patients with IBD and to perform a systematic review of these data with published cases and series. Methods: A retrospective observational study from the Spanish nationwide ENEIDA registry was performed. A systematic search of the literature was performed to identify studies with at least one case of SVT in IBD patients. Results: A new cohort of 49 episodes of SVT from the Eneida registry and 318 IBD patients with IBD identified from the literature review (sixty studies: two multicentre, six single-centre and fifty-two case reports or case series) were analysed. There was a mild predominance of Crohn’s disease and the most frequent clinical presentation was abdominal pain with or without fever followed by the incidental finding in cross-sectional imaging techniques. The most frequent SVT location was the main portal trunk in two-thirds of the cases, followed by the superior mesenteric vein. Anticoagulation therapy was prescribed in almost 90% of the cases, with a high rate of radiologic resolution of SVT. Thrombophilic conditions other than IBD itself were found in at least one-fifth of patients. Conclusions: SVT seems to be a rare (or underdiagnosed) complication in IBD patients. SVT is mostly associated with disease activity and evolves suitably when anticoagulation therapy is started.
Keywords	prevalence ; splanchnic vein thrombosis ; inflammatory bowel disease ; outcome ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Defective mitochondria remodelling in B cells leads to an aged immune response.

Iborra-Pernichi, Marta / Ruiz García, Jonathan / Velasco de la Esperanza, María / Estrada, Belén S / Bovolenta, Elena R / Cifuentes, Claudia / Prieto Carro, Cristina / González Martínez, Tamara / García-Consuegra, José / Rey-Stolle, María Fernanda / Rupérez, Francisco Javier / Guerra Rodriguez, Milagros / Argüello, Rafael J / Cogliati, Sara / Martín-Belmonte, Fernando / Martínez-Martín, Nuria

Nature communications

2024 Volume 15, Issue 1, Page(s) 2569

Abstract: The B cell response in the germinal centre (GC) reaction requires a unique bioenergetic supply. Although mitochondria are remodelled upon antigen-mediated B cell receptor stimulation, mitochondrial function in B cells is still poorly understood. To gain ... ...

Abstract	The B cell response in the germinal centre (GC) reaction requires a unique bioenergetic supply. Although mitochondria are remodelled upon antigen-mediated B cell receptor stimulation, mitochondrial function in B cells is still poorly understood. To gain a better understanding of the role of mitochondria in B cell function, here we generate mice with B cell-specific deficiency in Tfam, a transcription factor necessary for mitochondrial biogenesis. Tfam conditional knock-out (KO) mice display a blockage of the GC reaction and a bias of B cell differentiation towards memory B cells and aged-related B cells, hallmarks of an aged immune response. Unexpectedly, blocked GC reaction in Tfam KO mice is not caused by defects in the bioenergetic supply but is associated with a defect in the remodelling of the lysosomal compartment in B cells. Our results may thus describe a mitochondrial function for lysosome regulation and the downstream antigen presentation in B cells during the GC reaction, the dysruption of which is manifested as an aged immune response.
MeSH term(s)	Mice ; Animals ; Mitochondria/genetics ; B-Lymphocytes ; Germinal Center ; Mice, Knockout ; Lymphocyte Activation
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46763-1
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Article: Therapeutic drug monitoring in inflammatory bowel diseases. Position statement of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis.

Rodríguez-Moranta, Francisco / Argüelles-Arias, Federico / Hinojosa Del Val, Joaquín / Iborra Colomino, Marisa / Martín-Arranz, M Dolores / Menchén Viso, Luis / Muñoz Núñez, Fernando / Ricart Gómez, Elena / Sánchez-Hernández, José Germán / Valdés-Delgado, Teresa / Guardiola Capón, Jordi / Barreiro-de Acosta, Manuel / Mañosa Ciria, Míriam / Zabana Abdo, Yamile / Gutiérrez Casbas, Ana

Gastroenterologia y hepatologia

2024

Abstract: The treatment of inflammatory bowel disease has undergone a significant transformation following the introduction of biologic drugs. Thanks to these drugs, treatment goals have evolved from clinical response and remission to more ambitious objectives, ... ...

Title translation	Monitorización terapéutica de los fármacos biológicos en la enfermedad inflamatoria intestinal. Documento de Posicionamiento del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU).
Abstract	The treatment of inflammatory bowel disease has undergone a significant transformation following the introduction of biologic drugs. Thanks to these drugs, treatment goals have evolved from clinical response and remission to more ambitious objectives, such as endoscopic or radiologic remission. However, even though biologics are highly effective, a significant percentage of patients will not achieve an initial response or may lose it over time. We know that there is a direct relationship between the trough concentrations of the biologic and its therapeutic efficacy, with more demanding therapeutic goals requiring higher drug levels, and inadequate exposure being common. Therapeutic drug monitoring of biologic medications, along with pharmacokinetic models, provides us with the possibility of offering a personalized approach to treatment for patients with IBD. Over the past few years, relevant information has accumulated regarding its utility during or after induction, as well as in the maintenance of biologic treatment, in reactive or proactive strategies, and prior to withdrawal or treatment de-escalation. The aim of this document is to establish recommendations regarding the utility of therapeutic drug monitoring of biologics in patients with inflammatory bowel disease, in different clinical practice scenarios, and to identify areas where its utility is evident, promising, or controversial.
Language	Spanish
Publishing date	2024-02-02
Publishing country	Spain
Document type	Practice Guideline
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2024.01.007
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Article ; Online: Bacteria-instructed B cells cross-prime naïve CD8

García-Ferreras, Raquel / Osuna-Pérez, Jesús / Ramírez-Santiago, Guillermo / Méndez-Pérez, Almudena / Acosta-Moreno, Andrés M / Del Campo, Lara / Gómez-Sánchez, María J / Iborra, Marta / Herrero-Fernández, Beatriz / González-Granado, José M / Sánchez-Madrid, Francisco / Carrasco, Yolanda R / Boya, Patricia / Martínez-Martín, Nuria / Veiga, Esteban

EMBO reports

2023 Volume 24, Issue 7, Page(s) e56131

Abstract: In addition to triggering humoral responses, conventional B cells have been described in vitro to cross-present exogenous antigens activating naïve ... ...

Abstract	In addition to triggering humoral responses, conventional B cells have been described in vitro to cross-present exogenous antigens activating naïve CD8
MeSH term(s)	CD8-Positive T-Lymphocytes ; Dendritic Cells ; Antigen Presentation ; Cross-Priming ; Antigens, Bacterial
Chemical Substances	Antigens, Bacterial
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.202256131
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Article ; Online: Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming.

Soler Palacios, Blanca / Villares, Ricardo / Lucas, Pilar / Rodríguez-Frade, José Miguel / Cayuela, Ana / Piccirillo, Jonathan G / Lombardía, Manuel / Delgado Gestoso, David / Fernández-García, Miguel / Risco, Cristina / Barbas, Coral / Corrales, Fernando / Sorzano, Carlos Oscar S / Martínez-Martín, Nuria / Conesa, José Javier / Iborra, Francisco J / Mellado, Mario

Frontiers in immunology

2023 Volume 14, Page(s) 1200259

Abstract: Introduction: Macrophages are a heterogeneous population of innate immune cells that support tissue homeostasis through their involvement in tissue development and repair, and pathogen defense. Emerging data reveal that metabolism may control macrophage ...

Abstract	Introduction: Macrophages are a heterogeneous population of innate immune cells that support tissue homeostasis through their involvement in tissue development and repair, and pathogen defense. Emerging data reveal that metabolism may control macrophage polarization and function and, conversely, phenotypic polarization may drive metabolic reprogramming. Methods: Here we use biochemical analysis, correlative cryogenic fluorescence microscopy and cryo-focused ion-beam scanning electron microscopy. Results: We demonstrate that growth hormone (GH) reprograms inflammatory GM-CSF-primed monocyte-derived macrophages (GM-MØ) by functioning as a metabolic modulator. We found that exogenous treatment of GM-MØ with recombinant human GH reduced glycolysis and lactate production to levels similar to those found in anti-inflammatory M-MØ. Moreover, GH treatment of GM-MØ augmented mitochondrial volume and altered mitochondrial dynamics, including the remodeling of the inner membrane to increase the density of cristae. Conclusions: Our data demonstrate that GH likely serves a modulatory role in the metabolism of inflammatory macrophages and suggest that metabolic reprogramming of macrophages should be considered as a new target to intervene in inflammatory diseases.
MeSH term(s)	Humans ; Growth Hormone/pharmacology ; Growth Hormone/metabolism ; Macrophages ; Glycolysis ; Homeostasis ; Mitochondria/metabolism
Chemical Substances	Growth Hormone (9002-72-6)
Language	English
Publishing date	2023-07-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1200259
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Article: Predicting Scores on the Mini-Mental State Examination (MMSE) from Spontaneous Speech.

Bueno-Cayo, Alma M / Del Rio Carmona, Minerva / Castell-Enguix, Rosa / Iborra-Marmolejo, Isabel / Murphy, Mike / Irigaray, Tatiana Quarti / Cervera, José Francisco / Moret-Tatay, Carmen

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 9

Abstract: The aim of this study was to examine the relationship between language components, such as lexical density, length, and content in terms of "Time, Space and Action", with MMSE scores. For this reason, a group of 33 older participants, without a diagnosis ...

Abstract	The aim of this study was to examine the relationship between language components, such as lexical density, length, and content in terms of "Time, Space and Action", with MMSE scores. For this reason, a group of 33 older participants, without a diagnosis of dementia, was examined, providing information regarding recent and future events. Participants with higher MMSE scores showed higher lexical density, speech length, as well as number of tokens related to Time, Place and Action in their speech. However, these differences only reach the statistical level for lexical density when participants were divided into two groups (MCI and healthy controls). Word frequency was lower for participants with MCI but this difference was not statistically significant. Lastly, lexical density was positively correlated with MMSE scores and predicted MMSE scores. These results could be of interest at the applied level in the screening of MCI.
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12090339
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Article ; Online: El impacto territorial del uso agrícola y turístico del litoral

Daniel Ibarra Marinas / Francisco Belmonte Serrato / José Rubio Iborra

Boletín de la Asociación de Geógrafos Españoles, Iss

evolución de los cambios de uso del suelo en las cuencas litorales del sur de la Región de Murcia (1956-2013)

2017 Volume 73

Abstract: Las áreas litorales mediterráneas han experimentado importantes transformaciones desde mediados del siglo pasado. Este trabajo analiza los cambios en los usos del suelo de las cuencas del litoral septentrional de la Región de Murcia, durante el periodo ... ...

Abstract	Las áreas litorales mediterráneas han experimentado importantes transformaciones desde mediados del siglo pasado. Este trabajo analiza los cambios en los usos del suelo de las cuencas del litoral septentrional de la Región de Murcia, durante el periodo 1956-2013. Se ha elaborado una matriz de transición que contiene los cambios entre las coberturas. Los resultados muestran una evolución en la agricultura desde el secano tradicional al regadío con vocación de mercado. Los invernaderos, inéditos en 1956, pasan a ocupar una extensión significativa, a costa de los cultivos leñosos de secano tradicionales. Las áreas urbanas crecen debido al auge del turismo y a la necesidad de edificaciones para servicios agrícolas.
Keywords	Environmental sciences ; GE1-350 ; Geography (General) ; G1-922
Language	English
Publishing date	2017-04-01T00:00:00Z
Publisher	Asociación Española de Geografía
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Técnicas de hidroterapia y balneoterapia

Torre Iborra, José Francisco de la

2013

Author's details	José Francisco de la Torre Iborra
MeSH term(s)	Hydrotherapy/methods ; Balneology/methods
Language	Spanish
Size	179 pages :, illustrations
Document type	Book
ISBN	9788490512975 ; 8490512973
Database	Catalogue of the US National Library of Medicine (NLM)

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