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  1. Article ; Online: Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients: A Meta-Analysis.

    Hansrivijit, Panupong / Puthenpura, Max M / Thongprayoon, Charat / Brar, Himmat S / Bathini, Tarun / Kovvuru, Karthik / Kanduri, Swetha R / Wijarnpreecha, Karn / Cheungpasitporn, Wisit

    Medical sciences (Basel, Switzerland)

    2020  Volume 8, Issue 3

    Abstract: Background: The incidence of inflammatory bowel diseases (IBD) and its significance in kidney transplant recipients is not well established. We conducted this systematic review and meta-analysis to assess the incidence of and complications from IBD in ... ...

    Abstract Background: The incidence of inflammatory bowel diseases (IBD) and its significance in kidney transplant recipients is not well established. We conducted this systematic review and meta-analysis to assess the incidence of and complications from IBD in adult kidney transplant recipients.
    Methods: Eligible articles were searched through Ovid MEDLINE, EMBASE, and the Cochrane Library from inception through April 2020. The inclusion criteria were adult kidney transplant patients with reported IBD. Effect estimates from the individual studies were extracted and combined using the fixed-effects model when I
    Results: of 641 citations, a total of seven studies (
    Conclusion: Recurrent and de novo IBD is common among kidney transplant recipients and may result in adverse outcomes.
    Language English
    Publishing date 2020-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2754473-4
    ISSN 2076-3271 ; 2076-3271
    ISSN (online) 2076-3271
    ISSN 2076-3271
    DOI 10.3390/medsci8030039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hospitalizations for Acute Salicylate Intoxication in the United States.

    Thongprayoon, Charat / Petnak, Tananchai / Kaewput, Wisit / Mao, Michael A / Kovvuru, Karthik / Kanduri, Swetha R / Boonpheng, Boonphiphop / Bathini, Tarun / Vallabhajosyula, Saraschandra / Pivovarova, Aleksandra I / Brar, Himmat S / Medaura, Juan / Cheungpasitporn, Wisit

    Journal of clinical medicine

    2020  Volume 9, Issue 8

    Abstract: Background: The objective of this study was to describe inpatient prevalence, characteristics, outcomes, and resource use for acute salicylate intoxication hospitalizations in the United States.: Methods: A total of 13,805 admissions with a primary ... ...

    Abstract Background: The objective of this study was to describe inpatient prevalence, characteristics, outcomes, and resource use for acute salicylate intoxication hospitalizations in the United States.
    Methods: A total of 13,805 admissions with a primary diagnosis of salicylate intoxication from 2003 to 2014 in the National Inpatient Sample database were analyzed. Prognostic factors for in-hospital mortality were determined using multivariable logistic regression.
    Results: The overall inpatient prevalence of salicylate intoxication among hospitalized patients was 147.8 cases per 1,000,000 admissions in the United States. The average age was 34 ± 19 years. Of these, 35.0% were male and 65.4% used salicylate for suicidal attempts. Overall, 6% required renal replacement therapy. The most common complications of salicylate intoxication were electrolyte and acid-base disorders, including hypokalemia (25.4%), acidosis (19.1%), and alkalosis (11.1%). Kidney failure (9.3%) was the most common observed organ dysfunction. In-hospital mortality was 1.0%. Increased in-hospital mortality was associated with age ≥30, Asian/Pacific Islander race, diabetes mellitus, hyponatremia, ventricular arrhythmia, kidney failure, respiratory failure, and neurological failure, while decreased in-hospital mortality was associated with African American and Hispanic race.
    Conclusion: hospitalization for salicylate intoxication occurred in 148 per 1,000,000 admissions in the United States. Several factors were associated with in-hospital mortality.
    Language English
    Publishing date 2020-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9082638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hospitalizations for Acute Salicylate Intoxication in the United States

    Charat Thongprayoon / Tananchai Petnak / Wisit Kaewput / Michael A. Mao / Karthik Kovvuru / Swetha R. Kanduri / Boonphiphop Boonpheng / Tarun Bathini / Saraschandra Vallabhajosyula / Aleksandra I. Pivovarova / Himmat S. Brar / Juan Medaura / Wisit Cheungpasitporn

    Journal of Clinical Medicine, Vol 9, Iss 2638, p

    2020  Volume 2638

    Abstract: Background: The objective of this study was to describe inpatient prevalence, characteristics, outcomes, and resource use for acute salicylate intoxication hospitalizations in the United States. Methods: A total of 13,805 admissions with a primary ... ...

    Abstract Background: The objective of this study was to describe inpatient prevalence, characteristics, outcomes, and resource use for acute salicylate intoxication hospitalizations in the United States. Methods: A total of 13,805 admissions with a primary diagnosis of salicylate intoxication from 2003 to 2014 in the National Inpatient Sample database were analyzed. Prognostic factors for in-hospital mortality were determined using multivariable logistic regression. Results: The overall inpatient prevalence of salicylate intoxication among hospitalized patients was 147.8 cases per 1,000,000 admissions in the United States. The average age was 34 ± 19 years. Of these, 35.0% were male and 65.4% used salicylate for suicidal attempts. Overall, 6% required renal replacement therapy. The most common complications of salicylate intoxication were electrolyte and acid-base disorders, including hypokalemia (25.4%), acidosis (19.1%), and alkalosis (11.1%). Kidney failure (9.3%) was the most common observed organ dysfunction. In-hospital mortality was 1.0%. Increased in-hospital mortality was associated with age ≥30, Asian/Pacific Islander race, diabetes mellitus, hyponatremia, ventricular arrhythmia, kidney failure, respiratory failure, and neurological failure, while decreased in-hospital mortality was associated with African American and Hispanic race. Conclusion: hospitalization for salicylate intoxication occurred in 148 per 1,000,000 admissions in the United States. Several factors were associated with in-hospital mortality.
    Keywords salicylate ; salicylate intoxication ; epidemiology ; hospitalization ; outcomes ; Medicine ; R
    Subject code 310
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Incidence and Impacts of Inflammatory Bowel Diseases among Kidney Transplant Recipients

    Panupong Hansrivijit / Max M. Puthenpura / Charat Thongprayoon / Himmat S. Brar / Tarun Bathini / Karthik Kovvuru / Swetha R. Kanduri / Karn Wijarnpreecha / Wisit Cheungpasitporn

    Medical Sciences, Vol 8, Iss 39, p

    A Meta-Analysis

    2020  Volume 39

    Abstract: Background: The incidence of inflammatory bowel diseases (IBD) and its significance in kidney transplant recipients is not well established. We conducted this systematic review and meta-analysis to assess the incidence of and complications from IBD in ... ...

    Abstract Background: The incidence of inflammatory bowel diseases (IBD) and its significance in kidney transplant recipients is not well established. We conducted this systematic review and meta-analysis to assess the incidence of and complications from IBD in adult kidney transplant recipients. Methods: Eligible articles were searched through Ovid MEDLINE, EMBASE, and the Cochrane Library from inception through April 2020. The inclusion criteria were adult kidney transplant patients with reported IBD. Effect estimates from the individual studies were extracted and combined using the fixed-effects model when I 2 ≤ 50% and random-effects model when I 2 > 50%. Results: of 641 citations, a total of seven studies ( n = 212) were included in the systematic review. The mean age was 46.2 +/− 6.9 years and up to 51.1% were male. The mean duration of follow-up was 57.8 +/− 16.8 months. The pooled incidence of recurrent IBD was 27.6% (95% CI, 17.7–40.5%; I 2 0%) while the pooled incidence of de novo IBD was 18.8% (95% CI, 10.7–31.0%; I 2 61.3%). The pooled incidence of post-transplant IBD was similar across subgroup analyses. Meta-regression analyses showed no association between the incidence of IBD and age, male sex, and follow-up duration. For post-transplant complications, the pooled incidence of post-transplant infection was 4.7% (95% CI, 0.5–33.3%; I 2 73.7%). The pooled incidence of graft rejection and re-transplantation in IBD patients was 31.4% (95% CI, 14.1–56.1%; I 2 76.9%) and 30.4% (95% CI, 22.6–39.5%; I 2 0%). Conclusion: Recurrent and de novo IBD is common among kidney transplant recipients and may result in adverse outcomes.
    Keywords inflammatory bowel diseases ; kidney transplantation ; meta-analysis ; systematic reviews ; Medicine ; R
    Subject code 333
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Black Inflammatory Bowel Disease Patients Have Lower Response to Antitumor Necrosis Factor Agents Compared With White Patients.

    Burstiner, Landen Shane / Owings, Anna H / Royer, Amor / Hreish, Yousef / Johnson, Jeshanah / Barr, Madelyn / Laird, Hannah / Tarugu, Spurthi / Edwards, Kane / Bradley, Lauren / Brar, Himmat / Robinson, Tanya O / Hosseini-Carroll, Pegah / Liu, Julia / Glover, Sarah C

    Inflammatory bowel diseases

    2023  Volume 29, Issue 12, Page(s) 1847–1853

    Abstract: Background: Most studies on the safety and efficacy of antitumor necrosis factor alpha (anti-TNF) agents in the treatment of inflammatory bowel disease have included few Black patients.: Aims: We aimed to evaluate the therapeutic response rate in ... ...

    Abstract Background: Most studies on the safety and efficacy of antitumor necrosis factor alpha (anti-TNF) agents in the treatment of inflammatory bowel disease have included few Black patients.
    Aims: We aimed to evaluate the therapeutic response rate in Black IBD patients compared with White patients.
    Methods: We conducted a retrospective review of IBD patients who were treated with anti-TNF agents and assessed those with therapeutic drug levels for clinical, endoscopic, and radiologic response to anti-TNF treatment.
    Results: We identified 118 patients who met the inclusion criteria. Black IBD patients had significantly higher prevalence of endoscopic and radiologic active disease compared with White patients (62% and 34%, respectively; P = .023), despite similar proportions reaching therapeutic titers (67% and 55%, respectively; P = .20). Moreover, Black patients had significantly higher rate of IBD-related hospitalizations than White patients (30% vs 13%, respectively; P = .025) while on anti-TNF agents.
    Conclusions: Black IBD patients on anti-TNF agents had a significantly higher prevalence of active disease and more IBD-related hospitalizations than White patients.
    MeSH term(s) Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/epidemiology ; Retrospective Studies ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Black or African American ; White
    Chemical Substances Tumor Necrosis Factor Inhibitors
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izad005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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