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  1. Article ; Online: The 2024 ASM Awards and Prize Program-recognizing excellence in the microbiological sciences.

    Nachamkin, Irving / Babady, N Esther

    Journal of clinical microbiology

    2024  Volume 62, Issue 3, Page(s) e0001224

    Abstract: The ASM Awards and Prize Program recognizes outstanding achievements in basic and applied research, clinical microbiology, education, leadership, and service. This editorial briefly describes how the program works and highlights several awards of ... ...

    Abstract The ASM Awards and Prize Program recognizes outstanding achievements in basic and applied research, clinical microbiology, education, leadership, and service. This editorial briefly describes how the program works and highlights several awards of interest to the clinical microbiology community.
    MeSH term(s) Humans ; Awards and Prizes ; Leadership
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00012-24
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    Zs.A 1188: Show issues Location:
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  2. Article: Reduction in Sporadic Norovirus Infections Following the Start of the COVID-19 Pandemic, 2019-2020, Philadelphia.

    Nachamkin, Irving / Richard-Greenblatt, Melissa / Yu, Mei / Bui, Hong

    Infectious diseases and therapy

    2021  Volume 10, Issue 3, Page(s) 1793–1798

    Abstract: Introduction: Norovirus infections are common in the USA and worldwide. Detection of norovirus in fecal samples is now common in routine tests for enteric pathogens using molecular methods. We observed a change in positivity rates for norovirus after ... ...

    Abstract Introduction: Norovirus infections are common in the USA and worldwide. Detection of norovirus in fecal samples is now common in routine tests for enteric pathogens using molecular methods. We observed a change in positivity rates for norovirus after the beginning of the coronavirus disease 2019 (COVID-19) pandemic in our laboratory and performed a more detailed analysis of testing results.
    Methods: We reviewed the positivity rates for detection of common enteric pathogens from stool samples submitted to an academic medical center laboratory pre (2016-2019) and post the start of the COVID-19 pandemic (2020).
    Results: In contrast to other enteric pathogens, norovirus positivity rates dropped dramatically from a yearly average of 3.9% in 2016-2019 to 0.76% from March 2020 through the end of 2020.
    Conclusion: A sustained reduction in norovirus positivity rates was temporally associated with COVID-19 mitigation processes in the Philadelphia area, while positivity rates for other common enteric pathogens were only intermittently reduced.
    Language English
    Publishing date 2021-06-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-021-00473-z
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  3. Article ; Online: A Novel Needle-Free Blood Draw Device for Sample Collection From Short Peripheral Catheters.

    Cadacio, Caprice / Nachamkin, Irving

    Journal of infusion nursing : the official publication of the Infusion Nurses Society

    2017  Volume 40, Issue 3, Page(s) 156–162

    Abstract: A new US Food and Drug Administration-cleared needleless blood collection device (PIVO; Velano Vascular, San Francisco, CA) for short peripheral catheters was compared with conventional venipuncture for collecting blood samples for routine laboratory ... ...

    Abstract A new US Food and Drug Administration-cleared needleless blood collection device (PIVO; Velano Vascular, San Francisco, CA) for short peripheral catheters was compared with conventional venipuncture for collecting blood samples for routine laboratory analysis from adult healthy volunteers. The PIVO device was comparable with venipuncture in terms of providing high-integrity samples (no hemolysis or clotting), equivalent laboratory values, and better patient experience as assessed by pain scores. Further studies to assess the overall utility of the PIVO device are warranted.
    MeSH term(s) Adult ; Blood Specimen Collection/methods ; Catheterization, Peripheral ; Clinical Laboratory Services/utilization ; Female ; Healthy Volunteers ; Humans ; Male ; Needles ; Pain Measurement ; Phlebotomy ; Prospective Studies
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2083942-X
    ISSN 1539-0667 ; 1533-1458
    ISSN (online) 1539-0667
    ISSN 1533-1458
    DOI 10.1097/NAN.0000000000000222
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  4. Article ; Online: Isolation of Campylobacter Species from Stool Samples by Use of a Filtration Method: Assessment from a United States-Based Population.

    Nachamkin, Irving / Nguyen, Phi

    Journal of clinical microbiology

    2017  Volume 55, Issue 7, Page(s) 2204–2207

    Abstract: Fecal samples submitted to our clinical microbiology laboratory from patients in the Philadelphia region were prospectively analyzed ... ...

    Abstract Fecal samples submitted to our clinical microbiology laboratory from patients in the Philadelphia region were prospectively analyzed for
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00332-17
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    Zs.A 1188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Prevalence of ciprofloxacin resistance and associated genetic determinants differed among Campylobacter isolated from human and poultry meat sources in Pennsylvania.

    Yan, Runan / M'ikanatha, Nkuchia M / Nachamkin, Irving / Hudson, Lauren K / Denes, Thomas G / Kovac, Jasna

    Food microbiology

    2023  Volume 116, Page(s) 104349

    Abstract: Poultry is the primary source of Campylobacter infections and severe campylobacteriosis cases are treated with macrolides and fluoroquinolones. However, these drugs are less effective against antimicrobial-resistant strains. Here, we investigated the ... ...

    Abstract Poultry is the primary source of Campylobacter infections and severe campylobacteriosis cases are treated with macrolides and fluoroquinolones. However, these drugs are less effective against antimicrobial-resistant strains. Here, we investigated the prevalence of phenotypic antimicrobial resistance and associated resistance genetic determinants in Campylobacter isolates collected from human clinical (N = 123) and meat (N = 80) sources in Pennsylvania in 2017 and 2018. Our goal was to assess potential differences in the prevalence of antimicrobial resistance in Campylobacter isolated from human and poultry meat sources in Pennsylvania and to assess the accuracy of predicting antimicrobial resistance phenotypes based on resistance genotypes. We whole genome sequenced isolates and identified genetic resistance determinants using the National Antimicrobial Resistance Monitoring System Campylobacter AMR workflow v2.0 in GalaxyTrakr. Phenotypic antimicrobial susceptibility testing was carried out using the E-Test and Sensititre CAMPYCMV methods for human clinical and poultry meat isolates, respectively, and the results were interpreted using the EUCAST epidemiological cutoff values. The 193 isolates were represented by 85 MLST sequence types and 23 clonal complexes, suggesting high genetic diversity. Resistance to erythromycin was confirmed in 6% human and 4% meat isolates. Prevalence of ciprofloxacin resistance was significantly higher in human isolates as compared to meat isolates. A good concordance was observed between phenotypic resistance and the presence of the corresponding known resistance genetic determinants.
    MeSH term(s) Humans ; Animals ; Ciprofloxacin/pharmacology ; Campylobacter/genetics ; Pennsylvania/epidemiology ; Prevalence ; Multilocus Sequence Typing ; Poultry ; Campylobacter Infections/epidemiology ; Campylobacter Infections/veterinary ; Anti-Bacterial Agents/pharmacology ; Meat
    Chemical Substances Ciprofloxacin (5E8K9I0O4U) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 50892-5
    ISSN 1095-9998 ; 0740-0020
    ISSN (online) 1095-9998
    ISSN 0740-0020
    DOI 10.1016/j.fm.2023.104349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4667: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Gastrointestinal Infections.

    Alby, Kevin / Nachamkin, Irving

    Microbiology spectrum

    2016  Volume 4, Issue 3

    Abstract: Gastrointestinal infections in the immunocompromised host are caused by the common bacterial, viral, fungal, and parasitic agents that also cause infections in the immunocompetent host. Of special consideration is that immunocompromised patients may be ... ...

    Abstract Gastrointestinal infections in the immunocompromised host are caused by the common bacterial, viral, fungal, and parasitic agents that also cause infections in the immunocompetent host. Of special consideration is that immunocompromised patients may be at increased risk for infection or disease severity and by pathogens not seen in the competent host. This chapter reviews the various agents, risk factors, and diagnostic approaches to detect gastrointestinal infections in this patient population.
    MeSH term(s) Bacterial Infections/diagnosis ; Bacterial Infections/epidemiology ; Gastrointestinal Diseases/epidemiology ; Humans ; Immunocompromised Host ; Mycoses/diagnosis ; Mycoses/epidemiology ; Opportunistic Infections/diagnosis ; Opportunistic Infections/epidemiology ; Parasitic Diseases/diagnosis ; Parasitic Diseases/epidemiology ; Virus Diseases/diagnosis ; Virus Diseases/epidemiology
    Language English
    Publishing date 2016-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2165-0497
    ISSN (online) 2165-0497
    DOI 10.1128/microbiolspec.DMIH2-0005-2015
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  7. Article ; Online: Resistance patterns of refractory

    Kumar, Shria / Sangitha, Ravindra / Nachamkin, Irving / Metz, David C

    GastroHep

    2019  Volume 2, Issue 1, Page(s) 6–12

    Abstract: Introduction: H. pylori: Methods: A retrospective study of patients referred to the Hospital of the University of Pennsylvania, between 2009-2019 who underwent endoscopy for culture. Chart review identified demographics, history, endoscopic and ... ...

    Abstract Introduction: H. pylori
    Methods: A retrospective study of patients referred to the Hospital of the University of Pennsylvania, between 2009-2019 who underwent endoscopy for culture. Chart review identified demographics, history, endoscopic and culture results, treatment, and follow up.
    Results: Of 109 patients referred for refractory HP, 90 had identified HP. Median age was 53.2 years and the majority was female (74%), with median 2 previous antibiotic courses for HP. Gastric erythema was the most common endoscopic abnormality. 65 (72.2%) were culture positive, and 45 (69.2%) were resistant to levofloxacin, 27 (41.5%) to metronidazole, and 39 (43.3%) to clarithromycin.Being resistant to any one of the 3 antibiotics was associated with resistance to either of the other two. There was an association with number of previous antibiotics with resistance (OR 1.74, p<0.05).We prescribed therapy to 77 patients based on susceptibility profiles, and 34 (37.8%) were cured, 14 (15.6%) underwent endoscopic surveillance, 3 (3.3%) were followed by infectious disease, and 39 (43.3%) were lost to follow up.
    Conclusions: Antibiotic resistance is associated with refractory HP, and continues to rise. Culturing is associated with cure, and its use in clinical practice regarding efficacy, cost-effectiveness, and ability to minimize antibiotic resistance should be further studied. Overall follow-up is limited by loss to follow up, emphasizing the need for appropriate treatment.
    Language English
    Publishing date 2019-12-23
    Publishing country United States
    Document type Journal Article
    ISSN 1478-1239
    ISSN (online) 1478-1239
    DOI 10.1002/ygh2.382
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  8. Article: Reducing Blood Culture Contamination Rates: Experiences of Four Hospital Systems.

    Halstead, Diane C / Sautter, Robert L / Snyder, James W / Crist, Arthur E / Nachamkin, Irving

    Infectious diseases and therapy

    2020  Volume 9, Issue 2, Page(s) 389–401

    Abstract: Introduction: Blood cultures (BCs) frequently become contaminated during the pre-analytic phase of collection leading to downstream ramifications. We present a summary of performance improvement (PI) interventions provided by four hospital systems and ... ...

    Abstract Introduction: Blood cultures (BCs) frequently become contaminated during the pre-analytic phase of collection leading to downstream ramifications. We present a summary of performance improvement (PI) interventions provided by four hospital systems and common factors that contributed to decreased blood culture contamination (BCC) rates.
    Methods: Each hospital independently formed a multidisciplinary team and action plan for implementation of their intervention, focusing on the use of educational and training tools. Their goal was to significantly decrease their BCC rates. Pre- and post-intervention data were compared during the sustainment period to determine their success.
    Results: All hospitals met their goals of post-intervention BCC rates and with most achieving and sustaining BCC rates ≤ 1.0-2.0%.
    Conclusion: Our report highlights how four hospitals independently achieved their objective to decrease their BCC rate with the support of a multidisciplinary team. We propose a benchmark for BCC rates of 1.5 to < 2.0% as achievable and sustainable.
    Language English
    Publishing date 2020-04-30
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-020-00299-1
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  9. Article ; Online: Clinical Evaluation of a New Molecular Test for the Detection of Organisms Causing Vaginitis and Vaginosis.

    Lillis, Rebecca A / Parker, R Lamar / Ackerman, Ronald / Ackerman, Jamie / Young, Stephen / Weissfeld, Alice / Trevino, Ernest / Nachamkin, Irving / Crane, LaShonda / Brown, Jacqueline / Huang, Christina / Liu, Xiaohong / Van Der Pol, Barbara

    Journal of clinical microbiology

    2023  Volume 61, Issue 3, Page(s) e0174822

    Abstract: In this prospective, observational, method comparison clinical study, the Xpert Xpress MVP test (MVP) was evaluated using both clinician-collected (CVS) and self-collected vaginal swabs (SVS) collected in a clinical setting. The study was conducted at 12 ...

    Abstract In this prospective, observational, method comparison clinical study, the Xpert Xpress MVP test (MVP) was evaluated using both clinician-collected (CVS) and self-collected vaginal swabs (SVS) collected in a clinical setting. The study was conducted at 12 sites, including point-of-care (POC) settings, from geographically diverse locations in the United States. Participants were biologically female patients ≥ 14 years old with signs and/or symptoms of vaginitis/vaginosis. MVP test results for BV were compared to the BD MAX Vaginal Panel (BDVP). Results for Candida group and Candida glabrata and Candida krusei targets (species not differentiated) were assessed relative to yeast culture followed by mass spectrometry for species identification. Trichomonas vaginalis (TV) results were compared relative to a composite method that included results from the BDVP and InPouch TV culture. The investigational test demonstrated high positive percent agreement ranging from 93.6 to 99.0%, and negative percent agreement ranging from 92.1% to 99.8% for both CVS and SVS specimens, indicating it may be a valuable tool for the diagnosis of vaginitis/vaginosis in laboratory and POC settings.
    MeSH term(s) Humans ; Female ; Adolescent ; Trichomonas Vaginitis/diagnosis ; Candidiasis, Vulvovaginal/diagnosis ; Vaginosis, Bacterial/diagnosis ; Prospective Studies ; Vagina ; Trichomonas vaginalis/genetics
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.01748-22
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    Zs.A 1188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article: Rabbit model of Guillain-Barré syndrome.

    Nachamkin, Irving

    Annals of neurology

    2002  Volume 52, Issue 1, Page(s) 127–8; author reply 128–9

    MeSH term(s) Animals ; Cattle ; Disease Models, Animal ; Freund's Adjuvant/administration & dosage ; Gangliosides/administration & dosage ; Guillain-Barre Syndrome/chemically induced ; Rabbits
    Chemical Substances Gangliosides ; Freund's Adjuvant (9007-81-2)
    Language English
    Publishing date 2002-07
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.10223
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    Zs.MO 478: Show issues

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