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Article: Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease.

Piscaer, Ianthe / van den Ouweland, Jody M W / Vermeersch, Kristina / Reynaert, Niki L / Franssen, Frits M E / Keene, Spencer / Wouters, Emiel F M / Janssens, Wim / Vermeer, Cees / Janssen, Rob

Journal of clinical medicine

2019 Volume 8, Issue 8

Abstract: ... regulated by Matrix Gla Protein (MGP), via a vitamin K-dependent pathway. The aim was to assess vitamin K ... status in COPD as well as associations between vitamin K status, elastin degradation, lung function ... Vitamin K status was assessed by measuring plasma inactive MGP levels and rates of elastin degradation ...

Abstract	Elastin degradation is accelerated in chronic obstructive pulmonary disease (COPD) and is partially regulated by Matrix Gla Protein (MGP), via a vitamin K-dependent pathway. The aim was to assess vitamin K status in COPD as well as associations between vitamin K status, elastin degradation, lung function parameters and mortality. A total of 192 COPD patients and 186 age-matched controls were included. In addition to this, 290 COPD patients from a second independent longitudinal cohort were also included. Vitamin K status was assessed by measuring plasma inactive MGP levels and rates of elastin degradation by measuring plasma desmosine levels. Reduced vitamin K status was found in COPD patients compared to smoking controls (
Language	English
Publishing date	2019-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8081116
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: High foliar K and P resorption efficiencies in old-growth tropical forests growing on nutrient-poor soils.

Urbina, Ifigenia / Grau, Oriol / Sardans, Jordi / Margalef, Olga / Peguero, Guillermo / Asensio, Dolores / LLusià, Joan / Ogaya, Romà / Gargallo-Garriga, Albert / Van Langenhove, Leandro / Verryckt, Lore T / Courtois, Elodie A / Stahl, Clément / Soong, Jennifer L / Chave, Jerome / Hérault, Bruno / Janssens, Ivan A / Sayer, Emma / Peñuelas, Josep

Ecology and evolution

2021 Volume 11, Issue 13, Page(s) 8969–8982

Abstract: ... mean resorption efficiencies were higher for P (35.9%) and potassium (K; 44.6%) than for nitrogen (N ... 10.3%). K resorption was higher in the wet (70.2%) than in the dry (41.7%) season. P resorption ...

Abstract	Resorption is the active withdrawal of nutrients before leaf abscission. This mechanism represents an important strategy to maintain efficient nutrient cycling; however, resorption is poorly characterized in old-growth tropical forests growing in nutrient-poor soils. We investigated nutrient resorption from leaves in 39 tree species in two tropical forests on the Guiana Shield, French Guiana, to investigate whether resorption efficiencies varied with soil nutrient, seasonality, and species traits. The stocks of P in leaves, litter, and soil were low at both sites, indicating potential P limitation of the forests. Accordingly, mean resorption efficiencies were higher for P (35.9%) and potassium (K; 44.6%) than for nitrogen (N; 10.3%). K resorption was higher in the wet (70.2%) than in the dry (41.7%) season. P resorption increased slightly with decreasing total soil P; and N and P resorptions were positively related to their foliar concentrations. We conclude that nutrient resorption is a key plant nutrition strategy in these old-growth tropical forests, that trees with high foliar nutrient concentration reabsorb more nutrient, and that nutrients resorption in leaves, except P, are quite decoupled from nutrients in the soil. Seasonality and biochemical limitation played a role in the resorption of nutrients in leaves, but species-specific requirements obscured general tendencies at stand and ecosystem level.
Language	English
Publishing date	2021-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.7734
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Article ; Online: Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Coronavirus disease 2019.

Janssen, Rob / Visser, Margot P J / Dofferhoff, Anton S M / Vermeer, Cees / Janssens, Wim / Walk, Jona

The British journal of nutrition

2020 Volume 126, Issue 2, Page(s) 191–198

Abstract: ... to poor outcomes. Vitamin K plays a crucial role in the activation of both pro- and anticlotting factors ... thrombosis prevention. However, the role of vitamin K extends beyond coagulation. Matrix Gla protein (MGP) is ... a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre degradation. Severe ...

Abstract	Coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, exerts far-reaching effects on public health and socio-economic welfare. The majority of infected individuals have mild to moderate symptoms, but a significant proportion develops respiratory failure due to pneumonia. Thrombosis is another frequent manifestation of Covid-19 that contributes to poor outcomes. Vitamin K plays a crucial role in the activation of both pro- and anticlotting factors in the liver and the activation of extrahepatically synthesised protein S which seems to be important in local thrombosis prevention. However, the role of vitamin K extends beyond coagulation. Matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre degradation. Severe extrahepatic vitamin K insufficiency was recently demonstrated in Covid-19 patients, with high inactive MGP levels correlating with elastic fibre degradation rates. This suggests that insufficient vitamin K-dependent MGP activation leaves elastic fibres unprotected against SARS-CoV-2-induced proteolysis. In contrast to MGP, Covid-19 patients have normal levels of activated factor II, in line with previous observations that vitamin K is preferentially transported to the liver for activation of procoagulant factors. We therefore expect that vitamin K-dependent endothelial protein S activation is also compromised, which would be compatible with enhanced thrombogenicity. Taking these data together, we propose a mechanism of pneumonia-induced vitamin K depletion, leading to a decrease in activated MGP and protein S, aggravating pulmonary damage and coagulopathy, respectively. Intervention trials should be conducted to assess whether vitamin K administration plays a role in the prevention and treatment of severe Covid-19.
MeSH term(s)	COVID-19/complications ; COVID-19/pathology ; Calcium-Binding Proteins/metabolism ; Extracellular Matrix Proteins/metabolism ; Humans ; Lung/physiopathology ; Protein S/metabolism ; SARS-CoV-2 ; Thromboembolism/etiology ; Thromboembolism/prevention & control ; Thrombosis/etiology ; Thrombosis/prevention & control ; Vitamin K/antagonists & inhibitors ; Vitamin K/metabolism ; Vitamin K Deficiency/etiology ; Vitamin K Deficiency/metabolism ; Matrix Gla Protein
Chemical Substances	Calcium-Binding Proteins ; Extracellular Matrix Proteins ; Protein S ; Vitamin K (12001-79-5)
Keywords	covid19
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114520003979
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Article: Breakdown of K selection in 178Hf.

Hayes, A B / Cline, D / Wu, C Y / Ai, J / Amro, H / Beausang, C / Casten, R F / Gerl, J / Hecht, A A / Heinz, A / Hughes, R / Janssens, R V F / Lister, C J / Macchiavelli, A O / Meyer, D A / Moore, E F / Napiorkowski, P / Pardo, R C / Schlegel, Ch /

Seweryniak, D / Simon, M W / Srebrny, J / Teng, R / Vetter, K / Wollersheim, H J

Physical review letters

2006 Volume 96, Issue 4, Page(s) 42505

Abstract: ... revealed the onset and saturation of K mixing in low-K bands, whereas the mixing is negligible in the high ... K bands. The implications can be applied to other quadrupole-deformed nuclei. ...

Abstract	Coulomb activation of the four quasiparticle Kpi=16+ 178Hf isomer (t1/2=31 y) has led to the measurement of a set of Elamda matrix elements coupling the isomer band to the ground band. The present data combined with earlier 178 Hf Coulomb excitation data have probed the components in the wave functions and revealed the onset and saturation of K mixing in low-K bands, whereas the mixing is negligible in the high-K bands. The implications can be applied to other quadrupole-deformed nuclei.
Language	English
Publishing date	2006-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.96.042505
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Article ; Online: Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases?

Piscaer, Ianthe / Wouters, Emiel F M / Vermeer, Cees / Janssens, Wim / Franssen, Frits M E / Janssen, Rob

Respiratory research

2017 Volume 18, Issue 1, Page(s) 189

Abstract: ... by direct oral anticoagulants, vitamin K antagonists (VKAs) are still widely used. VKAs induce profound ... deficiency of vitamin K, a key activator in the coagulation pathway. It is recognized however that vitamin K is also ... cardiovascular disease. Vitamin K consumption, on the other hand, seems to have a protective effect on the mineralization ...

Abstract	Cardiovascular diseases are prevalent in patients with chronic obstructive pulmonary disease (COPD). Their coexistence implies that many COPD patients require anticoagulation therapy. Although more and more replaced by direct oral anticoagulants, vitamin K antagonists (VKAs) are still widely used. VKAs induce profound deficiency of vitamin K, a key activator in the coagulation pathway. It is recognized however that vitamin K is also an essential cofactor in the activation of other extrahepatic proteins, such as matrix Gla protein (MGP), a potent inhibitor of arterial calcification. No or insufficient MGP activation by the use of VKAs is associated with a rapid progression of vascular calcification, which may enhance the risk for overt cardiovascular disease. Vitamin K consumption, on the other hand, seems to have a protective effect on the mineralization of arteries. Furthermore, vascular calcification mutually relates to elastin degradation, which is accelerated in patients with COPD associating with impaired survival. In this commentary, we hypothesize that vitamin K is a critical determinant to the rate of elastin degradation. We speculate on the potential link between poor vitamin K status and crucial mechanisms of COPD pathogenesis and raise concerns about the use of VKAs in patients with this disease. Future intervention studies are needed to explore if vitamin K supplementation is able to reduce elastin degradation and vascular calcification in COPD patients.
MeSH term(s)	Animals ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/epidemiology ; Dietary Supplements ; Humans ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Vascular Calcification/blood ; Vascular Calcification/drug therapy ; Vascular Calcification/epidemiology ; Vitamin K/administration & dosage ; Vitamin K/antagonists & inhibitors ; Vitamin K/blood ; Vitamin K Deficiency/blood ; Vitamin K Deficiency/drug therapy ; Vitamin K Deficiency/epidemiology
Chemical Substances	Vitamin K (12001-79-5)
Language	English
Publishing date	2017--13
Publishing country	England
Document type	Letter ; Review
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-9921
ISSN (online)	1465-993X
ISSN	1465-9921
DOI	10.1186/s12931-017-0673-z
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Article: Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Coronavirus disease 2019

Janssen, Rob / Visser, Margot P. J / Dofferhoff, Anton S. M / Vermeer, Cees / Janssens, Wim / Walk, Jona

British journal of nutrition. 2021 July 28, v. 126, no. 2

2021

Abstract	Coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, exerts far-reaching effects on public health and socio-economic welfare. The majority of infected individuals have mild to moderate symptoms, but a significant proportion develops respiratory failure due to pneumonia. Thrombosis is another frequent manifestation of Covid-19 that contributes to poor outcomes. Vitamin K plays a crucial role in the activation of both pro- and anticlotting factors in the liver and the activation of extrahepatically synthesised protein S which seems to be important in local thrombosis prevention. However, the role of vitamin K extends beyond coagulation. Matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre degradation. Severe extrahepatic vitamin K insufficiency was recently demonstrated in Covid-19 patients, with high inactive MGP levels correlating with elastic fibre degradation rates. This suggests that insufficient vitamin K-dependent MGP activation leaves elastic fibres unprotected against SARS-CoV-2-induced proteolysis. In contrast to MGP, Covid-19 patients have normal levels of activated factor II, in line with previous observations that vitamin K is preferentially transported to the liver for activation of procoagulant factors. We therefore expect that vitamin K-dependent endothelial protein S activation is also compromised, which would be compatible with enhanced thrombogenicity. Taking these data together, we propose a mechanism of pneumonia-induced vitamin K depletion, leading to a decrease in activated MGP and protein S, aggravating pulmonary damage and coagulopathy, respectively. Intervention trials should be conducted to assess whether vitamin K administration plays a role in the prevention and treatment of severe Covid-19.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus ; calcification ; coagulation ; liver ; lungs ; metabolism ; pneumonia ; proteolysis ; public health ; socioeconomics ; thrombosis ; tissues ; vitamin K
Language	English
Dates of publication	2021-0728
Size	p. 191-198.
Publishing place	Cambridge University Press
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114520003979
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: High foliar K and P resorption efficiencies in old‐growth tropical forests growing on nutrient‐poor soils

Ifigenia Urbina / Oriol Grau / Jordi Sardans / Olga Margalef / Guillermo Peguero / Dolores Asensio / Joan LLusià / Romà Ogaya / Albert Gargallo‐Garriga / Leandro Van Langenhove / Lore T. Verryckt / Elodie A. Courtois / Clément Stahl / Jennifer L. Soong / Jerome Chave / Bruno Hérault / Ivan A. Janssens / Emma Sayer / Josep Peñuelas

Ecology and Evolution, Vol 11, Iss 13, Pp 8969-

2021 Volume 8982

Abstract	Abstract Resorption is the active withdrawal of nutrients before leaf abscission. This mechanism represents an important strategy to maintain efficient nutrient cycling; however, resorption is poorly characterized in old‐growth tropical forests growing in nutrient‐poor soils. We investigated nutrient resorption from leaves in 39 tree species in two tropical forests on the Guiana Shield, French Guiana, to investigate whether resorption efficiencies varied with soil nutrient, seasonality, and species traits. The stocks of P in leaves, litter, and soil were low at both sites, indicating potential P limitation of the forests. Accordingly, mean resorption efficiencies were higher for P (35.9%) and potassium (K; 44.6%) than for nitrogen (N; 10.3%). K resorption was higher in the wet (70.2%) than in the dry (41.7%) season. P resorption increased slightly with decreasing total soil P; and N and P resorptions were positively related to their foliar concentrations. We conclude that nutrient resorption is a key plant nutrition strategy in these old‐growth tropical forests, that trees with high foliar nutrient concentration reabsorb more nutrient, and that nutrients resorption in leaves, except P, are quite decoupled from nutrients in the soil. Seasonality and biochemical limitation played a role in the resorption of nutrients in leaves, but species‐specific requirements obscured general tendencies at stand and ecosystem level.
Keywords	nitrogen ; nutrient ; phosphorus ; potassium ; resorption ; soil ; Ecology ; QH540-549.5
Subject code	580
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A K-ATP channel gene effect on sleep duration

Allebrandt, K. V. / Amin, N. / Müller-Myhsok, B. / Esko, T. / Teder-Laving, M. / Azevedo, R. V. D. M. / Hayward, C. / van Mill, J. / Vogelzangs, N. / Green, E. W. / Melville, S. A. / Lichtner, P. / Wichmann, H.-E. / Oostra, B. A. / Janssens, A. C. J. W. / Campbell, H. / Wilson, J. F. / Hicks, A. A. / Pramstaller, P. P. /

Dogas, Z. / Rudan, I. / Merrow, M. / Penninx, B. / Kyriacou, C. P. / Metspalu, A. / van Duijn, C. M. / Meitinger, T. / Roennenberg, T.

Molecular Psychiatry

From genome-wide association studies to function in Drosophila

2013 Volume 18, Issue 1, Page(s) 122–132

Abstract: Humans sleep approximately a third of their lifetime. The observation that individuals with either long or short sleep duration show associations with metabolic syndrome and psychiatric disorders suggests that the length of sleep is adaptive. Although ... ...

Abstract	Humans sleep approximately a third of their lifetime. The observation that individuals with either long or short sleep duration show associations with metabolic syndrome and psychiatric disorders suggests that the length of sleep is adaptive. Although sleep duration can be influenced by photoperiod (season) and phase of entrainment (chronotype), human familial sleep disorders indicate that there is a strong genetic modulation of sleep. Therefore, we conducted high-density genome-wide association studies for sleep duration in seven European populations (N=4251). We identified an intronic variant (rs11046205; P=3.99 x 10(-8)) in the ABCC9 gene that explains approximate to 5% of the variation in sleep duration. An influence of season and chronotype on sleep duration was solely observed in the replication sample (N=5949). Meta-analysis of the associations found in a subgroup of the replication sample, chosen for season of entry and chronotype, together with the discovery results! showed genome-wide significance. RNA interference knockdown experiments of the conserved ABCC9 homologue in Drosophila neurons renders flies sleepless during the first 3 h of the night. ABCC9 encodes an ATP-sensitive potassium channel subunit (SUR2), serving as a sensor of intracellular energy metabolism. Molecular Psychiatry (2013) 18, 122-132; doi:10.1038/mp.2011.142; published online 22 November 2011
Keywords	Biologische Rhythmen beim Menschen ; Gene ; Genes ; Genetics ; Genetik ; Human Biological Rhythms ; Jahreszeitliche Schwankungen ; Schlaf ; Seasonal Variations ; Sleep
Language	English
Document type	Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/mp.2011.142
Database	PSYNDEX

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Article: Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Covid-19

Janssen, R. / Visser, M. P. J. / Dofferhoff, A. S. M. / Vermeer, C. / Janssens, W. / Walk, J.

Br J Nutr

Abstract: ... manifestation of Covid-19 that contributes to poor outcomes Vitamin K plays a crucial role in activation ... S which seems to be important in local thrombosis prevention However, the role of vitamin K extends ... beyond coagulation Matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and ...

Abstract	Coronavirus disease 2019 (Covid-19), caused by SARS-CoV-2, exerts far-reaching effects on public health and socioeconomic welfare The majority of infected individuals have mild to moderate symptoms but a significant proportion develops respiratory failure due to pneumonia Thrombosis is another frequent manifestation of Covid-19 that contributes to poor outcomes Vitamin K plays a crucial role in activation of both pro- and anticlotting factors in the liver, and the activation of extrahepatically synthesised protein S which seems to be important in local thrombosis prevention However, the role of vitamin K extends beyond coagulation Matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre degradation Severe extrahepatic vitamin K insufficiency was recently demonstrated in Covid-19 patients, with high inactive MGP levels correlating with elastic fibre degradation rates This suggests that insufficient vitamin K-dependent MGP activation leaves elastic fibres unprotected against SARS-CoV-2 induced proteolysis In contrast to MGP, Covid-19 patients have normal levels of activated factor II, in line with previous observations that vitamin K is preferentially transported to the liver for activation of procoagulant factors We therefore expect that vitamin K-dependent endothelial protein S activation is also compromised, which would be compatible with enhanced thrombogenicity Taking these data together, we propose a mechanism of pneumonia-induced vitamin K depletion, leading to a decrease in activated MGP and protein S, aggravating pulmonary damage and coagulopathy, respectively Intervention trials should be conducted to assess whether vitamin K administration plays a role in prevention and treatment of severe Covid-19
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #834834
Database	COVID19

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Article ; Online: Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Coronavirus disease 2019

Janssen, Rob / Visser, Margot P. J. / Dofferhoff, Anton S. M. / Vermeer, Cees / Janssens, Wim / Walk, Jona

British Journal of Nutrition

2020 , Page(s) 1–8

Abstract: ... that contributes to poor outcomes. Vitamin K plays a crucial role in the activation of both pro- and anticlotting ... important in local thrombosis prevention. However, the role of vitamin K extends beyond coagulation. Matrix ... Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre ...

Abstract	Abstract Coronavirus disease 2019 (Covid-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, exerts far-reaching effects on public health and socio-economic welfare. The majority of infected individuals have mild to moderate symptoms, but a significant proportion develops respiratory failure due to pneumonia. Thrombosis is another frequent manifestation of Covid-19 that contributes to poor outcomes. Vitamin K plays a crucial role in the activation of both pro- and anticlotting factors in the liver and the activation of extrahepatically synthesised protein S which seems to be important in local thrombosis prevention. However, the role of vitamin K extends beyond coagulation. Matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre degradation. Severe extrahepatic vitamin K insufficiency was recently demonstrated in Covid-19 patients, with high inactive MGP levels correlating with elastic fibre degradation rates. This suggests that insufficient vitamin K-dependent MGP activation leaves elastic fibres unprotected against SARS-CoV-2-induced proteolysis. In contrast to MGP, Covid-19 patients have normal levels of activated factor II, in line with previous observations that vitamin K is preferentially transported to the liver for activation of procoagulant factors. We therefore expect that vitamin K-dependent endothelial protein S activation is also compromised, which would be compatible with enhanced thrombogenicity. Taking these data together, we propose a mechanism of pneumonia-induced vitamin K depletion, leading to a decrease in activated MGP and protein S, aggravating pulmonary damage and coagulopathy, respectively. Intervention trials should be conducted to assess whether vitamin K administration plays a role in the prevention and treatment of severe Covid-19.
Keywords	Nutrition and Dietetics ; Medicine (miscellaneous) ; covid19
Language	English
Publisher	Cambridge University Press (CUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/s0007114520003979
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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