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  1. Article ; Online: Editorial: Molecular mechanisms regulating phenotypic heterogeneity in human inflammatory diseases.

    Kapellos, Theodore S / Nawijn, Martijn C

    Frontiers in immunology

    2023  Volume 14, Page(s) 1214255

    MeSH term(s) Humans ; Granulocytes ; Myeloid Cells
    Language English
    Publishing date 2023-05-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1214255
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  2. Article ; Online: See no allergen, hear no allergen, speak no allergen!

    Gay, Aurore C A / Nawijn, Martijn C

    Science immunology

    2023  Volume 8, Issue 83, Page(s) eadh0597

    Abstract: Segmental allergen challenge in allergic patients with asthma reveals a previously unknown role for monocytes in the T helper 2 ( ... ...

    Abstract Segmental allergen challenge in allergic patients with asthma reveals a previously unknown role for monocytes in the T helper 2 (T
    MeSH term(s) Humans ; Allergens ; Asthma ; Hypersensitivity ; Monocytes ; Myeloid Cells
    Chemical Substances Allergens
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adh0597
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  3. Article ; Online: Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?

    Nawijn, Martijn C / Timens, Wim

    Molecular systems biology

    2020  Volume 16, Issue 7, Page(s) e9841

    Abstract: Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on ... ...

    Abstract Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. The angiotensin converting enzyme 2 (ACE2) has been suggested to be the key protein used by SARS-CoV-2 for host cell entry. In their recent work, Lindskog and colleagues (Hikmet et al, 2020) report that ACE2 is expressed at very low protein levels-if at all-in respiratory epithelial cells. Severe COVID-19, however, is characterized by acute respiratory distress syndrome and extensive damage to the alveoli in the lung parenchyma. Then, what is the role of the airway epithelium in the early stages of COVID-19, and which cells need to be studied to characterize the biological mechanisms responsible for the progression to severe disease after initial infection by the novel coronavirus?
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Conjunctiva/metabolism ; Coronavirus Infections/enzymology ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Host Microbial Interactions/genetics ; Humans ; Organ Specificity ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/virology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/enzymology ; Severe Acute Respiratory Syndrome/metabolism ; Severe Acute Respiratory Syndrome/virology ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country England
    Document type News
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.15252/msb.20209841
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  4. Article ; Online: SARS-CoV-2-specific hotspots in virus-host interaction networks.

    Schiller, Herbert B / van Breugel, Merlijn / Nawijn, Martijn C

    Nature immunology

    2021  Volume 22, Issue 7, Page(s) 806–808

    MeSH term(s) A549 Cells ; COVID-19/immunology ; COVID-19/virology ; Cell Line, Tumor ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Host Microbial Interactions/immunology ; Host Microbial Interactions/physiology ; Humans ; Immunity, Innate/immunology ; Lung/immunology ; Lung/virology ; Proteomics/methods ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-00963-9
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  5. Article ; Online: Can ACE2 expression explain SARS‐CoV‐2 infection of the respiratory epithelia in COVID‐19?

    Martijn C Nawijn / Wim Timens

    Molecular Systems Biology, Vol 16, Iss 7, Pp n/a-n/a (2020)

    2020  

    Abstract: Infection with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) leads to coronavirus disease 2019 (COVID‐19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on ... ...

    Abstract Infection with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) leads to coronavirus disease 2019 (COVID‐19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. The angiotensin converting enzyme 2 (ACE2) has been suggested to be the key protein used by SARS‐CoV‐2 for host cell entry. In their recent work, Lindskog and colleagues (Hikmet et al, 2020) report that ACE2 is expressed at very low protein levels—if at all—in respiratory epithelial cells. Severe COVID‐19, however, is characterized by acute respiratory distress syndrome and extensive damage to the alveoli in the lung parenchyma. Then, what is the role of the airway epithelium in the early stages of COVID‐19, and which cells need to be studied to characterize the biological mechanisms responsible for the progression to severe disease after initial infection by the novel coronavirus?
    Keywords Biology (General) ; QH301-705.5 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33.

    Saikumar Jayalatha, Akshaya Keerthi / Jonker, Marnix R / Carpaij, Orestes A / van den Berge, Maarten / Affleck, Karen X / Koppelman, Gerard H / Nawijn, Martijn C

    American journal of physiology. Lung cellular and molecular physiology

    2023  Volume 326, Issue 1, Page(s) L65–L70

    Abstract: ... IL- ... ...

    Abstract IL-33
    MeSH term(s) Humans ; Immunity, Innate ; Interleukin-33/genetics ; Lymphocytes ; Asthma/metabolism ; Bronchi/metabolism ; Epithelial Cells/metabolism ; Cells, Cultured
    Chemical Substances Interleukin-33
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00298.2023
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    Uc I Zs.89: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.A 2749: Show issues Location:
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  7. Article ; Online: Early expansion of allergen-responsive LAP

    Voskamp, Astrid L / de Jong, Nicolette W / Jochems, Simon P / Ozir-Fazalalikhan, Arifa / van Hengel, Oscar R J / van der Vlugt, Luciën E P M / Stam, Koen Alexander / van den Berge, Maarten / Nawijn, Martijn C / Braunstahl, Gert-Jan / Möller, Gertrude M / van Wijk, Roy Gerth / Smits, Hermelijn H

    Allergy

    2024  Volume 79, Issue 4, Page(s) 1060–1064

    MeSH term(s) Humans ; Allergens ; Rhinitis, Allergic/therapy ; Asthma/therapy ; Desensitization, Immunologic
    Chemical Substances Allergens
    Language English
    Publishing date 2024-01-03
    Publishing country Denmark
    Document type Letter
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15973
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    Uh III Zs.150: Show issues Location:
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  8. Article: Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?

    Nawijn, Martijn C / Timens, Wim

    Mol Syst Biol

    Abstract: Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on ... ...

    Abstract Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. The angiotensin converting enzyme 2 (ACE2) has been suggested to be the key protein used by SARS-CoV-2 for host cell entry. In their recent work, Lindskog and colleagues (Hikmet et al, 2020) report that ACE2 is expressed at very low protein levels-if at all-in respiratory epithelial cells. Severe COVID-19, however, is characterized by acute respiratory distress syndrome and extensive damage to the alveoli in the lung parenchyma. Then, what is the role of the airway epithelium in the early stages of COVID-19, and which cells need to be studied to characterize the biological mechanisms responsible for the progression to severe disease after initial infection by the novel coronavirus?
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #680520
    Database COVID19

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  9. Article ; Online: Airway epithelial cell response to RSV is mostly impaired in goblet and multiciliated cells in asthma.

    Gay, Aurore C A / Banchero, Martin / Carpaij, Orestes / Kole, Tessa M / Apperloo, Leonie / van Gosliga, Djoke / Fajar, Putri Ayu / Koppelman, Gerard H / Bont, Louis / Hendriks, Rudi W / van den Berge, Maarten / Nawijn, Martijn C

    Thorax

    2024  

    Abstract: Background: In patients with asthma, respiratory syncytial virus (RSV) infections can cause disease exacerbation by infecting the epithelial layer of the airways, inducing subsequent immune response. The type I interferon antiviral response of ... ...

    Abstract Background: In patients with asthma, respiratory syncytial virus (RSV) infections can cause disease exacerbation by infecting the epithelial layer of the airways, inducing subsequent immune response. The type I interferon antiviral response of epithelial cells upon RSV infection is found to be reduced in asthma in most-but not all-studies. Moreover, the molecular mechanisms causing the differences in the asthmatic bronchial epithelium in response to viral infection are poorly understood.
    Methods: Here, we investigated the transcriptional response to RSV infection of primary bronchial epithelial cells (pBECs) from patients with asthma (n=8) and healthy donors (n=8). The pBECs obtained from bronchial brushes were differentiated in air-liquid interface conditions and infected with RSV. After 3 days, cells were processed for single-cell RNA sequencing.
    Results: A strong antiviral response to RSV was observed for all cell types, for all samples (p<1e-48). Most (1045) differentially regulated genes following RSV infection were found in cells transitioning to secretory cells. Goblet cells from patients with asthma showed lower expression of genes involved in the interferon response (false discovery rate <0.05), including
    Conclusion: Our results highlight that the response to RSV infection of the bronchial epithelium in asthma and healthy airways was largely similar. However, in asthma, the response of goblet and multiciliated cells is impaired, highlighting the need for studying airway epithelial cells at high resolution in the context of asthma exacerbation.
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-220230
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  10. Article ; Online: Methods for Experimental Allergen Immunotherapy: Subcutaneous and Sublingual Desensitization in Mouse Models of Allergic Asthma.

    Hesse, Laura / Petersen, Arjen H / Nawijn, Martijn C

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2223, Page(s) 295–335

    Abstract: Allergic asthma is characterized by airway hyperresponsiveness, remodeling, and reversible airway obstruction. This is associated with an eosinophilic inflammation of the airways, caused by inhaled allergens such as house dust mite or grass pollen. The ... ...

    Abstract Allergic asthma is characterized by airway hyperresponsiveness, remodeling, and reversible airway obstruction. This is associated with an eosinophilic inflammation of the airways, caused by inhaled allergens such as house dust mite or grass pollen. The inhaled allergens trigger a type-2 inflammatory response with the involvement of innate lymphoid cells (ILC2) and Th2 cells, resulting in high immunoglobulin E (IgE) antibody production by B cells and mucus production by airway epithelial cells. As a consequence of the IgE production, subsequent allergen reexposure results in a classic allergic response with distinct early and late phases, both resulting in bronchoconstriction and shortness of breath. Allergen-specific immunotherapy (AIT) is the only treatment that is capable of modifying the immunological process underlying allergic responses including allergic asthma. Both subcutaneous AIT (SCIT) as well as sublingual AIT (SLIT) have shown clinical efficacy in long-term suppression of the allergic response. Although AIT treatments are very successful for rhinitis, application in asthma is hampered by variable efficacy, long duration of treatment, and risk of severe side effects. A more profound understanding of the mechanisms by which AIT induces tolerance to allergens in sensitized individuals is needed to be able to improve its efficacy. Mouse models have been very valuable in preclinical research for characterizing the mechanisms of desensitization in AIT and evaluating novel approaches to improve its efficacy. Here, we present a rapid and reproducible mouse model for allergen-specific immunotherapy. In this model, mice are sensitized with two injections of allergen adsorbed to aluminum hydroxide, followed by subcutaneous injections (SCIT) or sublingual administrations (SLIT) of allergen extracts as an immunotherapy treatment. Finally, mice are challenged by intranasal allergen administrations. We will also describe the protocols as well as the most important readout parameters for the measurements of invasive lung function, serum immunoglobulin levels, isolation of bronchoalveolar lavage fluid (BALF), and preparation of cytospin slides. Moreover, we describe how to perform ex vivo restimulation of lung single-cell suspensions with allergens, flow cytometry for identification of relevant immune cell populations, and ELISAs and Luminex assays for assessment of the cytokine concentrations in BALF and lung tissue.
    MeSH term(s) Adjuvants, Immunologic/administration & dosage ; Administration, Intranasal ; Allergens/administration & dosage ; Allergens/immunology ; Aluminum Hydroxide/administration & dosage ; Animals ; Asthma/immunology ; Asthma/pathology ; Asthma/therapy ; Bronchoalveolar Lavage Fluid/chemistry ; Bronchoalveolar Lavage Fluid/cytology ; Bronchoalveolar Lavage Fluid/immunology ; Complex Mixtures/administration & dosage ; Complex Mixtures/immunology ; Cytokines/genetics ; Cytokines/immunology ; Disease Models, Animal ; Ear ; Eosinophils/immunology ; Eosinophils/pathology ; Female ; Humans ; Immunoglobulin E/genetics ; Immunoglobulin E/immunology ; Injections, Subcutaneous ; Lung/drug effects ; Lung/immunology ; Lung/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neutrophils/immunology ; Neutrophils/pathology ; Pollen/chemistry ; Pollen/immunology ; Pyroglyphidae/chemistry ; Pyroglyphidae/immunology ; Single-Cell Analysis/methods ; Sublingual Immunotherapy/methods
    Chemical Substances Adjuvants, Immunologic ; Allergens ; Complex Mixtures ; Cytokines ; Immunoglobulin E (37341-29-0) ; Aluminum Hydroxide (5QB0T2IUN0)
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1001-5_20
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