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  1. Book ; Online ; E-Book: Emerging programs for autism spectrum disorder

    Papaneophytou, Neophytos L. / Das, Undurti N.

    improving communication, behavior, and family dynamics

    2021  

    Author's details edited by Neophytos L. Papaneophytou, Undurti N. Das
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xvii, 557 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021052012
    ISBN 978-0-323-85977-6 ; 9780323850315 ; 0-323-85977-1 ; 0323850316
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Molecular Biochemical Aspects of Cancer

    Das, Undurti N.

    2020  

    Abstract: This book discusses the role of genes, oncogenes, anti-oncogenes, free radicals, PUFAs, anti-oxidants, lipid peroxidation process, telomere, and angiogenesis on the origin of cancer, cell proliferation, and cancer in general. It includes a broad ... ...

    Author's details by Undurti N. Das
    Abstract This book discusses the role of genes, oncogenes, anti-oncogenes, free radicals, PUFAs, anti-oxidants, lipid peroxidation process, telomere, and angiogenesis on the origin of cancer, cell proliferation, and cancer in general. It includes a broad introduction to cancer cells; genes, oncogenes, and anti-oncogenes; and free radicals. In later chapters, it discusses in depth the relationship among free radicals, lipid peroxidation and anti-oxidants in cell proliferation. It also discusses aerobic and anaerobic metabolism and their relationship to cancer, as well as the Warburg effect and its potential in the development of new targets for cancer management. Based on these and other evidences, Molecular Biochemical Aspects of Cancer introduces a novel concept that suggests that selective enhancement of free radical generation in tumor cells could form a strategy to induce apoptosis of cancer cells employing bioactive lipids. It presents a new method of treatment of cancer using in vitro, in vivo and clinical data. This book will interest oncologists, scientists, molecular biologists, life scientists.
    Keywords Cell biology ; Cancer research ; Molecular biology ; Cell Biology ; Cancer Research ; Molecular Medicine ; Biologia molecular ; Càncer
    Subject code 616.994
    Language English
    Size 1 online resource (xiii, 254 pages) :, illustrations
    Edition 1st ed. 2020.
    Publisher Springer US ; Imprint: Humana
    Publishing place New York, NY
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-0716-0741-3 ; 1-0716-0739-1 ; 978-1-0716-0741-1 ; 978-1-0716-0739-8
    DOI 10.1007/978-1-0716-0741-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Pyridoxine, essential fatty acids, and protection against doxorubicin-induced cardiotoxicity.

    Das, Undurti N

    Journal of biochemical and molecular toxicology

    2024  Volume 38, Issue 1, Page(s) e23639

    MeSH term(s) Humans ; Cardiotoxicity/etiology ; Cardiotoxicity/prevention & control ; Pyridoxine/pharmacology ; Pyridoxine/therapeutic use ; Doxorubicin/adverse effects ; Fatty Acids, Essential ; Myocytes, Cardiac
    Chemical Substances Pyridoxine (KV2JZ1BI6Z) ; Doxorubicin (80168379AG) ; Fatty Acids, Essential
    Language English
    Publishing date 2024-01-13
    Publishing country United States
    Document type Letter
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CUL4A-mediated ZEB1/microRNA-340-5p/HMGB1 axis in osteoporosis and their modulation by essential fatty acids (EFAs).

    Das, Undurti N

    Journal of biochemical and molecular toxicology

    2024  Volume 38, Issue 1, Page(s) e23633

    MeSH term(s) Humans ; HMGB1 Protein ; Fatty Acids, Essential ; MicroRNAs/genetics ; Osteoporosis/genetics ; Zinc Finger E-box-Binding Homeobox 1 ; Cullin Proteins
    Chemical Substances HMGB1 Protein ; Fatty Acids, Essential ; MicroRNAs ; ZEB1 protein, human ; Zinc Finger E-box-Binding Homeobox 1 ; CUL4A protein, human ; Cullin Proteins ; MIRN340 microRNA, human
    Language English
    Publishing date 2024-01-13
    Publishing country United States
    Document type Letter
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23633
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  5. Article: Can Post-Menopausal Osteoporosis Be Prevented by Essential Fatty Acids? [Letter].

    Das, Undurti N

    Journal of inflammation research

    2023  Volume 16, Page(s) 1553–1554

    Language English
    Publishing date 2023-04-12
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S412814
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  6. Article ; Online: Can essential fatty acids (EFAs) prevent and ameliorate post-COVID-19 long haul manifestations?

    Das, Undurti N

    Lipids in health and disease

    2024  Volume 23, Issue 1, Page(s) 112

    Abstract: It is hypothesized that COVID-19, post-COVID and post-mRNA COVID-19 (and other related) vaccine manifestations including "long haul syndrome" are due to deficiency of essential fatty acids (EFAs) and dysregulation of their metabolism. This proposal is ... ...

    Abstract It is hypothesized that COVID-19, post-COVID and post-mRNA COVID-19 (and other related) vaccine manifestations including "long haul syndrome" are due to deficiency of essential fatty acids (EFAs) and dysregulation of their metabolism. This proposal is based on the observation that EFAs and their metabolites can modulate the swift immunostimulatory response of SARS-CoV-2 and similar enveloped viruses, suppress inappropriate cytokine release, possess cytoprotective action, modulate serotonin and bradykinin production and other neurotransmitters, inhibit NF-kB activation, regulate cGAS-STING pathway, modulate gut microbiota, inhibit platelet activation, regulate macrophage and leukocyte function, enhance wound healing and facilitate tissue regeneration and restore homeostasis. This implies that administration of EFAs could be of benefit in the prevention and management of COVID-19 and its associated complications.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Fatty Acids, Essential/metabolism ; Syndrome ; Inflammation/metabolism
    Chemical Substances Fatty Acids, Essential
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2091381-3
    ISSN 1476-511X ; 1476-511X
    ISSN (online) 1476-511X
    ISSN 1476-511X
    DOI 10.1186/s12944-024-02090-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Molecular basis of health and disease

    Das, Undurti N.

    2011  

    Author's details Undurti N. Das
    Language English
    Size XX, 583 S. : Ill., 24 cm
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016801557
    ISBN 978-94-007-0494-7 ; 94-007-0494-1 ; 9789400704954 ; 940070495X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 1834 order for loan Magazin

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  8. Article ; Online: Infection, Inflammation, and Immunity in Sepsis.

    Das, Undurti N

    Biomolecules

    2023  Volume 13, Issue 9

    Abstract: Sepsis is triggered by microbial infection, injury, or even major surgery. Both innate and adaptive immune systems are involved in its pathogenesis. Cytoplasmic presence of DNA or RNA of the invading organisms or damaged nuclear material (in the form of ... ...

    Abstract Sepsis is triggered by microbial infection, injury, or even major surgery. Both innate and adaptive immune systems are involved in its pathogenesis. Cytoplasmic presence of DNA or RNA of the invading organisms or damaged nuclear material (in the form of micronucleus in the cytoplasm) in the host cell need to be eliminated by various nucleases; failure to do so leads to the triggering of inflammation by the cellular cGAS-STING system, which induces the release of IL-6, TNF-α, and IFNs. These cytokines activate phospholipase A2 (PLA2), leading to the release of polyunsaturated fatty acids (PUFAs), gamma-linolenic acid (GLA), arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), which form precursors to various pro- and anti-inflammatory eicosanoids. On the other hand, corticosteroids inhibit PLA2 activity and, thus, suppress the release of GLA, AA, EPA, and DHA. PUFAs and their metabolites have a negative regulatory action on the cGAS-STING pathway and, thus, suppress the inflammatory process and initiate inflammation resolution. Pro-inflammatory cytokines and corticosteroids (corticosteroids > IL-6, TNF-α) suppress desaturases, which results in decreased formation of GLA, AA, and other PUFAs from the dietary essential fatty acids (EFAs). A deficiency of GLA, AA, EPA, and DHA results in decreased production of anti-inflammatory eicosanoids and failure to suppress the cGAS-STING system. This results in the continuation of the inflammatory process. Thus, altered concentrations of PUFAs and their metabolites, and failure to suppress the cGAS-STING system at an appropriate time, leads to the onset of sepsis. Similar abnormalities are also seen in radiation-induced inflammation. These results imply that timely administration of GLA, AA, EPA, and DHA, in combination with corticosteroids and anti-IL-6 and anti-TNF-α antibodies, may be of benefit in mitigating radiation-induced damage and sepsis.
    MeSH term(s) Humans ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Tumor Necrosis Factor Inhibitors ; Inflammation/metabolism ; Fatty Acids, Unsaturated ; Eicosanoids ; Eicosapentaenoic Acid/pharmacology ; Arachidonic Acid ; Cytokines ; Docosahexaenoic Acids ; Anti-Inflammatory Agents ; Sepsis
    Chemical Substances Tumor Necrosis Factor-alpha ; Interleukin-6 ; Tumor Necrosis Factor Inhibitors ; Fatty Acids, Unsaturated ; Eicosanoids ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Arachidonic Acid (27YG812J1I) ; Cytokines ; Docosahexaenoic Acids (25167-62-8) ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13091332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pro- and anti-inflammatory bioactive lipids imbalance contributes to the pathobiology of autoimmune diseases.

    Das, Undurti N

    European journal of clinical nutrition

    2022  Volume 77, Issue 6, Page(s) 637–651

    Abstract: Autoimmune diseases are driven by ... ...

    Abstract Autoimmune diseases are driven by T
    MeSH term(s) Humans ; Interleukin-17 ; Dinoprostone ; Inflammation ; Autoimmune Diseases ; Cytokines ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Fatty Acids
    Chemical Substances Interleukin-17 ; Dinoprostone (K7Q1JQR04M) ; Cytokines ; Anti-Inflammatory Agents ; Fatty Acids
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/s41430-022-01173-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bioactive lipids and vascular disease.

    Das, Undurti N

    European journal of clinical nutrition

    2021  Volume 75, Issue 10, Page(s) 1528–1531

    MeSH term(s) Fatty Acids ; Humans ; Lipids ; Vascular Diseases
    Chemical Substances Fatty Acids ; Lipids
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/s41430-021-00925-2
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