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  1. Article ; Online: Ligature Mark: Crime or Suicide?

    Mansueto, Gelsomina

    International journal of environmental research and public health

    2022  Volume 19, Issue 21

    Abstract: Identifying the morphological findings of vitality is crucial when determining if a lesion was inflicted in life or postmortem [ ... ]. ...

    Abstract Identifying the morphological findings of vitality is crucial when determining if a lesion was inflicted in life or postmortem [...].
    MeSH term(s) Humans ; Suicide ; Autopsy ; Crime ; Asphyxia
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192114221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ligature Mark

    Gelsomina Mansueto

    International Journal of Environmental Research and Public Health, Vol 19, Iss 14221, p

    Crime or Suicide?

    2022  Volume 14221

    Abstract: Identifying the morphological findings of vitality is crucial when determining if a lesion was inflicted in life or postmortem [.] ...

    Abstract Identifying the morphological findings of vitality is crucial when determining if a lesion was inflicted in life or postmortem [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: COVID-19: Brief check through the pathologist's eye (autopsy archive).

    Mansueto, Gelsomina

    Pathology, research and practice

    2020  Volume 216, Issue 11, Page(s) 153195

    Abstract: During the COVID-19 pandemic, many deaths occurred especially among the old patients with cardiovascular comorbidities. Many questions have been asked and few simple answers have been given. The autopsy data are few and the aspects often observed are ... ...

    Abstract During the COVID-19 pandemic, many deaths occurred especially among the old patients with cardiovascular comorbidities. Many questions have been asked and few simple answers have been given. The autopsy data are few and the aspects often observed are pulmonary diffuse alveolar damage (DAD), myocarditis, acute myocardial infarction (AMI), and disseminated intravascular coagulation (DIC); these aspects are not only in COVID-19 but also in other viral infections and in sepsis. It should be considered that coronavirus with its pathological organ changes have already been described in the years preceding the pandemic.
    MeSH term(s) Autopsy/methods ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Humans ; Lung/pathology ; Lung/virology ; Myocarditis/pathology ; Pandemics ; Pathologists ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2020.153195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19

    Mansueto, Gelsomina

    Pathology - Research and Practice

    Brief check through the pathologist's eye (autopsy archive)

    2020  Volume 216, Issue 11, Page(s) 153195

    Keywords Pathology and Forensic Medicine ; Cell Biology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2020.153195
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: COVID-19: Brief check through the pathologist's eye (autopsy archive)

    Mansueto, Gelsomina

    Pathol Res Pract

    Abstract: During the COVID-19 pandemic, many deaths occurred especially among the old patients with cardiovascular comorbidities. Many questions have been asked and few simple answers have been given. The autopsy data are few and the aspects often observed are ... ...

    Abstract During the COVID-19 pandemic, many deaths occurred especially among the old patients with cardiovascular comorbidities. Many questions have been asked and few simple answers have been given. The autopsy data are few and the aspects often observed are pulmonary diffuse alveolar damage (DAD), myocarditis, acute myocardial infarction (AMI), and disseminated intravascular coagulation (DIC); these aspects are not only in COVID-19 but also in other viral infections and in sepsis. It should be considered that coronavirus with its pathological organ changes have already been described in the years preceding the pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #733660
    Database COVID19

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  6. Article: An Update on Myocarditis in Forensic Pathology.

    Falleti, Jessica / Orabona, Pasquale / Municinò, Maurizio / Castellaro, Gianluca / Fusco, Giovanna / Mansueto, Gelsomina

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 7

    Abstract: In forensic medicine, myocarditis is a complicated topic in the context of sudden death and medical malpractice. A good knowledge of the etiopathology, histopathology, and available literature are both indispensable and essential for the correct ... ...

    Abstract In forensic medicine, myocarditis is a complicated topic in the context of sudden death and medical malpractice. A good knowledge of the etiopathology, histopathology, and available literature are both indispensable and essential for the correct management and evaluation of the causal link. Some agents, which are rarely lethal for humans, are not necessarily related to death from myocarditis, even if an infection in other organs such as the gastrointestinal tract is documented. The diagnosis of the causes of death is often difficult and confusing. In some cases, the hypothetical diagnosis of myocarditis as the cause of death is formulated by deduction, causing error and misleading the correct temporal evaluation of pathological events. We reviewed the literature realizing that histomorphological data are scarce and often poorly documented. Only after COVID-19 have the histomorphological aspects of myocarditis been better documented. This is due to poor autopsy practice and poor accuracy in identifying the specific histotype of myocarditis with identification of the responsible agent. We believe that four points are essential for a better understanding and complete diagnosis of the disease: (1) clinical classification of myocarditis; (2) etiological classification of myocarditis; (3) pathophysiology of viral and bacterial infections with host response; and (4) histopathological diagnosis with precise identification of the histotype and pathogen. In the review we provide histological images from authoritative scientific references with the aim of providing useful information and food for thought to readers.
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14070760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunosenescence exacerbates the COVID-19.

    Napoli, Claudio / Tritto, Isabella / Mansueto, Gelsomina / Coscioni, Enrico / Ambrosio, Giuseppe

    Archives of gerontology and geriatrics

    2020  Volume 90, Page(s) 104174

    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2020.104174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hypoplastic Left Heart Syndrome: About a Postnatal Death.

    Giugliano, Pasquale / Ciamarra, Paola / De Simone, Mariavictoria / Feola, Alessandro / Zangani, Pierluca / Campobasso, Carlo Pietro / Mansueto, Gelsomina

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Background: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease that is associated with high mortality rates in the early neonatal period and during surgical treatments. This is mainly due to missed prenatal diagnosis, delayed ... ...

    Abstract Background: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease that is associated with high mortality rates in the early neonatal period and during surgical treatments. This is mainly due to missed prenatal diagnosis, delayed diagnostic suspicion, and consequent unsuccessful therapeutic intervention.
    Case report: twenty-six hours after birth, a female newborn died of severe respiratory failure. No cardiac abnormalities and no genetic diseases had been evidenced or documented during intrauterine life. The case became of medico-legal concern for the assessment of alleged medical malpractice. Therefore, a forensic autopsy was performed.
    Results: the macroscopic study of the heart revealed the hypoplasia of the left cardiac cavities with the left ventricle (LV) reduced to a slot and a right ventricular cavity that simulated the presence of a single and unique ventricular chamber. The predominance of the left heart was evident.
    Conclusions: HLHS is a rare condition that is incompatible with life, with very high mortality from cardiorespiratory insufficiency that occurs soon after birth. The prompt diagnosis of HLHS during pregnancy is crucial in managing the disease with surgery.
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13050821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evidence for human diabetic cardiomyopathy.

    Marfella, Raffaele / Sardu, Celestino / Mansueto, Gelsomina / Napoli, Claudio / Paolisso, Giuseppe

    Acta diabetologica

    2021  Volume 58, Issue 8, Page(s) 983–988

    Abstract: Growing interest has been accumulated in the definition of worsening effects of diabetes in the cardiovascular system. This is associated with epidemiological data regarding the high incidence of heart failure (HF) in diabetic patients. To investigate ... ...

    Abstract Growing interest has been accumulated in the definition of worsening effects of diabetes in the cardiovascular system. This is associated with epidemiological data regarding the high incidence of heart failure (HF) in diabetic patients. To investigate the detrimental effects both of hyperglycemia and insulin resistance, a lot of preclinical models were developed. However, the evidence of pathogenic and histological alterations of the so-called diabetic cardiomyopathy (DCM) is still poorly understood in humans. Here, we provide a stringent literature analysis to investigate unique data regarding human DCM. This approach established that lipotoxic-related events might play a central role in the initiation and progression of human DCM. The major limitation in the acquisition of human data is due to the fact of heart specimen availability. Postmortem analysis revealed the end stage of the disease; thus, we need to gain knowledge on the pathogenic events from the early stages until cardiac fibrosis underlying the end-stage HF.
    MeSH term(s) Diabetes Mellitus ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/pathology ; Diabetic Cardiomyopathies/physiopathology ; Disease Progression ; Heart/physiopathology ; Heart Failure/epidemiology ; Humans ; Hyperglycemia/complications ; Insulin Resistance/physiology ; Myocardium/pathology
    Language English
    Publishing date 2021-03-31
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-021-01705-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Can COVID 2019 induce a specific cardiovascular damage or it exacerbates pre-existing cardiovascular diseases?

    Mansueto, Gelsomina / Niola, Massimo / Napoli, Claudio

    Pathology, research and practice

    2020  Volume 216, Issue 9, Page(s) 153086

    Abstract: A novel coronavirus SARS-CoV-2 causes acute respiratory distress syndrome (ARDS) with cardiovascular and multiple organ failure till death. The main mechanisms of virus internalization and interaction with the host are down-regulation or upregulation of ... ...

    Abstract A novel coronavirus SARS-CoV-2 causes acute respiratory distress syndrome (ARDS) with cardiovascular and multiple organ failure till death. The main mechanisms of virus internalization and interaction with the host are down-regulation or upregulation of the ACE2 receptor, the surface glycoprotein competition mechanism for the binding of porphyrin to iron in heme formation as well as interference with the immune system. The interference on renin-angiotensin-aldosterone system (RAAS) activation, heme formation, and the immune response is responsible for infection diffusion, endothelial dysfunction, vasoconstriction, oxidative damage and releasing of inflammatory mediators. The main pathological findings are bilateral interstitial pneumonia with diffuse alveolar damage (DAD). Because ACE receptor is also present in the endothelium of other districts as well as in different cell types, and as porphyrins are transporters in the blood and other biological liquids of iron forming heme, which is important in the assembly of the hemoglobin, myoglobin and the cytochromes, multiorgan damage occurs both primitive and secondary to lung damage. More relevantly, myocarditis, acute myocardial infarction, thromboembolism, and disseminated intravasal coagulation (DIC) are described as complications in patients with poor outcome. Here, we investigated the role of SARSCoV-2 on the cardiovascular system and in patients with cardiovascular comorbidities, and possible drug interference on the heart.
    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular System/virology ; Coronavirus Infections/complications ; Coronavirus Infections/virology ; Humans ; Lung/metabolism ; Lung/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology ; Renin-Angiotensin System/physiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2020.153086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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