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Article ; Online: Hepatitis A susceptibility parallels high COVID-19 mortality.

Sarialioğlu, Faik / Belen, Fatma Burcu / Hayran, Kadir Mutlu

2021 Volume 51, Issue 1, Page(s) 382–384

MeSH term(s)	COVID-19/immunology ; COVID-19/mortality ; Disease Susceptibility/epidemiology ; Disease Susceptibility/immunology ; Hepatitis A/epidemiology ; Hepatitis A/immunology ; Hepatitis A virus/immunology ; Humans ; Middle Aged ; Risk Factors ; Ships
Keywords	covid19
Language	English
Publishing date	2021-02-26
Publishing country	Turkey
Document type	Letter
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2007-133
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Zs.A 3242: Show issues

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Article ; Online: Five Years Follow-up of Opsoclonus-Myoclonus-Ataxia Syndrome-Associated Neurogenic Tumors in Children.

Aktekin, Elif Habibe / Gezer, Hasan Özkan / Yazıcı, Nalan / Erol, İlknur / Erbay, Ayşe / Sarıalioğlu, Faik

Neuropediatrics

2023 Volume 55, Issue 1, Page(s) 57–62

Abstract: Aim: Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare autoimmune disorder. Approximately half of the cases are associated with neuroblastoma in children. This study's aim is to review management of our cases with OMAS-associated neuroblastoma for ... ...

Abstract	Aim: Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare autoimmune disorder. Approximately half of the cases are associated with neuroblastoma in children. This study's aim is to review management of our cases with OMAS-associated neuroblastoma for treatment approach as well as long-term follow-up. Methods: Age at onset of symptoms and tumor diagnosis, tumor location, histopathology, stage, chemotherapy, OMAS protocol, surgery, and follow-up period were evaluated retrospectively in six patients between 2007 and 2022. Results: Mean age of onset of OMAS findings was 13.5 months and mean age at tumor diagnosis was 15.1 months. Tumor was located at thorax in three patients and surrenal in others. Four patients underwent primary surgery. Histopathological diagnosis was ganglioneuroblastoma in three, neuroblastoma in two, and undifferentiated neuroblastoma in one. One patient was considered as stage 1 and rest of them as stage 2. Chemotherapy was provided in five cases. The OMAS protocol was applied to five patients. Our protocol is intravenous immunoglobulin (IVIG) 1 g/kg/d for 2 consecutive days once a month and dexamethasone for 5 days (20 mg/m Conclusion: In tumor-related cases, alternating use of corticosteroid and IVIG for suppression of autoimmunity as the OMAS protocol, total excision of the tumor as soon as possible, and chemotherapeutics in selected patients seem to be related to resolution of acute problems, long-term sequelae, and severity.
MeSH term(s)	Child ; Humans ; Infant ; Ocular Motility Disorders ; Follow-Up Studies ; Immunoglobulins, Intravenous/therapeutic use ; Retrospective Studies ; Opsoclonus-Myoclonus Syndrome/drug therapy ; Opsoclonus-Myoclonus Syndrome/etiology ; Neuroblastoma/complications ; Neuroblastoma/diagnosis ; Neuroblastoma/drug therapy ; Ataxia/complications
Chemical Substances	Immunoglobulins, Intravenous
Language	English
Publishing date	2023-04-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0043-1768143
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Zs.A 728: Show issues

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Article ; Online: Late effects of medulloblastoma treatment: multidisciplinary approach of survivors.

Aktekin, Elif Habibe / Kütük, Meryem Özlem / Sangün, Özlem / Yazıcı, Nalan / Çaylaklı, Fatma / Erol, İlknur / Sarıalioğlu, Faik

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2023 Volume 40, Issue 2, Page(s) 417–425

Abstract: Purpose: Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study's aim is to review long-term follow- ...

Abstract	Purpose: Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study's aim is to review long-term follow-up outcomes of our cases with medulloblastoma. Methods: Age at diagnosis, histological type of medulloblastoma, resection extension, chemotherapy and radiotherapy schemes, follow-up duration, and endocrinological, neuropsychiatric, cardiological, auditory, and visual examination results were evaluated in 20 patients diagnosed between 2007 and 2018 and followed 5 years and more. Results: Twenty of 53 patients were included to the study. Eleven (55%) were male. Mean age at diagnosis was 6.95 years; mean age at the time of the study was 14 years. Mean follow-up time was 8.95 years. In terms of surgery, 14 (70%) were gross total, 1 (5%) was near total, and 2 (10%) were subtotal resection. In histopathological examination, 14 (70%) were classical medulloblastoma, 4 (20%) were desmoplastic medulloblastoma, and 1 (5%) was anaplastic medulloblastoma. With regard to endocrinological evaluation, 15 (75%) patients had hypothyroidism, 5 (25%) had growth hormone deficiency, 7 (35%) had clinical growth hormone deficiency, and 5 (25%) had sex hormone disorders. In neuropsychiatric examination, 11 (55%) patients had neurological sequelae, 18 (90%) patients had psychiatric issues, and 14 (70%) patients had two or more neuropsychiatric problems simultaneously. One (5%) patient had mitral valve insufficiency. Twelve patients (60%) had hearing loss. According to visual examination, 6 (30%) patients had refraction problem, 4 (20%) had cataract, and 1 (5%) had dry eye. Conclusion: Careful monitoring of long-term side effects is important for improving the quality of life of medulloblastoma patients. Besides endocrinological and other somatic sequelae of the disease and treatment, increased neuropsychiatric problems showed us that only cure is not the issue while treating childhood medulloblastoma.
MeSH term(s)	Humans ; Male ; Child ; Adolescent ; Young Adult ; Adult ; Female ; Medulloblastoma/pathology ; Quality of Life ; Cerebellar Neoplasms/radiotherapy ; Disease Progression ; Survivors ; Growth Hormone
Chemical Substances	Growth Hormone (9002-72-6)
Language	English
Publishing date	2023-09-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-023-06146-1
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Zs.A 2036: Show issues

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Article ; Online: Can Hepatitis A Vaccine Provide Protection Against COVID-19?

Sarialioglu, Faik / Belen Apak, Fatma Burcu / Haberal, Mehmet

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2020 Volume 18, Issue 2, Page(s) 141–143

MeSH term(s)	Betacoronavirus ; COVID-19 ; Child ; China ; Coronavirus Infections ; Hepatitis A Vaccines ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Hepatitis A Vaccines
Keywords	covid19
Language	English
Publishing date	2020-04-11
Publishing country	Turkey
Document type	Journal Article ; Review ; Comment
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2020.0109
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Zs.A 6632: Show issues

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Article: Five Years Follow-up of Opsoclonus–Myoclonus–Ataxia Syndrome-Associated Neurogenic Tumors in Children

Aktekin, Elif Habibe / Gezer, Hasan Özkan / Yazıcı, Nalan / Erol, İlknur / Erbay, Ayşe / Sarıalioğlu, Faik

Neuropediatrics

2023 Volume 55, Issue 01, Page(s) 57–62

Abstract: Aim: Opsoclonus–myoclonus–ataxia syndrome (OMAS) is a rare autoimmune disorder. Approximately half of the cases are associated with neuroblastoma in children. This study's aim is to review management of our cases with OMAS-associated neuroblastoma for ... ...

Abstract	Aim: Opsoclonus–myoclonus–ataxia syndrome (OMAS) is a rare autoimmune disorder. Approximately half of the cases are associated with neuroblastoma in children. This study's aim is to review management of our cases with OMAS-associated neuroblastoma for treatment approach as well as long-term follow-up. Methods: Age at onset of symptoms and tumor diagnosis, tumor location, histopathology, stage, chemotherapy, OMAS protocol, surgery, and follow-up period were evaluated retrospectively in six patients between 2007 and 2022. Results: Mean age of onset of OMAS findings was 13.5 months and mean age at tumor diagnosis was 15.1 months. Tumor was located at thorax in three patients and surrenal in others. Four patients underwent primary surgery. Histopathological diagnosis was ganglioneuroblastoma in three, neuroblastoma in two, and undifferentiated neuroblastoma in one. One patient was considered as stage 1 and rest of them as stage 2. Chemotherapy was provided in five cases. The OMAS protocol was applied to five patients. Our protocol is intravenous immunoglobulin (IVIG) 1 g/kg/d for 2 consecutive days once a month and dexamethasone for 5 days (20 mg/m 2 /d for 1–2 days, 10 mg/m 2 /d for 3–4 days, and 5 mg/m 2 /d for the fifth day) once a month, alternatively by 2-week intervals. Patients were followed up for a mean of 8.1 years. Neuropsychiatric sequelae were detected in two patients. Conclusion: In tumor-related cases, alternating use of corticosteroid and IVIG for suppression of autoimmunity as the OMAS protocol, total excision of the tumor as soon as possible, and chemotherapeutics in selected patients seem to be related to resolution of acute problems, long-term sequelae, and severity.
Keywords	opsoclonus–myoclonus–ataxia syndrome ; neuroblastoma ; immunosuppression ; tumor ; surgery ; sequelae
Language	English
Publishing date	2023-04-05
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0043-1768143
Database	Thieme publisher's database

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Zs.A 728: Show issues

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Article ; Online: Cardiac evaluation in children with hemangiomas.

Erdoğan, İlkay / Sarıalioğlu, Faik

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

2016 Volume 44, Issue 6, Page(s) 498–502

Abstract: Objective: Hemangiomas are tumors most commonly encountered in pediatric patients, and are frequently treated with propranolol. However, there are currently no standard methods for evaluating cardiac function in patients prior to propranolol treatment. ... ...

Abstract	Objective: Hemangiomas are tumors most commonly encountered in pediatric patients, and are frequently treated with propranolol. However, there are currently no standard methods for evaluating cardiac function in patients prior to propranolol treatment. The present study was designed to aid in the evaluation of pretreatment cardiac and effects of propranolol on vital signs in pediatric hemangioma patients. Methods: A pediatric oncology specialist and a pediatric cardiology specialist examined all patients prior to initiation of propranolol treatment. All patients were examined by the same 2 physicians. Cardiac evaluation included complete echocardiogram and electrocardiography. From September 2009 to January 2014, 146 patients aged 4 days to 10 years were screened. Results: No patient had cardiac contraindication to propranolol. The effect of hemangioma on left ventricle size was examined, but left ventricle dilatation was found in only 3 patients. However, 68 patients had abnormal echocardiogram: 17 had patent foramen ovale, 4 had ventricular septal defect, 9 had atrial septal defect (associated with right heart enlargement), 8 had patent ductus arteriosus, 6 had physiologic pulmonary stenosis, and 1 had an aortic coarctation. No contraindications to propranolol or side effects were observed. However, cardiac anatomic defects were more common in this patient group than in the general population. Conclusion: Hemangiomas in infants or children, even in small or premature infants, can be treated with propranolol without significant cardiac side effects. In addition, large dermal hemangiomas were not found to affect ventricular size in pediatric patients.
MeSH term(s)	Contraindications ; Echocardiography ; Female ; Heart Diseases/complications ; Heart Diseases/physiopathology ; Heart Ventricles/physiopathology ; Hemangioma/complications ; Hemangioma/drug therapy ; Humans ; Infant ; Infant, Newborn ; Male ; Propranolol/therapeutic use ; Retrospective Studies ; Vasodilator Agents/therapeutic use
Chemical Substances	Vasodilator Agents ; Propranolol (9Y8NXQ24VQ)
Language	English
Publishing date	2016-09
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1215217-1
ISSN	1308-4488 ; 1016-5169
ISSN (online)	1308-4488
ISSN	1016-5169
DOI	10.5543/tkda.2016.65171
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Zs.A 4156: Show issues

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Article: Medulloblastoma: Clinicopathological Correlates of SHH, WNT, and Non-WNT/SHH Molecular Subgroups Analysis and Prognostic Significance: Mono-Institutional Series.

Hasbay, Bermal / Kayaselcuk, Fazilet / Suner, Halil Ibrahim / Sarialioglu, Faik

Turkish neurosurgery

2021 Volume 32, Issue 4, Page(s) 595–602

Abstract: Aim: To reevaluate the medulloblastoma cases according to histomorphological and molecular features, and to investigate the relationship between the prognostic factors of the new WHO classification by applying Beta-catenin, YAP1, GAP1, p53, and INI1 ... ...

Abstract	Aim: To reevaluate the medulloblastoma cases according to histomorphological and molecular features, and to investigate the relationship between the prognostic factors of the new WHO classification by applying Beta-catenin, YAP1, GAP1, p53, and INI1 antibodies immunohistochemically. Material and methods: This study includes 41 patients who have been diagnosed with medulloblastoma between 2007-2019 in pathology department. Immunohistochemically, p53, beta-catenin, YAP1, GAP1, and INI1 immune markers were applied, and the relationship between the results and the prognostic parameters was evaluated statistically. Results: When 41 patients were classified into WHO medulloblastoma histological subtype groups according to histomorphological features, 22 (53.7%) patients were classified as classical type, 11 (26.8%) patients as desmoplastic nodular type, and 8 (19.5%) patients as large cell/anaplastic type medulloblastoma. According to their molecular characteristics, 14 (34.1%) patients were in the Non-WNT/SHH group, 5 (12.2%) patients were SHH mutant, 17 (41.5%) patients were SHH wild, and 5 (12.2%) patients were in the WNT active group. There was no statistically significant correlation between age, gender, tumor size, recurrence, Ki67 proliferation index with molecular types and histopathological types. Conclusion: In our study, metastasis at the time of diagnosis, histological large cell anaplastic type, immunohistochemical p53 positivity, molecular SHH mutant type were the statistically significant indicators of worse prognosis and shorter survival time.
MeSH term(s)	Cerebellar Neoplasms/diagnosis ; Hedgehog Proteins ; Humans ; Medulloblastoma/diagnosis ; Prognosis ; Tumor Suppressor Protein p53 ; beta Catenin
Chemical Substances	Hedgehog Proteins ; SHH protein, human ; Tumor Suppressor Protein p53 ; beta Catenin
Language	English
Publishing date	2021-12-06
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1203779-5
ISSN	1019-5149
ISSN	1019-5149
DOI	10.5137/1019-5149.JTN.34490-21.3
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Zs.A 4081: Show issues

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Article ; Online: Seventeen Years of Pediatric Liver Transplantation Experience for Cirrhosis and Hepatocellular Carcinoma.

Özçay, Figen / Balci Sezer, Oya / Sarialioğlu, Faik / Boyvat, Fatih / Coşkun, Mehmet / Haberal Reyhan, Nihan / Haberal, Mehmet

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2022

Abstract: Objectives: This was a retrospective analysis of liver transplant for pediatric patients with liver cirrhosis and hepatocellular carcinoma.: Materials and methods: Fourteen pediatric patients with chronic liver disease and hepatocellular carcinoma ... ...

Abstract	Objectives: This was a retrospective analysis of liver transplant for pediatric patients with liver cirrhosis and hepatocellular carcinoma. Materials and methods: Fourteen pediatric patients with chronic liver disease and hepatocellular carcinoma underwent liver transplant from 2004 to 2021. Preexisting diseases were tyrosinemia (n = 6), progressive familial intrahepatic cholestasis type 2 (n = 2) and type 3 (n = 3), cryptogenic cirrhosis (n = 2), hepatitis B and D (n = 1), and biliary atresia (n = 1). Results: Mean age was 9.43 ± 4.9 years (range, 13 months to 16 years). Three patients had 1 tumor, 4 had 2 tumors, and 7 had multiple (≥3) lesions. Six patients were classified as Pretreatment Extent of Disease Staging System for Hepatoblastoma (PRETEXT) stage IV, 3 as stage II, and 5 as stage I. Some patients received systemic chemotherapy before (n = 4) or after transplant (n = 3) or transarterial chemoembolization and microwave ablation pretransplant (n = 1). Hepatocellular carcinoma posttransplant recurrence was observed at 23, 47, and 108 months in 3 patients (21%). Recurrence sites were omentum (n = 1) and liver graft (n = 2). One patient was treated with hepatic resection, radiofrequency ablation, and radiotherapy, while the other received radiofrequency ablation and chemotherapy for graft tumor recurrence. Relapse-free patient survival rates were 92%, 82.5%, and 72.2% at 2, 4, and 10 years, respectively. Four recipients (28.5%) died; posttransplant cause of death was infection at 19 (n = 1) and 188 months (n = 1) or hepatocellular carcinoma recurrence at 79 (n = 1) and 165 months (n = 1). Median follow-up was 178 months (range, 13-204 months). Mean estimated survival was 171.25 ± 16.6 months. Overall patient posttransplant survival was 100%, 92.3%, 92.3%, 83%, and 72% at 1, 2, 5, 10, and 15 years, respectively. Conclusions: Hepatocellular carcinoma was mainly associated with inherited liver diseases in our pediatric series. Liver transplant provided a long-term survival advantage to pediatric patients with preexisting cirrhosis and hepatocellular carcinoma.
Language	English
Publishing date	2022-03-15
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2021.0469
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Zs.A 6632: Show issues

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Article: Can Hepatitis A Vaccine Provide Protection Against COVID-19?

Sarialioglu, Faik / Belen Apak, Fatma Burcu / Haberal, Mehmet

Exp Clin Transplant

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32279655
Database	COVID19

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Article ; Online: COVID-19 Patogenezinde Pulmoner İntravasküler Koagülasyon ve Tedavi Önerileri ; Pulmonary Intravascular Coagulation Pathogenesis in COVID-19 and Treatment Recommendations

SARIALİOĞLU, Faik / BELEN APAK, Fatma Burcu

Volume: 3, Issue: S1 106-110 ; 2651-4060 ; Sağlık Bilimlerinde İleri Araştırmalar Dergisi

2020

Abstract: Tüm dünyayı ve ülkemizi etkisi altına alan COVID-19 hastalığının patogenezinde koagülasyon sisteminin aktive olmasının önemli rolü olduğu, dissemine intravasküler koagülasyonun (DİK) laboratuvar bulgularından D-dimer değeri yüksek olan olgulara erken ... ...

Abstract	Tüm dünyayı ve ülkemizi etkisi altına alan COVID-19 hastalığının patogenezinde koagülasyon sisteminin aktive olmasının önemli rolü olduğu, dissemine intravasküler koagülasyonun (DİK) laboratuvar bulgularından D-dimer değeri yüksek olan olgulara erken dönemde düşük molekül ağırlıklı heparin (DMAH) başlanması durumunda mortalitenin azaldığı bilinmektedir. COVID-19 enfeksiyonundaki ana mekanizmalardan birinin sepsis ilişkili DİK’ten farklı organa özgü ‘Pulmoner İntravasküler Koagülasyon-PİK’ olduğunu düşünmekteyiz. Patogenetik mekanizmaları açıkladığımız derlememizde PİK erken dönemlerinde profilaktik dozda DMAH, D-dimer artışı devam etmesi durumunda tedavi dozunda DMAH, respiratuar yetmezlik gelişmesi durumunda kanama riski göz önünde bulundurularak doku plazminojen aktivatörü (tPA) ve defibrotid tedavilerinin kullanımı konusunda tedavi önerileri yer almaktadır. Bu tedavilerin COVID-19 enfeksiyonunun hangi aşamalarında kullanılmasının uygun olacağının netleştirilmesi için klinik araştırmalara gerek duyulmaktadır. It has been recently shown that the activation of the coagulation system takes an important part in the pathogenesis of COVID-19. It has come into insight that the mortality rate is lower in patients who were administered low molecular weight heparin (LMWH) during the course of COVID-19 when compared with those who were treated without LMWH. However, we observe that the coagulopathy accompanying COVID-19 seems to be different from sepsis associated disseminated intravascular coagulation (DIC), therefore we think that organ specific coagulopathy should be better named ‘Pulmonary Intravascular CoagulationPIC’. Here we provide possible pathogenetic mechanisms underlying COVID-19 including PIC and give treatment recommendations as administration of prophylactic LMWH at patients with increased D-dimer levels at early phase, escalation to treatment dose of LMWH in case of increasing D-dimers and usage of tPA or defibrotide with evaluation of bleeding risk in patients with respiratory insufficiency. However, in what point of COVID-19 disease shall those anticoagulant/antitrombotic-thrombolytic agents used must be evaluated with further studies.
Keywords	COVID-19,pulmoner intravasküler koagülasyon (PİK),düşük molekül ağırlıklı heparin (DMAH),doku plazminojen aktivatörü (tPA),defibrotid ; COVID-19,pulmonary intravascular coagulation (PİC),low molecular weight heparin,tissue plasminogen activator (tPA),defibrotide ; covid19
Language	Turkish
Publishing date	2020-05-15T00:00:00Z
Publisher	İstanbul Üniversitesi
Publishing country	tr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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