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  1. Article ; Online: Evolution and Impact of Nucleic Acid Amplification Test (NAAT) for Diagnosis of Coronavirus Disease.

    Khan, Sumbul Fatma / Rathod, Priyanka / Gupta, Vivek K / Khedekar, Pramod B / Chikhale, Rupesh V

    Analytical chemistry

    2024  

    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c05225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Methoxyacetone revisited.

    Sharma, Archna / Gupta, Vivek K / Reva, Igor

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2023  Volume 308, Page(s) 123651

    Abstract: Conformational space of methoxyacetone (MA) was studied at the MP2/6-311++G(d,p) and DFT(B3LYP)/6-311++G(d,p) levels of theory. Computations predict MA to adopt four conformations, resulting from internal rotations around the O=C-C-O (Trans, Cis) and C-C- ...

    Abstract Conformational space of methoxyacetone (MA) was studied at the MP2/6-311++G(d,p) and DFT(B3LYP)/6-311++G(d,p) levels of theory. Computations predict MA to adopt four conformations, resulting from internal rotations around the O=C-C-O (Trans, Cis) and C-C-O-C (trans, gauche) dihedral angles. The Tt (Trans-trans) conformer is the most stable. The computed energies of two gauche (Tg and Cg) conformers fall in the 3-8 kJ mol
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2023.123651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 51/98: Show issues
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  3. Article ; Online: Mechanical regulation of cell-cycle progression and division.

    Gupta, Vivek K / Chaudhuri, Ovijit

    Trends in cell biology

    2022  Volume 32, Issue 9, Page(s) 773–785

    Abstract: Cell-cycle progression and division are fundamental biological processes in animal cells, and their biochemical regulation has been extensively studied. An emerging body of work has revealed how mechanical interactions of cells with their ... ...

    Abstract Cell-cycle progression and division are fundamental biological processes in animal cells, and their biochemical regulation has been extensively studied. An emerging body of work has revealed how mechanical interactions of cells with their microenvironment in tissues, including with the extracellular matrix (ECM) and neighboring cells, also plays a crucial role in regulating cell-cycle progression and division. We review recent work on how cells interpret physical cues and alter their mechanics to promote cell-cycle progression and initiate cell division, and then on how dividing cells generate forces on their surrounding microenvironment to successfully divide. Finally, the article ends by discussing how force generation during division potentially contributes to larger tissue-scale processes involved in development and homeostasis.
    MeSH term(s) Animals ; Cell Division ; Extracellular Matrix ; Homeostasis ; Mechanotransduction, Cellular
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2022.03.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.MG 25: Show issues
    Zs.MO 113: Show issues
    Zs.A 3410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Development and Characterization of Folic Acid-Conjugated Amodiaquine-Loaded Nanoparticles-Efficacy in Cancer Treatment.

    Parvathaneni, Vineela / Shukla, Snehal K / Gupta, Vivek

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: The objective of this study was to construct amodiaquine-loaded, folic acid-conjugated polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial production. In this study, folic acid (FA) was conjugated with a PLGA polymer ... ...

    Abstract The objective of this study was to construct amodiaquine-loaded, folic acid-conjugated polymeric nanoparticles (FA-AQ NPs) to treat cancer that could be scaled to commercial production. In this study, folic acid (FA) was conjugated with a PLGA polymer followed by the formulation of drug-loaded NPs. The results of the conjugation efficiency confirmed the conjugation of FA with PLGA. The developed folic acid-conjugated nanoparticles demonstrated uniform particle size distributions and had visible spherical shapes under transmission electron microscopy. The cellular uptake results suggested that FA modification could enhance the cellular internalization of nanoparticulate systems in non-small cell lung cancer, cervical, and breast cancer cell types. Furthermore, cytotoxicity studies showed the superior efficacy of FA-AQ NPs in different cancer cells such as MDAMB-231 and HeLA. FA-AQ NPs had better anti-tumor abilities demonstrated via 3D spheroid cell culture studies. Therefore, FA-AQ NPs could be a promising drug delivery system for cancer therapy.
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15031001
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  5. Article ; Online: Analytical challenges and advancements in bioanalysis of therapeutic proteins.

    K Shukla, Snehal / Gupta, Vivek

    Bioanalysis

    2020  Volume 12, Issue 4, Page(s) 207–209

    MeSH term(s) Biosimilar Pharmaceuticals/chemistry ; Chromatography, Liquid/methods ; Electrophoresis, Capillary/methods ; Humans
    Chemical Substances Biosimilar Pharmaceuticals
    Language English
    Publishing date 2020-02-21
    Publishing country England
    Document type Editorial
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio-2020-0006
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  6. Article ; Online: Hash and Physical Unclonable Function (PUF)-Based Mutual Authentication Mechanism.

    Bhatia, Kavita / Pandey, Santosh K / Singh, Vivek K / Gupta, Deena Nath

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 14

    Abstract: The security of web applications in an enterprise is of paramount importance. To strengthen the security of applications, the identification and mitigation of vulnerabilities through appropriate countermeasures becomes imperative. The Open Web ... ...

    Abstract The security of web applications in an enterprise is of paramount importance. To strengthen the security of applications, the identification and mitigation of vulnerabilities through appropriate countermeasures becomes imperative. The Open Web Application Security Project (OWASP) Top 10 API Security Risks, 2023 Edition, indicates the prominent vulnerabilities of API security risks. Broken authentication, however, is placed in second position with level-3 exploitability, level-2 prevalence, level-3 detectability, and level-3 technical impact. To mitigate this vulnerability, many mitigation strategies have been proposed by using the cryptographic primitives wherein two techniques, namely hashing and PUF, are used. Some of the proposals have integrated the concepts of hashing and PUF. However, the unnecessarily lengthy and complex mathematics used in these proposals makes them unsuitable for current API-based application scenarios. Therefore, in this paper, the authors propose a privacy-preserving authentication protocol that incorporates the capability of both mechanisms in an easy and low-complexity manner. In addition to overcoming existing limitations, the proposed protocol is tested to provide more security properties over existing schemes. Analysis of their performance has demonstrated that the proposed solutions are secure, efficient, practical, and effective for API-based web applications in an enterprise environment.
    Language English
    Publishing date 2023-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23146307
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  7. Article ; Online: Transboundary hazard and downstream impact of glacial lakes in Hindu-Kush Karakoram Himalayas.

    Dubey, Saket / Sattar, Ashim / Gupta, Vivek / Goyal, Manish Kumar / Haritashya, Umesh K / Kargel, Jeffrey S

    The Science of the total environment

    2024  Volume 914, Page(s) 169758

    Abstract: Glacial Lake Outburst Floods (GLOFs) can generate catastrophic flash floods when the damming structure is breached or overtopped. Some of these glacial lakes are located in transboundary regions where floods originating from the lake in one country could ...

    Abstract Glacial Lake Outburst Floods (GLOFs) can generate catastrophic flash floods when the damming structure is breached or overtopped. Some of these glacial lakes are located in transboundary regions where floods originating from the lake in one country could inundate a neighboring country, devastating the population and infrastructure of both nations and influencing socio-political relationships. Therefore, assessing the lakes' hazard is crucial. This study investigates transboundary glacial lakes, considering their GLOF hazard, including potential mass movement intrusion, moraine's stability, upstream and downstream process cascades, downstream flood extents, and the exposure and vulnerability of the downstream infrastructure and affected population. GLOF exposure assessments were carried out to identify exposed buildings, bridges, and hydropower systems in transboundary regions. China currently has the highest number of transboundary lakes, with most of them potentially impacting India and Nepal. Most of the transboundary lakes in China, and many in India and Nepal, are susceptible to mass movements. Among the 230 transboundary glacial lakes in the Hindu Kush Karakoram Himalaya, 55 lakes can potentially impact other glacial lakes along their flow path, creating a cascade of events. Five transboundary lakes could potentially impact over 1000 buildings, and 16 lakes could impact over 500 buildings. A total of 35 lakes can impact at least one hydropower station along their flow path, and 4 lakes can impact two hydropower stations. This research emphasizes the critical importance of conducting comprehensive risk analyses of GLOFs in transboundary regions to inform policy-makers. It calls for investing in broad-scale assessments and data-driven decision-making for mitigating and adapting to GLOF risks effectively. Finally, by raising awareness among policy-makers, the study aims to drive actions that safeguard communities and infrastructure vulnerable to GLOF.
    Language English
    Publishing date 2024-01-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.169758
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Imaging human macular pigments with visible light optical coherence tomography and superluminescent diodes.

    Gupta, Alok K / Meng, Ruoyu / Modi, Yasha S / Srinivasan, Vivek J

    Optics letters

    2023  Volume 48, Issue 18, Page(s) 4737–4740

    Abstract: We demonstrate superluminescent diodes (SLDs) for visible light optical coherence tomography (OCT) of the human retina. SLDs are less costly than supercontinuum sources and have lower intrinsic excess noise, enabling imaging closer to the shot noise ... ...

    Abstract We demonstrate superluminescent diodes (SLDs) for visible light optical coherence tomography (OCT) of the human retina. SLDs are less costly than supercontinuum sources and have lower intrinsic excess noise, enabling imaging closer to the shot noise limit. While single SLDs are not broadband, they provide power concentrated at specific wavelengths relevant to retinal function. As a new, to the best of our knowledge, application, we image human macular pigments (MPs), which are thought to both aid vision and protect against advanced age-related macular degeneration. Using the unique depth-resolved capabilities of OCT, we localize MPs in depth to Henle's fibers beneath the foveal pit in the living human retina. Our approach reduces the cost of visible light OCT to nearly that of near-infrared (NIR) OCT while also providing information about clinically relevant MPs which cannot be measured in the NIR.
    MeSH term(s) Humans ; Tomography, Optical Coherence ; Macular Pigment ; Light ; Retina/diagnostic imaging
    Chemical Substances Macular Pigment
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.495247
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  9. Article: Subcutaneous dirofilariasis in children-An emerging zoonotic nematodal infection: A case series.

    Varghese Tharakan, K O / Chandran, Chandana / Pranala, Maanasi / Sanker, Vivek / Gupta, Umang

    Clinical case reports

    2023  Volume 11, Issue 6, Page(s) e7604

    Abstract: Human subcutaneous dirofilariasis is an infection caused by filarial worms. Due to the recent rise of human disease, it is considered as an emerging zoonosis. Most of the cases in children recorded in India had ocular infection; very few subcutaneous ... ...

    Abstract Human subcutaneous dirofilariasis is an infection caused by filarial worms. Due to the recent rise of human disease, it is considered as an emerging zoonosis. Most of the cases in children recorded in India had ocular infection; very few subcutaneous cases of dirofilariasis have been reported in children.
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7604
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  10. Article: Prevalence of Periodontal Disease among Patients Reporting to Tertiary Care Hospital in Ranchi.

    Verma, Santosh K / Singh, Neha / Jha, Awanindra K / Tigga, Chandmani / Noorani, Mohammad K / Ekram, Subia / Gupta, Vivek

    Journal of pharmacy & bioallied sciences

    2024  Volume 16, Issue Suppl 1, Page(s) S838–S840

    Abstract: Background: Despite a huge number of advancements in the medical field, periodontitis still remains one of the most prevalent oral diseases worldwide.: Aim: Thus, the primary aim of our study was to evaluate the prevalence of periodontal diseases in ... ...

    Abstract Background: Despite a huge number of advancements in the medical field, periodontitis still remains one of the most prevalent oral diseases worldwide.
    Aim: Thus, the primary aim of our study was to evaluate the prevalence of periodontal diseases in patients reporting to the tertiary healthcare setup in Ranchi.
    Materials and methods: Based on inclusion criteria, subjects aged 18-60 years were selected and a per forma was filled by the observer. The prevalence of periodontal disease was measured using the community periodontal index, simplified oral hygiene index, and stage of periodontitis.
    Results: Descriptive variables were assessed using frequency, percentage, mean, and standard deviations, while the categorical analysis was performed using the Chi-square tests.
    Conclusion: General awareness about periodontal health and regular dental visits should be given utmost importance among the rural populations of every developing country.
    Language English
    Publishing date 2024-02-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_1051_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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