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Article: Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis.

Cevher, Erdal / Orhan, Zafer / Sensoy, Demet / Ahiskali, Rengin / Kan, Pei Lee / Sağirli, Olcay / Mülazimoğlu, Lütfiye

2007 Volume 24, Issue 6, Page(s) 577–595

Abstract: Purpose: The aim of this study was to prepare poly(D,L-lactide-co-glycolide) (PLGA) microspheres ...

Abstract	Purpose: The aim of this study was to prepare poly(D,L-lactide-co-glycolide) (PLGA) microspheres containing sodium fusidate (SF) using a double emulsion solvent evaporation method with varying polymer:drug ratios (1:1, 2.5:1, 5:1) and to evaluate its efficiency for the local treatment of chronic osteomyelitis. Methods: The particle size and distribution, morphological characteristics, thermal behaviour, drug content, encapsulation efficiency and in vitro release assessments of the formulations had been carried out. Sterilized SF-PLGA microspheres were implanted in the proximal tibia of rats with methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. After 3 weeks of treatment, bone samples were analysed with a microbiological assay. Results: PLGA microspheres between the size ranges of 2.16-4.12 microm were obtained. Production yield of all formulations was found to be higher than 79% and encapsulation efficiencies of 19.8-34.3% were obtained. DSC thermogram showed that the SF was in an amorphous state in the microspheres and the glass transition temperature (T(g)) of PLGA was not influenced by the preparation procedure. In vitro drug release studies had indicated that these microspheres had significant burst release and their drug release rates were decreased upon increasing the polymer:drug ratio (p < 0.05). Based on the in vivo data, rats implanted with SF-PLGA microspheres and empty microspheres showed 1987 +/- 1196 and 55526 +/- 49086 colony forming unit of MRSA in 1 g bone samples (CFU/g), respectively (p < 0.01). Conclusion: The in vitro and in vivo studies had shown that the implanted SF loaded microspheres were found to be effective for the treatment of chronic osteomyelitis in an animal experimental model. Hence, these microspheres may be potentially useful in the clinical setting.
MeSH term(s)	Animals ; Calorimetry, Differential Scanning ; Chronic Disease ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Fusidic Acid/chemistry ; Lactic Acid/chemistry ; Male ; Methicillin Resistance/drug effects ; Microscopy, Electron, Scanning ; Microspheres ; Osteogenesis ; Osteomyelitis/diagnostic imaging ; Osteomyelitis/drug therapy ; Osteomyelitis/pathology ; Polyglycolic Acid/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polymers/chemistry ; Polyvinyl Alcohol/chemistry ; Radiography ; Rats ; Rats, Wistar ; Staphylococcus aureus/drug effects
Chemical Substances	Drug Carriers ; Polymers ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT) ; Fusidic Acid (59XE10C19C) ; Polyvinyl Alcohol (9002-89-5)
Language	English
Publishing date	2007-07-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652040701472584
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Article ; Online: Purely Endonasal Endoscopic Approaches for Extracranial Trigeminal Nerve Schwannoma.

Başak, Hazan / Mulazimoglu, Selcuk / Yucel, Levent / Beton, Suha / Meco, Cem

The Journal of craniofacial surgery

2022 Volume 33, Issue 8, Page(s) 2473–2476

Abstract: Objective: The aim of this study is to assess the effectiveness and safety of purely endonasal endoscopic resection of extracranial trigeminal schwannomas (TGSs), with assessment of surgical and clinical outcomes in order to identify optimal candidates ... ...

Abstract	Objective: The aim of this study is to assess the effectiveness and safety of purely endonasal endoscopic resection of extracranial trigeminal schwannomas (TGSs), with assessment of surgical and clinical outcomes in order to identify optimal candidates for an endonasal endoscopic approach (EEA). Methods: A retrospective review of patient's records operated for TGSs between 2008 and 2021 was conducted. Patients operated with a purely EEA were included in this study. Pictures from a frozen fresh cadaver head dissection were used to demonstrate the surgical approach and to show anatomic relationships, complexity of the surgical area and safe corridors for surgery. Results: A total of 5 patients (4 females and 1 male) were operated for TGS. All patients had facial numbness (100%) as a presenting symptom, followed by facial pain in 2 patients (40%), and orbital pain in 1 (20%). Also, 3 patients (60%) had a tumor originating at the level of the foramen ovale and 2 (40%) at the foramen rotundum. The mean tumor diameter was 3,7 ± 2 cm. Gross total resection were achieved in all cases. Postoperatively, 1 patient had severe mastication problems, 1 had blurred vision, and in the long-term follow-up, 1 had frontal sinusitis. The mean follow up was 106.6 (min:49, max:132, SD: 29.82) months. No recurrences were detected. Conclusions: In cases with the extradural TGS having limited extension into Posterior Cranial Fossa, or located in the Middle Cranial Fossa, a purely EEA is possible even for tumors bigger in size. Unilateral endonasal corridors are adequate for resection in most cases.
MeSH term(s)	Female ; Humans ; Male ; Cranial Nerve Neoplasms/surgery ; Neurilemmoma/surgery ; Neurilemmoma/pathology ; Nose/surgery ; Endoscopy ; Trigeminal Nerve/pathology
Language	English
Publishing date	2022-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000008687
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Role of Vitamin D, ACE2 and the Proteases as TMPRSS2 and Furin on SARS-CoV-2 Pathogenesis and COVID-19 Severity.

Ortatatli, Mesut / Fatsa, Tugba / Mulazimoglu, Deniz Dogan / Oren, Sema / Artuk, Cumhur / Hosbul, Tugrul / Kulahlioglu, Neslihan / Kenar, Levent

Archives of medical research

2023 Volume 54, Issue 3, Page(s) 223–230

Abstract: Background: COVID-19, the 21: Objective: In our study, the relationship between the pathogenesis and clinical severity of COVID-19 and vitamin D, ACE2, Furin and TMPRSS2 was investigated.: Methods: Serum 25(OH)D, 1,25(OH): Results: ... ...

Abstract	Background: COVID-19, the 21 Objective: In our study, the relationship between the pathogenesis and clinical severity of COVID-19 and vitamin D, ACE2, Furin and TMPRSS2 was investigated. Methods: Serum 25(OH)D, 1,25(OH) Results: Statistically significant differences were found between the severity of COVID-19 and all study parameters, except for serum 25(OH)D. A strong negative correlation was found between serum ACE2 protein, 1,25(OH) Conclusion: This study suggests that vitamin D supplementation could be beneficial in the treatment and/or prevention of COVID-19.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Furin/genetics ; Angiotensin-Converting Enzyme 2/genetics ; Peptide Hydrolases ; Vitamin D ; Leukocytes, Mononuclear/metabolism ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Serine Endopeptidases/genetics
Chemical Substances	Furin (EC 3.4.21.75) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Peptide Hydrolases (EC 3.4.-) ; Vitamin D (1406-16-2) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; TMPRSS2 protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1156844-6
ISSN	1873-5487 ; 0188-4409 ; 0188-0128
ISSN (online)	1873-5487
ISSN	0188-4409 ; 0188-0128
DOI	10.1016/j.arcmed.2023.02.002
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Article ; Online: Abdominal Splenosis Mimicking Peritoneal Metastasis in Prostate-Specific Membrane Antigen PET/CT, Confirmed With Selective Spleen SPECT/CT.

Demirci, Emre / Has Simsek, Duygu / Kabasakal, Levent / Mülazimoğlu, Mehmet

Clinical nuclear medicine

2017 Volume 42, Issue 12, Page(s) e504–e505

Abstract: Ga-prostate-specific membrane antigen (PSMA) PET/CT is a rapidly evolving diagnostic technique to image prostate cancer. In contrast to the name PSMA, various tissues show Ga-PSMA uptake in PET/CT imaging. We present a case of a 68-year-old man with ... ...

Abstract	Ga-prostate-specific membrane antigen (PSMA) PET/CT is a rapidly evolving diagnostic technique to image prostate cancer. In contrast to the name PSMA, various tissues show Ga-PSMA uptake in PET/CT imaging. We present a case of a 68-year-old man with prostate cancer who underwent Ga-PSMA PET/CT. Along with metastatic lymph nodes, multiple nodular lesions within the peritoneal spaces of all 4 quadrants of the abdomen showed high PSMA expression. Because of a history of splenic rupture, a Tc-labeled heat-denatured erythrocyte scintigraphy and SPECT were performed. Peritoneal lesions showed high uptake, confirming widespread peritoneal splenosis.
MeSH term(s)	Aged ; Antigens, Surface/metabolism ; Diagnosis, Differential ; Glutamate Carboxypeptidase II/metabolism ; Humans ; Male ; Peritoneal Neoplasms/diagnostic imaging ; Peritoneal Neoplasms/secondary ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/pathology ; Single Photon Emission Computed Tomography Computed Tomography ; Spleen/diagnostic imaging ; Splenosis/diagnostic imaging
Chemical Substances	Antigens, Surface ; FOLH1 protein, human (EC 3.4.17.21) ; Glutamate Carboxypeptidase II (EC 3.4.17.21)
Language	English
Publishing date	2017-11-16
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000001878
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Zs.A 1276: Show issues

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Article ; Online: A prospective study: inflammation, infection and comorbidity in patients on long-term dialysis.

Akbaş, Türkay / Mülazımoğlu, Lütfiye / Aksu, Burak / Akoğlu, Emel

Journal of renal care

2014 Volume 40, Issue 1, Page(s) 6–13

Abstract: ... 3 mg/l, ESR >50 mm/hour and fibrinogen >4 g/l were, respectively, 63.1%, 60.4%, 48.6% and 42.3 ...

Abstract	Background: The goal of this study was to identify inflammatory and infectious markers and their roles in mortality. Methods: We enrolled 111 patients on haemodialysis (HD) and collected data at three time points (baseline, 33 and 76 months). Results: Rates of Chlamydophila pneumoniae IgG, CRP ≥3 mg/l, ESR >50 mm/hour and fibrinogen >4 g/l were, respectively, 63.1%, 60.4%, 48.6% and 42.3%. Mortality was 21.6% and 43.2% at 33 and 76 months where 58.3% of all deaths were cardiocerebrovascular (CCV) related. Non-survivors were older than survivors. Univariate analysis showed diabetes mellitus (DM) and cerebrovascular accident (CVA) as important for the 33-month all-cause mortality, and CRPlog , fibrinogen, ESR >50 mm/hour, cardiovascular disease (CVD) and DM for the 76-month all-cause mortality. CVA was meaningful for the 33-month CCV mortality, and CVD, DM and ESR >50 mm/hour for the 76-month CCV mortality. Kaplan-Meier revealed poorer survival for patients with ESR >50 mm/hour at 76 months. Cox regression showed CVD, CVA and age as mortality predictors. Conclusion: Age, CVD and CVA are predictors for mortality in patients on HD patients, but the presence of C. pneumoniae IgG and inflammation are not.
MeSH term(s)	Aged ; Antibodies, Bacterial/blood ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Cardiovascular Diseases/epidemiology ; Chlamydophila Infections/epidemiology ; Chlamydophila pneumoniae/immunology ; Chlamydophila pneumoniae/isolation & purification ; Comorbidity ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Humans ; Immunoglobulin G/blood ; Inflammation/epidemiology ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Renal Dialysis ; Risk Factors ; Stroke/epidemiology ; Survival Analysis
Chemical Substances	Antibodies, Bacterial ; Biomarkers ; Immunoglobulin G ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2014-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375362-6
ISSN	1755-6686 ; 1755-6678 ; 1019-083X
ISSN (online)	1755-6686
ISSN	1755-6678 ; 1019-083X
DOI	10.1002/jorc.12042
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Article ; Online: Factors Associated with 28-day Critical Illness Development During the First Wave of COVID-19.

Infectious diseases & clinical microbiology

2023 Volume 5, Issue 2, Page(s) 94–105

Abstract: Objective: This study aimed to define the predictors of critical illness development within 28 days postadmission during the first wave of the COVID-19 pandemic.: Materials and methods: We conducted a prospective cohort study including 477 PCR- ... ...

Abstract	Objective: This study aimed to define the predictors of critical illness development within 28 days postadmission during the first wave of the COVID-19 pandemic. Materials and methods: We conducted a prospective cohort study including 477 PCR-positive COVID-19 patients admitted to a tertiary care hospital in Istanbul from March 12 to May 12, 2020. Results: The most common presenting symptoms were cough, dyspnea, and fatigue. Critical illness developed in 45 (9.4%; 95% CI=7.0%-12.4%) patients. In the multivariable analysis, age (hazard ratio (HR)=1.05, Conclusion: Age, comorbidity number, the WHO scale, LDH, and procalcitonin were independently associated with critical illness development. Mortality from COVID-19 seemed to be decreasing as the first wave of the pandemic advanced. Graphic abstract: Graphic Abstract.
Language	English
Publishing date	2023-06-23
Publishing country	Turkey
Document type	Journal Article
ISSN	2667-646X
ISSN (online)	2667-646X
DOI	10.36519/idcm.2023.206
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Article: Alloprevotella rava

Ulger Toprak, N / Duman, N / Sacak, B / Ozkan, M C / Sayın, E / Mulazimoglu, L / Soyletir, G

New microbes and new infections

2021 Volume 42, Page(s) 100880

Abstract: The anaerobic, Gram-negative ... ...

Abstract	The anaerobic, Gram-negative bacillus
Language	English
Publishing date	2021-04-14
Publishing country	England
Document type	Case Reports
ZDB-ID	2750179-6
ISSN	2052-2975
ISSN	2052-2975
DOI	10.1016/j.nmni.2021.100880
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Article: Treatment of community-acquired pneumonia in hospitalised patients.

Mulazimoglu, L

International journal of antimicrobial agents

2001 Volume 18 Suppl 1, Page(s) S63–70

Abstract: Community-acquired pneumonia (CAP) can be life-threatening. The prognosis is generally poorest in elderly patients and/or those with underlying chronic conditions, but fatalities can occur in all age groups. Current challenges in the clinical management ... ...

Abstract	Community-acquired pneumonia (CAP) can be life-threatening. The prognosis is generally poorest in elderly patients and/or those with underlying chronic conditions, but fatalities can occur in all age groups. Current challenges in the clinical management of CAP are discussed, and the criteria for identifying those patients who should be treated in hospital with initial intravenous therapy are considered. Rapid initiation of therapy is important, using an agent that provides coverage against the most likely pathogens--Streptococcus pneumoniae and the atypical organisms. There is an increasing tendency to minimise the duration of intravenous therapy, with an early transition to oral therapy and the rapid return of the patient to the community. The efficacy of oral macrolides in the treatment of CAP is well established. Evidence for the use of intravenous azithromycin to provide effective and well-tolerated, first-line intervention in the hospitalized CAP patient is summarised.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/economics ; Anti-Bacterial Agents/therapeutic use ; Community-Acquired Infections/complications ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Community-Acquired Infections/mortality ; Drug Interactions ; Drug Therapy, Combination ; Hospitalization ; Humans ; Injections, Intravenous ; Macrolides ; Pneumonia, Bacterial/diagnosis ; Pneumonia, Bacterial/drug therapy ; Pneumonia, Bacterial/microbiology ; Pneumonia, Bacterial/mortality ; Risk Factors
Chemical Substances	Anti-Bacterial Agents ; Macrolides
Language	English
Publishing date	2001
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/s0924-8579(01)00400-9
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 500: Show issues

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Article: Pulmonary Delivery of Favipiravir in Rats Reaches High Local Concentrations without Causing Oxidative Lung Injury or Systemic Side Effects.

Akbal-Dagistan, Ozlem / Sevim, Mustafa / Sen, Leyla Semiha / Basarir, Nur Sena / Culha, Meltem / Erturk, Aybige / Fael, Hanan / Kaptan, Engin / Sancar, Serap / Mulazimoglu Durmusoglu, Lutfiye / Yegen, Berrak C / Yildiz-Pekoz, Ayca

Pharmaceutics

2022 Volume 14, Issue 11

Abstract: Favipiravir displays a rapid viral clearance, a high recovery rate and broad therapeutic safety; however, its oral administration was associated with systemic side effects in susceptible patients. Considering that the pulmonary route could provide a high ...

Abstract	Favipiravir displays a rapid viral clearance, a high recovery rate and broad therapeutic safety; however, its oral administration was associated with systemic side effects in susceptible patients. Considering that the pulmonary route could provide a high drug concentration, and a safer application with less absorption into systemic circulation, it was aimed to elucidate whether favipiravir delivered via soft-mist inhaler has any deleterious effects on lung, liver and kidney tissues of healthy rats. Wistar albino rats of both sexes (n = 72) were placed in restrainers, and were given either saline or favipiravir (1, 2.5, 5 or 10 mg/kg in 1 mL saline) by inhalation within 2 min for 5 consecutive days. On the 6th day, electrocardiographic recording was obtained, and cardiac blood and lung tissues were collected. Favipiravir did not alter cardiac rhythm, blood cell counts, serum levels of alanine transaminase, aspartate transaminase, blood urea nitrogen, creatinine, urea or uric acid, and did not cause any significant changes in the pulmonary malondialdehyde, myeloperoxidase activity or antioxidant glutathione levels. Our data revealed that pulmonary use of favipiravir via soft-mist inhaler enables a high local concentration compared to plasma without oxidative lung injury or cardiac or hepatorenal dysfunction.
Language	English
Publishing date	2022-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14112375
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Article ; Online: The effect of immunization with inactivated SARS-CoV-2 vaccine (CoronaVac) and/or SARS-CoV-2 infection on antibody levels, plasmablasts, long-lived-plasma-cells, and IFN-γ release by natural killer cells.

Bilgin, Huseyin / Marku, Marisa / Yilmaz, Sultan Seval / Karahasan Yagci, Aysegul / Sili, Uluhan / Can, Baris / Can Sarinoglu, Rabia / Mulazimoglu Durmusoglu, Lutfiye / Haklar, Goncagul / Sirikci, Onder / Eksioglu Demiralp, Emel

Vaccine

2022 Volume 40, Issue 18, Page(s) 2619–2625

Abstract: Objectives: We evaluated the antibody response, natural killer cell response and B cell phenotypes in healthcare workers (HCW) who are vaccinated with two doses of CoronaVac with or without documented SARS-CoV-2 infection and unvaccinated HCWs with SARS- ...

Abstract	Objectives: We evaluated the antibody response, natural killer cell response and B cell phenotypes in healthcare workers (HCW) who are vaccinated with two doses of CoronaVac with or without documented SARS-CoV-2 infection and unvaccinated HCWs with SARS-CoV-2 infection. Methods: HCWs were divided into four groups: vaccine only (VO), vaccine after SARS-CoV-2 infection (VAI), SARS-CoV-2 infection only (IO), and SARS-CoV-2 infection after vaccine (IAV). Anti-SARS-CoV-2 spike protein (Anti-S) antibodies were measured by Elecsys Anti-SARS-CoV-2 S ELISA kit. Memory B cells (CD19 Results: The Anti-S antibodies were detectable in all HCWs (n: 224). The median Anti-S titers (BAU/mL) was significantly higher in VAI (620 25-75% 373-1341) compared to VO (136, 25-75% 85-283) and IO (111, 25-75% 54-413, p < 0.01). VAI group had significantly lower percentage of plasmablasts (2.9; 0-8.7) compared to VO (6.8; 3.5-12.0) and IO (9.9; 4.7-47.5, p < 0.01) (n:74). Percentage of LLPCs in groups VO, VAI and IO was similar. There was no difference of IFN-γ levels between the study groups (n: 76). Conclusion: The antibody response was similar between uninfected vaccinated HCWs and unvaccinated HCWs who had natural infection. HCWs who had two doses of CoronaVac either before or after the natural SARS-CoV-2 infection elicited significantly higher antibody responses compared to uninfected vaccinated HCWs. The lower percentages of plasmablasts in the VAI group may indicate their migration to lymph nodes and initiation of the germinal center reaction phase. IFN-γ response did not differ among the groups.
MeSH term(s)	Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Interferon-gamma ; Killer Cells, Natural ; Plasma Cells ; SARS-CoV-2 ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2022-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.03.001
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